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  1. Article ; Online: Recollections - Dr. Yasuhiro Furuichi.

    Sonenberg, Nahum / Filipowicz, Witold

    RNA (New York, N.Y.)

    2022  

    Language English
    Publishing date 2022-12-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1241540-6
    ISSN 1469-9001 ; 1355-8382
    ISSN (online) 1469-9001
    ISSN 1355-8382
    DOI 10.1261/rna.079517.122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Traversing the RNA world.

    Filipowicz, Witold

    The Journal of biological chemistry

    2017  Volume 292, Issue 20, Page(s) 8122–8135

    Abstract: An invitation to write a "Reflections" type of article creates a certain ambivalence: it is a great honor, but it also infers the end of your professional career. Before you vanish for good, your colleagues look forward to an interesting but entertaining ...

    Abstract An invitation to write a "Reflections" type of article creates a certain ambivalence: it is a great honor, but it also infers the end of your professional career. Before you vanish for good, your colleagues look forward to an interesting but entertaining account of the ups-and-downs of your past research and your views on science in general, peppered with indiscrete anecdotes about your former competitors and collaborators. What follows will disappoint those who await complaint and criticism, for example, about the difficulties of doing research in the 1960s and 1970s in Eastern Europe, or those seeking very personal revelations. My scientific life has in fact seen many happy coincidences, much good fortune, and several lucky escapes from situations that at the time were quite scary. I have also been fortunate with regard to competitors and collaborators, particularly because, whenever possible, I tried to "neutralize" my rivals by collaborating with them - to the benefit of all. I recommend this strategy to young researchers to dispel the nightmares that can occur when competing against powerful contenders. I have been blessed with the selection of my research topic: RNA biology. Over the last five decades, new and unexpected RNA-related phenomena emerged almost yearly. I experienced them very personally while studying transcription, translation, RNA splicing, ribosome biogenesis, and more recently, different classes of regulatory non-coding RNAs, including microRNAs. Some selected research and para-research stories, also covering many wonderful people I had a privilege to work with, are summarized below.
    MeSH term(s) Periodicals as Topic ; RNA
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2017-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.X117.789065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: RNA 3'-terminal phosphate cyclases and cyclase-like proteins.

    Filipowicz, Witold

    Postepy biochemii

    2016  Volume 62, Issue 3, Page(s) 327–334

    Abstract: RNA molecules bearing terminal 2', 3'-cyclic phosphate are quite common in nature. For example, 2', 3'-cyclic phosphate termini are produced during RNA cleavage by many endoribonucleases either as intermediates or final products. Many RNA-based nucleases ...

    Title translation Cyklazy 3'-końcowego fosforanu RNA.
    Abstract RNA molecules bearing terminal 2', 3'-cyclic phosphate are quite common in nature. For example, 2', 3'-cyclic phosphate termini are produced during RNA cleavage by many endoribonucleases either as intermediates or final products. Many RNA-based nucleases (ribozymes) also generate cyclic phosphate termini. However, cleavage reactions are not the only way in which RNAs bearing cyclic phosphate ends are produced. They can also be generated by RNA 3'-terminal phosphate cyclases (RtcA), a family of enzymes conserved in eukaryotes, bacteria, and archaea. These enzymes catalyze the ATP-dependent conversion of the 3'-phosphate to a 2', 3'-cyclic phosphodiester at the end of RNA. In this article, I review knowledge about the biochemistry and structure of RNA 3'-phosphate cyclases and also proteins of the RNA cyclase-like (Rcl1) family, and discuss their documented or possible roles in different RNA metabolic reactions.
    Language English
    Publishing date 2016
    Publishing country Poland
    Document type Journal Article ; Review
    ZDB-ID 414019-9
    ISSN 0032-5422
    ISSN 0032-5422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Making ends meet: a role of RNA ligase RTCB in unfolded protein response.

