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  1. Book ; Online: Introducing Foreign Models for Development

    Ohno, Izumi / Jin, Kimiaki / Amatsu, Kuniaki / Mori, Junichi

    Japanese Experience and Cooperation in the Age of New Technology

    (Emerging-Economy State and International Policy Studies)

    2024  

    Series title Emerging-Economy State and International Policy Studies
    Keywords Development economics & emerging economies ; Development studies ; Economic growth ; Globalization ; Asian history ; Translative adaptation ; Local learning ; Industrialization ; Industrial policy ; Industrial catch-up ; Kaizen ; Technology transfer ; Development cooperation ; Developing countries, latecomer economies
    Language English
    Size 1 electronic resource (338 pages)
    Publisher Springer Nature
    Publishing place Singapore
    Document type Book ; Online
    Note English
    HBZ-ID HT030612641
    ISBN 9789819942374 ; 9819942373
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Privacy e gestione del dato sanitario.

    Mori, Isabella

    Recenti progressi in medicina

    2023  Volume 114, Issue 6, Page(s) 327–328

    Abstract: The effective use of data in healthcare, and the use of information to support decision-making processes is a key issue. Experiencing the Covid-19 pandemic drove to important developments in a relatively short time. In this context, Cittadinanzattiva, ... ...

    Title translation Privacy and health data management.
    Abstract The effective use of data in healthcare, and the use of information to support decision-making processes is a key issue. Experiencing the Covid-19 pandemic drove to important developments in a relatively short time. In this context, Cittadinanzattiva, which has been dealing with citizens' rights in the health field for years, is really interested in exploring the boundaries between citizens' right to privacy and the promotion of health as a fundamental human right. New strategies to protect the individual and his dignity should be identified, without hindering the use of data to support health policy. The relationship between health and privacy is a pivotal issue because it involves two of the fundamental rights that are most exposed to the evolution of technology and innovation.
    MeSH term(s) Humans ; Privacy ; COVID-19 ; Pandemics ; Data Management ; Health Policy
    Language Italian
    Publishing date 2023-05-25
    Publishing country Italy
    Document type English Abstract ; Journal Article
    ZDB-ID 138266-4
    ISSN 2038-1840 ; 0034-1193
    ISSN (online) 2038-1840
    ISSN 0034-1193
    DOI 10.1701/4042.40222
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article: Current Status of Whole Slide Image (WSI) Standardization in Japan.

    Mori, Ichiro

    Acta histochemica et cytochemica

    2022  Volume 55, Issue 3, Page(s) 85–91

    Abstract: A whole slide image (WSI) is a digitized microscopic image that is particularly useful in histochemistry and cytochemistry. Several WSI scanners have been introduced in Japan and all use their own native format. Thus, there is basically no ... ...

    Abstract A whole slide image (WSI) is a digitized microscopic image that is particularly useful in histochemistry and cytochemistry. Several WSI scanners have been introduced in Japan and all use their own native format. Thus, there is basically no interchangeability. However, the Digital Imaging and Communications in Medicine (DICOM) standard format for WSI has been available since 2010. In this review, the configuration and differences among the native WSI and DICOM formats are examined, and the advantages and issues of DICOM standardization are discussed.
    Language English
    Publishing date 2022-06-25
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 280005-6
    ISSN 1347-5800 ; 0044-5991
    ISSN (online) 1347-5800
    ISSN 0044-5991
    DOI 10.1267/ahc.22-00009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Lincosamide Antibiotics: Structure, Activity, and Biosynthesis.

    Mori, Takahiro / Abe, Ikuro

    Chembiochem : a European journal of chemical biology

    2024  Volume 25, Issue 6, Page(s) e202300840

    Abstract: Lincosamides are naturally occurring antibiotics isolated from Streptomyces sp. Currently, lincomycin A and its semisynthetic analogue clindamycin are used as clinical drugs. Due to their unique structures and remarkable biological activities, ... ...

