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Book ; Online ; Thesis: Von Morphologie zu Molekularbiologie: Charakterisierung HPV-induzierter zervikaler Läsionen auf der Basis einer quantitativen, mRNA-basierten Messung zellulärer und viraler Biomarker

Nevermann, Nora [Verfasser]

ein diagnostischer Paradigmenwechsel?

2019

Author's details	Nora Nevermann
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	German
Publisher	Medizinische Fakultät Charité - Universitätsmedizin Berlin
Publishing place	Berlin
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: Gallengangsverletzung im Rahmen der laparoskopischen Cholezystektomie : Klassifikation, Erkennung und Reparation.

Nevermann, Nora / Schöning, Wenzel / Malinka, Thomas / Fehrenbach, Uli / Müller, Tobias / Pratschke, Johann / Schmelzle, Moritz

Chirurgie (Heidelberg, Germany)

2022 Volume 93, Issue 6, Page(s) 554–565

Abstract: Background: Bile duct injuries during laparoscopic cholecystectomy are rare but serious complications.: Classification and diagnostics: Bile duct injuries can be classified based on their location, injury pattern and possible concomitant vascular ... ...

Title translation	Bile duct injuries during laparoscopic cholecystectomy : Classification, recognition and repair.
Abstract	Background: Bile duct injuries during laparoscopic cholecystectomy are rare but serious complications. Classification and diagnostics: Bile duct injuries can be classified based on their location, injury pattern and possible concomitant vascular injury. Several classifications exist with the Neuhaus classification, which is widely used in Germany, allowing a clinically oriented classification of bile duct injuries. The diagnostic algorithm is based on whether the injury is diagnosed due to bile leakage or bile duct occlusion and whether there is also a circulatory disturbance of the liver. The differentiated use of laboratory, image-based, endoscopic and interventional methods enables not only classification but also treatment planning. Treatment: About half of all bile duct lesions can be treated by an endoscopic intervention; however, with increasing size of the defect, with complete occlusion of the bile duct or with relevant circulatory disturbances of the liver, the probability for the need of a surgical procedure increases. Intraoperatively, a distinction must be made between repair by suturing and splinting and reconstruction of the bile duct by patch plasty or hepaticojejunostomy. Partial liver resection or liver transplantation may be necessary, especially in cases of circulatory disorders. In addition to appropriate experience, good communication and interdisciplinary cooperation between endoscopy, interventional radiology and surgery are crucial for the success of the treatment. In this respect, contacting a specialized center for liver and transplantation surgery as soon as possible is advised.
MeSH term(s)	Abdominal Injuries/surgery ; Bile Ducts/diagnostic imaging ; Cholecystectomy, Laparoscopic/adverse effects ; Cholestasis/surgery ; Humans ; Liver Transplantation
Language	German
Publishing date	2022-02-16
Publishing country	Germany
Document type	Journal Article ; Review
ISSN	2731-698X
ISSN (online)	2731-698X
DOI	10.1007/s00104-022-01592-0
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Article ; Online: Simplifying minimally invasive right hepatectomy.

Nevermann, Nora / Feldbrügge, Linda / Knitter, Sebastian / Krenzien, Felix / Raschzok, Nathanael / Lurje, Georg / Schöning, Wenzel / Pratschke, Johann / Schmelzle, Moritz

Surgical endoscopy

2023 Volume 37, Issue 7, Page(s) 5430–5437

Abstract: Background: Extrahepatic transection of the right hepatic artery and right portal vein before parenchymal dissection is a widely used standard for minimal invasive right hepatectomy. Hereby, hilar dissection represents a technical difficulty. We report ... ...

