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Article: Real-World Study on Chai-Shi-Jie-Du Granules for the Treatment of Dengue Fever and the Possible Mechanisms Based on Network Pharmacology.

Yang, Huiqin / Ma, Dehong / Li, Qin / Zhou, Wen / Chen, Hongyi / Shan, Xiyun / Zheng, Haipeng / Luo, Chun / Ou, Zhiyue / Xu, Jielan / Wang, Changtai / Zhao, Lingzhai / Su, Rui / Chen, Yuehong / Liu, Qingquan / Tan, Xinghua / Lin, Luping / Jiang, Tao / Zhang, Fuchun

Evidence-based complementary and alternative medicine : eCAM

2023 Volume 2023, Page(s) 9942842

Abstract: ... for dengue fever. This real-world study aimed to evaluate the effects of Chai-Shi-Jie-Du (CSJD) granules ...

Abstract	Objectives: Traditional Chinese medicine (TCM) is a widely used method for treating dengue fever in China. TCM improves the symptoms of patients with dengue, but there is no standard TCM prescription for dengue fever. This real-world study aimed to evaluate the effects of Chai-Shi-Jie-Du (CSJD) granules for the treatment of dengue fever and the underlying mechanisms. Methods: We implemented a multicenter real-world study, an Results: 137 pairs of patients were successfully matched according to age, sex, and the time from onset to presentation. The time to defervescence (1.7 days vs. 2.5 days, Conclusions: CSJD granules exhibit high potential for the treatment of dengue fever, and the therapeutic mechanisms involved could be related to regulating immunity, moderating the oxidative stress response, and the response to lipopolysaccharide.
Language	English
Publishing date	2023-08-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2023/9942842
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5995: Show issues

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Article: Identification of Significant Modules and Targets of Xian-Lian-Jie-Du Decoction Based on the Analysis of Transcriptomics, Proteomics and Single-Cell Transcriptomics in Colorectal Tumor.

Yu, Cheng-Tao / Chen, Tongqing / Lu, Sicheng / Hu, Wenlong / Zhang, Qinchang / Tan, Jiani / Sun, Dongdong / Li, Liu / Sun, Xin / Xu, Changliang / Lai, Yueyang / Fan, Minmin / Shen, Zhengjie / Shen, Weixing / Cheng, Haibo

Journal of inflammation research

2022 Volume 15, Page(s) 1483–1499

Abstract: ... medicine prescription, Xian-Lian-Jie-Du decoction (XLJDD), has been proven its efficacy in some UC-CRC ...

Abstract	Purpose: Colorectal cancer (CRC) remains the third most common tumor worldwide. Ulcerative colitis (UC) could cause chronic inflammation and ulcers in the colon and rectum. UC is a risk factor for a high incidence of CRC, and the incidence of UC-associated CRC (UC-CRC) is still increasing. Chinese medicine prescription, Xian-Lian-Jie-Du decoction (XLJDD), has been proven its efficacy in some UC-CRC patients. However, the mechanism of XLJDD in treating UC-CRC remains unknown. This study aimed to investigate the mechanism of XLJDD in treating UC-CRC. Methods: We constructed an AOM/DSS mouse model that could simulate the various stages of UC-CRC in humans. XLJDD and its 5 main components are used to treat the AOM/DSS model, respectively. With the power of high-throughput sequencing technology, we described the mechanism of XLJDD from transcriptomics, proteomics, and single-cell transcriptomics. Results: Our results showed that XLJDD could effectively suppress the occurrence and development of colorectal tumors. Using the weighted correlation network analysis (WGCNA), several mRNA and protein modules that respond to XLJDD have been identified. Moreover, two essential genes, Mfsd2a and Ccdc85c, were caught our attention. They were prognostic markers in CRC patients, and their expression could be significantly modulated by XLJDD, showing their potential as effective targets of XLJDD. In addition, we also discovered that XLJDD could affect the cell composition of the colorectal tumor environment, especially in the infiltration of B cells. Conclusion: We demonstrated that XLJDD could prevent the initiation and development of colorectal tumors by modulating the expression of Mfsd2a and Ccdc85c and reducing the infiltration of B cells in the tumor microenvironment of colorectal tumor.
Language	English
Publishing date	2022-03-01
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494878-0
ISSN	1178-7031
ISSN	1178-7031
DOI	10.2147/JIR.S344861
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Article ; Online: Effects and mechanism of action of Huang-Lian-Jie-Du-Tang in atopic dermatitis-like skin dysfunction in vivo and in vitro.

