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Article ; Online: Persistence of ex vivo expanded tumour and pathogen specific T-cells after allogeneic stem cell transplant for myeloid malignancies (the INTACT study).

Jiang, Wei / Avdic, Selmir / Lee, Koon H / Street, Janine / Castellano-González, Gloria / Simms, Renee / Clancy, Leighton E / Blennerhassett, Richard / Patrick, Ellis / Chan, Adam S / McGuire, Helen M / Myers, Nadav / Gloss, Brian S / Gabriel, Melissa / Bateman, Caroline M / Micklethwaite, Ken / Gottlieb, David J / Blyth, Emily

Leukemia

2023 Volume 37, Issue 11, Page(s) 2330–2333

MeSH term(s)	Humans ; T-Lymphocytes ; Neoplasms ; Stem Cell Transplantation ; Myeloproliferative Disorders ; Hematopoietic Stem Cell Transplantation
Language	English
Publishing date	2023-09-15
Publishing country	England
Document type	Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	807030-1
ISSN	1476-5551 ; 0887-6924
ISSN (online)	1476-5551
ISSN	0887-6924
DOI	10.1038/s41375-023-02033-5
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Article ; Online: Survivorship of high tibial osteotomy in the treatment of osteoarthritis of the knee: a retrospective cohort study with fourteen years' follow-up.

Bhattacharyya, Rahul / Alloush, Almothenna / Wilson, Christina / Doonan, James / Rooney, Brian / Walker, Colin / Maclean, Angus / Blyth, Mark

International orthopaedics

2023 Volume 47, Issue 7, Page(s) 1765–1770

Abstract: Purpose: This study was to evaluate the survivorship of HTO for the treatment of medial compartment osteoarthritis (OA) in young and active patients from two teaching hospitals in a single city.: Methods: This is a retrospective cohort multicenter ... ...

Abstract	Purpose: This study was to evaluate the survivorship of HTO for the treatment of medial compartment osteoarthritis (OA) in young and active patients from two teaching hospitals in a single city. Methods: This is a retrospective cohort multicenter study looking at HTO for treatment of medial compartment OA. We analyzed a case series of HTO's performed by four surgeons in two centres over a 14-year period. Failure was defined as conversion to total knee replacement (TKR). All cases where additional procedures for instability of the knee were performed at the time of the index surgery were excluded. Time to failure was recorded, and a Kaplan-Meir (KM) analysis was performed to evaluate survivorship. Univariate binary regression analysis was undertaken to identify associations between risk factors and failure. Results: A total of 96 patients were included in the study with a median age was 45 years. The survivorship at five years post-op was 90.3%, and at ten years post-op, it was 82%. Patients that were 14 years after surgery had a survivorship of 65%. Also, 18.8% of patients required the removal of their metalwork. The overall complication rate was 6.3%. The univariate regression analysis showed that higher age (p = 0.02) and larger corrections requiring the use of bone graft increased the risk of failure (p = 0.02). There was no statistically significant correlation between laterality, gender, complication rate, and pre-operative alignment to survivorship. Conclusion: This is one of the largest reported case series of HTO's with comparable survivorship at five and ten year follow-up compared to the reported literature. There was an association found between increasing age and larger corrections requiring bone graft at index procedure to increasing failure rate.
MeSH term(s)	Humans ; Middle Aged ; Osteoarthritis, Knee/surgery ; Osteoarthritis, Knee/etiology ; Retrospective Studies ; Follow-Up Studies ; Survivorship ; Tibia/surgery ; Knee Joint/surgery ; Osteotomy/adverse effects ; Osteotomy/methods ; Treatment Outcome
Language	English
Publishing date	2023-04-11
Publishing country	Germany
Document type	Multicenter Study ; Journal Article
ZDB-ID	80384-4
ISSN	1432-5195 ; 0341-2695
ISSN (online)	1432-5195
ISSN	0341-2695
DOI	10.1007/s00264-023-05802-0
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Zs.A 1324: Show issues

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Article ; Online: Combining CD34+ stem cell selection with prophylactic pathogen and leukemia directed T-cell immunotherapy to simultaneously reduce graft versus host disease, infection, and leukemia recurrence after allogeneic stem cell transplant.

