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Article ; Online: Modification of the Physical Properties of a Nafion Film Due to Inclusion of n-Dodecyltriethylammonium Cation: Time Effect.

Zamudio-García, Javier / Martínez de Yuso, María V / Cuevas, Ana L / Marrero-López, David / Benavente, Juana

2023 Volume 15, Issue 11

Abstract: This study investigates the effects of modifying commercial Nafion-212 thin films with dodecyltriethylammonium cation (DTA+) on their electrical resistance, elastic modulus, light transmission/reflection and photoluminescence properties. The films were ... ...

Abstract	This study investigates the effects of modifying commercial Nafion-212 thin films with dodecyltriethylammonium cation (DTA+) on their electrical resistance, elastic modulus, light transmission/reflection and photoluminescence properties. The films were modified through a proton/cation exchange process for immersion periods ranging from 1 to 40 h. X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) were employed to analyze the crystal structure and surface composition of the modified films. The electrical resistance and the different resistive contributions were determined via impedance spectroscopy. Changes in the elastic modulus were evaluated using stress-strain curves. Additionally, optical characterization tests, including light/reflection (250-2000 nm) and photoluminescence spectra, were also performed on both unmodified and DTA
Language	English
Publishing date	2023-05-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym15112527
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Article ; Online: Altered Arylamine N-acetyltransferase 1 and miR-1290 Levels in Childhood Acute Lymphoblastic Leukemia: A Pilot Study.

Hernandez-Gonzalez, Oswaldo / Del Carmen Milan-Segovia, Rosa / Zavala-Reyes, Daniel / Alvarado-Zamarripa, Dinora Margarita / Ortiz-Zamudio, Juan Jose / Correa-Gonzalez, Lourdes Cecilia / Vargas-Morales, Juan Manuel / Uresti-Rivera, Edith Elena / Portales-Perez, Diana Patricia

In vivo (Athens, Greece)

2023 Volume 37, Issue 3, Page(s) 1129–1144

Abstract: Background/aim: Arylamine N-acetyltransferase 1 and 2 (NAT1 and NAT2) are drug-metabolizing ... in peripheral blood mononuclear cells (PBMC) from patients with ALL (n=20) and healthy children (n=19) and ...

Abstract	Background/aim: Arylamine N-acetyltransferase 1 and 2 (NAT1 and NAT2) are drug-metabolizing enzymes that play a key role in the development of acute lymphoblastic leukemia (ALL). Materials and methods: This study evaluated NAT1 and NAT2 mRNA and protein expression and their enzymatic activity in peripheral blood mononuclear cells (PBMC) from patients with ALL (n=20) and healthy children (n=19) and explored the mechanisms that regulate these enzymes in ALL such as microRNAs (miR-1290, miR-26b) and SNPs. Results: PBMC from patients with ALL showed a decrease in NAT1 mRNA and protein expression. In addition, NAT1 enzymatic activity was decreased in patients with ALL. There was no influence of SNP 559 C>T or 560 G>A on low NAT1 activity. The lower expression of NAT1 might be related to the loss of acetylated histone H3K14 in the NAT1 gene promoter in patients with ALL and the higher relative expression of miR-1290 in the plasma of patients with relapsed ALL compared with healthy controls. There were significantly fewer CD3+/NAT1+ double-positive cells in patients who relapsed compared with control subjects. Based on a t-distributed stochastic neighbor embedding algorithm, CD19+ cells that reappeared in patients with relapse showed low NAT1 expression. In contrast, for NAT2, there were no significant results. Conclusion: The expression and function of NAT1 and miR-1290 levels could be involved in modulating immune cells altered in ALL.
MeSH term(s)	Child ; Humans ; Leukocytes, Mononuclear/metabolism ; Pilot Projects ; Arylamine N-Acetyltransferase/genetics ; Arylamine N-Acetyltransferase/metabolism ; MicroRNAs/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; RNA, Messenger
Chemical Substances	N-acetyltransferase 1 (EC 2.3.1.5) ; Arylamine N-Acetyltransferase (EC 2.3.1.5) ; MicroRNAs ; RNA, Messenger ; NAT2 protein, human (EC 2.3.1.5) ; MIRN1290 microRNA, human
Language	English
Publishing date	2023-04-27
Publishing country	Greece
Document type	Journal Article
ZDB-ID	807031-3
ISSN	1791-7549 ; 0258-851X
ISSN (online)	1791-7549
ISSN	0258-851X
DOI	10.21873/invivo.13188
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Article ; Online: Modification of the Physical Properties of a Nafion Film Due to Inclusion of n-Dodecyltriethylammonium Cation

