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  1. Article ; Online: Tratamiento farmacológico en tiempos de incertidumbre: uso de la hidroxicloroquina/cloroquina en el tratamiento de COVID-19.

    Mayayo-Vicente, S / Rodriguez Salvanés, F / Gallego-Arenas, A / Sánchez-Gómez, L M / Ruiz-López, M / Sierra García, B / Jurado-López, A / Arriola-Bolado, P / Cervera Cano, M / Novella-Arribas, B

    Semergen

    2020  Volume 46 Suppl 1, Page(s) 20–27

    Abstract: Background and objectives: In this moments, of extreme gravity in which we find ourselves, and in the uncertainty face about the most effective treatment against COVID-19 disease and with the aim of find the evidence that support the chloroquine/ ... ...

    Title translation Pharmacological treatment in uncertainty times: Hydroxychloroquine/chloroquine use in the COVID-19 treatment.
    Abstract Background and objectives: In this moments, of extreme gravity in which we find ourselves, and in the uncertainty face about the most effective treatment against COVID-19 disease and with the aim of find the evidence that support the chloroquine/hydroxychloroquine use recommendation to treat COVID-19 disease, a systematic review of published studies and RCT studies publishes until April 28, 2020 was carried out.
    Material and methods: A systematic search was carried out in PubMed with the keywords COVID-19 and their synonyms and hydroxychloroquine/chloroquine. The data selection and extraction was elaborated by two researchers, independently. The results were discussed with a Primary Care physicians clinical group and the results were synthesized using GRADE methodology.
    Results: A good quality systematic review was found that includes articles with a high risk of bias. And 8 EC launched that will produce results beyond May 2020.
    Conclusions: Although the conclusions of the systematic review generate a low confidence in the results, and the clinical variables that show benefit are intermediate variables, the side effects are acceptable and could be minimized with the use of QT lengthening risk tools, so it is could make a weak recommendation in favor of the use of chloroquine/hydroxychloroquine in patients with mild-moderate stage COVID-19.
    MeSH term(s) COVID-19/drug therapy ; Chloroquine/therapeutic use ; Coronavirus Infections/drug therapy ; Humans ; Hydroxychloroquine/therapeutic use ; Uncertainty
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH) ; Chloroquine (886U3H6UFF)
    Keywords covid19
    Language Spanish
    Publishing date 2020-07-11
    Publishing country Spain
    Document type Journal Article ; Systematic Review
    ISSN 1578-8865
    ISSN (online) 1578-8865
    DOI 10.1016/j.semerg.2020.06.016
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  2. Article ; Online: Tratamiento farmacológico en tiempos de incertidumbre

    Mayayo-Vicente, S. / Rodriguez Salvanés, F. / Gallego-Arenas, A. / Sánchez-Gómez, L.M. / Ruiz-López, M. / Sierra García, B. / Jurado-López, A. / Arriola-Bolado, P. / Cervera Cano, M. / Novella-Arribas, B.

    Medicina de Familia. SEMERGEN

    uso de la hidroxicloroquina/cloroquina en el tratamiento de COVID-19

    2020  Volume 46, Page(s) 20–27

    Keywords Family Practice ; Public Health, Environmental and Occupational Health ; covid19
    Language Spanish
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 1138-3593
    DOI 10.1016/j.semerg.2020.06.016
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Tratamiento farmacológico en tiempos de incertidumbre: uso de la hidroxicloroquina/cloroquina en el tratamiento de COVID-19./ [Pharmacological treatment in uncertainty times: Hydroxychloroquine/chloroquine use in the COVID-19 treatment]

    Mayayo-Vicente, S / Rodriguez Salvanés, F / Gallego-Arenas, A / Sánchez-Gómez, L M / Ruiz-López, M / Sierra García, B / Jurado-López, A / Arriola-Bolado, P / Cervera Cano, M / Novella-Arribas, B

    Semergen

    Abstract: BACKGROUND AND OBJECTIVES: In this moments, of extreme gravity in which we find ourselves, and in the uncertainty face about the most effective treatment against COVID-19 disease and with the aim of find the evidence that support the chloroquine/ ... ...

