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  1. Article: Editorial: Improving quality of life in patients with differentiated thyroid cancer.

    Khafif, Avi Hefetz / Cohen, Oded / Dionigi, Gianlorenzo

    Frontiers in oncology

    2023  Volume 13, Page(s) 1154569

    Language English
    Publishing date 2023-02-20
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1154569
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Surgery for benign thyroid disease in 2018.

    Dionigi, Gianlorenzo

    Gland surgery

    2018  Volume 7, Issue 2, Page(s) 239–241

    Language English
    Publishing date 2018-05-02
    Publishing country China (Republic : 1949- )
    Document type Editorial ; Comment
    ZDB-ID 3016969-0
    ISSN 2227-8575 ; 2227-684X
    ISSN (online) 2227-8575
    ISSN 2227-684X
    DOI 10.21037/gs.2017.12.07
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  3. Article: Is advocacy for active surveillance over definitive intervention in papillary thyroid microcarcinoma applicable to European patients?

    Dionigi, Gianlorenzo

    Gland surgery

    2018  Volume 7, Issue 2, Page(s) 242–243

    Language English
    Publishing date 2018-01-16
    Publishing country China (Republic : 1949- )
    Document type Editorial
    ZDB-ID 3016969-0
    ISSN 2227-8575 ; 2227-684X
    ISSN (online) 2227-8575
    ISSN 2227-684X
    DOI 10.21037/gs.2017.12.06
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  4. Article ; Online: Postcholecystectomy syndrome: biliary-related complications.

    Sangiorgio, Giuseppe / Zanghì, Marta / Dionigi, Gianlorenzo / Zanghì, Guido

    Minerva surgery

    2023  Volume 78, Issue 6, Page(s) 684–691

    Abstract: In Italy, about 100,000 cholecystectomies are carried out annually, the majority of them laparoscopically. Complications following cholecystectomy are common and increase morbidity and cost burden. Biliary damage (0.08-0.5%), bile leak (0.42-1.1%), ... ...

    Abstract In Italy, about 100,000 cholecystectomies are carried out annually, the majority of them laparoscopically. Complications following cholecystectomy are common and increase morbidity and cost burden. Biliary damage (0.08-0.5%), bile leak (0.42-1.1%), retained common bile duct stones (0.8-5.7%), postcholecystectomy syndrome (10-15%), and postcholecystectomy diarrhea (5-12%) are a few of the most often occurring laparoscopic cholecystectomy consequences. In many instances, endoscopy can offer conclusive management and is crucial for the identification and treatment of biliary problems. Regarding the ideal treatment strategy for biliary problems, there is no universal agreement. A skilled interdisciplinary team should therefore approach biliary problems. The surgeon must be knowledgeable on how to handle these issues.
    MeSH term(s) Humans ; Postcholecystectomy Syndrome/diagnosis ; Postcholecystectomy Syndrome/etiology ; Cholecystectomy/adverse effects ; Cholecystectomy, Laparoscopic/adverse effects ; Biliary Tract Diseases ; Gallstones
    Language English
    Publishing date 2023-07-24
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3067899-7
    ISSN 2724-5438
    ISSN (online) 2724-5438
    DOI 10.23736/S2724-5691.23.09942-2
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  5. Article: The relationship between subclinical hypothyroidism and invasive papillary thyroid cancer.

    Li, Changlin / Zhang, Jiao / Dionigi, Gianlorenzo / Sun, Hui

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1294441

    Abstract: Background: Subclinical hypothyroidism is the most common thyroid dysfunction. Approximately 10% of patients with thyroid cancer have subclinical hypothyroidism. There is a paucity of real-world studies examining the relationship between subclinical ... ...