Fan, Hui-Jie / Zhao, Xiao-Shan / Tan, Zhang-Bin / Liu, Bin / Xu, Hong-Lin / Wu, Yu-Ting / Xie, Ling-Peng / Bi, Yi-Ming / Lai, Yi-Gui / Liang, Hong-Feng / Zhou, Ying-Chun

Journal of ethnopharmacology

2019 Volume 240, Page(s) 111937

Abstract: ... adulthood, seriously affects the patient's quality of life. Although Huang-Lian-Jie-Du-Tang (HLJDT) has ...

Abstract	Ethnopharmacological relevance: Atopic dermatitis (AD), a disorder prevalent during childhood and adulthood, seriously affects the patient's quality of life. Although Huang-Lian-Jie-Du-Tang (HLJDT) has shown anti-inflammatory effects in previous studies, its effects and mechanism of action underlying AD disorder are still largely unknown. Objective: This study explored the anti-inflammatory and immunomodulatory effects of HLJDT on the AD-like dermal disorder, induced in vitro by lipopolysaccharide (LPS)-triggered inflammation, and in vivo by 2,4-dinitrochlorobenzene (DNCB). Materials and methods: In vivo HLJDT effects were investigated by determining the severity of dermatitis, which consisted of observing signs of skin lesions, visually and through haematoxylin and eosin (HE) staining, in mouse ears and dorsal skin, measuring serum levels of interleukin (IL)-1α, IL-1β, IL-2, IL-4, IL-5, IL-6, interferon (IFN)-γ, the tumour necrosis factor (TNF)-α, and determining the splenic index, number of splenic CD4 Results: HLJDT could remarkably mitigate DNCB-induced AD-like lesion symptoms, alleviating inflammatory mediator infiltration in mouse ears and dorsal skin tissue, down-regulating serum expression levels of IL-1α, IL-1β, IL-2, IL-4, IL-5, IL-6, IFN-γ, and TNF-α, normalising the splenic CD4 Conclusions: HLJDT significantly improved AD-like symptoms via inhibition of the MAPKs/NF-κB pathway. Therefore, administration of HLJDT might be a potential treatment for AD in the clinical setting.
MeSH term(s)	Animals ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; CD4-CD8 Ratio ; Cytokines/immunology ; Dermatitis, Atopic/chemically induced ; Dermatitis, Atopic/drug therapy ; Dermatitis, Atopic/immunology ; Dinitrochlorobenzene ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Immunologic Factors/pharmacology ; Immunologic Factors/therapeutic use ; Lipopolysaccharides ; Male ; Mice ; Mitogen-Activated Protein Kinases/immunology ; NF-kappa B/immunology ; RAW 264.7 Cells ; Skin/drug effects ; Skin/immunology
Chemical Substances	Anti-Inflammatory Agents ; Cytokines ; Drugs, Chinese Herbal ; Immunologic Factors ; Lipopolysaccharides ; NF-kappa B ; huang-lien-chieh-tu-tang ; Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Dinitrochlorobenzene (GE3IBT7BMN)
Language	English
Publishing date	2019-05-07
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2019.111937
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Zs.A 1494: Show issues

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Article: Effects and mechanism of action of Huang-Lian-Jie-Du-Tang in atopic dermatitis-like skin dysfunction in vivo and in vitro

Fan, Hui-Jie / Zhao, Xiao-Shan / Tan, Zhang-Bin / Liu, Bin / Xu, Hong-Lin / Wu, Yu-Ting / Xie, Ling-Peng / Bi, Yi-Ming / Lai, Yi-Gui / Liang, Hong-Feng / Zhou, Ying-Chun

Journal of ethnopharmacology. 2019 Aug. 10, v. 240

2019

Abstract: ... the patient's quality of life. Although Huang-Lian-Jie-Du-Tang (HLJDT) has shown anti-inflammatory effects ...