    Abstract Lincosamides are naturally occurring antibiotics isolated from Streptomyces sp. Currently, lincomycin A and its semisynthetic analogue clindamycin are used as clinical drugs. Due to their unique structures and remarkable biological activities, derivatizations of lincosamides via semi-synthesis and biosynthetic studies have been reported. This review summarizes the structures and biological activities of lincosamides, and the recent studies of lincosamide biosynthetic enzymes.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Lincosamides/pharmacology ; Lincosamides/chemistry ; Lincomycin/chemistry ; Macrolides
    Chemical Substances Anti-Bacterial Agents ; Lincosamides ; Lincomycin (BOD072YW0F) ; Macrolides
    Language English
    Publishing date 2024-01-15
    Publishing country Germany
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020469-3
    ISSN 1439-7633 ; 1439-4227
    ISSN (online) 1439-7633
    ISSN 1439-4227
    DOI 10.1002/cbic.202300840
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Analyses of Neural Circuits Governing Behavioral Plasticity in the Nematode Caenorhabditis elegans.

    Huang, Tzu-Ting / Mori, Ikue

    Methods in molecular biology (Clifton, N.J.)

    2024  Volume 2794, Page(s) 321–330

    Abstract: Behavioral plasticity is subjected to various sensory stimuli, experiences, and physiological states, representing the temporal and spatial patterns of neural circuit dynamics. Elucidation of how genes and neural circuits in our brain actuate behavioral ... ...

    Abstract Behavioral plasticity is subjected to various sensory stimuli, experiences, and physiological states, representing the temporal and spatial patterns of neural circuit dynamics. Elucidation of how genes and neural circuits in our brain actuate behavioral plasticity requires functional imaging during behavioral assays to manifest temporal and spatial neural regulation in behaviors. The exploration of the nervous systems of Caenorhabditis elegans has catalyzed substantial scientific advancements in elucidating the mechanistic link between circuit dynamics and behavioral plasticity. The analyses of the nervous system of C. elegans have technologically flourished owing to the development of optogenetic instruments and fluorescent protein-based imaging compatible with its optically transparent body and the understanding of its completely revealed neural connectome and gene expression profiles at single-neuron resolution (The C. elegans Neuronal Gene Expression Map & Network, CeNGEN project). Using examples of the two temperature learning behaviors in C. elegans, this chapter delves into a selection of pivotal imaging tools, including genetically encoded calcium indicators, biosensors for second messenger imaging, and their usage in freely moving worms that have propelled our grasp of sensory representation in C. elegans neural circuits. To further connect the circuit dynamics to behavioral plasticity, this chapter will focus on technological advancements enabling simultaneous imaging and tracking system together with methodologies to quantify multiple behavioral elements of freely behaving C. elegans in a dynamic environment.
    MeSH term(s) Animals ; Caenorhabditis elegans/genetics ; Brain ; Neurons ; Biological Assay ; Chromosome Mapping
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3810-1_27
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Analyses of Genetic Regulation of the Nervous System in the Nematode Caenorhabditis elegans.

    Huang, Tzu-Ting / Mori, Ikue

    Methods in molecular biology (Clifton, N.J.)

    2024  Volume 2794, Page(s) 313–319

    Abstract: This chapter aims to provide a comprehensive overview of the methodologies available to dissect genetic regulation of the nervous systems in the nematode Caenorhabditis elegans. These techniques encompass genetic screens and genetic tools to unravel the ... ...