Javier Zamudio-García / María V. Martínez de Yuso / Ana L. Cuevas / David Marrero-López / Juana Benavente

Polymers, Vol 15, Iss 2527, p

Time Effect

2023 Volume 2527

Abstract	This study investigates the effects of modifying commercial Nafion-212 thin films with dodecyltriethylammonium cation (DTA+) on their electrical resistance, elastic modulus, light transmission/reflection and photoluminescence properties. The films were modified through a proton/cation exchange process for immersion periods ranging from 1 to 40 h. X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) were employed to analyze the crystal structure and surface composition of the modified films. The electrical resistance and the different resistive contributions were determined via impedance spectroscopy. Changes in the elastic modulus were evaluated using stress–strain curves. Additionally, optical characterization tests, including light/reflection (250–2000 nm) and photoluminescence spectra, were also performed on both unmodified and DTA + -modified Nafion films. The results reveal significant changes in the electrical, mechanical and optical properties of the films, depending on the exchange process time. In particular, the inclusion of the DTA + into the Nafion structure improved the elastic behavior of the films by significantly decreasing the Young modulus. Furthermore, the photoluminescence of the Nafion films was also enhanced. These findings can be used to optimize the exchange process time to achieve specific desired properties.
Keywords	Nafion ; dodecyltriethylammonium cation ; electrical resistance ; optical properties ; elastic modules ; Organic chemistry ; QD241-441
Subject code	620
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: X-Ray Absorption Spectrum of the N_{2}^{+} Molecular Ion.

Lindblad, R / Kjellsson, L / Couto, R C / Timm, M / Bülow, C / Zamudio-Bayer, V / Lundberg, M / von Issendorff, B / Lau, J T / Sorensen, S L / Carravetta, V / Ågren, H / Rubensson, J-E

Physical review letters

2020 Volume 124, Issue 20, Page(s) 203001

Abstract: The x-ray absorption spectrum of N_{2}^{+} in the K-edge region has been measured by irradiation ...

Abstract	The x-ray absorption spectrum of N_{2}^{+} in the K-edge region has been measured by irradiation of ions stored in a cryogenic radio frequency ion trap with synchrotron radiation. We interpret the experimental results with the help of restricted active space multiconfiguration theory. Spectroscopic constants of the 1σ_{u}^{-1} ^{2}Σ_{u}^{+} state, and the two 1σ_{u}^{-1}3σ_{g}^{-1}1π_{g} ^{2}Π_{u} states are determined from the measurements. The charge of the ground state together with spin coupling involving several open shells give rise to double excitations and configuration mixing, and a complete breakdown of the orbital picture for higher lying core-excited states.
Language	English
Publishing date	2020-05-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.124.203001
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Article ; Online: Breaking inversion symmetry by protonation: experimental and theoretical NEXAFS study of the diazynium ion, N

Couto, Rafael C / Hua, Weijie / Lindblad, Rebecka / Kjellsson, Ludvig / Sorensen, Stacey L / Kubin, Markus / Bülow, Christine / Timm, Martin / Zamudio-Bayer, Vicente / von Issendorff, Bernd / Söderström, Johan / Lau, J Tobias / Rubensson, Jan-Erik / Ågren, Hans / Carravetta, Vincenzo

Physical chemistry chemical physics : PCCP

2021 Volume 23, Issue 32, Page(s) 17166–17176

Abstract: ... resolution NEXAFS spectrum of protonated dinitrogen, the diazynium ion N ...

