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  1. Article ; Online: An explanation for the accuracy of sensor-based measures of energy intake: Amount of food consumed matters more than dietary composition.

    Chou, Tommy / Hoover, Adam W / Goldstein, Stephanie P / Greco-Henderson, Dante / Martin, Corby K / Raynor, Hollie A / Muth, Eric R / Thomas, J Graham

    Appetite

    2023  Volume 194, Page(s) 107176

    Abstract: Understanding and intervening on eating behavior often necessitates measurement of energy intake (EI); however, commonly utilized and widely accepted methods vary in accuracy and place significant burden on users (e.g., food diaries), or are costly to ... ...

    Abstract Understanding and intervening on eating behavior often necessitates measurement of energy intake (EI); however, commonly utilized and widely accepted methods vary in accuracy and place significant burden on users (e.g., food diaries), or are costly to implement (e.g., doubly labeled water). Thus, researchers have sought to leverage inexpensive and low-burden technologies such as wearable sensors for EI estimation. Paradoxically, one such methodology that estimates EI via smartwatch-based bite counting has demonstrated high accuracy in laboratory and free-living studies, despite only measuring the amount, not the composition, of food consumed. This secondary analysis sought to further explore this phenomenon by evaluating the degree to which EI can be explained by a sensor-based estimate of the amount consumed versus the energy density (ED) of the food consumed. Data were collected from 82 adults in free-living conditions (51.2% female, 31.7% racial and/or ethnic minority; M
    MeSH term(s) Adult ; Humans ; Female ; Male ; Ethnicity ; Minority Groups ; Diet ; Energy Intake ; Meals
    Language English
    Publishing date 2023-12-27
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1461347-5
    ISSN 1095-8304 ; 0195-6663
    ISSN (online) 1095-8304
    ISSN 0195-6663
    DOI 10.1016/j.appet.2023.107176
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Treating Alzheimer's Dementia With CT-Induced Low-Dose Ionizing Radiation: Problematic, Yet Potential for More Precise Inquiry.

    Raynor, Stephanie / Giordano, James

    Dose-response : a publication of International Hormesis Society

    2017  Volume 15, Issue 3, Page(s) 1559325817729247

    Abstract: This commentary evaluates a recent single-case study by Cuttler et al that posits that a series of computerized tomographic (CT) scans ameliorated symptoms and signs of advanced Alzheimer's dementia in an elderly female patient. The report proposes that ... ...

    Abstract This commentary evaluates a recent single-case study by Cuttler et al that posits that a series of computerized tomographic (CT) scans ameliorated symptoms and signs of advanced Alzheimer's dementia in an elderly female patient. The report proposes that CT scanning delivered low-dose ionizing radiation (LDIR) that activated adaptive mechanisms in the brain to induce the effects observed and reported. However, the report evidenced methodologic problems that threaten the validity and value of its approach, stated results, and conclusions. We provide discussion of these issues, with view and intent toward developing more precise investigations of the potential mechanisms and utility of LDIR in treating Alzheimer's dementia and possibly other neurodegenerative disorders.
    Language English
    Publishing date 2017-09-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2440820-7
    ISSN 1559-3258
    ISSN 1559-3258
    DOI 10.1177/1559325817729247
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  3. Article ; Online: Analytical performance of Abbott C-16000 analyser haemolysis index and its potential use in measuring plasma cell-free haemoglobin.

    Schapira, Anne-Julie / Lunte, Klara / Hennequin, Carole / Vicca, Stéphanie / Beaudeux, Jean-Louis / Alkoury, Rana / Nivet-Antoine, Valérie / Raynor, Alexandre / Cottart, Charles-Henry

    Annales de biologie clinique

    2023  Volume 81, Issue 1, Page(s) 44–51

    Abstract: Purpose: Measurement of the haemolysis index (HI) is usually performed in clinical chemistry laboratories in order to inform about whether biological analyses are influenced by in vivo or in vitro haemolysis of the specimen. Our aim was to evaluate the ... ...