    Abstract Background: Subclinical hypothyroidism is the most common thyroid dysfunction. Approximately 10% of patients with thyroid cancer have subclinical hypothyroidism. There is a paucity of real-world studies examining the relationship between subclinical hypothyroidism and known correlates of invasiveness of papillary thyroid carcinoma (PTC).
    Materials and methods: A retrospective cohort study of 13,717 patients with PTC was conducted. Odds ratios were calculated to assess the relationship between subclinical hypothyroidism and extrathyroidal extension (ETE) after adjusting for BMI and genders. The Cancer Genome Atlas (TCGA) data were utilized for the analysis of TSHR-associated pathways, while qRT-PCR was employed to validate the expression levels of pivotal genes in the relevant signaling pathways.
    Results: In total, 13,717 PTC patients (10,769 women and 2,948 men; mean [SD] age, 42.90 [9.43] years) were included in the retrospective study. Subclinical hypothyroidism was an independent risk factor for ETE (OR adjusted, 1.168 [95% CI, 1.028-1.327];
    Conclusion: Subclinical hypothyroidism was an independent risk factor for ETE in patients with PTC. This association was particularly significant in normal-weight and younger patients. The risk of ETE associated with subclinical hypothyroidism was higher in males compared to females. Our study indicates a potential involvement of the autophagy pathway in regulating the ETE phenotype in thyroid cancer, specifically in the context of subclinical hypothyroidism.
    MeSH term(s) Humans ; Male ; Female ; Adult ; Thyroid Cancer, Papillary/pathology ; Retrospective Studies ; Carcinoma, Papillary/pathology ; Thyroidectomy ; Thyroid Neoplasms/complications ; Thyroid Neoplasms/genetics ; Thyroid Neoplasms/metabolism ; Hypothyroidism/complications
    Language English
    Publishing date 2023-12-20
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1294441
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Assessment of different classification systems for predicting the risk of superior laryngeal nerve injury during thyroid surgery: a prospective cohort study.

    Li, Changlin / Zhang, Jiao / Dionigi, Gianlorenzo / Sun, Hui

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1301838

    Abstract: Background: A multitude of anatomical variations have been noted in the external branch of the superior laryngeal nerve (EBSLN). In this study, intraoperative neuromonitoring (IONM) was used to assess the potential value of the different classical EBSLN ...

    Abstract Background: A multitude of anatomical variations have been noted in the external branch of the superior laryngeal nerve (EBSLN). In this study, intraoperative neuromonitoring (IONM) was used to assess the potential value of the different classical EBSLN classifications for predicting the risk of EBSLN injury.
    Methods: In total, 136 patients with thyroid nodules were included in this prospective cohort study, covering 242 nerves at risk (NAR). The EBSLN was identified by observing the cricothyroid muscle twitch and/or typical electromyography (EMG) biphasic waveform. The EBSLNs were classified by Cernea classification, Kierner classification, and Friedman classification, respectively. The EMG parameters and outcomes of vocal acoustic assessment were recorded.
    Results: The distribution of Cernea, Kiernea, and Friedman subtypes were, respectively, Cernea 1 (40.9%), Cernea 2A (45.5%), Cernea 2B (10.7%), Kierner 1 (40.9%), Kierner 2 (45.5%), Kierner 3 (10.7%), Kierner 4 (2.9%) and Friedman 1 (15.7%), Friedman 2 (33.9%), Friedman 3 (50.4%). The amplitudes of EBSLN decreased significantly after superior thyroid pole operation, respectively, in Cernea 2A (193.7 vs. 226.6μV,
    Conclusion: Cernea 2A and 2B; Kierner 2, 3, and 4; and Friedman 2 were defined as the high-risk subtypes of EBSLN. The risk prediction ability of the Friedman classification was found to be superior compared to other classifications.
    MeSH term(s) Humans ; Thyroid Gland/surgery ; Thyroidectomy/adverse effects ; Prospective Studies ; Monitoring, Intraoperative ; Laryngeal Nerves/physiology ; Laryngeal Nerve Injuries/etiology ; Risk Factors
    Language English
    Publishing date 2023-11-22
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1301838
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  7. Article ; Online: Correction: Modified Larssen solution (MLS)-fixed cadaver model for transoral endoscopic thyroidectomy vestibular approach (TOETVA) education: a feasibility study.