    Abstract This chapter aims to provide a comprehensive overview of the methodologies available to dissect genetic regulation of the nervous systems in the nematode Caenorhabditis elegans. These techniques encompass genetic screens and genetic tools to unravel the spatial-temporal contribution of genes on neural structure and function. Unbiased genetic screens on random mutations induced by ethyl methanesulfonate (EMS) or target gene silencing by genome-wide RNA interference (RNAi) help progress our understanding of the genetic control of neural development and functions. Complement to unbiased genetic approaches, gene- and protein-targeted manipulation by Cre/LoxP recombination system and auxin-inducible degron (AID) protein degradation system, respectively, helps identify tissues/cells and the time window critical for gene and protein function during the proper execution of a particular behavior. Considering the remarkable conservation of genetic pathways between C. elegans and mammalian systems, elucidating the genetic underpinnings of neural functions and learning behaviors in C. elegans may furnish invaluable insights into analogous processes in more complex organisms. As shown in the following chapter, leveraging these diverse methodologies enable researchers to elucidate the intricate network governing neural function and structure, laying the foundation for innovating strategies to ameliorate cognitive alterations.
    MeSH term(s) Animals ; Caenorhabditis elegans/genetics ; Gene Expression Regulation ; Neurogenesis ; Learning ; Central Nervous System Depressants ; Nervous System ; Mammals
    Chemical Substances Central Nervous System Depressants
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Review ; Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3810-1_26
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Functional analysis of a fungal P450 enzyme.

    Mori, Takahiro / Abe, Ikuro

    Methods in enzymology

    2023  Volume 693, Page(s) 171–190

    Abstract: Fungal cytochrome P450s participate in various physiological reactions, including the synthesis of internal cellular components, metabolic detoxification of xenobiotic compounds, and oxidative modification of natural products. Although functional ... ...

    Abstract Fungal cytochrome P450s participate in various physiological reactions, including the synthesis of internal cellular components, metabolic detoxification of xenobiotic compounds, and oxidative modification of natural products. Although functional analysis reports of fungal P450s continue to grow, there are still some difficulties as compared to prokaryotic P450s, because most of these fungal enzymes are transmembrane proteins. In this chapter, we will describe the methods for heterologous expression, in vivo analysis, enzyme preparation, and in vitro enzyme assays of the fungal P450 enzyme Trt6 and isomerase Trt14, which play important roles in the divergence of the biosynthetic pathway of terretonins, as a model for the functional analysis of fungal P450 enzymes.
    MeSH term(s) Cytochrome P-450 Enzyme System/genetics ; Cytochrome P-450 Enzyme System/metabolism ; Oxidation-Reduction
    Chemical Substances Cytochrome P-450 Enzyme System (9035-51-2)
    Language English
    Publishing date 2023-10-13
    Publishing country United States
    Document type Journal Article
    ISSN 1557-7988
    ISSN (online) 1557-7988
    DOI 10.1016/bs.mie.2023.09.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Highlighting the 'blood-nerve barrier' in virology research.

    Mori, I

    Acta virologica

    2018  Volume 62, Issue 1, Page(s) 28–32

    Abstract: The blood-nerve barrier (BNB) shields peripheral nerves from the blood in order to maintain the homeostasis of the nervous system. In the field of infectious diseases, little information is currently available concerning the BNB. Recently documented ... ...

    Abstract The blood-nerve barrier (BNB) shields peripheral nerves from the blood in order to maintain the homeostasis of the nervous system. In the field of infectious diseases, little information is currently available concerning the BNB. Recently documented evidence in virology suggests that elevated permeability of the BNB by immune cells and the natural absence of the BNB in the olfactory mucosa play significant roles in neuroprotection as well as neuropathogenesis. Importantly, the BNB can behave more flexibly than previously thought. In the near future, drug delivery via manipulation of the BNB will shed light on new therapeutic and prophylactic strategies for serious and intractable nervous system infections.
    MeSH term(s) Animals ; Blood-Nerve Barrier/immunology ; Blood-Nerve Barrier/pathology ; Blood-Nerve Barrier/physiology ; Humans ; Peripheral Nerves/anatomy & histology ; Peripheral Nerves/virology ; Virus Diseases/pathology ; Virus Diseases/virology
    Language English
    Publishing date 2018
    Publishing country Slovakia
    Document type Journal Article ; Review
    ZDB-ID 210452-0
    ISSN 1336-2305 ; 0001-723X
    ISSN (online) 1336-2305
    ISSN 0001-723X
    DOI 10.4149/av_2018_103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 336: Show issues Location:
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  9. Article ; Online: The olfactory bulb: A link between environmental agents and narcolepsy.