    Abstract BACKGROUND AND OBJECTIVES: In this moments, of extreme gravity in which we find ourselves, and in the uncertainty face about the most effective treatment against COVID-19 disease and with the aim of find the evidence that support the chloroquine/hydroxychloroquine use recommendation to treat COVID-19 disease, a systematic review of published studies and RCT studies publishes until April 28, 2020 was carried out. MATERIAL AND METHODS: A systematic search was carried out in PubMed with the keywords COVID-19 and their synonyms and hydroxychloroquine/chloroquine. The data selection and extraction was elaborated by two researchers, independently. The results were discussed with a Primary Care physicians clinical group and the results were synthesized using GRADE methodology. RESULTS: A good quality systematic review was found that includes articles with a high risk of bias. And 8 EC launched that will produce results beyond May 2020. CONCLUSIONS: Although the conclusions of the systematic review generate a low confidence in the results, and the clinical variables that show benefit are intermediate variables, the side effects are acceptable and could be minimized with the use of QT lengthening risk tools, so it is could make a weak recommendation in favor of the use of chloroquine/hydroxychloroquine in patients with mild-moderate stage COVID-19.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #640474
    Database COVID19

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  4. Article ; Online: Characteristics and long-term outcome in a large series of chronic myelomonocytic leukaemia patients including 104 formerly referred to as oligomonocytic.

    Castaño-Díez, Sandra / Pomares, Helena / Esteban, Daniel / Guijarro, Francesca / Jiménez-Vicente, Carlos / Zugasti, Inés / Álamo, José Ramón / Mayayo, Víctor Torrecillas / López-Guerra, Mònica / de la Fuente, Cristina / Charry, Paola / Cortés-Bullich, Albert / Bataller, Álex / Maluquer, Clara / Colomer, Dolors / Rozman, María / Arnan, Montserrat / Xicoy, Blanca / Esteve, Jordi /
    Díaz-Beyá, Marina

    British journal of haematology

    2023  Volume 204, Issue 3, Page(s) 892–897

    Abstract: Recently modified diagnostic criteria for chronic myelomonocytic leukaemia (CMML) have lowered the cut-off for absolute monocytosis. In the largest series to date, we have analysed 313 CMML patients, including 104 with oligomonocytic (OM)-CMML. Five-year ...

    Abstract Recently modified diagnostic criteria for chronic myelomonocytic leukaemia (CMML) have lowered the cut-off for absolute monocytosis. In the largest series to date, we have analysed 313 CMML patients, including 104 with oligomonocytic (OM)-CMML. Five-year survival was longer for OM-CMML than for other patients (p < 0.001). Multivariate analysis identified OM-CMML as a favourable prognostic factor (HR 0.58; p = 0.002). The 5-year cumulative incidence of progression to classical CMML was 47%. Older age and transfusion dependence were adverse prognostic factors for OM-CMML. Our results support the inclusion of OM-CMML in the CMML category as a subtype with superior outcomes.
    MeSH term(s) Humans ; Leukemia, Myelomonocytic, Chronic/diagnosis ; Leukocytosis ; Prognosis
    Language English
    Publishing date 2023-11-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.19217
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  5. Article: A quantitative study of ganglion cells in the goat retina.

    Gonzalez-Soriano, J / Mayayo-Vicente, S / Martinez-Sainz, P / Contreras-Rodriguez, J / Rodriguez-Veiga, E

    Anatomia, histologia, embryologia

    1997  Volume 26, Issue 1, Page(s) 39–44

    Abstract: As in a number of mammals, the most prominent feature of the ganglion-cell layer in the retina of the murciano-granadina goat is an increase in the density of ganglion cells in the central area, as well as a concentration along a ridge extending ... ...

