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  1. Article: Re: Jena R, Sharma AP, Madhavan K, Sridhar AN, Parmar K, Shrivastava N. What should urologists know about pseudojournals and open access publishing? A narrative review of the literature. Indian J Urol 2022;38:184-90.

    Kumar, Naveen / Tillu, Neeraja Deepak / Jain, Shrey

    Indian journal of urology : IJU : journal of the Urological Society of India

    2022  Volume 39, Issue 1, Page(s) 77–78

    Language English
    Publishing date 2022-12-29
    Publishing country India
    Document type Journal Article
    ZDB-ID 639268-4
    ISSN 1998-3824 ; 0970-1591
    ISSN (online) 1998-3824
    ISSN 0970-1591
    DOI 10.4103/iju.iju_290_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3165: Show issues Location:
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  2. Book: Environmental implications of mining and mineral processing: crucial economic development and environmental issues

    Jain, Ravinder K.

    (International journal of environment and pollution ; volume 59, nos. 2/3/4 (2016))

    2016  

    Author's details guest editors: professor Ravi K. Jain and Jeremy K. Domen
    Series title International journal of environment and pollution ; volume 59, nos. 2/3/4 (2016)
    Collection
    Language English
    Size Seite 93-312, Illustrationen, Diagramme, Karten
    Publisher Inderscience Enterprises Ltd
    Publishing place Genève
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT019318444
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    Z 7294 (59,2-4) available for loan (reading room) Freihandmagazin (U1)

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  3. Article: [Besprechung von:] Jain, R. K.: Detente in Europe. Implications for Asia. New Delhi 1977

    Chopra, H. S / Jain, R. K

    International studies : journal of the School of International Studies, Jawaharlal Nehru University Vol. 17, No. 1 , p. 113-114

    1978  Volume 17, Issue 1, Page(s) 113–114

    Author's details H. S. Chopra
    Publisher Sage Publ.
    Publishing place New Delhi
    Document type Article
    ZDB-ID 280771-3
    Database ECONomics Information System

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  4. Book ; Conference proceedings: Solid waste management

    Jain, Ravinder K.

    focusing on sustainability ; [these papers are derived from a workshop/conference that was held in May 2008, in San Francisco, California, USA]

    (International journal of environmental technology and management ; 13,1)

    2010  

    Author's details guest ed.: Ravi Jain
    Series title International journal of environmental technology and management ; 13,1
    Collection
    Language English
    Size 112 S. : Ill., graph. Darst.
    Publisher Inderscience Enterprises
    Publishing place Genève
    Publishing country Switzerland
    Document type Book ; Conference proceedings
    HBZ-ID HT016351640
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    Z 7461 (13,1) available for loan (reading room) Freihandmagazin (U1)

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  5. Book: Sustainable deconstruction and recycle strategies

    Jain, Ravinder K.

    (International journal of environmental technology and management ; 8,2/3)

    2008  

    Author's details guest ed.: Ravi Jain
    Series title International journal of environmental technology and management ; 8,2/3
    Collection
    Language English
    Size S. 113 - 321 : Ill., graph. Darst., Kt.
    Publisher Inderscience Enterprises
    Publishing place Genève
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT015485572
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

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    Z 7461 (8,2/3) available for loan (reading room) Freihandmagazin (U1)

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  6. Article ; Online: A Correlation of Tumour Budding and Tumour-Stroma Ratio with Clinicopathological Factors in Oral Squamous Cell Carcinoma.

    Verma, Leena / Singh, Kanika / Pujani, Mukta / Jain, Manjula / Chandoke, R K / Agarwal, Charu / Chauhan, Varsha / Raychaudhuri, Sujata / Jain, Avani

    Sultan Qaboos University medical journal

    2024  Volume 24, Issue 1, Page(s) 52–57

    Abstract: Objectives: This study aimed to analyse the association of tumour budding (TB) and tumour-stroma ratio (TSR) with clinicopathological parameters that can be easily viewed on routine haematoxylin and eosin (H&E)-stained slides to provide an easy and cost- ...