Gottlieb, David J / Sutrave, Gaurav / Jiang, Wei / Avdic, Selmir / Street, Janine A / Simms, Renee / Clancy, Leighton E / Antonenas, Vicki / Gloss, Brian S / Bateman, Caroline / Bishop, David C / Micklethwaite, Kenneth P / Blyth, Emily

American journal of hematology

2022 Volume 98, Issue 1, Page(s) 159–165

Abstract: We designed a trial to simultaneously address the problems of graft versus host disease (GVHD), infection, and recurrence of malignancy after allogeneic stem cell transplantation. ... ...

Abstract	We designed a trial to simultaneously address the problems of graft versus host disease (GVHD), infection, and recurrence of malignancy after allogeneic stem cell transplantation. CD34
MeSH term(s)	Humans ; T-Lymphocytes ; Epstein-Barr Virus Infections/complications ; Epstein-Barr Virus Infections/therapy ; Transplantation, Homologous ; Treatment Outcome ; Herpesvirus 4, Human ; Graft vs Host Disease/etiology ; Graft vs Host Disease/prevention & control ; Hematopoietic Stem Cell Transplantation ; Stem Cell Transplantation ; Immunotherapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy
Language	English
Publishing date	2022-05-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	196767-8
ISSN	1096-8652 ; 0361-8609
ISSN (online)	1096-8652
ISSN	0361-8609
DOI	10.1002/ajh.26594
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Zs.A 1251: Show issues

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Article ; Online: Traumatic alterations in consciousness: traumatic brain injury.

Blyth, Brian J / Bazarian, Jeffrey J

Emergency medicine clinics of North America

2010 Volume 28, Issue 3, Page(s) 571–594

Abstract: Mild traumatic brain injury (mTBI) refers to the clinical condition of transient alteration of consciousness as a result of traumatic injury to the brain. The priority of emergency care is to identify and facilitate the treatment of rare but potentially ... ...

Abstract	Mild traumatic brain injury (mTBI) refers to the clinical condition of transient alteration of consciousness as a result of traumatic injury to the brain. The priority of emergency care is to identify and facilitate the treatment of rare but potentially life-threatening intracranial injuries associated with mTBI through the judicious application of appropriate imaging studies and neurosurgical consultation. Although post-mTBI symptoms quickly and completely resolve in the vast majority of cases, a significant number of patients will complain of lasting problems that may cause significant disability. Simple and early interventions such as patient education and appropriate referral can reduce the likelihood of chronic symptoms. Although definitive evidence is lacking, mTBI is likely to be related to significant long-term sequelae such as Alzheimer disease and other neurodegenerative processes.
MeSH term(s)	Biomarkers/blood ; Brain Injuries/complications ; Brain Injuries/diagnosis ; Brain Injuries/physiopathology ; Cognition Disorders/etiology ; Consciousness Disorders/diagnosis ; Consciousness Disorders/etiology ; Consciousness Disorders/physiopathology ; Diagnosis, Differential ; Emergency Service, Hospital ; Fatigue/etiology ; Headache/etiology ; Humans ; Physical Examination ; Seizures/etiology ; Time Factors ; Vertigo/etiology
Chemical Substances	Biomarkers
Language	English
Publishing date	2010-08-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	605637-4
ISSN	1558-0539 ; 0733-8627
ISSN (online)	1558-0539
ISSN	0733-8627
DOI	10.1016/j.emc.2010.03.003
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Article ; Online: Position Effect on Facial Soft Tissue Depths: A Sonographic Investigation.

Baillie, Louisa J / Muirhead, Jillian C / Blyth, Phil / Niven, Brian E / Dias, George J

Journal of forensic sciences

2016 Volume 61 Suppl 1, Page(s) S60–70

Abstract: The head is positioned erect for an approximation; yet most facial soft tissue depths (FSTD) used are measured from supine subjects. Depth difference might be significant, but there is a paucity of data to verify. This study compared erect and supine ... ...