    Abstract As in a number of mammals, the most prominent feature of the ganglion-cell layer in the retina of the murciano-granadina goat is an increase in the density of ganglion cells in the central area, as well as a concentration along a ridge extending horizontally across the retina, below the optic disc, and in the upper temporal retina. Thus, there is an area of maximum density and two streaks that are known as the 'horizontal' and 'vertical' streak. The isodensity lines of ganglion-cell distribution is toughly concentric, with their values varying from 304 cells/mm2 in the periphery to 3592 cells/mm2 in the central area, with the cells densely packed. There were some individual differences amongst the animal studied, although all of them were purebred animals.
    MeSH term(s) Animals ; Cell Count ; Goats/anatomy & histology ; Male ; Retinal Ganglion Cells/cytology
    Language English
    Publishing date 1997-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 537922-2
    ISSN 1439-0264 ; 0340-2096 ; 0044-4294
    ISSN (online) 1439-0264
    ISSN 0340-2096 ; 0044-4294
    DOI 10.1111/j.1439-0264.1997.tb00101.x
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  6. Article: A quantitative study of ganglion cells in the German shepherd dog retina.

    Gonzalez-Soriano, J / Rodriguez-Veiga, E / Martinez-Sainz, P / Mayayo-Vicente, S / Marin-Garcia, P

    Anatomia, histologia, embryologia

    1995  Volume 24, Issue 1, Page(s) 61–65

    Abstract: As in the number of mammals, the most prominent feature of the ganglion-cell layer in the retina of the German shepherd dog is the sharp increase in the density of ganglion cells in the central area. There is an area of maximum density and also a 'cat- ... ...

    Abstract As in the number of mammals, the most prominent feature of the ganglion-cell layer in the retina of the German shepherd dog is the sharp increase in the density of ganglion cells in the central area. There is an area of maximum density and also a 'cat-like' visual streak, located dorsal to the optic disc. The isodensity lines of ganglion-cell distribution is roughly concentric. Their values vary from 5300-13,000 cells/mm2 in the central area, with the cells densely packed, to 1000 cells/mm2 or less in the periphery, where the cells are sparsely distributed. There were some individual differences amongst the animals studied, although all of them were pure-bred dogs. This suggests that the configuration of the retina in the canine species is not only dependent on the breed itself but also on some other parameters such as phylogenetic heritage, environment, aptitude, lifestyle, or even training.
    MeSH term(s) Animals ; Cell Count ; Dogs/anatomy & histology ; Female ; Male ; Retina/anatomy & histology ; Retina/cytology ; Retinal Ganglion Cells/cytology
    Language English
    Publishing date 1995-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 537922-2
    ISSN 1439-0264 ; 0340-2096 ; 0044-4294
    ISSN (online) 1439-0264
    ISSN 0340-2096 ; 0044-4294
    DOI 10.1111/j.1439-0264.1995.tb00010.x
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  7. Article ; Online: A cluster-randomised clinical trial comparing two cardiovascular health education strategies in a child population: the Savinghearts project.

    Sánchez-Gómez, Luis María / Fernández-Luque, María Jesús / Ruiz-Díaz, Lourdes / Sánchez-Alcalde, Rosa / Sierra-García, Belén / Mayayo-Vicente, Soledad / Ruiz-López, Marta / Loeches-Belinchón, Pilar / López-Gónzález, Javier / González-Gamarra, Amelia / Gallego-Arenas, Angela / Cubillo-Serna, Ana / Gil-Juberias, Gema / Pérez-Cayuela, Pilar / Cañedo-Arguelles, Celina Arana / García-Pascual, Julia Natividad / Ruiz-Chércoles, Esther / Suarez-Fernández, Carmen / Garcia-Polo, Iluminada /
    Abad-Perez, Daniel / Ballesteros-Arribas, Juan M / Izquierdo-Martínez, Maravillas / Salvador-Alcaide, Elena / Arribas-Vela, Ana B / Alonso-Pérez, Juan M / Veja-Piris, Lorena / Rodríguez-Salvanés, Francisco / Novella-Arribas, Blanca

    BMC public health

    2012  Volume 12, Page(s) 1024

    Abstract: Background: This paper describes a methodology for comparing the effects of an eduentertainment strategy involving a music concert, and a participatory class experience involving the description and making of a healthy breakfast, as educational vehicles ...