    Abstract Objectives: This study aimed to analyse the association of tumour budding (TB) and tumour-stroma ratio (TSR) with clinicopathological parameters that can be easily viewed on routine haematoxylin and eosin (H&E)-stained slides to provide an easy and cost-effective method for prognosticating oral squamous cell carcinoma (OSCC).
    Methods: This study was conducted at the ESIC Medical College and Hospital in Faridabad, India, from July 2022 to October 2022. In patients with histologically diagnosed OSCC, TB and TSR were evaluated via routine H&E-stained sections and correlated with clinicopathological parameters. Statistical analysis was performed using Chi-squared test.
    Results: A total of 50 patients were included. The mean age of participants was 61 ± 12.72, and the male-to-female ratio was 7.1:1. Most of the tumours were located on the tongue (46%), followed by the buccal mucosa (26%), gingivobuccal sulcus (12%) and retromolar trigone (8%). The palate and alveolus were the other sites involved, constituting 4% each. TB and TSR were both found to be significantly associated with the tumour grade, lymph node metastasis and tumour size. A highly significant correlation was also found between TB and TSR (
    Conclusions: Both TB and TSR can be easily evaluated on routine H&E sections; they are highly reproducible and were found to be reliable independent prognostic markers in OSCC. Therefore, this simple and cost-effective method of prognostication, which is currently lacking in clinical practice, will help clinicians to identify patients with poor prognosis and thus individualise their treatment plan.
    MeSH term(s) Humans ; Female ; Male ; Carcinoma, Squamous Cell ; Mouth Neoplasms ; Squamous Cell Carcinoma of Head and Neck ; Hospitals ; Head and Neck Neoplasms
    Language English
    Publishing date 2024-02-28
    Publishing country Oman
    Document type Journal Article
    ZDB-ID 2650196-X
    ISSN 2075-0528 ; 2075-0528
    ISSN (online) 2075-0528
    ISSN 2075-0528
    DOI 10.18295/squmj.9.2023.048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Modulation of the conformation, fibrillation, and fibril morphologies of human brain α-, β-, and γ-synuclein proteins by the disaccharide chemical chaperone trehalose.

    Jain, Manish K / Bhat, Rajiv

    Biochimica et biophysica acta. Proteins and proteomics

    2023  Volume 1871, Issue 5, Page(s) 140932

    Abstract: Human α-, β-, and γ-synuclein (syn) are natively unfolded proteins present in the brain. Deposition of aggregated α-syn in Lewy bodies is associated with Parkinson's disease (PD) and γ-syn is known to be involved in both neurodegeneration and breast ... ...

    Abstract Human α-, β-, and γ-synuclein (syn) are natively unfolded proteins present in the brain. Deposition of aggregated α-syn in Lewy bodies is associated with Parkinson's disease (PD) and γ-syn is known to be involved in both neurodegeneration and breast cancer. At physiological pH, while α-syn has the highest propensity for fibrillation followed by γ-syn, β-syn does not form any fibrils. Fibril formation in these proteins could be modulated by protein structure stabilizing osmolytes such as trehalose which has an exceptional stabilizing effect for globular proteins. We present a comprehensive study of the effect of trehalose on the conformation, aggregation, and fibril morphology of α-, β-, and γ-syn proteins. Rather than stabilizing the intrinsically disordered state of the synucleins, trehalose accelerates the rate of fibril formation by forming aggregation-competent partially folded intermediate structures. Fibril morphologies are also strongly dependent on the concentration of trehalose with ≤ 0.4M favoring the formation of mature fibrils in α-, and γ-syn with no effect on the fibrillation of β-syn. At ≥ 0.8M, trehalose promotes the formation of smaller aggregates that are more cytotoxic. Live cell imaging of preformed aggregates of a labeled A90C α-syn shows their rapid internalization into neural cells which could be useful in reducing the load of aggregated species of α-syn. The findings throw light on the differential effect of trehalose on the conformation and aggregation of disordered synuclein proteins with respect to globular proteins and could help in understanding the effect of osmolytes on intrinsically disordered proteins under cellular stress conditions.
    MeSH term(s) Humans ; Trehalose ; gamma-Synuclein/chemistry ; Disaccharides ; alpha-Synuclein/chemistry ; Protein Conformation ; Intrinsically Disordered Proteins/chemistry ; Brain/metabolism ; Molecular Chaperones/metabolism
    Chemical Substances Trehalose (B8WCK70T7I) ; gamma-Synuclein ; Disaccharides ; alpha-Synuclein ; Intrinsically Disordered Proteins ; Molecular Chaperones
    Language English
    Publishing date 2023-07-09
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2918798-9
    ISSN 1878-1454 ; 1570-9639
    ISSN (online) 1878-1454
    ISSN 1570-9639
    DOI 10.1016/j.bbapap.2023.140932
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7161: Show issues Location:
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  8. Article ; Online: Direct Access to α

    Rathod, Gajanan K / Jain, Rahul

    The Journal of organic chemistry

    2023  Volume 88, Issue 11, Page(s) 7219–7227

    Abstract: We describe the first-time use of a palladium-di(1-adamantyl)- ...

    Abstract We describe the first-time use of a palladium-di(1-adamantyl)-
    Language English
    Publishing date 2023-05-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.3c00460
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4473: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Serum Resistin as a Potential Mortality Predictor in Neonatal Sepsis.