Abstract	The head is positioned erect for an approximation; yet most facial soft tissue depths (FSTD) used are measured from supine subjects. Depth difference might be significant, but there is a paucity of data to verify. This study compared erect and supine values for 17 landmarks from 30 healthy New Zealand (European population affinity) women (18-30 or 40-55 years) in erect then supine positions. Height, weight, and sonographic FSTD data, totaling 1020 measurements, were obtained. Three midline and seven averaged bilateral values were compared using ANOVA, p values, and Pearson's correlations. Correlative strength of age and body mass index, BMI (kg/m(2) ), was determined by values. Results showed averaged erect and supine differences were significant for four of ten FSTDs. Between individuals, difference was various and not unidirectional. In conclusion, depth differences were observed but not all significant or unidirectional, BMI significantly influenced nine FSTD values, but age group did not.
Language	English
Publishing date	2016-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	219216-0
ISSN	1556-4029 ; 0022-1198
ISSN (online)	1556-4029
ISSN	0022-1198
DOI	10.1111/1556-4029.12935
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Article: Inclusion, Diversity, Access, and Equity in Infectious Diseases Fellowship Training: Tools for Program Directors.

Luther, Vera P / Barsoumian, Alice E / Konold, Victoria J L / Vijayan, Tara / Balba, Gayle / Benson, Constance / Blackburn, Brian / Cariello, Paloma / Perloff, Sarah / Razonable, Raymund / Acharya, Kartikey / Azar, Marwan M / Bhanot, Nitin / Blyth, Dana / Butt, Saira / Casanas, Beata / Chow, Brian / Cleveland, Kerry / Cutrell, James B /

Doshi, Saumil / Finkel, Diana / Graber, Christopher J / Hazra, Aniruddha / Hochberg, Natasha S / James, Scott H / Kaltsas, Anna / Kodiyanplakkal, Rosy Priya L / Lee, Mikyung / Marcos, Luis / Mena Lora, Alfredo J / Moore, Christopher C / Nnedu, Obinna / Osorio, Georgina / Paras, Molly L / Reece, Rebecca / Salas, Natalie Mariam / Sanasi-Bhola, Kamla / Schultz, Sara / Serpa, Jose A / Shnekendorf, Rachel / Weisenberg, Scott / Wooten, Darcy / Zuckerman, Richard A / Melia, Michael / Chirch, Lisa M

Open forum infectious diseases

2023 Volume 10, Issue 6, Page(s) ofad289

Abstract: The Infectious Diseases Society of America (IDSA) has set clear priorities in recent years to promote inclusion, diversity, access, and equity (IDA&E) in infectious disease (ID) clinical practice, medical education, and research. The IDSA IDA&E Task ... ...

Abstract	The Infectious Diseases Society of America (IDSA) has set clear priorities in recent years to promote inclusion, diversity, access, and equity (IDA&E) in infectious disease (ID) clinical practice, medical education, and research. The IDSA IDA&E Task Force was launched in 2018 to ensure implementation of these principles. The IDSA Training Program Directors Committee met in 2021 and discussed IDA&E best practices as they pertain to the education of ID fellows. Committee members sought to develop specific goals and strategies related to recruitment, clinical training, didactics, and faculty development. This article represents a presentation of ideas brought forth at the meeting in those spheres and is meant to serve as a reference document for ID training program directors seeking guidance in this area.
Language	English
Publishing date	2023-05-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2757767-3
ISSN	2328-8957
ISSN	2328-8957
DOI	10.1093/ofid/ofad289
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Article ; Online: Inhibition of METTL3 Results in a Cell-Intrinsic Interferon Response That Enhances Antitumor Immunity.