Abstract	As an example of symmetry breaking in NEXAFS spectra of protonated species we present a high resolution NEXAFS spectrum of protonated dinitrogen, the diazynium ion N
Language	English
Publishing date	2021-08-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d1cp02002a
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Article ; Online: Synthesis of Polyheterocyclic Pyrrolo[3,4-b]pyridin-5-ones via a One-Pot (Ugi-3CR/aza Diels-Alder/N-acylation/aromatization/S

Zamudio-Medina, Angel / García-González, Ailyn N / Herrera-Carrillo, Genesis K / Zárate-Zárate, Daniel / Benavides-Macías, Adriana / Tamariz, Joaquín / Ibarra, Ilich A / Islas-Jácome, Alejandro / González-Zamora, Eduardo

Molecules (Basel, Switzerland)

2018 Volume 23, Issue 4

Abstract: We describe the one-pot synthesis of twenty polyheterocyclic pyrrolo[3,4- ...

Abstract	We describe the one-pot synthesis of twenty polyheterocyclic pyrrolo[3,4-
MeSH term(s)	Acylation ; Cyclization ; Molecular Structure ; Phthalimides/chemistry ; Pyridones/chemical synthesis ; Pyridones/chemistry ; Pyrroles/chemical synthesis ; Pyrroles/chemistry ; Stereoisomerism
Chemical Substances	Phthalimides ; Pyridones ; Pyrroles ; falipamil (N6A93ZMN7U)
Language	English
Publishing date	2018-03-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules23040763
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Article ; Online: Loss of Ethanol Inhibition of N-Methyl-D-Aspartate Receptor-Mediated Currents and Plasticity of Cerebellar Synapses in Mice Expressing the GluN1(F639A) Subunit.

Zamudio-Bulcock, Paula A / Homanics, Gregg E / Woodward, John J

Alcoholism, clinical and experimental research

2018 Volume 42, Issue 4, Page(s) 698–705

Abstract: Background: Glutamatergic N-methyl-d-aspartate receptors (NMDARs) are well known ...

Abstract	Background: Glutamatergic N-methyl-d-aspartate receptors (NMDARs) are well known for their sensitivity to ethanol (EtOH) inhibition. However, the specific manner in which EtOH inhibits channel activity and how such inhibition affects neurotransmission, and ultimately behavior, remains unclear. Replacement of phenylalanine 639 with alanine (F639A) in the GluN1 subunit reduces EtOH inhibition of recombinant NMDARs. Mice expressing this subunit show reduced EtOH-induced anxiolysis, blunted locomotor stimulation following low-dose EtOH administration, and faster recovery of motor function after moderate doses of EtOH, suggesting that cerebellar dysfunction may contribute to some of these behaviors. In the mature mouse cerebellum, NMDARs at the cerebellar climbing fiber (CF) to Purkinje cell (PC) synapse are inhibited by low concentrations of EtOH and the long-term depression (LTD) of parallel fiber (PF)-mediated currents induced by concurrent activation of PFs and CFs (PF-LTD) requires activation of EtOH-sensitive NMDARs. In this study, we examined cerebellar NMDA responses and NMDA-mediated synaptic plasticity in wild-type (WT) and GluN1(F639A) mice. Methods: Patch-clamp electrophysiological recordings were performed in acute cerebellar slices from adult WT and GluN1(F639A) mice. NMDAR-mediated currents at the CF-PC synapse and NMDAR-dependent PF-LTD induction were compared for genotype-dependent differences. Results: Stimulation of CFs evoked robust NMDA-mediated excitatory postsynaptic currents (EPSCs) in PCs that were similar in amplitude and kinetics between WT and GluN1(F639A) mice. NMDA-mediated CF-PC EPSCs in WT mice were significantly inhibited by EtOH (50 mM) while those in mutant mice were unaffected. Concurrent stimulation of CF and PF inputs induced synaptic depression of PF-PC EPSCs in both WT and mutant mice, and this depression was blocked by the NMDA antagonist DL-APV. The synaptic depression of PF-PC EPSCs in WT mice was also blocked by a low concentration of EtOH (10 mM) that had no effect on plasticity in GluN1(F639A) mice. Conclusions: These results demonstrate that inhibition of cerebellar NMDARs may be a key mechanism by which EtOH affects cerebellar-dependent behaviors.
MeSH term(s)	Animals ; Cerebellum/physiology ; Deep Brain Stimulation ; Ethanol/pharmacology ; Excitatory Postsynaptic Potentials/drug effects ; Excitatory Postsynaptic Potentials/physiology ; Long-Term Synaptic Depression/physiology ; Mice ; Mutation ; Nerve Tissue Proteins/antagonists & inhibitors ; Nerve Tissue Proteins/genetics ; Neural Inhibition/drug effects ; Neuronal Plasticity/physiology ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors ; Receptors, N-Methyl-D-Aspartate/genetics ; Synapses/physiology
Chemical Substances	Gprin1 protein, mouse ; Nerve Tissue Proteins ; Receptors, N-Methyl-D-Aspartate ; Ethanol (3K9958V90M)
Language	English
Publishing date	2018-02-09
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	428999-7
ISSN	1530-0277 ; 0145-6008
ISSN (online)	1530-0277
ISSN	0145-6008
DOI	10.1111/acer.13597
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Article ; Online: Large orbital magnetic moments of small, free cobalt cluster ions Co[Formula: see text] with n [Formula: see text].

