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Article ; Online: Involved-field radiotherapy in older patients with superficial thoracic esophageal squamous cell carcinoma: long-term outcomes and recurrence patterns.

Kono, Sawa / Hashimoto, Yaichiro / Ohmatsu, Kenta / Tsujii, Miki / Kuribayashi, Shigehiko / Karasawa, Kumiko

2024

Abstract: Purpose: An optimal radiotherapy field for superficial esophageal carcinoma is yet to be established. We evaluated the long-term outcomes and recurrence patterns of involved-field radiotherapy (IFRT) in older patients with superficial thoracic ... ...

Abstract	Purpose: An optimal radiotherapy field for superficial esophageal carcinoma is yet to be established. We evaluated the long-term outcomes and recurrence patterns of involved-field radiotherapy (IFRT) in older patients with superficial thoracic esophageal squamous cell carcinoma (ESCC). Materials and methods: Fifty-four patients (49 men and 5 women; mean age, 77 [range: 66-90] years) who underwent IFRT for superficial thoracic ESCC between January 2003 and January 2019 were retrospectively reviewed. Concurrent chemotherapy was administered at the discretion of the attending physician. The primary endpoint was overall survival. The secondary endpoints were progression-free survival and complete response rate. Results: The tumors were localized in the upper, middle, and lower thoracic esophagus in 2, 40, and 12 patients, respectively. All patients underwent IFRT using anteroposterior and anterior-posterior oblique opposed beams (off-cord). The prescribed total doses were 50.4, 59.4-61.2, and 66-70 Gy for 6, 40, and 8 patients, respectively. Concurrent chemotherapy was administered to 33 patients. The median follow-up duration was 57 months. The median overall survival was 115 months. The 5-year overall and progression-free survival rates were 71.7% and 60.1%, respectively. Forty-nine patients had a complete response at one month after IFRT (complete response rate: 90.7%). Twenty patients had recurrence; there were 13 in-field and 7 out-of-field recurrence cases. The radiation-related adverse events were generally mild. Grade 3 late toxicity was observed in one patient. Conclusions: The efficacy of IFRT was suggested to be comparable to that of standard treatments. Therefore, IFRT can be a promising approach for treating superficial ESCC in older adults, especially those with severe comorbidities.
Language	English
Publishing date	2024-04-22
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2488907-6
ISSN	1867-108X ; 1867-1071
ISSN (online)	1867-108X
ISSN	1867-1071
DOI	10.1007/s11604-024-01564-w
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Article: Pattern enrichment analysis for phage selection of stapled peptide ligands.

Miki, Takayuki / Namii, Keigo / Seko, Kenta / Kakehi, Shota / Moro, Goshi / Mihara, Hisakazu

Chemical science

2022 Volume 13, Issue 43, Page(s) 12634–12642

Abstract: Phage display is the most widely used technique to ... ...

Abstract	Phage display is the most widely used technique to discover
Language	English
Publishing date	2022-10-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2559110-1
ISSN	2041-6539 ; 2041-6520
ISSN (online)	2041-6539
ISSN	2041-6520
DOI	10.1039/d2sc04058a
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Article ; Online: Bone-Modifying Agents in Patients With High-Risk Metastatic Castration-Sensitive Prostate Cancer Treated With Abiraterone Acetate.

Fukuokaya, Wataru / Mori, Keiichiro / Urabe, Fumihiko / Igarashi, Taro / Yanagisawa, Takafumi / Tsuzuki, Shunsuke / Honda, Mariko / Miki, Kenta / Kimura, Takahiro

JAMA network open

2024 Volume 7, Issue 3, Page(s) e242467

Abstract: Importance: The association between the use of bone-modifying agents (BMAs) and the outcomes among patients with metastatic castration-sensitive prostate cancer (mCSPC) treated with abiraterone acetate plus prednisone (AAP) remains unclear.: Objective! ...