Abstract	Background: Extrahepatic transection of the right hepatic artery and right portal vein before parenchymal dissection is a widely used standard for minimal invasive right hepatectomy. Hereby, hilar dissection represents a technical difficulty. We report our results of a simplified approach in which the hilar dissection is omitted and the line of dissection is defined with ultrasound. Methods: Patients undergoing minimally invasive right hepatectomy were included. Ultrasound-guided hepatectomy (UGH) was defined by the following main steps: (1) ultrasound-guided definition of the transection line, (2) dissection of the liver parenchyma according to the caudal approach, (3) intraparenchymal transection of the right pedicle and (4) of the right liver vein, respectively. Intra- and postoperative outcomes of UGH were compared to the standard technique. Propensity score matching was performed to adjust for parameters of perioperative risk. Results: Median operative time was 310 min in the UGH group compared to 338 min in the control group (p = 0.013). No differences were observed for Pringle maneuver duration (35 min vs. 25 min; p = ns) nor postoperative transaminases levels (p = ns). There was a trend toward a lower major complication rate in the UGH group (13 vs. 25%) and a shorter median hospital stay (8 days vs. 10 days); however, both being short of statistical significance (p = ns). Bile leak was observed in zero cases of UGH compared to 9 out of 32 cases (28%) for the control group (p = 0.020). Conclusions: UGH appears to be at least comparable to the standard technique in terms of intraoperative and postoperative outcomes. Accordingly, transection of the right hepatic artery and right portal vein prior to the transection phase can be omitted, at least in selected cases. These results need to be confirmed in a prospective and randomized trial.
MeSH term(s)	Humans ; Hepatectomy/methods ; Liver Neoplasms/surgery ; Prospective Studies ; Hepatic Veins/surgery ; Laparoscopy/methods
Language	English
Publishing date	2023-04-07
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639039-0
ISSN	1432-2218 ; 0930-2794
ISSN (online)	1432-2218
ISSN	0930-2794
DOI	10.1007/s00464-023-09996-7
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Article ; Online: Is Repeat Resection for Recurrent Intrahepatic Cholangiocarcinoma Warranted? Outcomes of an International Analysis.

Holzner, Matthew L / Mazzaferro, Vincenzo / Busset, Michele Droz Dit / Aldrighetti, Luca / Ratti, Francesca / Hasegawa, Kiyoshi / Arita, Junichi / Sapisochin, Gonzalo / Abreu, Phillipe / Schoning, Wenzel / Schmelzle, Mortiz / Nevermann, Nora / Pratschke, Johann / Florman, Sander / Halazun, Karim / Schwartz, Myron E / Tabrizian, Parissa

Annals of surgical oncology

2024

Abstract: Background: Recurrence of intrahepatic cholangiocarcinoma (ICC) after liver resection (LR) remains high, and optimal therapy for recurrent ICC is challenging. Herein, we assess the outcomes of patients undergoing repeat resection for recurrent ICC in a ... ...

Abstract	Background: Recurrence of intrahepatic cholangiocarcinoma (ICC) after liver resection (LR) remains high, and optimal therapy for recurrent ICC is challenging. Herein, we assess the outcomes of patients undergoing repeat resection for recurrent ICC in a large, international multicenter cohort. Patients and methods: Outcomes of adults from six large hepatobiliary centers in North America, Europe, and Asia with recurrent ICC following primary LR between 2001 and 2015 were analyzed. Cox models determined predictors of post-recurrence survival. Results: Of patients undergoing LR for ICC, 499 developed recurrence. The median time to recurrence was 10 months, and 47% were intrahepatic. Overall 3-year post-recurrence survival rate was 28.6%. In total, 121 patients (25%) underwent repeat resection, including 74 (61%) repeat LRs. Surgically treated patients were more likely to have solitary intrahepatic recurrences and significantly prolonged survival compared with those receiving locoregional or systemic therapy alone with a 3-year post-recurrence survival rate of 47%. Independent predictors of post-recurrence death included time to recurrence < 1 year [HR 1.66 (1.32-2.10), p < 0.001], site of recurrence [HR 1.74 (1.28-2.38), p < 0.001], macrovascular invasion [HR 1.43 (1.05-1.95), p = 0.024], and size of recurrence > 3 cm [HR 1.68 (1.24-2.29), p = 0.001]. Repeat resection was independently associated with decreased post-recurrence death [HR 0.58 0.43-0.78), p < 0.001]. Conclusions: Repeat resection for recurrent ICC in select patients can result in extended survival. Thus, challenging the paradigm of offering these patients locoregional or chemo/palliative therapy alone as the mainstay of treatment.
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-024-14975-w
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Article ; Online: Robotic versus laparoscopic versus open major hepatectomy - an analysis of costs and postoperative outcomes in a single-center setting.