Zamudio-Bayer, V / Hirsch, K / Langenberg, A / Ławicki, A / Terasaki, A / von Issendorff, B / Lau, J T

Journal of physics. Condensed matter : an Institute of Physics journal

2018 Volume 30, Issue 46, Page(s) 464002

Abstract: ... contribution increases from a local minimum at n = 2 to a local maximum at n = 5 and then decreases ...

Abstract	The size dependent electronic structure and separate spin and orbital magnetic moments of free Co[Formula: see text] ([Formula: see text]) cluster ions have been investigated by x-ray absorption and x-ray magnetic circular dichroism spectroscopy in a cryogenic ion trap. A very large orbital magnetic moment of [Formula: see text] per atom was determined for Co[Formula: see text], which is one order of magnitude larger than in the bulk metal. Large orbital magnetic moments per atom of ≈1 [Formula: see text] were also found for Co[Formula: see text], Co[Formula: see text], and Co[Formula: see text]. The orbital contribution to the total magnetic moment shows a non-monotonic cluster size dependence: The orbital contribution increases from a local minimum at n = 2 to a local maximum at n = 5 and then decreases with increasing cluster size. The 3d spin magnetic moment per atom is nearly constant and is solely defined by the number of 3d holes which shows that the 3d majority spin states are fully occupied, that is, 3d hole spin polarization is 100%.
Language	English
Publishing date	2018-10-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1472968-4
ISSN	1361-648X ; 0953-8984
ISSN (online)	1361-648X
ISSN	0953-8984
DOI	10.1088/1361-648X/aae54a
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Article ; Online: Genetic polymorphisms of arylamine N-acetyltransferases 1 and 2 and the likelihood of developing pediatric acute lymphoblastic leukemia.

Hernández-González, Oswaldo / Ortiz-Zamudio, Juan José / Rodríguez-Pinal, Cristian Jazmín / Alvarado-Morales, Ildemar / Martínez-Jiménez, Verónica Del Carmen / Salazar-González, Raúl Alejandro / Correa-González, Lourdes Cecilia / Gómez, Rocío / Portales-Pérez, Diana Patricia / Milán-Segovia, Rosa Del Carmen

Leukemia & lymphoma

2017 Volume 59, Issue 8, Page(s) 1968–1975

Abstract: ... with both genetic susceptibility and environmental factors. Genes encoding the arylamine N-acetyltransferases 1 and ...

