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  1. Article ; Online: New Editor-in-Chief for Avian Pathology.

    Bradbury, Janet M

    Avian pathology : journal of the W.V.P.A

    2017  Volume 46, Issue 4, Page(s) 345

    Language English
    Publishing date 2017-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476380-1
    ISSN 1465-3338 ; 0307-9457
    ISSN (online) 1465-3338
    ISSN 0307-9457
    DOI 10.1080/03079457.2017.1330005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Editorial.

    Bradbury, Janet M

    Avian pathology : journal of the W.V.P.A

    2016  Volume 45, Issue 6, Page(s) 605

    Language English
    Publishing date 2016-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476380-1
    ISSN 1465-3338 ; 0307-9457
    ISSN (online) 1465-3338
    ISSN 0307-9457
    DOI 10.1080/03079457.2016.1245517
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A New Year, a new look for Avian Pathology and a special issue on necrotic enteritis.

    Bradbury, Janet M

    Avian pathology : journal of the W.V.P.A

    2016  Volume 45, Issue 1, Page(s) 1

    MeSH term(s) Animals ; Enteritis/diagnosis ; Enteritis/veterinary ; Poultry ; Poultry Diseases/diagnosis
    Language English
    Publishing date 2016
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1476380-1
    ISSN 1465-3338 ; 0307-9457
    ISSN (online) 1465-3338
    ISSN 0307-9457
    DOI 10.1080/03079457.2016.1148317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Overexpression of soluble epoxide hydrolase reduces post-ischemic recovery of cardiac contractile function.

    Edin, Matthew L / Gruzdev, Artiom / Bradbury, J Alyce / Graves, Joan P / Muse, Ginger W / Goulding, David R / Lih, Fred B / DeGraff, Laura M / Zeldin, Darryl C

    Biochemical pharmacology

    2024  , Page(s) 116237

    Abstract: Cytochromes P450 can metabolize endogenous fatty acids, such as arachidonic acid, to bioactive lipids such as epoxyeicosatrienoic acids (EETs) that have beneficial effects. EETs protect hearts against ischemic damage, heart failure or fibrosis; however, ... ...

    Abstract Cytochromes P450 can metabolize endogenous fatty acids, such as arachidonic acid, to bioactive lipids such as epoxyeicosatrienoic acids (EETs) that have beneficial effects. EETs protect hearts against ischemic damage, heart failure or fibrosis; however, their effects are limited by hydrolysis to less active dihydroxy oxylipins by soluble epoxide hydrolase (sEH), encoded by the epoxide hydrolase 2 gene (EPHX2, EC 3.3.2.10). Pharmacological inhibition or genetic disruption of sEH/EPHX2 have been widely studied for their impact on cardiovascular diseases. Less well studied is the role of increased EPHX2 expression, which occurs in a substantial human population that carries the EPHX2 K55R polymorphism or after induction by inflammatory stimuli. Herein, we developed a mouse model with cardiomyocyte-selective expression of human EPHX2 (Myh6-EPHX2) that has significantly increased total EPHX2 expression and activity. Myh6-EPHX2 hearts exhibit strong, cardiomyocyte-selective expression of EPHX2. EPHX2 mRNA, protein, and epoxide hydrolysis measurements suggest that Myh6-EPHX2 hearts have 12-fold increase in epoxide hydrolase activity relative to wild type (WT) hearts. This increased activity significantly decreased epoxide:diol ratios in vivo. Isolated, perfused Myh6-EPHX2 hearts were not significantly different from WT hearts in basal parameters of cardiac function; however, compared to WT hearts, Myh6-EPHX2 hearts demonstrated reduced recovery of heart contractile function after ischemia and reperfusion (I/R). This impaired recovery after I/R correlated with reduced activation of PI3K/AKT and GSK3β signaling pathways in Myh6-EPHX2 hearts compared to WT hearts. In summary, the Myh6-EPHX2 mouse line represents a novel model of cardiomyocyte-selective overexpression of EPHX2 that has detrimental effects on cardiac function.
    Language English
    Publishing date 2024-04-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 208787-x
    ISSN 1873-2968 ; 0006-2952
    ISSN (online) 1873-2968
    ISSN 0006-2952
    DOI 10.1016/j.bcp.2024.116237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 19: Show issues Location:
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  5. Article ; Online: Combination of the lateral-flow immunoassay with multicolor gold nanorod etching for the semi-quantitative detection of digoxin.

    Bradbury, Daniel W / Trinh, Jasmine T / Ryan, Milo J / Chen, Kyle J / Battikha, Adel A / Wu, Benjamin M / Kamei, Daniel T

    The Analyst

    2022  Volume 147, Issue 18, Page(s) 4000–4007

    Abstract: We are the first to combine the lateral-flow immunoassay (LFA) with gold nanorod (GNR) etching to achieve a multicolor readout where the color produced was correlated with digoxin concentrations in human serum in the relevant range for therapeutic drug ... ...

    Abstract We are the first to combine the lateral-flow immunoassay (LFA) with gold nanorod (GNR) etching to achieve a multicolor readout where the color produced was correlated with digoxin concentrations in human serum in the relevant range for therapeutic drug monitoring of 0.5-3.0 ng mL
    MeSH term(s) Digoxin ; Gold ; Humans ; Immunoassay ; Limit of Detection ; Nanotubes
    Chemical Substances Digoxin (73K4184T59) ; Gold (7440-57-5)
    Language English
    Publishing date 2022-09-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 210747-8
    ISSN 1364-5528 ; 0003-2654
    ISSN (online) 1364-5528
    ISSN 0003-2654
    DOI 10.1039/d2an01047j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2423: Show issues Location:
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  6. Article ; Online: ASCO Ethical Guidance for the Practical Management of Oncology Drug Shortages.