    Celik, Servet / Bilge, Okan / Ozdemir, Murat / Dionigi, Gianlorenzo / Anuwong, Angkoon / Makay, Ozer

    Surgical endoscopy

    2023  Volume 37, Issue 3, Page(s) 2419

    Language English
    Publishing date 2023-01-25
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 639039-0
    ISSN 1432-2218 ; 0930-2794
    ISSN (online) 1432-2218
    ISSN 0930-2794
    DOI 10.1007/s00464-022-09850-2
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2214: Show issues Location:
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  8. Article ; Online: Adiponectin Inhibits the Progression of Obesity-Associated Papillary Thyroid Carcinoma Through Autophagy.

    Li, Changlin / Zhang, Jiao / Dionigi, Gianlorenzo / Liang, Nan / Guan, Haixia / Sun, Hui

    Endocrinology

    2024  Volume 165, Issue 5

    Abstract: Context: Obesity is a risk factor for the development of papillary thyroid cancer (PTC). However, the molecular mechanisms by which obesity promotes PTC are unclear.: Objective: This study aims to identify adipokines that are linked to PTC ... ...

    Abstract Context: Obesity is a risk factor for the development of papillary thyroid cancer (PTC). However, the molecular mechanisms by which obesity promotes PTC are unclear.
    Objective: This study aims to identify adipokines that are linked to PTC progression.
    Methods: An adipokine antibody array was used to determine the serum levels of 40 adipokines in normal-weight and obese PTC patients. Enzyme-linked immunosorbent assay was used to determine the serum levels of adiponectin. Recombinant human adiponectin was produced by human adipose-derived stem cells and used to treat PTC cells. Cell proliferation and migration were evaluated using the CCK8 and Transwell assays. Bioinformatics analysis was used to predict mechanisms by which adiponectin affects PTC.
    Results: Adipokines differentially expressed between normal-weight and obese patients showed a gender-dependent pattern. Obese PTC patients had a significantly lower serum adiponectin level than normal-weight patients, especially in female individuals. Adiponectin levels were negatively correlated with aggressive features of PTC, including tumor diameter > 1 cm, extrathyroidal extension, and lymph node metastasis. Recombinant human adiponectin inhibited the proliferation and migration of human PTC cells in vitro. Bioinformatics analysis identified adiponectin receptor 2 (ADIPOR2) and the autophagy pathway as possible mediators of adiponectin function in TC. In vitro experiments confirmed that adiponectin activated autophagy in PTC cells. These findings shed new lights into the role and mechanisms of adiponectin in TC pathogenesis.
    Conclusion: Adiponectin is involved in development of obesity-related PTC. Adiponectin can directly inhibit thyroid cancer growth and metastasis through the autophagy pathway.
    MeSH term(s) Female ; Humans ; Adipokines ; Adiponectin ; Autophagy ; Carcinoma, Papillary/metabolism ; Carcinoma, Papillary/pathology ; Cell Line, Tumor ; Cell Proliferation ; Obesity/complications ; Thyroid Cancer, Papillary/metabolism ; Thyroid Neoplasms/pathology
    Chemical Substances Adipokines ; Adiponectin ; ADIPOQ protein, human
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
    DOI 10.1210/endocr/bqae030
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  9. Article ; Online: Correction to: Minimally invasive video-assisted thyroidectomy (MIVAT): the quest for a scarless approach.