Abstract	Importance: The association between the use of bone-modifying agents (BMAs) and the outcomes among patients with metastatic castration-sensitive prostate cancer (mCSPC) treated with abiraterone acetate plus prednisone (AAP) remains unclear. Objective: To investigate the association between BMA use and the outcomes of patients with mCSPC receiving AAP. Design, setting, and participants: In this cohort study, a post hoc analysis of individual participant data from the LATITUDE trial was performed. The LATITUDE trial, a phase 3 randomized clinical trial, aimed to assess the efficacy of AAP and androgen deprivation therapy (ADT) vs dual-placebo and ADT in patients with high-risk mCSPC (data cutoff, August 15, 2018). Eligible patients had newly diagnosed prostate cancer with metastases and at least 2 of 3 high-risk factors (Gleason score ≥8, presence of ≥3 lesions on bone scan, or presence of measurable visceral metastasis). The trial was conducted at 235 sites in 34 countries. Data for the present study were evaluated from July 18 to September 23, 2023. Exposures: Use of BMAs was defined as the administration of bisphosphonates and denosumab within 90 days before and after randomization. Main outcomes and measures: The primary outcomes were time to skeletal-related events (SREs) and overall survival (OS). An SRE was defined as a clinical or pathological fracture, spinal cord compression, palliative radiation to bone, or surgery involving bone. Differences in these outcomes were examined using the restricted mean survival time from inverse probability of treatment weighting-adjusted Kaplan-Meier curves, estimated until the last event was observed (longest time observed, 63.9 months). Treatment × covariate interactions were analyzed using weighted Cox proportional hazards regression models for the total cohort. Results: In the total cohort of 1199 patients (956 [79.7%] younger than 75 years), 597 (49.8%) received AAP and ADT, including 474 (79.4%) younger than 75 years and 384 (64.3%) with more than 10 bone metastases (AAP cohort); 602 (50.2%) were treated with dual placebo and ADT, including 482 (80.1%) younger than 75 years and 377 (62.6%) with more than 10 bone metastases (ADT cohort). In the AAP cohort, 132 patients (22.1%) received BMAs, while in the ADT cohort, 131 (21.8%) did. Zoledronic acid was the most frequently administered BMA in both the AAP (93 [70.5%]) and the ADT (88 [67.2%]) cohorts. During the median follow-up of 51.8 (IQR, 47.2-57.0) months in the AAP cohort, BMA use was associated with a longer time to SRE (difference, 7.8 [95% CI, 4.2-11.3] months) but not with OS (difference, 1.6 [95% CI, -2.5 to 5.8] months). In the ADT cohort, BMA use was associated with both time to SRE (difference, 9.3 [95% CI, 5.2-13.3] months) and OS (difference, 5.5 [95% CI, 3.2-9.8] months). No evidence was found that the outcomes of BMA varied by AAP or ADT (hazard ratio for time to SRE, 0.99 [95% CI, 0.48-2.08]; P = .99 for interaction; hazard ratio for OS, 1.31 [95% CI, 0.88-1.96]; P = .18 for interaction). Conclusions and relevance: The findings of this cohort study suggest that use of BMAs was associated with a longer time to SRE in patients with high-risk mCSPC treated with ADT, with or without AAP, suggesting that BMA use might provide benefits to this population.
MeSH term(s)	Male ; Humans ; Abiraterone Acetate/therapeutic use ; Abiraterone Acetate/adverse effects ; Prostatic Neoplasms/pathology ; Androgen Antagonists/therapeutic use ; Cohort Studies ; Prednisone/therapeutic use ; Prednisone/adverse effects ; Castration
Chemical Substances	Abiraterone Acetate (EM5OCB9YJ6) ; Androgen Antagonists ; Prednisone (VB0R961HZT)
Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Randomized Controlled Trial ; Clinical Trial, Phase III ; Journal Article
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2024.2467
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Article: Seasonal Variations in the Assembly of Dung Beetles (Coleoptera: Geotrupidae and Scarabaeidae) Attracted to Macaque Feces in Temperate Forests in Japan

Tsuji, Yamato / Matsubara, Miki / Sawada, Kenta / Shiraishi, Toshiaki

Coleopterists' bulletin. 2022 June 21, v. 76, no. 2

2022

Abstract: Dung beetles attracted to the feces of wild Japanese macaques (Primates: Macaca fuscata Blyth) were studied at two temperate sites in Japan, Kinkazan (dominated by deciduous forest) and Yakushima (dominated by evergreen forest), to determine if temporal ... ...