    Jain, Rashika / Acharya, Rohan / Kumud / Bhalla, Kapil / Yadav, Dinkar / Jain, Naman / Jakhar, Sunisha

    Cureus

    2024  Volume 16, Issue 2, Page(s) e55289

    Abstract: Aim The aim of this study was to investigate the utility of serum resistin levels as a prognostic indicator for mortality in neonates diagnosed with sepsis. Methodology This one-year prospective study at Pandit Bhagwat Dayal Sharma Post Graduate ... ...

    Abstract Aim The aim of this study was to investigate the utility of serum resistin levels as a prognostic indicator for mortality in neonates diagnosed with sepsis. Methodology This one-year prospective study at Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences (PGIMS), Rohtak, India, included 151 neonates categorized into two groups based on blood culture results: group 1 (n=86) included those with culture-negative, probable sepsis and group 2 (n=65) included those with culture-positive, proven sepsis. Blood samples obtained pre-treatment underwent comprehensive analysis, including complete blood count, C-reactive protein assessment, micro-erythrocyte sedimentation rate, and resistin level measurement via enzyme-linked immunosorbent assay. The comparison between groups was conducted using either the Student t-test or the Mann-Whitney U test, while correlations were assessed using the Spearman correlation. These analyses were employed to identify the optimal resistin cut-off for distinguishing patients with sepsis. A p-value of <0.05 was considered statistically significant. Results This study with 151 neonates diagnosed with sepsis found a significant association (p < 0.05) between elevated serum resistin levels and increased mortality risk. Multivariate analysis confirmed an independent predictive role of resistin. Elevated resistin levels correlate with higher chances of requiring mechanical ventilation and prolonged hospital stays. These findings highlight serum resistin's potential as a prognostic tool for the early identification of high-risk neonatal sepsis patients. Conclusion This study highlights the link between elevated serum resistin levels and increased mortality risk in neonatal sepsis, supported by strong multivariate analysis, indicating an independent predictive role. Additionally, resistin correlates with higher chances of mechanical ventilation and prolonged hospitalization, suggesting its potential as a prognostic marker for early identification of high-risk neonatal sepsis cases.
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.55289
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Computational simulations of tumor growth and treatment response: Benefits of high-frequency, low-dose drug regimens and concurrent vascular normalization.

    Nikmaneshi, Mohammad R / Jain, Rakesh K / Munn, Lance L

    PLoS computational biology

    2023  Volume 19, Issue 6, Page(s) e1011131

    Abstract: Implementation of effective cancer treatment strategies requires consideration of how the spatiotemporal heterogeneities within the tumor microenvironment (TME) influence tumor progression and treatment response. Here, we developed a multi-scale three- ... ...

    Abstract Implementation of effective cancer treatment strategies requires consideration of how the spatiotemporal heterogeneities within the tumor microenvironment (TME) influence tumor progression and treatment response. Here, we developed a multi-scale three-dimensional mathematical model of the TME to simulate tumor growth and angiogenesis and then employed the model to evaluate an array of single and combination therapy approaches. Treatments included maximum tolerated dose or metronomic (i.e., frequent low doses) scheduling of anti-cancer drugs combined with anti-angiogenic therapy. The results show that metronomic therapy normalizes the tumor vasculature to improve drug delivery, modulates cancer metabolism, decreases interstitial fluid pressure and decreases cancer cell invasion. Further, we find that combining an anti-cancer drug with anti-angiogenic treatment enhances tumor killing and reduces drug accumulation in normal tissues. We also show that combined anti-angiogenic and anti-cancer drugs can decrease cancer invasiveness and normalize the cancer metabolic microenvironment leading to reduced hypoxia and hypoglycemia. Our model simulations suggest that vessel normalization combined with metronomic cytotoxic therapy has beneficial effects by enhancing tumor killing and limiting normal tissue toxicity.
    MeSH term(s) Humans ; Pharmaceutical Preparations ; Angiogenesis Inhibitors/pharmacology ; Angiogenesis Inhibitors/therapeutic use ; Neoplasms/pathology ; Antineoplastic Agents/pharmacology ; Immunotherapy ; Neovascularization, Pathologic/metabolism ; Tumor Microenvironment
    Chemical Substances Pharmaceutical Preparations ; Angiogenesis Inhibitors ; Antineoplastic Agents
    Language English
    Publishing date 2023-06-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2193340-6
    ISSN 1553-7358 ; 1553-734X
    ISSN (online) 1553-7358
    ISSN 1553-734X
    DOI 10.1371/journal.pcbi.1011131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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