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Article ; Online: Intracellular C3 protects β-cells from IL-1β-driven cytotoxicity via interaction with Fyn-related kinase.

Kulak, Klaudia / Kuska, Katarzyna / Colineau, Lucie / Mckay, Marina / Maziarz, Karolina / Slaby, Julia / Blom, Anna M / King, Ben C

Proceedings of the National Academy of Sciences of the United States of America

2024 Volume 121, Issue 8, Page(s) e2312621121

Abstract: One of the hallmarks of type 1 but also type 2 diabetes is pancreatic islet inflammation, associated with altered pancreatic islet function and structure, if unresolved. IL-1β is a proinflammatory cytokine which detrimentally affects β-cell function. In ... ...

Abstract	One of the hallmarks of type 1 but also type 2 diabetes is pancreatic islet inflammation, associated with altered pancreatic islet function and structure, if unresolved. IL-1β is a proinflammatory cytokine which detrimentally affects β-cell function. In the course of diabetes, complement components, including the central complement protein C3, are deregulated. Previously, we reported high C3 expression in human pancreatic islets, with upregulation after IL-1β treatment. In the current investigation, using primary human and rodent material and CRISPR/Cas9 gene-edited β-cells deficient in C3, or producing only cytosolic C3 from a noncanonical in-frame start codon, we report a protective effect of C3 against IL-1β-induced β-cell death, that is attributed to the cytosolic fraction of C3. Further investigation revealed that intracellular C3 alleviates IL-1β-induced β-cell death, by interaction with and inhibition of Fyn-related kinase (FRK), which is involved in the response of β-cells to cytokines. Furthermore, these data were supported by increased β-cell death in vivo in a β-cell-specific C3 knockout mouse. Our data indicate that a functional, cytoprotective association exists between FRK and cytosolic C3.
MeSH term(s)	Mice ; Animals ; Humans ; Diabetes Mellitus, Type 2/metabolism ; Insulin-Secreting Cells/metabolism ; Islets of Langerhans/metabolism ; Cell Death ; Cytokines/metabolism ; Mice, Knockout
Chemical Substances	Cytokines
Language	English
Publishing date	2024-02-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2312621121
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Bone disease after transplantation: osteoporosis and fractures risk.

Kulak, Carolina A M / Borba, Victoria Z C / Kulak Júnior, Jaime / Custódio, Melani Ribeiro

Arquivos brasileiros de endocrinologia e metabologia

2014 Volume 58, Issue 5, Page(s) 484–492

Abstract: Organ transplantation is the gold standard therapy for several end-stage diseases. Bone loss is a common complication that occurs in transplant recipients. Osteoporosis and fragility fractures are serious complication, mainly in the first year post ... ...

Abstract	Organ transplantation is the gold standard therapy for several end-stage diseases. Bone loss is a common complication that occurs in transplant recipients. Osteoporosis and fragility fractures are serious complication, mainly in the first year post transplantation. Many factors contribute to the pathogenesis of bone disease following organ transplantation. This review address the mechanisms of bone loss including the contribution of the immunosuppressive agents as well as the specific features to bone loss after kidney, lung, liver, cardiac and bone marrow transplantation. Prevention and management of bone loss in the transplant recipient should be included in their post transplant follow-up in order to prevent fractures.
MeSH term(s)	Bone Diseases/etiology ; Bone Diseases/prevention & control ; Bone Marrow Transplantation/adverse effects ; Bone Resorption/etiology ; Calcium/blood ; Diphosphonates/therapeutic use ; Heart Transplantation/adverse effects ; Humans ; Immunosuppressive Agents/adverse effects ; Kidney Transplantation/adverse effects ; Liver Transplantation/adverse effects ; Lung Transplantation/adverse effects ; Osteoporotic Fractures/etiology ; Transplantation/adverse effects ; Vitamin D/therapeutic use
Chemical Substances	Diphosphonates ; Immunosuppressive Agents ; Vitamin D (1406-16-2) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2014-08-25
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	603919-4
ISSN	1677-9487 ; 0004-2730
ISSN (online)	1677-9487
ISSN	0004-2730
DOI	10.1590/0004-2730000003343
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Bone disease after transplantation

Carolina A. M. Kulak / Victoria Z. C. Borba / Jaime Kulak Júnior / Melani Ribeiro Custódio