Knitter, Sebastian / Feldbrügge, Linda / Nevermann, Nora / Globke, Brigitta / Galindo, Santiago Andres Ortiz / Winklmann, Thomas / Krenzien, Felix / Haber, Philipp K / Malinka, Thomas / Lurje, Georg / Schöning, Wenzel / Pratschke, Johann / Schmelzle, Moritz

Langenbeck's archives of surgery

2023 Volume 408, Issue 1, Page(s) 214

Abstract: Purpose: In the era of minimal-invasive surgery, the introduction of robotic liver surgery (RS) was accompanied by concerns about the increased financial expenses of the robotic technique in comparison to the established laparoscopic (LS) and ... ...

Abstract	Purpose: In the era of minimal-invasive surgery, the introduction of robotic liver surgery (RS) was accompanied by concerns about the increased financial expenses of the robotic technique in comparison to the established laparoscopic (LS) and conventional open surgery (OS). Therefore, we aimed to evaluate the cost-effectiveness of RS, LS and OS for major hepatectomies in this study. Methods: We analyzed financial and clinical data on patients who underwent major liver resection for benign and malign lesions from 2017 to 2019 at our department. Patients were grouped according to the technical approach in RS, LS, and OS. For better comparability, only cases stratified to the Diagnosis Related Groups (DRG) H01A and H01B were included in this study. Financial expenses were compared between RS, LS, and OS. A binary logistic regression model was used to identify parameters associated with increased costs. Results: RS, LS and OS accounted for median daily costs of 1,725 €, 1,633 € and 1,205 €, respectively (p < 0.0001). Median daily (p = 0.420) and total costs (16,648 € vs. 14,578 €, p = 0.076) were comparable between RS and LS. Increased financial expenses for RS were mainly caused by intraoperative costs (7,592 €, p < 0.0001). Length of procedure (hazard ratio [HR] = 5.4, 95% confidence interval [CI] = 1.7-16.9, p = 0.004), length of stay (HR [95% CI] = 8.8 [1.9-41.6], p = 0.006) and development of major complications (HR [95% CI] = 2.9 [1.7-5.1], p < 0.0001) were independently associated with higher costs. Conclusions: From an economic perspective, RS may be considered a valid alternative to LS for major liver resections.
MeSH term(s)	Humans ; Hepatectomy/methods ; Robotic Surgical Procedures/methods ; Robotics ; Liver ; Laparoscopy/methods
Language	English
Publishing date	2023-05-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1423681-3
ISSN	1435-2451 ; 1435-2443
ISSN (online)	1435-2451
ISSN	1435-2443
DOI	10.1007/s00423-023-02953-x
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Article ; Online: A surgical strategy for intrahepatic cholangiocarcinoma - the hilar first concept.

Nevermann, Nora / Bode, Julia / Vischer, Maxine / Feldbrügge, Lina / Knitter, Sebastian / Krenzien, Felix / Pelzer, Uwe / Fehrenbach, Uli / Auer, Timo Alexander / Lurje, Georg / Schmelzle, Moritz / Pratschke, Johann / Schöning, Wenzel

Langenbeck's archives of surgery

2023 Volume 408, Issue 1, Page(s) 296

Abstract: Purpose: The present study assesses long-term overall survival (OS) and disease-free survival (DFS) after curative resection for intrahepatic cholangiocarcinoma (ICCA) depending on resection margin (RM) status and lymph node (LN) status.: Methods: ... ...