Abstract	Atopic dermatitis (AD), a disorder prevalent during childhood and adulthood, seriously affects the patient's quality of life. Although Huang-Lian-Jie-Du-Tang (HLJDT) has shown anti-inflammatory effects in previous studies, its effects and mechanism of action underlying AD disorder are still largely unknown.This study explored the anti-inflammatory and immunomodulatory effects of HLJDT on the AD-like dermal disorder, induced in vitro by lipopolysaccharide (LPS)-triggered inflammation, and in vivo by 2,4-dinitrochlorobenzene (DNCB).In vivo HLJDT effects were investigated by determining the severity of dermatitis, which consisted of observing signs of skin lesions, visually and through haematoxylin and eosin (HE) staining, in mouse ears and dorsal skin, measuring serum levels of interleukin (IL)-1α, IL-1β, IL-2, IL-4, IL-5, IL-6, interferon (IFN)-γ, the tumour necrosis factor (TNF)-α, and determining the splenic index, number of splenic CD4+/CD8+ T-lymphocytes, as well as the phosphorylation levels of mitogen-activated protein kinases (including MAPKs-p38, ERK, and JNK), IκB-α, and nuclear factor kappa B (NF-κB) (p65) within dermal lesions. Morphological changes in LPS-induced inflammation were observed under a microscope, and ELISA and qPCR assays were used to measure IL-1α, IL-1β, IL-6, and TNF-α expression levels. The protein expression levels of P-ERK/ERK, P-p38/p38, P-JNK/JNK, P-IKβ-α, and P-p65 were measured through western blotting. Additionally, p65 expression was assessed by immunofluorescence, and LPS binding to RAW264.7 cell membrane was studied with laser confocal microscopy.HLJDT could remarkably mitigate DNCB-induced AD-like lesion symptoms, alleviating inflammatory mediator infiltration in mouse ears and dorsal skin tissue, down-regulating serum expression levels of IL-1α, IL-1β, IL-2, IL-4, IL-5, IL-6, IFN-γ, and TNF-α, normalising the splenic CD4+/CD8+ T-lymphocyte ratio, and inactivating MAPKs (including p38, ERK, and JNK), IκB-α, and NF-κB (p65) in dorsal skin. Furthermore, HLJDT inhibited LPS-induced differentiation of RAW264.7 cells, as evidenced by the decreased protein and mRNA expression of IL-1α, IL-1β, IL-6, and TNF-α. Additionally, it decreased ERK, p38, JNK, IKβ-α, and p65 phosphorylation levels in the MAPKs/NF-κB pathway, inhibited p65 nuclear translocation, and reduced LPS binding to the RAW264.7 cell membrane.HLJDT significantly improved AD-like symptoms via inhibition of the MAPKs/NF-κB pathway. Therefore, administration of HLJDT might be a potential treatment for AD in the clinical setting.
Keywords	CD8-positive T-lymphocytes ; Western blotting ; adulthood ; anti-inflammatory activity ; atopic dermatitis ; blood serum ; cell membranes ; childhood ; ears ; enzyme-linked immunosorbent assay ; eosin ; fluorescent antibody technique ; gene expression ; inflammation ; interferon-gamma ; interleukin-1alpha ; interleukin-1beta ; interleukin-2 ; interleukin-4 ; interleukin-5 ; interleukin-6 ; lipopolysaccharides ; mechanism of action ; mice ; mitogen-activated protein kinase ; patients ; phosphorylation ; protein synthesis ; quality of life ; quantitative polymerase chain reaction ; skin lesions ; staining ; traditional medicine ; transcription factor NF-kappa B ; tumor necrosis factor-alpha
Language	English
Dates of publication	2019-0810
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2019.111937
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Identification of the absorbed components and metabolites of Xiao-Ai-Jie-Du decoction and their distribution in rats using ultra high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry.