    Abstract Background: This paper describes a methodology for comparing the effects of an eduentertainment strategy involving a music concert, and a participatory class experience involving the description and making of a healthy breakfast, as educational vehicles for delivering obesity-preventing/cardiovascular health messages to children aged 7-8 years.
    Methods/design: This study will involve a cluster-randomised trial with blinded assessment. The study subjects will be children aged 7-8 years of both sexes attending public primary schools in the Madrid Region. The participating schools (n=30) will be randomly assigned to one of two groups: 1) Group MC, in which the children will attend a music concert that delivers obesity-preventing/cardiovascular health messages, or 2) Group HB, in which the children will attend a participatory class providing the same information but involving the description and making of a healthy breakfast. The main outcome measured will be the increase in the number of correct answers scored on a knowledge questionnaire and in an attitudes test administered before and after the above interventions. The secondary outcome recorded will be the reduction in BMI percentile among children deemed overweight/obese prior to the interventions. The required sample size (number of children) was calculated for a comparison of proportions with an α of 0.05 and a β of 0.20, assuming that the Group MC subjects would show values for the measured variables at least 10% higher than those recorded for the subjects of Group HB. Corrections were made for the design effect and assuming a loss to follow-up of 10%. The maximum sample size required will be 2107 children. Data will be analysed using summary measurements for each cluster, both for making estimates and for hypothesis testing. All analyses will be made on an intention-to-treat basis.
    Discussion: The intervention providing the best results could be recommended as part of health education for young schoolchildren.
    Trial registration: Clinicaltrials.gov: NCT01418872.
    MeSH term(s) Breakfast ; Cardiovascular Diseases/prevention & control ; Child ; Cluster Analysis ; Female ; Follow-Up Studies ; Health Education/methods ; Health Knowledge, Attitudes, Practice ; Health Promotion/methods ; Humans ; Male ; Music ; Obesity/prevention & control ; Program Evaluation ; Single-Blind Method
    Language English
    Publishing date 2012-11-23
    Publishing country England
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial
    ISSN 1471-2458
    ISSN (online) 1471-2458
    DOI 10.1186/1471-2458-12-1024
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  8. Article: Hemorragia intraperitoneal por hemangioma cavernoso de intestino delgado.

    Castellote Caixal, J M / Luengo, R / Ledesma, L / Gómez Sugrañes, J R / Ros López, S / Gris Yraizoz, F / Mayayo Artal, E / Vicente Guillén, V

    Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

    1995  Volume 87, Issue 2, Page(s) 155–157

    Abstract: We report a case of hemorrhage into the abdominal cavity due to the rupture of an intestinal cavernous hemangioma. Out of the 30 published cases from 1976 to 1993 dealing with hemangioma of the small intestine, none presented with intraperitoneal ... ...

    Title translation Intraperitoneal hemorrhage caused by cavernous hemangioma of the small intestine.
    Abstract We report a case of hemorrhage into the abdominal cavity due to the rupture of an intestinal cavernous hemangioma. Out of the 30 published cases from 1976 to 1993 dealing with hemangioma of the small intestine, none presented with intraperitoneal bleeding.
    MeSH term(s) Adult ; Female ; Hemangioma, Cavernous/complications ; Hemorrhage/etiology ; Humans ; Ileal Neoplasms/complications ; Peritoneal Diseases/etiology
    Language Spanish
    Publishing date 1995-02
    Publishing country Spain
    Document type Case Reports ; English Abstract ; Journal Article ; Review
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
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