    Mori, Isamu

    Medical hypotheses

    2019  Volume 126, Page(s) 66–68

    Abstract: Narcolepsy with cataplexy is a lifelong sleep disorder associated with orexin/hypocretin deficiency in the central nervous system. In addition to a genetic predisposition, a variety of environmental factors, such as influenza viruses, have been ... ...

    Abstract Narcolepsy with cataplexy is a lifelong sleep disorder associated with orexin/hypocretin deficiency in the central nervous system. In addition to a genetic predisposition, a variety of environmental factors, such as influenza viruses, have been implicated in the pathogenesis of the disease. In this article, a hypothesis is proposed that environmental agents access the olfactory bulb and trigger neuroinflammation, which in turn induces neurodegeneration of orexinergic neurons in the lateral hypothalamus and other neuronal subpopulations regulating the sleep-wake cycle, which triggers the development of narcolepsy.
    MeSH term(s) Animals ; Cataplexy ; Cytokines/metabolism ; Humans ; Hypothalamus/metabolism ; Hypothalamus/physiopathology ; Inflammation ; Intracellular Signaling Peptides and Proteins ; Mice ; Models, Anatomic ; Narcolepsy/physiopathology ; Neurons/physiology ; Neuropeptides/physiology ; Olfactory Bulb/metabolism ; Olfactory Bulb/physiopathology ; Orexins/metabolism ; Sleep ; Wakefulness
    Chemical Substances Cytokines ; Intracellular Signaling Peptides and Proteins ; Neuropeptides ; Orexins
    Language English
    Publishing date 2019-03-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2019.03.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1132: Show issues Location:
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  10. Article ; Online: The olfactory bulb: A link between environmental agents and narcolepsy, from the standpoint of autoimmune etiology.

    Mori, Isamu

    Medical hypotheses

    2019  Volume 131, Page(s) 109294

    Abstract: Narcolepsy type 1 is a lifelong sleep disorder characterized by the loss of hypocretin-producing neurons in the brain. Environmental agents, including influenza, neurotoxic metals, and combustion smoke, have been implicated in the pathogenesis, ... ...

    Abstract Narcolepsy type 1 is a lifelong sleep disorder characterized by the loss of hypocretin-producing neurons in the brain. Environmental agents, including influenza, neurotoxic metals, and combustion smoke, have been implicated in the pathogenesis, especially in carriers of the human leukocyte antigen class II DQB1*06:02 allele. Sensitive experimental approaches have recently revealed hypocretin-autoreactive CD4
    MeSH term(s) Animals ; Autoantigens/immunology ; Autoantigens/metabolism ; Blood-Brain Barrier/physiology ; Cytokines/physiology ; Environmental Pollutants/pharmacokinetics ; Environmental Pollutants/toxicity ; HLA-DQ beta-Chains/immunology ; Hemagglutinin Glycoproteins, Influenza Virus/immunology ; Humans ; Mice ; Mice, Transgenic ; Microglia/metabolism ; Models, Immunological ; Molecular Mimicry ; Narcolepsy/etiology ; Narcolepsy/immunology ; Narcolepsy/physiopathology ; Neurons/metabolism ; Neurons/pathology ; Olfactory Bulb/drug effects ; Olfactory Bulb/physiopathology ; Orexins/immunology ; Orexins/metabolism ; T-Cell Antigen Receptor Specificity ; T-Lymphocyte Subsets/immunology
    Chemical Substances Autoantigens ; Cytokines ; Environmental Pollutants ; HLA-DQ beta-Chains ; HLA-DQB1 antigen ; Hemagglutinin Glycoproteins, Influenza Virus ; Orexins ; hemagglutinin, human influenza A virus
    Language English
    Publishing date 2019-06-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2019.109294
    Database MEDical Literature Analysis and Retrieval System OnLINE

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