    Filipowicz, Witold

    The EMBO journal

    2014  Volume 33, Issue 24, Page(s) 2887–2889

    MeSH term(s) Amino Acyl-tRNA Synthetases/metabolism ; Animals ; Antibodies/metabolism ; DNA-Binding Proteins/metabolism ; Humans ; Plasma Cells/physiology ; Proteins/metabolism ; Proteins/physiology ; RNA Splicing/genetics ; RNA, Messenger/metabolism ; RNA-Binding Proteins ; Regulatory Factor X Transcription Factors ; Transcription Factors/metabolism ; Unfolded Protein Response
    Chemical Substances Antibodies ; DNA-Binding Proteins ; Proteins ; RNA, Messenger ; RNA-Binding Proteins ; Regulatory Factor X Transcription Factors ; Transcription Factors ; ZBTB8OS protein, human ; Amino Acyl-tRNA Synthetases (EC 6.1.1.-) ; FAAP protein, mouse (EC 6.1.1.-)
    Language English
    Publishing date 2014-11-17
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 586044-1
    ISSN 1460-2075 ; 0261-4189
    ISSN (online) 1460-2075
    ISSN 0261-4189
    DOI 10.15252/embj.201490425
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Elisa Izaurralde (1959-2018).

    Conti, Elena / Filipowicz, Witold

    RNA (New York, N.Y.)

    2018  Volume 24, Issue 8, Page(s) ix–x

    MeSH term(s) Biology/history ; Famous Persons ; History, 20th Century ; History, 21st Century ; RNA ; Switzerland ; Uruguay
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2018-05-24
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 1241540-6
    ISSN 1469-9001 ; 1355-8382
    ISSN (online) 1469-9001
    ISSN 1355-8382
    DOI 10.1261/rna.067397.118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Parental knowledge about development and care of a child aged 0–12 months

    Monika Filipowicz / Witold Rekowski

    Pediatria i Medycyna Rodzinna, Vol 14, Iss 2, Pp 201-

    2018  Volume 212

    Abstract: Aim: The aim of the study was to assess parental knowledge about the development and care of a child aged 0–12 months as well as to verify whether this knowledge is sufficient to detect potential abnormalities and thus allow for early intervention. ... ...

    Abstract Aim: The aim of the study was to assess parental knowledge about the development and care of a child aged 0–12 months as well as to verify whether this knowledge is sufficient to detect potential abnormalities and thus allow for early intervention. Another aim of the study was to determine the effects of selected sociodemographic characteristics of respondents on their knowledge about the development and care of a child aged up to 1 year. Material and methods: A total of 99 parents (82 women and 17 men) with children aged 0–12 months were included in the study. The study was conducted using an author’s online questionnaire. Two scales were the main dependent variables. One scale allowed for an assessment of respondents’ knowledge about child development, while the other scale verified the knowledge about childcare. The obtained data were analysed statistically using the IBM SPSS Statistics version 20. The analysis of contingency tables used percentage profiles and the Pearson Chi-square independence test as well as Cramér’s V association. The results were considered statistically significant at α = 0.05. Results: Statistical analysis of data points to an insufficient level of parental knowledge about the development and care of a small child. Factors such as education, place of residence and attending childbirth classes have a significant impact on this knowledge. Conclusions: Parental education on normal child development and childcare is necessary. This will help prevent many abnormalities by proper care as well as earlier detection of disorders and, consequently, early intervention.
    Keywords newborn ; infant ; childbirth ; motor activity ; care ; Medicine ; R
    Language English
    Publishing date 2018-06-01T00:00:00Z
    Publisher Medical Communications Sp. z o.o.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: The long unfinished march towards understanding microRNA-mediated repression.

    Filipowicz, Witold / Sonenberg, Nahum

    RNA (New York, N.Y.)

    2015  Volume 21, Issue 4, Page(s) 519–524

    MeSH term(s) Gene Expression Regulation/physiology ; MicroRNAs/physiology ; Publishing ; RNA Interference
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2015-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1241540-6
    ISSN 1469-9001 ; 1355-8382
    ISSN (online) 1469-9001
    ISSN 1355-8382
    DOI 10.1261/rna.051219.115
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  8. Book: Regulating the regulators

    Filipowicz, Witold

    mechanisms controlling function and metabolism of microRNAs

    (NIH Wednesday afternoon lecture)

    2012  

    Abstract: CIT): Micro-Ribonucleic Acids (miRNAs) are a novel class of 20-nucleotide-long regulatory RNAs expressed in eukaryotes. MiRNAs regulate gene expression post-transcriptionally by imperfectly base-pairing to the three prime untranslated region of mRNAs ... ...

