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  1. Article ; Online: Cadmium-Induced Proteinuria: Mechanistic Insights from Dose-Effect Analyses.

    Satarug, Soisungwan / Vesey, David A / Gobe, Glenda C

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: Cadmium (Cd) is a toxic metal that accumulates in kidneys, especially in the proximal tubular epithelial cells, where virtually all proteins in the glomerular ultrafiltrate are reabsorbed. Here, we analyzed archived data on the estimated glomerular ... ...

    Abstract Cadmium (Cd) is a toxic metal that accumulates in kidneys, especially in the proximal tubular epithelial cells, where virtually all proteins in the glomerular ultrafiltrate are reabsorbed. Here, we analyzed archived data on the estimated glomerular filtration rate (eGFR) and excretion rates of Cd (E
    MeSH term(s) Humans ; Cadmium/toxicity ; Proteinuria ; Kidney ; Kidney Glomerulus ; Glomerular Filtration Rate ; beta 2-Microglobulin ; Albumins ; Creatinine
    Chemical Substances Cadmium (00BH33GNGH) ; beta 2-Microglobulin ; Albumins ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2023-01-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24031893
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The pathogenesis of albuminuria in cadmium nephropathy.

    Satarug, Soisungwan / Vesey, David A / Gobe, Glenda C / Phelps, Kenneth R

    Current research in toxicology

    2023  Volume 6, Page(s) 100140

    Abstract: Background: Urinary cadmium excretion (E: Methods: To depict excretion rates per functional nephron, E: Results: As age or E: Conclusions: Our data indicate that Cd in renal tissue affected tubular reabsorption of albumin and ... ...

    Abstract Background: Urinary cadmium excretion (E
    Methods: To depict excretion rates per functional nephron, E
    Results: As age or E
    Conclusions: Our data indicate that Cd in renal tissue affected tubular reabsorption of albumin and β
    Language English
    Publishing date 2023-12-06
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-027X
    ISSN (online) 2666-027X
    DOI 10.1016/j.crtox.2023.100140
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Estimation of health risks associated with dietary cadmium exposure.

    Satarug, Soisungwan / Vesey, David A / Gobe, Glenda C / Phelps, Kenneth R

    Archives of toxicology

    2023  Volume 97, Issue 2, Page(s) 329–358

    Abstract: In much of the world, currently employed upper limits of tolerable intake and acceptable excretion of cadmium (Cd) ( ... ...

    Abstract In much of the world, currently employed upper limits of tolerable intake and acceptable excretion of cadmium (Cd) (E
    MeSH term(s) Humans ; Environmental Exposure/adverse effects ; Environmental Exposure/analysis ; Cadmium/toxicity ; Creatinine ; Diabetes Mellitus, Type 2/chemically induced ; Kidney
    Chemical Substances Cadmium (00BH33GNGH) ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2023-01-02
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 124992-7
    ISSN 1432-0738 ; 0340-5761
    ISSN (online) 1432-0738
    ISSN 0340-5761
    DOI 10.1007/s00204-022-03432-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uf I Zs.90: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Multiple Targets of Toxicity in Environmental Exposure to Low-Dose Cadmium.

    Satarug, Soisungwan / Gobe, Glenda C / Vesey, David A

    Toxics

    2022  Volume 10, Issue 8

    Abstract: Dietary assessment reports and population surveillance programs show that chronic exposure to low levels of environmental cadmium (Cd) is inevitable for most people, and adversely impacts the health of children and adults. Based on a risk assessment ... ...

    Abstract Dietary assessment reports and population surveillance programs show that chronic exposure to low levels of environmental cadmium (Cd) is inevitable for most people, and adversely impacts the health of children and adults. Based on a risk assessment model that considers an increase in the excretion of β
    Language English
    Publishing date 2022-08-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics10080472
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Dose-Response Analysis of the Tubular and Glomerular Effects of Chronic Exposure to Environmental Cadmium.

    Satarug, Soisungwan / Vesey, David A / Gobe, Glenda C

    International journal of environmental research and public health

    2022  Volume 19, Issue 17

    Abstract: We retrospectively analyzed data on the excretion of cadmium ( ... ...

    Abstract We retrospectively analyzed data on the excretion of cadmium (E
    MeSH term(s) Biomarkers ; Cadmium/toxicity ; Creatinine ; Environmental Exposure ; Glomerular Filtration Rate/physiology ; Humans ; Kidney Diseases ; Retrospective Studies
    Chemical Substances Biomarkers ; Cadmium (00BH33GNGH) ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2022-08-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph191710572
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  6. Article ; Online: Cadmium-Induced Proteinuria

    Soisungwan Satarug / David A. Vesey / Glenda C. Gobe

    International Journal of Molecular Sciences, Vol 24, Iss 1893, p

    Mechanistic Insights from Dose–Effect Analyses

    2023  Volume 1893

    Abstract: Cadmium (Cd) is a toxic metal that accumulates in kidneys, especially in the proximal tubular epithelial cells, where virtually all proteins in the glomerular ultrafiltrate are reabsorbed. Here, we analyzed archived data on the estimated glomerular ... ...