Arquivos brasileiros de Endocrinologia e Metabologia, Vol 58, Iss 5, Pp 484-

osteoporosis and fractures risk

2014 Volume 492

Abstract	Organ transplantation is the gold standard therapy for several end-stage diseases. Bone loss is a common complication that occurs in transplant recipients. Osteoporosis and fragility fractures are serious complication, mainly in the first year post transplantation. Many factors contribute to the pathogenesis of bone disease following organ transplantation. This review address the mechanisms of bone loss including the contribution of the immunosuppressive agents as well as the specific features to bone loss after kidney, lung, liver, cardiac and bone marrow transplantation. Prevention and management of bone loss in the transplant recipient should be included in their post transplant follow-up in order to prevent fractures.
Keywords	Transplante ; perda óssea ; osteoporose ; fraturas ; agentes imunossupressores ; Diseases of the endocrine glands. Clinical endocrinology ; RC648-665 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
Subject code	610
Language	Portuguese
Publishing date	2014-07-01T00:00:00Z
Publisher	Sociedade Brasileira de Endocrinologia e Metabologia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Bone disease after transplantation

Carolina A. M. Kulak / Victoria Z. C. Borba / Jaime Kulak Júnior / Melani Ribeiro Custódio

Arquivos brasileiros de Endocrinologia e Metabologia, Vol 58, Iss 5, Pp 484-

osteoporosis and fractures risk

2014 Volume 492

Abstract	Organ transplantation is the gold standard therapy for several end-stage diseases. Bone loss is a common complication that occurs in transplant recipients. Osteoporosis and fragility fractures are serious complication, mainly in the first year post transplantation. Many factors contribute to the pathogenesis of bone disease following organ transplantation. This review address the mechanisms of bone loss including the contribution of the immunosuppressive agents as well as the specific features to bone loss after kidney, lung, liver, cardiac and bone marrow transplantation. Prevention and management of bone loss in the transplant recipient should be included in their post transplant follow-up in order to prevent fractures.
Keywords	Transplante ; perda óssea ; osteoporose ; fraturas ; agentes imunossupressores ; Diseases of the endocrine glands. Clinical endocrinology ; RC648-665 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
Subject code	610
Language	Portuguese
Publishing date	2014-07-01T00:00:00Z
Publisher	Sociedade Brasileira de Endocrinologia e Metabologia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Bone disease after transplantation

Carolina A. M. Kulak / Victoria Z. C. Borba / Jaime Kulak Júnior / Melani Ribeiro Custódio

Arquivos brasileiros de Endocrinologia e Metabologia, Vol 58, Iss 5, Pp 484-

osteoporosis and fractures risk

2014 Volume 492

Abstract	Organ transplantation is the gold standard therapy for several end-stage diseases. Bone loss is a common complication that occurs in transplant recipients. Osteoporosis and fragility fractures are serious complication, mainly in the first year post transplantation. Many factors contribute to the pathogenesis of bone disease following organ transplantation. This review address the mechanisms of bone loss including the contribution of the immunosuppressive agents as well as the specific features to bone loss after kidney, lung, liver, cardiac and bone marrow transplantation. Prevention and management of bone loss in the transplant recipient should be included in their post transplant follow-up in order to prevent fractures.
Keywords	Transplante ; perda óssea ; osteoporose ; fraturas ; agentes imunossupressores ; Diseases of the endocrine glands. Clinical endocrinology ; RC648-665 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
Subject code	610
Language	Portuguese
Publishing date	2014-07-01T00:00:00Z
Publisher	Sociedade Brasileira de Endocrinologia e Metabologia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

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Article ; Online: Bone disease after transplantation

Carolina A. M. Kulak / Victoria Z. C. Borba / Jaime Kulak Júnior / Melani Ribeiro Custódio

Arquivos brasileiros de Endocrinologia e Metabologia, Vol 58, Iss 5, Pp 484-

osteoporosis and fractures risk

2014 Volume 492

Abstract	Organ transplantation is the gold standard therapy for several end-stage diseases. Bone loss is a common complication that occurs in transplant recipients. Osteoporosis and fragility fractures are serious complication, mainly in the first year post transplantation. Many factors contribute to the pathogenesis of bone disease following organ transplantation. This review address the mechanisms of bone loss including the contribution of the immunosuppressive agents as well as the specific features to bone loss after kidney, lung, liver, cardiac and bone marrow transplantation. Prevention and management of bone loss in the transplant recipient should be included in their post transplant follow-up in order to prevent fractures.
Keywords	Transplante ; perda óssea ; osteoporose ; fraturas ; agentes imunossupressores ; Diseases of the endocrine glands. Clinical endocrinology ; RC648-665 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
Subject code	610
Language	Portuguese
Publishing date	2014-07-01T00:00:00Z
Publisher	Sociedade Brasileira de Endocrinologia e Metabologia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

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Article ; Online: Bone disease after transplantation

Carolina A. M. Kulak / Victoria Z. C. Borba / Jaime Kulak Júnior / Melani Ribeiro Custódio