Abstract	Purpose: The present study assesses long-term overall survival (OS) and disease-free survival (DFS) after curative resection for intrahepatic cholangiocarcinoma (ICCA) depending on resection margin (RM) status and lymph node (LN) status. Methods: Clinical data of all consecutively resected patients with ICCA at a single high-volume center between 2005 and 2018 were collected. Minimum follow-up was 36 months. Perioperative and long-term oncological outcome was assessed. Results: One hundred ninety-two cases were included in the analysis. Thirty- and 90-day-mortality was 5.2% (n = 10) and 10.9% (n = 21). OS was 26 months with 1-, 2-, and 5-year-OS rates of 72%, 53%, and 26%. One-, 2-, and 5-year-DFS rates were 54%, 42%, and 35% (N0 vs. N1: 29 vs. 9 months, p = 0.116). R1 was not found to be an independent risk factor for reduced survival in the overall cohort (p = 0.098). When differentiating according to the LN status, clear resection margins were significantly associated with increased DFS for N0 cases (50 months vs. 9 months, p = 0.004). For N1 cases, no significant difference in DFS was calculated for R0 compared to R1 cases (9 months vs. 9 months, p = 0.88). For N0 cases, clear resection margins > 10 mm were associated with prolonged OS (p = 0.048). Conclusion: For N1 cases, there was no significant survival benefit when comparing R0 versus R1, while the complication rate remained high for the extended resection types. In view of merging multimodal treatment, the hilar first concept assesses locoregional LN status for optimal surgical therapy.
MeSH term(s)	Humans ; Margins of Excision ; Hepatectomy ; Retrospective Studies ; Cholangiocarcinoma/pathology ; Bile Ducts, Intrahepatic/surgery ; Bile Duct Neoplasms/pathology ; Treatment Outcome ; Survival Rate
Language	English
Publishing date	2023-08-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1423681-3
ISSN	1435-2451 ; 1435-2443
ISSN (online)	1435-2451
ISSN	1435-2443
DOI	10.1007/s00423-023-03023-y
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Article ; Online: Gd-EOB-DTPA-MRCP to localize bile leakage after liver trauma and surgery: impact on treatment and outcome.

Marth, Adrian A / Auer, Timo A / Walter-Rittel, Thula C / Nevermann, Nora / Krenzien, Felix / Schmelzle, Moritz / Müller, Tobias / Kolck, Johannes / Wieners, Gero / Geisel, Dominik / Gebauer, Bernhard / Hamm, Bernd / Schöning, Wenzel / Fehrenbach, Uli

European radiology

2023 Volume 33, Issue 9, Page(s) 5933–5942

Abstract: Objectives: Bile leakage (BL) is a challenging complication after hepatobiliary surgery and liver trauma. Gadolinium ethoxybenzyl (Gd-EOB-DTPA)-enhanced magnetic resonance cholangiopancreatography (MRCP) is used to diagnose BL non-invasively. We ... ...

Abstract	Objectives: Bile leakage (BL) is a challenging complication after hepatobiliary surgery and liver trauma. Gadolinium ethoxybenzyl (Gd-EOB-DTPA)-enhanced magnetic resonance cholangiopancreatography (MRCP) is used to diagnose BL non-invasively. We assessed the value of Gd-EOB-DTPA-MRCP in the detection of postoperative and post-traumatic BL hypothesizing that exact identification of the leakage site is pivotal for treatment planning and outcome. Methods: We retrospectively enrolled 39 trauma and postoperative patients who underwent Gd-EOB-DTPA-MRCP for suspected BL. Three readers rated the presence of BL and leakage site (intraparenchymal, central, peripheral ± aberrant or disconnected ducts). Imaging findings were compared to subsequent interventional procedures and their complexity and outcome. Results: BL was detected in Gd-EOB-DTPA-MRCP in 25 of patients and was subsequently confirmed. Sites of BL differed significantly between postoperative (central [58%] and peripheral [42%]) and trauma patients (intraparenchymal [100%]; p < 0.001). Aberrant or disconnected ducts were diagnosed in 8%/26% of cases in the postoperative subgroup. Inter-rater agreement for the detection and localization of BL was almost perfect (Κ = 0.85 and 0.88; p < 0.001). Intraparenchymal BL required significantly less complex interventional procedures (p = 0.002), whereas hospitalization and mortality did not differ between the subgroups (p > 0.05). Conclusions: Gd-EOB-DTPA-MRCP reliably detects and exactly locates BL in postoperative and trauma patients. Exact localization of biliary injuries enables specific treatment planning, as intraparenchymal leakages, which occur more frequently after trauma, require less complex interventions than central or peripheral leaks in the postoperative setting. As a result of specific treatment based on exact BL localization, there was no difference in the duration of hospitalization or mortality. Clinical relevance statement: Gd-EOB-DTPA-MRCP is a reliable diagnostic tool for exactly localizing iatrogenic and post-traumatic biliary leakage. Its precise localization helps tailor local therapies for different injury patterns, resulting in comparable clinical outcomes despite varying treatments. Key points: • Gd-EOB-DTPA-MRCP enables adequate detection and localization of bile leakages in both postoperative and post-traumatic patients. • The site of bile leakage significantly impacts the complexity of required additional interventions. • Intraparenchymal bile leakage is commonly seen in patients with a history of liver trauma and requires less complex interventions than postoperative central or peripheral bile leakages, while hospitalization and mortality are similar.
MeSH term(s)	Humans ; Cholangiopancreatography, Magnetic Resonance/methods ; Contrast Media ; Retrospective Studies ; Bile ; Gadolinium DTPA ; Biliary Tract Diseases ; Liver/diagnostic imaging ; Liver/surgery ; Liver/pathology ; Treatment Outcome ; Magnetic Resonance Imaging/methods ; Liver Neoplasms
Chemical Substances	gadolinium ethoxybenzyl DTPA ; Contrast Media ; Gadolinium DTPA (K2I13DR72L)
Language	English
Publishing date	2023-04-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-023-09608-x
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Article ; Online: Gd-EOB MRI for HCC subtype differentiation in a western population according to the 5