Abstract	Acute lymphoblastic leukemia (ALL) is one of the main causes of death in children and is associated with both genetic susceptibility and environmental factors. Genes encoding the arylamine N-acetyltransferases 1 and 2 (NAT1 and NAT2) isoenzymes are highly polymorphic among populations. Single-nucleotide polymorphism analysis was performed by real-time polymerase chain reaction from the genomic DNA of 225 healthy subjects and 57 children with ALL diagnoses. Significant associations were found between the development of ALL and the presence of the haplotypes NAT13 (Odds ratio [OR], 2.1), NAT14 (OR, 1.92), NAT26B (OR, 3.30), NAT26J (OR, 3.25) and NAT2*7A (OR, 2.45) and the NAT1 rapid (OR, 6.69) and NAT2 slow phenotypes (OR, 2.95). Our results indicate that haplotypes that provide rapid NAT1 and slow NAT2 acetylating phenotypes may influence the development of ALL in children.
MeSH term(s)	Adolescent ; Adult ; Aged ; Arylamine N-Acetyltransferase/genetics ; Child ; Child, Preschool ; Gene Frequency ; Genetic Predisposition to Disease/genetics ; Genotype ; Haplotypes ; Humans ; Infant ; Isoenzymes/genetics ; Middle Aged ; Polymorphism, Single Nucleotide ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Young Adult
Chemical Substances	Isoenzymes ; Arylamine N-Acetyltransferase (EC 2.3.1.5) ; N-acetyltransferase 1 (EC 2.3.1.5) ; NAT2 protein, human (EC 2.3.1.5)
Language	English
Publishing date	2017-12-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1042374-6
ISSN	1029-2403 ; 1042-8194
ISSN (online)	1029-2403
ISSN	1042-8194
DOI	10.1080/10428194.2017.1406090
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Zs.A 2997: Show issues

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Article ; Online: Synthesis of Polyheterocyclic Pyrrolo[3,4-b]pyridin-5-ones via a One-Pot (Ugi-3CR/aza Diels-Alder/N-acylation/aromatization/SN2) Process. A Suitable Alternative towards Novel Aza-Analogues of Falipamil

Angel Zamudio-Medina / Ailyn N. García-González / Genesis K. Herrera-Carrillo / Daniel Zárate-Zárate / Adriana Benavides-Macías / Joaquín Tamariz / Ilich A. Ibarra / Alejandro Islas-Jácome / Eduardo González-Zamora

Molecules, Vol 23, Iss 4, p

2018 Volume 763

Abstract: ... a cascade process (Ugi-3CR/aza Diels-Alder/N-acylation/aromatization) in 20 to 95% overall yields, as well ... as four pharmacologically promising analogues via an improved cascade process (Ugi-3CR/aza Diels-Alder/N ...

Abstract	We describe the one-pot synthesis of twenty polyheterocyclic pyrrolo[3,4-b]pyridin-5-ones via a cascade process (Ugi-3CR/aza Diels-Alder/N-acylation/aromatization) in 20 to 95% overall yields, as well as four pharmacologically promising analogues via an improved cascade process (Ugi-3CR/aza Diels-Alder/N-acylation/aromatization/SN2): two piperazine-linked pyrrolo[3,4-b]pyridin-5-ones in 33 and 34%, and a couple of Falipamil aza-analogues in 30 and 35% overall yields. It is worth highlighting the good substrate scope found, because final products are furnished with alkyl, aryl, and heterocyclic substituents. The use of chain-ring tautomerizable isocyanides (as key reagents for the Ugi-type three component reaction) allowed for a rapid and efficient assembly of the polysubstituted oxindoles, which were used in situ toward the complex products, conferring features like robustness, sustainability, and the one-pot approach to this synthetic methodology.
Keywords	one-pot procedures ; cascade processes ; multicomponent reactions ; Ugi-3CR ; aza Diels-Alder Cycloadditions ; microwave assisted synthesis ; Pyrrolo[3,4-b]pyridin-5-ones ; Falipamil ; piperazine-linker ; Organic chemistry ; QD241-441
Subject code	540
Language	English
Publishing date	2018-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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