    Mangano, Alberto / Ferrari, Cesare Carlo / Dionigi, Gianlorenzo

    Surgical endoscopy

    2021  Volume 35, Issue 6, Page(s) 3232

    Language English
    Publishing date 2021-02-02
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 639039-0
    ISSN 1432-2218 ; 0930-2794
    ISSN (online) 1432-2218
    ISSN 0930-2794
    DOI 10.1007/s00464-021-08299-z
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  10. Article ; Online: Impact of near-infrared fluorescence imaging plus indocyanine green fluorescence on postoperative hypoparathyroidism rates after total thyroidectomy and central neck lymph node dissection.

    Di Lorenzo, Sofia / Carrillo Lizarazo, Jose Luis / Dionigi, Gianlorenzo / Kraimps, Jean-Louis / Donatini, Gianluca

    The British journal of surgery

    2024  Volume 111, Issue 2

    Abstract: Background: Patients with thyroid carcinoma often undergo cervical lymph node dissection, which is associated with high rates of both transient and permanent postoperative hypoparathyroidism. The impact of near-infrared fluorescence imaging + ... ...

    Abstract Background: Patients with thyroid carcinoma often undergo cervical lymph node dissection, which is associated with high rates of both transient and permanent postoperative hypoparathyroidism. The impact of near-infrared fluorescence imaging + indocyanine green (ICG) fluorescence on postoperative hypoparathyroidism rates after total thyroidectomy and central neck lymph node dissection was evaluated.
    Methods: All patients undergoing surgery between January 2019 and March 2023 were included and divided into three groups: a control group (parathyroid glands identified visually), a near-infrared fluorescence imaging alone group, and a near-infrared fluorescence imaging + ICG fluorescence group. The primary outcome was the transient and permanent postoperative hypoparathyroidism rates. Secondary outcomes were: length of surgery and number of parathyroid glands identified, inadvertently resected, and autotransplanted.
    Results: A total of 131 patients were included in the study (47 in the control group, 45 in the near-infrared fluorescence imaging alone group, and 39 in the near-infrared fluorescence imaging + ICG fluorescence group). The transient hypoparathyroidism rate was 48.9% in the control group, 37.8% in the near-infrared fluorescence imaging alone, and 5.1% in the near-infrared fluorescence imaging + ICG fluorescence group (P < 0.0001), while the permanent hypoparathyroidism rate was 8.5% in the control group, 2.2% in the near-infrared fluorescence imaging alone group, and 0% in the near-infrared fluorescence imaging + ICG fluorescence group (P = 0.096). The number of parathyroid glands identified was 159 of 188 in the control group, 165 of 180 in the near-infrared fluorescence imaging alone group, and 149 of 156 in the near-infrared fluorescence imaging + ICG fluorescence group (P = 0.002). Inadvertent resection of parathyroid glands occurred for 29 of 188 in the control group, 15 of 180 in the near-infrared fluorescence imaging alone group, and 7 of 156 in the near-infrared fluorescence imaging + ICG fluorescence group (P = 0.002), with subsequent parathyroid gland autotransplantation for 2 of 29 in the control group, 2 of 15 in the near-infrared fluorescence imaging alone group, and 3 of 7 in the near-infrared fluorescence imaging + ICG fluorescence group (P = 0.040). There was no difference in the median operating time between groups.
    Conclusion: The use of near-infrared fluorescence imaging + ICG fluorescence decreased both transient and permanent hypoparathyroidism rates in patients undergoing total thyroidectomy and central neck lymph node dissection.
    MeSH term(s) Humans ; Thyroidectomy/adverse effects ; Thyroidectomy/methods ; Indocyanine Green ; Hypoparathyroidism/etiology ; Parathyroid Glands/diagnostic imaging ; Parathyroid Glands/surgery ; Neck Dissection/adverse effects ; Neck Dissection/methods ; Lymph Node Excision ; Postoperative Complications/diagnostic imaging ; Postoperative Complications/etiology ; Postoperative Complications/surgery ; Optical Imaging/methods
    Chemical Substances Indocyanine Green (IX6J1063HV)
    Language English
    Publishing date 2024-02-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znae022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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