Fan, Huisen / Liu, Shijia / Shen, Weixing / Kang, An / Tan, Jiani / Li, Liu / Liu, Xiao / Xu, Changliang / Xu, Xuefen / Lai, Yueyang / Cheng, Haibo / Sun, Dongdong

Journal of pharmaceutical and biomedical analysis

2019 Volume 179, Page(s) 112984

Abstract: Xiao-Ai-Jie-Du decoction (XAJDD), a traditional Chinese medicine formula, has long been used ...

Abstract	Xiao-Ai-Jie-Du decoction (XAJDD), a traditional Chinese medicine formula, has long been used for the treatment of hepatocarcinoma, gastric cancer and colorectal cancer. It is composed of six herbal medicines, including Scutellariae Barbatae Herba, Pseudostellariae Radix, Ophiopogonis Radix, Cremastrae Pseudobulbus, Curcumae Rhizoma and Akebiae Fructus. Despite the in-depth study on its pharmacological effects on cancer prevention and treatment, the comprehensive analysis of the chemical components and the absorbed bioactive constituents are not well studied. Thus, an ultra-high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS) method was established to detect and identify the chemical constituents in XAJDD. The absorbed components and metabolites after oral administration of XAJDD in rats were also studied. In total, 102 components were identified or tentatively characterized in XAJDD, including 30 flavonoids, 19 triterpenoids, 12 organic acids, 9 steroidal saponins, 9 cyclic peptides, 7 phenanthrenes, 5 amino acids, 3 alkaloids and 8 other compounds. After analysing the metabolites in rat plasma and urine after oral administration of XAJDD, a total of 70 compounds were identified, including 15 primary components and 55 metabolites, and metabolic pathways, including hydrogenation, hydroxylation, methylation, sulfonation, and glucuronidation were evaluated. Among these, methylation and glucuronidation were the main metabolic pathways. In conclusion, the developed UHPLC-Q-TOF-MS method with high sensitivity and resolution is suitable for identifying and characterizing the chemical constituents of XAJDD in vitro and characterizing the primary components and their metabolites in vivo; moreover, the results will provide essential data for further studying the relationship between the chemical components and pharmacological activity of XAJDD.
MeSH term(s)	Acids/analysis ; Animals ; Chromatography, High Pressure Liquid/methods ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacokinetics ; Flavonoids/analysis ; Male ; Rats ; Saponins/analysis ; Tandem Mass Spectrometry/methods ; Tissue Distribution ; Triterpenes/analysis
Chemical Substances	Acids ; Drugs, Chinese Herbal ; Flavonoids ; Saponins ; Triterpenes ; xiaoai jiedu recipe
Language	English
Publishing date	2019-11-10
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2019.112984
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Zs.A 1850: Show issues

Location:
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Jg. 1995 - 2021: Lesesall (1.OG)
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Book: Duan wu jie

Tan, Shaobing

(Zhong guo chuan tong jie ri wen hua yan jiu : 中国传统节日文化研究 ; / Zhang xiao hua zhu bian ; 1)

2007

Author's details	Tan shao bing bian zhu
Series title	Zhong guo chuan tong jie ri wen hua yan jiu : 中国传统节日文化研究 / Zhang xiao hua zhu bian ; 1
Language	Chinese
Size	6, 2, 125 p
Edition	Bei jing di 1 ban
Publisher	Zhong guo qing nian chu ban she
Publishing place	Bei jing
Document type	Book
ISBN	9787500675372 ; 7500675372
Database	Former special subject collection: coastal and deep sea fishing

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Book: Tu jie Si bu yi dian

Gʼyu-thog Yon-tan-mgon-po

(Tu jie jing dian xi lie ; 3)