Arquivos brasileiros de Endocrinologia e Metabologia, Vol 58, Iss 5, Pp 484-

osteoporosis and fractures risk

2014 Volume 492

Abstract	Organ transplantation is the gold standard therapy for several end-stage diseases. Bone loss is a common complication that occurs in transplant recipients. Osteoporosis and fragility fractures are serious complication, mainly in the first year post transplantation. Many factors contribute to the pathogenesis of bone disease following organ transplantation. This review address the mechanisms of bone loss including the contribution of the immunosuppressive agents as well as the specific features to bone loss after kidney, lung, liver, cardiac and bone marrow transplantation. Prevention and management of bone loss in the transplant recipient should be included in their post transplant follow-up in order to prevent fractures.
Keywords	Transplante ; perda óssea ; osteoporose ; fraturas ; agentes imunossupressores ; Diseases of the endocrine glands. Clinical endocrinology ; RC648-665 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
Subject code	610
Language	Portuguese
Publishing date	2014-07-01T00:00:00Z
Publisher	Sociedade Brasileira de Endocrinologia e Metabologia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Osteocalcin, energy and glucose metabolism.

Zanatta, Leila C B / Boguszewski, Cesar L / Borba, Victoria Z C / Kulak, Carolina A M

Arquivos brasileiros de endocrinologia e metabologia

2014 Volume 58, Issue 5, Page(s) 444–451

Abstract: Osteocalcin is a bone matrix protein that has been associated with several hormonal actions on energy and glucose metabolism. Animal and experimental models have shown that osteocalcin is released into the bloodstream and exerts biological effects on ... ...

Abstract	Osteocalcin is a bone matrix protein that has been associated with several hormonal actions on energy and glucose metabolism. Animal and experimental models have shown that osteocalcin is released into the bloodstream and exerts biological effects on pancreatic beta cells and adipose tissue. Undercarboxylated osteocalcin is the hormonally active isoform and stimulates insulin secretion and enhances insulin sensitivity in adipose tissue and muscle. Insulin and leptin, in turn, act on bone tissue, modulating the osteocalcin secretion, in a traditional feedback mechanism that places the skeleton as a true endocrine organ. Further studies are required to elucidate the role of osteocalcin in the regulation of glucose and energy metabolism in humans and its potential therapeutic implications in diabetes, obesity and metabolic syndrome.
MeSH term(s)	Adipose Tissue/metabolism ; Animals ; Bone and Bones/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Energy Metabolism/physiology ; Glucose/metabolism ; Humans ; Insulin/metabolism ; Insulin Resistance ; Insulin-Secreting Cells/metabolism ; Leptin/metabolism ; Metabolic Syndrome/metabolism ; Muscles/drug effects ; Obesity/metabolism ; Osteocalcin/blood ; Osteocalcin/physiology
Chemical Substances	Insulin ; Leptin ; Osteocalcin (104982-03-8) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2014-08-25
Publishing country	Brazil
Document type	Journal Article ; Review
ZDB-ID	603919-4
ISSN	1677-9487 ; 0004-2730
ISSN (online)	1677-9487
ISSN	0004-2730
DOI	10.1590/0004-2730000003333
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Patient-Reported Outcome Measures in Atopic Dermatitis and Chronic Urticaria are Underused in Clinical Practice.

Cherrez-Ojeda, Ivan / Bousquet, Jean / Giménez-Arnau, Ana / Godse, Kiran / Krasowska, Dorota / Bartosińska, Joanna / Szczepanik-Kułak, Paulina / Wawrzycki, Bartłomiej / Kolkhir, Pavel / Allenova, Anastasiia / Allenov, Andrey / Tkachenko, Sergey / Teovska Mitrevska, Natasa / Mijakoski, Dragan / Stoleski, Sasho / Kolacinska-Flont, Marta / Kuprys-Lipinska, Izabela / Molinska, Joanna / Kasperska-Zając, Alicja /

Zajac, Magdalena / Zamlynski, Mateusz / Mihaltan, Florin / Ulmeanu, Ruxandra / Zalewska-Janowska, Anna / Tomaszewska, Katarzyna / Al-Ahmad, Mona / Al-Nesf, Maryam Ali / Ibrahim, Tayseer / Aqel, Sami / Pesqué, David / Rodríguez-González, Mónica / Wakida-Kuzunoki, Guillermo Hideo / Ramon, German D / Ramon, Gonzalo N / Neisinger, Sophia / Bonnekoh, Hanna / Rukhadze, Maia / Khoshkhui, Maryam / Fomina, Daria / Larenas-Linnemann, Désirée / Košnik, Mitja / Oztas Kara, Rabia / Caballero López, Chrystopherson Gengyny / Liu, Qiang / Ivancevich Juan, Carlos / Ensina, Luis Felipe / Rosario, Nelson / Kvedariene, Violeta / Ben-Shoshan, Moshe / Criado, Roberta Fachini Jardim / Bauer, Andrea / Cherrez, Annia / Chong-Neto, Herberto / Rojo-Gutierrez, Maria Isabel / Rudenko, Michael / Larco Sousa, José Ignacio / Lesiak, Aleksandra / Matos, Edgar / Muñoz, Nelson / Tinoco, Ivan / Moreno, Jaime / Crespo Shijin, Carolina / Hinostroza Logroño, Romina / Sagñay, Juan C / Faytong-Haro, Marco / Robles-Velasco, Karla / Zuberbier, Torsten / Maurer, Marcus

The journal of allergy and clinical immunology. In practice

2024

Abstract: Background: Patient-reported outcome measures (PROMs) are validated and standardized tools that complement physician evaluations and guide treatment decisions. PROMs are crucial for monitoring atopic dermatitis (AD) and chronic urticaria (CU) in ... ...