    Abstract Cadmium (Cd) is a toxic metal that accumulates in kidneys, especially in the proximal tubular epithelial cells, where virtually all proteins in the glomerular ultrafiltrate are reabsorbed. Here, we analyzed archived data on the estimated glomerular filtration rate (eGFR) and excretion rates of Cd (E Cd ), total protein (E Prot ), albumin (E alb ), β 2 -microglobulin (E β2M ), and α1-microglobulin (E α1M ), which were recorded for residents of a Cd contamination area and a low-exposure control area of Thailand. Excretion of Cd and all proteins were normalized to creatinine clearance (C cr ) as E Cd /C cr and E Prot /C cr to correct for differences among subjects in the number of surviving nephrons. Low eGFR was defined as eGFR ≤ 60 mL/min/1.73 m 2 , while proteinuria was indicted by E Pro /C cr ≥ 20 mg/L of filtrate. E Prot /C cr varied directly with E Cd /C cr (β = 0.263, p < 0.001) and age (β = 0.252, p < 0.001). In contrast, eGFR values were inversely associated with E Cd /C cr (β = −0.266, p < 0.001) and age (β = −0.558, p < 0.001). At E Cd /C cr > 8.28 ng/L of filtrate, the prevalence odds ratios for proteinuria and low eGFR were increased 4.6- and 5.1-fold, respectively ( p < 0.001 for both parameters). Thus, the eGFR and tubular protein retrieval were both simultaneously diminished by Cd exposure. Of interest, E Cd /C cr was more closely correlated with E Prot /C cr ( r = 0.507), E β2M ( r = 0.430), and E α1M /C cr ( r = 0.364) than with E Alb /C cr ( r = 0.152). These data suggest that Cd may differentially reduce the ability of tubular epithelial cells to reclaim proteins, resulting in preferential reabsorption of albumin.
    Keywords albumin ; albumin-to-creatinine ratio ; α1-microglobulin ; β 2 -microglobulin ; cadmium ; creatinine clearance ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 290
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Gender Differences in the Severity of Cadmium Nephropathy.

    Yimthiang, Supabhorn / Vesey, David A / Gobe, Glenda C / Pouyfung, Phisit / Khamphaya, Tanaporn / Satarug, Soisungwan

    Toxics

    2023  Volume 11, Issue 7

    Abstract: The excretion of ... ...

    Abstract The excretion of β
    Language English
    Publishing date 2023-07-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics11070616
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Cadmium-Induced Tubular Dysfunction in Type 2 Diabetes: A Population-Based Cross-Sectional Study.

    Satarug, Soisungwan / Yimthiang, Supabhorn / Pouyfung, Phisit / Khamphaya, Tanaporn / Vesey, David A

    Toxics

    2023  Volume 11, Issue 4

    Abstract: The global prevalence of diabetes, and its major complication, diabetic nephropathy, have reached epidemic proportions. The toxic metal cadmium (Cd) also induces nephropathy, indicated by a sustained reduction in the estimated glomerular filtration rate ( ...

    Abstract The global prevalence of diabetes, and its major complication, diabetic nephropathy, have reached epidemic proportions. The toxic metal cadmium (Cd) also induces nephropathy, indicated by a sustained reduction in the estimated glomerular filtration rate (eGFR) and the excretion of β
    Language English
    Publishing date 2023-04-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics11040390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Estimation of the Cadmium Nephrotoxicity Threshold from Loss of Glomerular Filtration Rate and Albuminuria.

    Satarug, Soisungwan / Vesey, David A / Khamphaya, Tanaporn / Pouyfung, Phisit / Gobe, Glenda C / Yimthiang, Supabhorn

    Toxics

    2023  Volume 11, Issue 9

    Abstract: Cadmium (Cd) is a pervasive, toxic environmental pollutant that preferentially accumulates in the tubular epithelium of the kidney. Current evidence suggests that the cumulative burden of Cd here leads to the progressive loss of the glomerular filtration ...

    Abstract Cadmium (Cd) is a pervasive, toxic environmental pollutant that preferentially accumulates in the tubular epithelium of the kidney. Current evidence suggests that the cumulative burden of Cd here leads to the progressive loss of the glomerular filtration rate (GFR). In this study, we have quantified changes in estimated GFR (eGFR) and albumin excretion (E
    Language English
    Publishing date 2023-09-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics11090755
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Evidence Linking Cadmium Exposure and β

    Yimthiang, Supabhorn / Pouyfung, Phisit / Khamphaya, Tanaporn / Vesey, David A / Gobe, Glenda C / Satarug, Soisungwan

    Toxics

    2023  Volume 11, Issue 6

    Abstract: The most common causes of chronic kidney disease, diabetes, and hypertension are significant public health issues worldwide. Exposure to the heavy metal pollutant, cadmium (Cd), which is particularly damaging to the kidney, has been associated with both ... ...

    Abstract The most common causes of chronic kidney disease, diabetes, and hypertension are significant public health issues worldwide. Exposure to the heavy metal pollutant, cadmium (Cd), which is particularly damaging to the kidney, has been associated with both risk factors. Increased levels of urinary β
    Language English
    Publishing date 2023-06-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics11060516
    Database MEDical Literature Analysis and Retrieval System OnLINE

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