Abstract	Dung beetles attracted to the feces of wild Japanese macaques (Primates: Macaca fuscata Blyth) were studied at two temperate sites in Japan, Kinkazan (dominated by deciduous forest) and Yakushima (dominated by evergreen forest), to determine if temporal variations occur in the dung beetle community. Data from 428 pitfall traps baited with fresh Japanese macaque feces and placed during 15 sampling periods from 2015 to 2019 were analyzed. We captured 1,682 beetles (two families, five genera, and nine species) from Kinkazan and 1,102 beetles (two families, four genera, and nine species) from Yakushima. More than 50% of the beetles captured were small (body size < 10 mm) tunnelers (species of Onthophagus Latreille and Caccobius Thomson). Large (body size > 10 mm) tunnelers (species of Phelotrupes Jekel and Copris acutidens Motschulsky) were common in Kinkazan, and dwellers (species of Aphodius Illiger) were frequently obtained in Yakushima. At both sites, the capture rate and number of trapped beetles were greater during the summer and autumn (Kinkazan: 90–100%; Yakushima: 64–95%) than during other seasons. For several species, the number of beetles collected in each trap was positively correlated with mean temperature, but no relationship with rainfall was observed. From an ecological viewpoint, dung beetles burying seeds embedded in macaque feces might affect plant fitness in the initial stages.
Keywords	Aphodius ; Copris ; Geotrupidae ; Japan ; Macaca fuscata ; Onthophagus ; autumn ; body size ; deciduous forests ; dung beetles ; evergreen forests ; feces ; insect communities ; rain ; summer ; temperature
Language	English
Dates of publication	2022-0621
Size	p. 251-262.
Publishing place	Coleopterists Society
Document type	Article
ZDB-ID	2175913-3
ISSN	0010-065X
ISSN	0010-065X
DOI	10.1649/0010-065X-76.2.251
Database	NAL-Catalogue (AGRICOLA)

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Article: Unified synthesis of multiply arylated alkanes by catalytic deoxygenative transformation of diarylketones.

Kurosawa, Miki B / Kato, Kenta / Muto, Kei / Yamaguchi, Junichiro

Chemical science

2022 Volume 13, Issue 36, Page(s) 10743–10751

Abstract: A deoxygenative transformation of diarylketones leading to multiply arylated alkanes was developed. Diarylketones were reacted with diphenylphosphine oxide resulting in a phospha-Brook rearrangement, followed by palladium-catalyzed cross-couplings or a ... ...

Abstract	A deoxygenative transformation of diarylketones leading to multiply arylated alkanes was developed. Diarylketones were reacted with diphenylphosphine oxide resulting in a phospha-Brook rearrangement, followed by palladium-catalyzed cross-couplings or a Friedel-Crafts type alkylation to afford the corresponding multiply arylated alkanes. A variety of diarylketones can be converted to multiply arylated alkanes such as diarylmethanes, tetraarylethanes, and triarylmethanes by reduction, dimerization, and arylation in one pot. Furthermore, a one-pot conversion from arylcarboxylic acids to diarylmethanes and tetraarylethanes, and a synthesis of tetraarylmethane and triphenylethane using sequential coupling reactions are also presented.
Language	English
Publishing date	2022-08-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2559110-1
ISSN	2041-6539 ; 2041-6520
ISSN (online)	2041-6539
ISSN	2041-6520
DOI	10.1039/d2sc03720c
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Article: [Advancement in prostatectomy].

Miki, Kenta

Nihon rinsho. Japanese journal of clinical medicine

2011 Volume 69 Suppl 5, Page(s) 330–333

MeSH term(s)	Humans ; Male ; Prostatectomy/trends ; Prostatic Neoplasms/surgery
Language	Japanese
Publishing date	2011-06
Publishing country	Japan
Document type	Journal Article
ZDB-ID	390903-7
ISSN	0047-1852
ISSN	0047-1852
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Zs.A 429: Show issues

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Article ; Online: Novel technique for cognitive magnetic resonance imaging-transperineal ultrasound fusion transperineal prostate biopsy with injection of bubbled jelly into urethra after abdominoperineal excision.