Abstract	Background: Patient-reported outcome measures (PROMs) are validated and standardized tools that complement physician evaluations and guide treatment decisions. PROMs are crucial for monitoring atopic dermatitis (AD) and chronic urticaria (CU) in clinical practice, but there are unmet needs and knowledge gaps regarding their use in clinical practice. Objective: We investigated the global real-world use of AD and CU PROMs in allergology and dermatology clinics as well as their associated local and regional networks. Methods: Across 72 specialized allergy and dermatology centers and their local and regional networks, 2,534 physicians in 73 countries completed a 53-item questionnaire on the use of PROMs for AD and CU. Results: Of 2,534 physicians, 1,308 were aware of PROMs. Of these, 14% and 15% used PROMs for AD and CU, respectively. Half of physicians who use PROMs do so only "rarely" or "sometimes". AD and CU PROM usage is associated with being female, younger, and a dermatologist. POSCORAD and UAS were the most utilized PROMs for AD and CU, respectively. Monitoring disease control and activity are the main drivers of the use of PROMs. Time constraints were the primary obstacle to using PROMs, followed by the impression that patients dislike PROMs. AD and CU PROM users would like training in selecting the proper PROM. Conclusion: Even though PROMs offer several benefits, their use in routine practice is suboptimal, and physicians perceive barriers to their use. It is essential to attain higher levels of PROM implementation in accordance with national and international standards.
Language	English
Publishing date	2024-04-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2843237-X
ISSN	2213-2201 ; 2213-2198
ISSN (online)	2213-2201
ISSN	2213-2198
DOI	10.1016/j.jaip.2024.03.050
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 7086: Show issues

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Article ; Online: Gene expression evolution in pattern-triggered immunity within Arabidopsis thaliana and across Brassicaceae species.

Winkelmüller, Thomas M / Entila, Frederickson / Anver, Shajahan / Piasecka, Anna / Song, Baoxing / Dahms, Eik / Sakakibara, Hitoshi / Gan, Xiangchao / Kułak, Karolina / Sawikowska, Aneta / Krajewski, Paweł / Tsiantis, Miltos / Garrido-Oter, Ruben / Fukushima, Kenji / Schulze-Lefert, Paul / Laurent, Stefan / Bednarek, Paweł / Tsuda, Kenichi

The Plant cell

2021 Volume 33, Issue 6, Page(s) 1863–1887

Abstract: Plants recognize surrounding microbes by sensing microbe-associated molecular patterns (MAMPs) to activate pattern-triggered immunity (PTI). Despite their significance for microbial control, the evolution of PTI responses remains largely uncharacterized. ...

Abstract	Plants recognize surrounding microbes by sensing microbe-associated molecular patterns (MAMPs) to activate pattern-triggered immunity (PTI). Despite their significance for microbial control, the evolution of PTI responses remains largely uncharacterized. Here, by employing comparative transcriptomics of six Arabidopsis thaliana accessions and three additional Brassicaceae species to investigate PTI responses, we identified a set of genes that commonly respond to the MAMP flg22 and genes that exhibit species-specific expression signatures. Variation in flg22-triggered transcriptome responses across Brassicaceae species was incongruent with their phylogeny, while expression changes were strongly conserved within A. thaliana. We found the enrichment of WRKY transcription factor binding sites in the 5'-regulatory regions of conserved and species-specific responsive genes, linking the emergence of WRKY-binding sites with the evolution of gene expression patterns during PTI. Our findings advance our understanding of the evolution of the transcriptome during biotic stress.
MeSH term(s)	Arabidopsis/metabolism ; Arabidopsis Proteins/metabolism ; Brassicaceae/genetics ; Brassicaceae/metabolism ; Gene Expression ; Gene Expression Regulation, Plant/genetics ; Plant Immunity/genetics
Chemical Substances	Arabidopsis Proteins
Language	English
Publishing date	2021-03-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	623171-8
ISSN	1532-298X ; 1040-4651
ISSN (online)	1532-298X
ISSN	1040-4651
DOI	10.1093/plcell/koab073
Database	MEDical Literature Analysis and Retrieval System OnLINE

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