Guirguis, Andrew A / Ofir-Rosenfeld, Yaara / Knezevic, Kathy / Blackaby, Wesley / Hardick, David / Chan, Yih-Chih / Motazedian, Ali / Gillespie, Andrea / Vassiliadis, Dane / Lam, Enid Y N / Tran, Kevin / Andrews, Byron / Harbour, Michael E / Vasiliauskaite, Lina / Saunders, Claire J / Tsagkogeorga, Georgia / Azevedo, Aleksandra / Obacz, Joanna / Pilka, Ewa S /

Carkill, Marie / MacPherson, Laura / Wainwright, Elanor N / Liddicoat, Brian / Blyth, Benjamin J / Albertella, Mark R / Rausch, Oliver / Dawson, Mark A

Cancer discovery

2023 Volume 13, Issue 10, Page(s) 2228–2247

Abstract: Therapies that enhance antitumor immunity have altered the natural history of many cancers. Consequently, leveraging nonoverlapping mechanisms to increase immunogenicity of cancer cells remains a priority. Using a novel enzymatic inhibitor of the RNA ... ...

Abstract	Therapies that enhance antitumor immunity have altered the natural history of many cancers. Consequently, leveraging nonoverlapping mechanisms to increase immunogenicity of cancer cells remains a priority. Using a novel enzymatic inhibitor of the RNA methyl-transferase METTL3, we demonstrate a global decrease in N6-methyladenosine (m6A) results in double-stranded RNA (dsRNA) formation and a profound cell-intrinsic interferon response. Through unbiased CRISPR screens, we establish dsRNA-sensing and interferon signaling are primary mediators that potentiate T-cell killing of cancer cells following METTL3 inhibition. We show in a range of immunocompetent mouse models that although METTL3 inhibition is equally efficacious to anti-PD-1 therapy, the combination has far greater preclinical activity. Using SPLINTR barcoding, we demonstrate that anti-PD-1 therapy and METTL3 inhibition target distinct malignant clones, and the combination of these therapies overcomes clones insensitive to the single agents. These data provide the mole-cular and preclinical rationale for employing METTL3 inhibitors to promote antitumor immunity in the clinic. Significance: This work demonstrates that METTL3 inhibition stimulates a cell-intrinsic interferon response through dsRNA formation. This immunomodulatory mechanism is distinct from current immunotherapeutic agents and provides the molecular rationale for combination with anti-PD-1 immune-checkpoint blockade to augment antitumor immunity. This article is featured in Selected Articles from This Issue, p. 2109.
MeSH term(s)	Animals ; Mice ; Interferons/genetics ; Methyltransferases/genetics ; Methyltransferases/metabolism ; RNA, Double-Stranded
Chemical Substances	Interferons (9008-11-1) ; Methyltransferases (EC 2.1.1.-) ; RNA, Double-Stranded
Language	English
Publishing date	2023-08-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2625242-9
ISSN	2159-8290 ; 2159-8274
ISSN (online)	2159-8290
ISSN	2159-8274
DOI	10.1158/2159-8290.CD-23-0007
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Article ; Online: Development of CAR T-cell lymphoma in 2 of 10 patients effectively treated with piggyBac-modified CD19 CAR T cells.

Blood

2021 Volume 138, Issue 16, Page(s) 1504–1509

MeSH term(s)	Adult ; Aged ; DNA Transposable Elements ; Female ; Hematopoietic Stem Cell Transplantation ; Humans ; Immunotherapy, Adoptive/adverse effects ; Immunotherapy, Adoptive/methods ; Leukemia, B-Cell/genetics ; Leukemia, B-Cell/therapy ; Lymphoma/etiology ; Lymphoma/genetics ; Lymphoma, B-Cell/genetics ; Lymphoma, B-Cell/therapy ; Male ; Middle Aged ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/therapeutic use ; Treatment Outcome ; Young Adult
Chemical Substances	CD19-specific chimeric antigen receptor ; DNA Transposable Elements ; Receptors, Antigen, T-Cell
Language	English
Publishing date	2021-07-15
Publishing country	United States
Document type	Clinical Trial, Phase I ; Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood.2021010813
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Uh III Zs.140: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Ancestry and BMI Influences on Facial Soft Tissue Depths for A Cohort of Chinese and Caucasoid Women in Dunedin, New Zealand.

