Article ; Online: Inflammatory biomarkers in polymyositis/dermatomyositis patients with interstitial lung disease: a retrospective study.
Current medical research and opinion
2024 Volume 40, Issue 1, Page(s) 113–122
Abstract: Background: Dermatomyositis (DM)/polymyositis (PM) is a systemic autoimmune disease characterized by proximal limb muscle with high morbidity and mortality and poor prognosis mediated by immune dysfunction; its etiology is unknown. DM/PM patients are at ...
| Abstract | Background: Dermatomyositis (DM)/polymyositis (PM) is a systemic autoimmune disease characterized by proximal limb muscle with high morbidity and mortality and poor prognosis mediated by immune dysfunction; its etiology is unknown. DM/PM patients are at excessive risk of interstitial lung disease (ILD) and a higher risk of death. However, the role of circulating lymphocyte subsets, which play a pivotal role in occurrence and progression of DM/PM and ILD, respectively, remains unclear in DM/PM patients with ILD. Methods: Demographic characteristics, general data, and peripheral lymphocyte levels measured by flow cytometry were collected and analyzed in 47 DM/PM patients with ILD, 65 patients without ILD, and 105 healthy controls (HCs). Results: The most important first symptom of DM/PM patients is rash. Compared with non-ILD patients, the levels of neutrophil/lymphocyte ratio (NLR), systemic inflammatory response index (SIRI) were significantly higher and the levels of C reactive protein (CRP) were significantly lower in patients with ILD. Compared with HCs, DM/PM patients, with or without ILD, had decreased absolute counts of T, CD4 + T, CD8 + T, natural killer (NK), helper T (Th) 1, Th2, Th17, and regulatory T (Treg)cells. The fewest Th1 and Treg cells and the the lowest CD8 + T and Th1 cells percentages were seen in peripheral blood of patients with ILD. Longer duration, decreased lymphocyte/monocyte ratio (LMR)levels and CD8 + T and Th1 cells proportions, and fewer circulating Treg cells were independent risk factors for DM/PM with ILD. Conclusions: The identification of peripheral blood T lymphocyte subsets, especially Treg cells, and blood count in DM/PM appears to be useful in the comprehensive assessment of clinical lung involvement. |
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| MeSH term(s) | Humans ; Dermatomyositis/complications ; Retrospective Studies ; Polymyositis/complications ; Lung Diseases, Interstitial/complications ; Lung Diseases, Interstitial/diagnosis ; Biomarkers ; Prognosis |
| Chemical Substances | Biomarkers |
| Language | English |
| Publishing date | 2024-01-03 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 80296-7 |
| ISSN | 1473-4877 ; 0300-7995 |
| ISSN (online) | 1473-4877 |
| ISSN | 0300-7995 |
| DOI | 10.1080/03007995.2023.2281501 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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