2006

Title translation	Rgyud bźiʼi brda bkrol.
Author's details	Yutuo Yuandangongbu yuan zhu ; Zitu bian hui
Series title	Tu jie jing dian xi lie ; 3
MeSH term(s)	Medicine, Tibetan Traditional
Language	Chinese
Size	287 p. :, col. ill. (1 folded) ;, 24 cm.
Edition	Di 1 ban.
Publisher	Shaanxi shi fan da xue chu ban she
Publishing place	Xi'an
Document type	Book
ISBN	9787561337424 ; 7561337426
Database	Catalogue of the US National Library of Medicine (NLM)

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Book: Tu jie Si bu yi dian

Gʼyu-thog Yon-tan-mgon-po

(Tu jie jing dian xi lie ; 10)

2006

Title translation	Rgyud bźi.
Title variant	Ren shi Zang shi yang sheng mi fa
Author's details	Yutuo Yuandangongbu yuan zhu ; Disi Sangjijiacuo yuan hui ; Zitu bian hui
Series title	Tu jie jing dian xi lie ; 10
MeSH term(s)	Medicine, Tibetan Traditional
Language	Chinese
Size	311 p. :, col. ill. ;, 24 cm.
Edition	Di 1 ban.
Publisher	Shaanxi shi fan da xue chu ban she
Publishing place	Xi'an
Document type	Book
ISBN	9787561337691 ; 7561337698
Database	Catalogue of the US National Library of Medicine (NLM)

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Book: Kou qiang zhong zhi guan jian ji shu shi zhan tu jie

Tan, Zhen

Color atlas of the key techniques in implant dentistry

2014

Title variant	Color atlas of the key techniques in implant dentistry
Author's details	zhu bian Tan Zhen
MeSH term(s)	Dental Implantation/methods ; Dental Implants ; Technology, Dental/methods
Language	Chinese
Size	403 pages :, illustrations, portrait
Edition	Di 1 ban.
Document type	Book
ISBN	9787117186186 ; 7117186186
Database	Catalogue of the US National Library of Medicine (NLM)

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Article: [The effect of "huang lian jie du tang" active fraction on experimental cerebral ischemia].

Wu, Yan / Sun, Jianning / Zhang, Ailin / Deng, Yun / Shi, Renbing / Tan, Tao / Sun, Wenyan

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials

2004 Volume 27, Issue 5, Page(s) 357–360

Abstract: Objective: To study the protective effect of "Huang Lian Jie Du Tang" active fraction (HLJDTAF ...

Abstract	Objective: To study the protective effect of "Huang Lian Jie Du Tang" active fraction (HLJDTAF) on experimental cerebral ischemia. Methods: Middle cerebral artery occlusion (MCAO) in rats was used to observe the protective effect of HLJDTAF on ischemia stroke. Common carotid artery occlusion (CCAO) rat was used to analyse the effect of HLJDTAF on blood brain barrier (BBB) permeability. Common carotid artery occlusion and reperfusion repeatedly (CCAORR) in mice were used to test effect of HLJDTAF on gasp time, brain exponential and water content of brain. Results: HLJDTAF could improve the abnormal behavior of MCAO rats and decrease the infarction area (P < 0. 05, P < 0. 01). HLJDTAF could also significantly prolong the shorten gasp time of CCAORR mice, reduce the brain exponential and decrease the water content in brain (P < 0. 05, P < 0. 01). Conclusions: HLJDTAF can protect the brain ischemia injury.
MeSH term(s)	Animals ; Brain/drug effects ; Brain/pathology ; Brain Edema/pathology ; Brain Edema/prevention & control ; Brain Ischemia/pathology ; Capillary Permeability/drug effects ; Cerebral Infarction/pathology ; Cerebral Infarction/prevention & control ; Disease Models, Animal ; Drug Combinations ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/pharmacology ; Mice ; Mice, Inbred ICR ; Rats ; Rats, Sprague-Dawley ; Water/metabolism
Chemical Substances	Drug Combinations ; Drugs, Chinese Herbal ; Water (059QF0KO0R)
Language	Chinese
Publishing date	2004-05
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	1001-4454
ISSN	1001-4454
Database	MEDical Literature Analysis and Retrieval System OnLINE

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