Baillie, Louisa J / Mirijali, Seyed Ali / Niven, Brian E / Blyth, Phil / Dias, George J

Journal of forensic sciences

2015 Volume 60, Issue 5, Page(s) 1146–1154

Abstract: This study measured and assessed facial soft tissue depths (FSTDs) in adult female Chinese and New Zealand (NZ) Europeans (Caucasoids). Ultrasound was used to obtain depths at nine landmarks on 108 healthy subjects (51 Chinese, 57 NZ European), erect ... ...

Abstract	This study measured and assessed facial soft tissue depths (FSTDs) in adult female Chinese and New Zealand (NZ) Europeans (Caucasoids). Ultrasound was used to obtain depths at nine landmarks on 108 healthy subjects (51 Chinese, 57 NZ European), erect positioned, of same age group (18-29 years). Height and weight were also recorded. Statistical analysis focused on comparison of tissue depth between the two ancestry groups and the influence of Body Mass Index (BMI) (kg/m2). Results showed mean depth differences at Supra M2 and Infra M2 landmarks significantly greater for Chinese than Caucasoid women for all three BMI Classes (BMI<20, 20≤BMI<25, 25≤BMI<30), even BMI<20. For both groups BMI positively correlated with FSTD values at all landmarks except Labrale superius. This study enabled ancestry and BMI influence on FSTDs to be observed and compared for two distinct groups. Results add to knowledge about facial tissue depth variation.
MeSH term(s)	Adolescent ; Adult ; Asian Continental Ancestry Group ; Body Mass Index ; China/ethnology ; Cohort Studies ; European Continental Ancestry Group ; Face/anatomy & histology ; Face/diagnostic imaging ; Female ; Humans ; New Zealand ; Ultrasonography ; Young Adult
Language	English
Publishing date	2015-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	219216-0
ISSN	1556-4029 ; 0022-1198
ISSN (online)	1556-4029
ISSN	0022-1198
DOI	10.1111/1556-4029.12799
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Article ; Online: Canonical T cell receptor docking on peptide-MHC is essential for T cell signaling.

Science (New York, N.Y.)

2021 Volume 372, Issue 6546

Abstract: T cell receptor (TCR) recognition of peptide-major histocompatibility complexes (pMHCs) is characterized by a highly conserved docking polarity. Whether this polarity is driven by recognition or signaling constraints remains unclear. Using "reversed- ... ...

Abstract	T cell receptor (TCR) recognition of peptide-major histocompatibility complexes (pMHCs) is characterized by a highly conserved docking polarity. Whether this polarity is driven by recognition or signaling constraints remains unclear. Using "reversed-docking" TCRβ-variable (TRBV) 17
MeSH term(s)	Animals ; CD3 Complex/metabolism ; CD8 Antigens/immunology ; CD8 Antigens/metabolism ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Epitopes, T-Lymphocyte ; Female ; Histocompatibility Antigen H-2D/chemistry ; Histocompatibility Antigen H-2D/immunology ; Histocompatibility Antigen H-2D/metabolism ; Influenza A virus ; Lymphocyte Activation ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/metabolism ; Major Histocompatibility Complex ; Mice ; Mice, Inbred C57BL ; Models, Molecular ; Nucleocapsid Proteins/chemistry ; Nucleocapsid Proteins/immunology ; Nucleocapsid Proteins/metabolism ; Orthomyxoviridae Infections/immunology ; Peptide Fragments/immunology ; Peptide Fragments/metabolism ; Protein Binding ; Protein Conformation ; Receptors, Antigen, T-Cell, alpha-beta/chemistry ; Receptors, Antigen, T-Cell, alpha-beta/immunology ; Receptors, Antigen, T-Cell, alpha-beta/metabolism ; Signal Transduction
Chemical Substances	CD3 Complex ; CD8 Antigens ; Epitopes, T-Lymphocyte ; Histocompatibility Antigen H-2D ; NP protein, Influenza A virus ; Nucleocapsid Proteins ; Peptide Fragments ; Receptors, Antigen, T-Cell, alpha-beta ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck) (EC 2.7.10.2)
Language	English
Publishing date	2021-06-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.abe9124
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