Auer, Timo A / Halskov, Sebastian / Fehrenbach, Uli / Nevermann, Nora F / Pelzer, Uwe / Mohr, Raphael / Hamm, Bernd / Schöning, Wenzel / Horst, David / Ihlow, Jana / Geisel, Dominik

European radiology

2023 Volume 33, Issue 10, Page(s) 6902–6915

Abstract: Objectives: To investigate the value of gadoxetic acid (Gd-EOB)-enhanced magnetic resonance imaging (MRI) for noninvasive subtype differentiation of HCCs according to the 5: Methods: This retrospective study included 262 resected lesions in 240 ... ...

Abstract	Objectives: To investigate the value of gadoxetic acid (Gd-EOB)-enhanced magnetic resonance imaging (MRI) for noninvasive subtype differentiation of HCCs according to the 5 Methods: This retrospective study included 262 resected lesions in 240 patients with preoperative Gd-EOB-enhanced MRI. Subtypes were assigned by two pathologists. Gd-EOB-enhanced MRI datasets were assessed by two radiologists for qualitative and quantitative imaging features, including imaging features defined in LI-RADS v2018 and area of hepatobiliary phase (HBP) iso- to hyperintensity. Results: The combination of non-rim arterial phase hyperenhancement with non-peripheral portal venous washout was more common in "not otherwise specified" (nos-ST) (88/168, 52%) than other subtypes, in particular macrotrabecular massive (mt-ST) (3/15, 20%), chromophobe (ch-ST) (1/8, 13%), and scirrhous subtypes (sc-ST) (2/9, 22%) (p = 0.035). Macrovascular invasion was associated with mt-ST (5/16, p = 0.033) and intralesional steatosis with steatohepatitic subtype (sh-ST) (28/32, p < 0.001). Predominant iso- to hyperintensity in the HBP was only present in nos-ST (16/174), sh-ST (3/33), and clear cell subtypes (cc-ST) (3/13) (p = 0.031). Associations were found for the following non-imaging parameters: age and sex, as patients with fibrolamellar subtype (fib-ST) were younger (median 44 years (19-66), p < 0.001) and female (4/5, p = 0.023); logarithm of alpha-fetoprotein (AFP) was elevated in the mt-ST (median 397 µg/l (74-5370), p < 0.001); type II diabetes mellitus was more frequent in the sh-ST (20/33, p = 0.027). Conclusions: Gd-EOB-MRI reproduces findings reported in the literature for extracellular contrast-enhanced MRI and CT and may be a valuable tool for noninvasive HCC subtype differentiation. Clinical relevance statement: Better characterization of the heterogeneous phenotypes of HCC according to the revised WHO classification potentially improves both diagnostic accuracy and the precision of therapeutic stratification for HCC. Key points: • Previously reported imaging features of common subtypes in CT and MRI enhanced with extracellular contrast agents are reproducible with Gd-EOB-enhanced MRI. • While uncommon, predominant iso- to hyperintensity in the HBP was observed only in NOS, clear cell, and steatohepatitic subtypes. • Gd-EOB-enhanced MRI offers imaging features that are of value for HCC subtype differentiation according to the 5
MeSH term(s)	Humans ; Female ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/pathology ; Retrospective Studies ; Diabetes Mellitus, Type 2 ; Gadolinium DTPA ; Contrast Media/pharmacology ; Magnetic Resonance Imaging/methods ; Fatty Liver ; Sensitivity and Specificity
Chemical Substances	Gadolinium DTPA (K2I13DR72L) ; Contrast Media
Language	English
Publishing date	2023-04-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-023-09669-y
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Article ; Online: Robotic Liver Surgery: Technical Advantages Over Laparoscopic Technique Based on Parameters of Surgical Complexity and Perioperative Outcomes.