Miyajima, Keiichiro / Urabe, Fumihiko / Nakano, Juria / Iwatani, Kosuke / Tashiro, Kojiro / Tsuzuki, Shunsuke / Sato, Shun / Takahashi, Hiroyuki / Kimura, Takahiro / Miki, Kenta

IJU case reports

2023 Volume 6, Issue 6, Page(s) 365–369

Abstract: Introduction: Prostate biopsy is commonly performed using a transrectal ultrasound probe through a transrectal or transperineal approach. However, this is not possible for patients without a rectum.: Case presentation: A 75-year-old male was referred ...

Abstract	Introduction: Prostate biopsy is commonly performed using a transrectal ultrasound probe through a transrectal or transperineal approach. However, this is not possible for patients without a rectum. Case presentation: A 75-year-old male was referred to our hospital because of an elevated prostate-specific antigen and a suspicious prostate lesion (PIRADS 5) in the left peripheral zone. The patient had previously undergone abdominoperineal resection for rectal cancer, which excluded the use of transrectal ultrasound. We describe the use of the transperineal ultrasound-guided biopsy with cognitive magnetic resonance imaging-transperineal ultrasound fusion and the utility of the injection of bubbled lidocaine jelly into urethra to improve its visualization. The pathological findings revealed clinically significant cancer with a Gleason score of 5 + 4. Conclusion: Cognitive magnetic resonance imaging-transperineal ultrasound fusion transperineal prostate biopsy with injection of bubbled jelly into urethra is a feasible and practical technique that does not require any specialized equipment.
Language	English
Publishing date	2023-08-14
Publishing country	Australia
Document type	Case Reports
ISSN	2577-171X
ISSN (online)	2577-171X
DOI	10.1002/iju5.12624
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Article ; Online: Radiographic Progression at Castration-Resistant Prostate Cancer Diagnosis: A Prognostic Indicator of Metastatic Hormone-Sensitive Prostate Cancer.

Tashiro, Kojiro / Kimura, Shoji / Tsuzuki, Shunsuke / Urabe, Fumihiko / Fukuokaya, Wataru / Mori, Keiichiro / Aikawa, Koichi / Murakami, Masaya / Sasaki, Hiroshi / Miki, Kenta / Miki, Jun / Shimomura, Tatsuya / Yamada, Hiroki / Hata, Kenichi / Nishikawa, Hideomi / Abe, Hirokazu / Watanabe, Ken / Kimura, Takahiro

Clinical genitourinary cancer

2024 Volume 22, Issue 3, Page(s) 102075

Abstract: Background: The critical role of radiographic assessment at the time of castration-resistant prostate cancer (CRPC) diagnosis is underscored by this study. We performed a retrospective analysis of radiographic changes in metastasis from the time of ... ...

Abstract	Background: The critical role of radiographic assessment at the time of castration-resistant prostate cancer (CRPC) diagnosis is underscored by this study. We performed a retrospective analysis of radiographic changes in metastasis from the time of diagnosis of metastatic hormone-sensitive prostate cancer (mHSPC) to CRPC diagnosis. We also explored its impact on prognosis post-CRPC. Materials and methods: We retrospectively analyzed 98 men who underwent radiographic examinations (bone scans and computed tomography [CT]) at the time of CRPC diagnosis. When radiographic studies demonstrated progression at CRPC diagnosis, patients were assigned to the radiographic progressive disease (rPD) group. The remaining patients were placed in the "non-rPD" group. The overall survival (OS) post-CRPC was compared between the 2 groups. Results: The median OS post-CRPC was significantly shorter in the rPD group (n = 50) compared to the non-rPD group (n = 48) (32 months vs. not reached, P = .0124). Multivariate analysis showed that radiographic progression and shorter time to CRPC were associated with a shorter OS post-CRPC (hazard ratio [HR] = 3.14; 95% confidence interval [CI], 1.21-8.12, P = .019). Conclusion: Radiographic progression at the point of CRPC diagnosis independently predicts a shorter OS post-CRPC in patients with mHSPC. Therefore, assessing radiographic changes at the time of CRPC diagnosis could be instrumental in managing CRPC in patients with mHSPC.
Language	English
Publishing date	2024-03-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2225121-2
ISSN	1938-0682 ; 1558-7673
ISSN (online)	1938-0682
ISSN	1558-7673
DOI	10.1016/j.clgc.2024.102075
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Article ; Online: Correction to: Comparison of outcomes in high‑risk prostate cancer patients treated with low‑/high‑dose‑rate brachytherapy plus external beam radiotherapy.