    Hantel, Andrew / Spence, Rebecca / Camacho, Polo / Bradbury, Angela R / Denburg, Avram E / Jagsi, Reshma / Moy, Beverly / Rathmell, W Kimryn / Rosenberg, Abby R / Symington, Banu / Marron, Jonathan M / Peppercorn, Jeffrey

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2023  Volume 42, Issue 3, Page(s) 358–365

    MeSH term(s) Humans ; Medical Oncology ; Neoplasms/drug therapy
    Language English
    Publishing date 2023-12-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.23.01941
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1847: Show issues Location:
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    Zs.MO 650: Show issues

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  7. Article: The blood-brain barrier in vitro.

    Bradbury, M W

    Neurochemistry international

    2009  Volume 7, Issue 1, Page(s) 27–28

    Language English
    Publishing date 2009-11-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 283190-9
    ISSN 1872-9754 ; 0197-0186
    ISSN (online) 1872-9754
    ISSN 0197-0186
    DOI 10.1016/0197-0186(85)90003-8
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    Zs.A 1610: Show issues Location:
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  8. Article ; Online: Timothy Grass Pollen Induces Spatial Reorganisation of F-Actin and Loss of Junctional Integrity in Respiratory Cells.

    Bradbury, Peta / Cidem, Aylin / Mahmodi, Hadi / Davies, Janet M / Spicer, Patrick T / Prescott, Stuart W / Kabakova, Irina / Ong, Hui Xin / Traini, Daniela

    Inflammation

    2022  Volume 45, Issue 3, Page(s) 1209–1223

    Abstract: Grass pollens have been identified as mediators of respiratory distress, capable of exacerbating respiratory diseases including epidemic thunderstorm asthma (ETSA). It is hypothesised that during thunderstorms, grass pollen grains swell to absorb ... ...

    Abstract Grass pollens have been identified as mediators of respiratory distress, capable of exacerbating respiratory diseases including epidemic thunderstorm asthma (ETSA). It is hypothesised that during thunderstorms, grass pollen grains swell to absorb atmospheric water, rupture, and release internal protein content to the atmosphere. The inhalation of atmospheric grass pollen proteins results in deadly ETSA events. We sought to identify the underlying cellular mechanisms that may contribute towards the severity of ETSA in temperate climates using Timothy grass (Phleum pratense). Respiratory cells exposed to Timothy grass pollen protein extract (PPE) caused cells to undergo hypoxia ultimately triggering the subcellular re-organisation of F-actin from the peri junctional belt to cytoplasmic fibre assembly traversing the cell body. This change in actin configuration coincided with the spatial reorganisation of microtubules and importantly, decreased cell compressibility specifically at the cell centre. Further to this, we find that the pollen-induced reorganisation of the actin cytoskeleton prompting secretion of the pro-inflammatory cytokine, interleukin-8. In addition, the loss of peri-junctional actin following exposure to pollen proteins was accompanied by the release of epithelial transmembrane protein, E-cadherin from cell-cell junctions resulting in a decrease in epithelial barrier integrity. We demonstrate that Timothy grass pollen regulates F-actin dynamics and E-cadherin localisation in respiratory cells to mediate cell-cell junctional integrity highlighting a possible molecular pathway underpinning ETSA events.
    MeSH term(s) Actin Cytoskeleton ; Actins ; Allergens ; Asthma ; Cadherins ; Humans ; Phleum ; Poaceae ; Pollen
    Chemical Substances Actins ; Allergens ; Cadherins
    Language English
    Publishing date 2022-01-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 434408-x
    ISSN 1573-2576 ; 0360-3997
    ISSN (online) 1573-2576
    ISSN 0360-3997
    DOI 10.1007/s10753-021-01614-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1401: Show issues Location:
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  9. Article ; Online: Re: 'more studies are needed to determine which exercise programmes for intermittent claudication should be funded'.

    Popplewell, M A / Bradbury, A W

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

    2015  Volume 50, Issue 2, Page(s) 262–263

    MeSH term(s) Exercise Therapy/economics ; Health Care Costs ; Health Expenditures ; Humans ; Intermittent Claudication/therapy ; State Medicine/economics
    Language English
    Publishing date 2015-08
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 1225869-6
    ISSN 1532-2165 ; 1078-5884
    ISSN (online) 1532-2165
    ISSN 1078-5884
    DOI 10.1016/j.ejvs.2015.04.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2283: Show issues Location:
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    Zs.MO 381: Show issues

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  10. Article ; Online: Why do health systems not fund supervised exercise programmes for intermittent claudication?

    Popplewell, M A / Bradbury, A W

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

    2014  Volume 48, Issue 6, Page(s) 608–610

    MeSH term(s) Attitude of Health Personnel ; Evidence-Based Medicine/economics ; Exercise Therapy/economics ; Health Care Costs ; Health Expenditures ; Health Knowledge, Attitudes, Practice ; Humans ; Intermittent Claudication/economics ; Intermittent Claudication/physiopathology ; Intermittent Claudication/therapy ; Patient Compliance ; Practice Patterns, Physicians'/economics ; State Medicine/economics ; Treatment Outcome ; United Kingdom
    Language English
    Publishing date 2014-12
    Publishing country England
    Document type Editorial
    ZDB-ID 1225869-6
    ISSN 1532-2165 ; 1078-5884
    ISSN (online) 1532-2165
    ISSN 1078-5884
    DOI 10.1016/j.ejvs.2014.07.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 381: Show issues

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