Nevermann, Nora / Feldbrügge, Linda / Krenzien, Felix / Ortiz Galindo, Santiago / Knitter, Sebastian / Haber, Philipp / Malinka, Thomas / Lurje, Georg / Schöning, Wenzel / Schmelzle, Moritz / Pratschke, Johann

Journal of laparoendoscopic & advanced surgical techniques. Part A

2022

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2022-07-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	1381909-4
ISSN	1557-9034 ; 1092-6429
ISSN (online)	1557-9034
ISSN	1092-6429
DOI	10.1089/lap.2022.0129
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Article ; Online: Short-term postoperative outcomes of lymphadenectomy for cholangiocarcinoma, hepatocellular carcinoma and colorectal liver metastases in the modern era of liver surgery: Insights from the StuDoQ|Liver registry.

Knitter, Sebastian / Raschzok, Nathanael / Hillebrandt, Karl-Herbert / Benzing, Christian / Moosburner, Simon / Nevermann, Nora / Haber, Philipp / Gül-Klein, Safak / Fehrenbach, Uli / Lurje, Georg / Schöning, Wenzel / Fangmann, Josef / Glanemann, Matthias / Kalff, Jörg C / Mehrabi, Arianeb / Michalski, Christoph / Reißfelder, Christoph / Schmeding, Maximilian / Schnitzbauer, Andreas A /

Stavrou, Gregor A / Werner, Jens / Pratschke, Johann / Krenzien, Felix

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

2024 Volume 50, Issue 4, Page(s) 108010

Abstract: Introduction: The clinical role of lymphadenectomy (LAD) as part of hepatic resection for malignancies of the liver remains unclear. In this study, we aimed to report on the use cases and postoperative outcomes of liver resection and simultaneous LAD ... ...

Abstract	Introduction: The clinical role of lymphadenectomy (LAD) as part of hepatic resection for malignancies of the liver remains unclear. In this study, we aimed to report on the use cases and postoperative outcomes of liver resection and simultaneous LAD for hepatic malignancies (HM). Materials and methods: Clinicopathological data from patients who underwent surgery at 13 German centers from 2017 to 2022 (n = 3456) was extracted from the StuDoQ\|Liver registry of the German Society of General and Visceral Surgery. Propensity-score matching (PSM) was performed to account for the extent of liver resection and patient demographics. Results: LAD was performed in 545 (16%) cases. The most common indication for LAD was cholangiocarcinoma (CCA), followed by colorectal liver metastases (CRLM) and hepatocellular carcinoma (HCC). N+ status was found in 7 (8%), 59 (35%), and 56 cases (35%) for HCC, CCA, and CRLM, respectively (p < 0.001). The LAD rate was highest for robotic-assisted resections (28%) followed by open (26%) and laparoscopic resections (13%), whereas the number of resected lymph nodes was equivalent between the techniques (p = 0.303). LAD was associated with an increased risk of liver-specific postoperative complications, especially for patients with HCC. Conclusion: In this multicenter registry study, LAD was found to be associated with an increased risk of liver-specific complications. The highest rate of LAD was observed among robotic liver resections.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/surgery ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/secondary ; Colorectal Neoplasms/pathology ; Retrospective Studies ; Hepatectomy/methods ; Cholangiocarcinoma/surgery ; Laparoscopy/methods ; Lymph Node Excision ; Bile Ducts, Intrahepatic/pathology ; Bile Duct Neoplasms/surgery ; Registries ; Postoperative Complications/epidemiology ; Postoperative Complications/surgery ; Propensity Score
Language	English
Publishing date	2024-02-08
Publishing country	England
Document type	Multicenter Study ; Journal Article
ZDB-ID	632519-1
ISSN	1532-2157 ; 0748-7983
ISSN (online)	1532-2157
ISSN	0748-7983
DOI	10.1016/j.ejso.2024.108010
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Zs.A 1149: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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