Imai, Yu / Urabe, Fumihiko / Iwatani, Kosuke / Nakazono, Minoru / Tashiro, Kojiro / Honda, Mariko / Aoki, Manabu / Sato, Shun / Takahashi, Hiroyuki / Miki, Kenta / Kimura, Takahiro

International journal of clinical oncology

2023 Volume 28, Issue 12, Page(s) 1697

Language	English
Publishing date	2023-10-09
Publishing country	Japan
Document type	Published Erratum
ZDB-ID	1400227-9
ISSN	1437-7772 ; 1341-9625
ISSN (online)	1437-7772
ISSN	1341-9625
DOI	10.1007/s10147-023-02415-w
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Zs.A 4828: Show issues

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Article ; Online: Effectiveness of Magnetic Resonance Imaging/Ultrasound-guided Target Biopsy in Detecting Clinically Significant Prostate Cancer.

Kurokawa, Gaku / Mori, Keiichiro / Sasaki, Hiroshi / Nakano, Juria / Takahashi, Yusuke / Iwatani, Kosuke / Urabe, Fumihiko / Tsuzuki, Shunsuke / Koike, Yusuke / Sato, Shun / Takahashi, Hiroyuki / Miki, Kenta / Kimura, Takahiro

Anticancer research

2024 Volume 44, Issue 2, Page(s) 679–686

Abstract: Background/aim: To evaluate the effectiveness of magnetic resonance imaging/ultrasound (MRI-US)-guided fusion biopsy in the detection of clinically significant prostate cancer (CSPC) and analyze the clinical features of patients highly suspected of ... ...

Abstract	Background/aim: To evaluate the effectiveness of magnetic resonance imaging/ultrasound (MRI-US)-guided fusion biopsy in the detection of clinically significant prostate cancer (CSPC) and analyze the clinical features of patients highly suspected of having prostate cancer (PCa) but shown to be negative in target biopsies (TB) among patients with prostate imaging reporting and data system (PI-RADS) 4 or 5 lesions on multiparametric MRI (mpMRI) evaluations. Patients and methods: We retrospectively evaluated all patients who underwent MRI/transrectal ultrasound (TRUS)-guided fusion biopsies at our institution between April 2018 and April 2022. All patients with at least one PI-RADS 3 or higher lesion and prostate-specific antigen (PSA) ≤20 ng/ml were enrolled in our study and subjected to TB in the region of interest (ROI). CSPC was defined as grade group (GG) ≥2 (equivalent to a Gleason score of 3+4). Results: The detection rates of CSPC were higher in patients who underwent systematic biopsy (SB) and TB (54%; 177/328) than in those who underwent SB alone (39%; 128/328). Significant differences were noted in the detection of CSPC depending on age, prostate volume, PI-RADS score, PSA density (PSAD), number of biopsies obtained, lesion location, and ROI. Conclusion: MRI/TRUS-guided fusion prostate biopsy increased the detection rate of CSPC. PCa was less likely to be detected in patients with a low PSAD, large prostate volume and no family history among those with PI-RADS 4 or 5 lesions and should be considered in such patients and addressed by performing additional SB for improving CSPC detection rate.
MeSH term(s)	Male ; Humans ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology ; Magnetic Resonance Imaging/methods ; Prostate-Specific Antigen ; Retrospective Studies ; Image-Guided Biopsy/methods ; Ultrasonography, Interventional/methods
Chemical Substances	Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2024-02-02
Publishing country	Greece
Document type	Journal Article
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
DOI	10.21873/anticanres.16858
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