    Institution National Institutes of Health (U.S.)
    Author's details Witold Filipowicz
    Series title NIH Wednesday afternoon lecture
    Abstract (CIT): Micro-Ribonucleic Acids (miRNAs) are a novel class of 20-nucleotide-long regulatory RNAs expressed in eukaryotes. MiRNAs regulate gene expression post-transcriptionally by imperfectly base-pairing to the three prime untranslated region of mRNAs which results in translational repression or mRNA deadenylation and degradation. The number of different miRNAs in human"s reaches 1,000, and 50 percent of all human genes are predicted to be subject to miRNA regulation. Although specific functions and target mRNAs have been assigned to only a fraction of identified miRNAs, much evidence exists that miRNAs participate in the regulation of nearly all cellular and developmental processes. Expression of many miRNAs is tissue or development specific and major changes in miRNA expression are observed in human pathologies, including cancer. Clearly, discovery of miRNAs added a new dimension to the complexity and regulation of eukaryotic genomes. I will discuss current knowledge about the mechanism of miRNA-mediated repression of gene expression, particularly a role of Argonaute and GW182 proteins, and a large multiprotein CCR4-NOT complex which functions downstream and mediates both mRNA deadenylation and translational repression. In addition, biogenesis and turnover of miRNAs, and also the miRNA-mediated repression itself, were recently found to be highly regulated processes involving a plethora of factors with many of them implicated in human pathologies. Finally, I will discuss regulation of miRNA function and turnover in neurons. Our recent work revealed that miRNAs in retinal, hippocampal, and cortical neurons turn over much faster than in non-neuronal cells and that miRNA turnover in neurons may be subject to a complex activity-dependent regulation. Blocking action potentials with tetrodotoxin prevents rapid turnover of miRNAs in neurons. Blocking glutamate receptors likewise prevents decay of many miRNAs in hippocampal and embryonic stem cell derived neurons, while the addition of glutamate accelerates it. The NIH Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide. For more information, visit: The NIH Director's Wednesday Afternoon Lecture Series.
    MeSH term(s) MicroRNAs/physiology ; MicroRNAs/metabolism ; MicroRNAs/genetics ; Gene Expression Regulation/physiology
    Language English
    Size 1 online resource (1 streaming video file (1 hr.) :, sd., col.).
    Publisher National Institutes of Health
    Publishing place Bethesda, Md
    Document type Book
    Note Closed-captioned.
    Database Catalogue of the US National Library of Medicine (NLM)

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  9. Article: RNAi: the nuts and bolts of the RISC machine.

    Filipowicz, Witold

    Cell

    2005  Volume 122, Issue 1, Page(s) 17–20

    Abstract: Research on RNA interference and microRNA pathways continues to accelerate. Combinations of biochemical, genetic, and structural approaches are providing new insights into the mechanism by which small, approximately 21 nt long RNAs find their way into ... ...

    Abstract Research on RNA interference and microRNA pathways continues to accelerate. Combinations of biochemical, genetic, and structural approaches are providing new insights into the mechanism by which small, approximately 21 nt long RNAs find their way into the RISC effector complexes and how the RISCs execute their mission of RNA-guided posttranscriptional gene silencing.
    MeSH term(s) Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Gene Silencing ; MicroRNAs/chemistry ; MicroRNAs/genetics ; MicroRNAs/physiology ; Models, Biological ; RNA Interference/physiology ; RNA-Induced Silencing Complex/chemistry ; RNA-Induced Silencing Complex/genetics ; RNA-Induced Silencing Complex/physiology
    Chemical Substances MicroRNAs ; RNA-Induced Silencing Complex
    Language English
    Publishing date 2005-07-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2005.06.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Retrospective. Aaron Shatkin (1934-2012).

    Sonenberg, Nahum / Filipowicz, Witold

    Science (New York, N.Y.)

    2012  Volume 337, Issue 6092, Page(s) 309

    MeSH term(s) Animals ; Gene Expression Regulation ; History, 20th Century ; History, 21st Century ; Humans ; RNA Caps/history ; RNA Caps/physiology ; RNA Stability ; RNA, Messenger/chemistry ; RNA, Messenger/history ; RNA, Messenger/metabolism ; United States ; Virology/history
    Chemical Substances RNA Caps ; RNA, Messenger
    Language English
    Publishing date 2012-07-20
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.1226820
    Database MEDical Literature Analysis and Retrieval System OnLINE

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