    Title translation Performance analytique de l’index d’hémolyse sur l’analyseur Abbott C-16000 et son utilisation potentielle pour la mesure de l’hémoglobine plasmatique.
    Abstract Purpose: Measurement of the haemolysis index (HI) is usually performed in clinical chemistry laboratories in order to inform about whether biological analyses are influenced by in vivo or in vitro haemolysis of the specimen. Our aim was to evaluate the analytical performance of Abbott C-16000 analyser HI measurement in order to determine whether this could be used to reliably measure cell-free haemoglobin (fHB) in plasma samples.
    Methods: The repeatability, reproducibility, lower limit of detection (LLOD) and lower limit of quantification (LLOQ) of C-16000 HI measurement were determined as well as the potential interference of bilirubin, triglycerides and myoglobin. C-16000 HI values of biological samples with various ranges of fHB were compared to those measured using the established reference method, second-derivate spectroscopy.
    Results: Results: C-16000 HI determination showed excellent linear correlation with the reference method (y = 1.0043x – 1.248, R² = 0.998), a broad analytical measurement range (400-20,000 mg/L; y = 0.9904x + 72.972, R² = 0.999), clinically relevant LLOD (56 mg/L) and LLOQ (84 mg/L), good repeatability (coefficient of variation (CV) = 1-15%) and good reproducibility (CV = 5-7%). No interference was observed with myoglobin at concentrations as high as 35,447 mg/L, unconjugated and conjugated bilirubin (at concentrations up to 500 mg/L and 375 mg/L, respectively) or triglycerides up to 6.8 mmol/L. However, a significant underestimation of fHB concentrations was observed at higher triglyceride levels.
    Conclusion: This study demonstrates that Abbott C-16000 analyser HI is reliable and accurately measures plasma fHB concentrations under pathophysiological conditions except when there are high blood concentrations of triglycerides.
    MeSH term(s) Humans ; Hemolysis ; Reproducibility of Results ; Myoglobin ; Hemoglobins/analysis ; Bilirubin ; Triglycerides
    Chemical Substances Myoglobin ; Hemoglobins ; Bilirubin (RFM9X3LJ49) ; Triglycerides
    Language English
    Publishing date 2023-02-10
    Publishing country France
    Document type Journal Article
    ZDB-ID 418098-7
    ISSN 1950-6112 ; 0003-3898
    ISSN (online) 1950-6112
    ISSN 0003-3898
    DOI 10.1684/abc.2023.1785
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  4. Article ; Online: Sequence and Structural Motifs Controlling the Broad Substrate Specificity of the Mycobacterial Hormone-Sensitive Lipase LipN.

    Schemenauer, Daniel E / Pool, Emily H / Raynor, Stephanie N / Ruiz, Gabriela P / Goehring, Leah M / Koelper, Andrew J / Wilson, Madeleine A / Durand, Anthony J / Kourtoglou, Elexi C / Larsen, Erik M / Lavis, Luke D / Esteb, John J / Hoops, Geoffrey C / Johnson, R Jeremy

    ACS omega

    2023  Volume 8, Issue 14, Page(s) 13252–13264

    Abstract: Mycobacterium ... ...

    Abstract Mycobacterium tuberculosis
    Language English
    Publishing date 2023-03-30
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c00534
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  5. Article ; Online: Addressing the Mental Health of Nursing Students During the Pandemic: The Evaluation of a Needs Assessment by a College of Nursing Mental Health Task Force.

    Vick, Lori L / Raynor, Phyllis A / Bush, Rachel / Hutto, April / Potts, Maryellen / Inman, Dianna / Schaller, Stephanie / Nelson, Cheryl / Ribar, Alicia / Worthy, Karen / McCormick, Jessica / Baliko, Beverly

    Journal of the American Psychiatric Nurses Association

    2023  Volume 29, Issue 6, Page(s) 447–456

    Abstract: Background: A Mental Health Task Force (MHTF) was developed in a large public college of nursing in the Southeastern United States to address the urgent mental health needs expressed by growing numbers of nursing students related to the coronavirus ... ...

    Abstract Background: A Mental Health Task Force (MHTF) was developed in a large public college of nursing in the Southeastern United States to address the urgent mental health needs expressed by growing numbers of nursing students related to the coronavirus disease 2019 (COVID-19).
    Aims: The purpose of this study was to report on a needs assessment conducted by the MHTF.
    Methods: The needs assessment study design was a 16-item cross-sectional online survey and four "Town Hall" focus groups with nursing students, faculty, and staff (
    Results: Undergraduate and graduate students (
    Conclusions: The administration of the survey provided an opportunity for students to communicate concerns and make requests. To address the ongoing effects of the COVID-19 pandemic on nursing students, multi-modal needs assessments should be conducted periodically to identify priority mental health needs.
    MeSH term(s) Humans ; Female ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Male ; Mental Health ; Needs Assessment ; Pandemics ; Students, Nursing/psychology ; Cross-Sectional Studies ; COVID-19
    Language English
    Publishing date 2023-11-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2252638-9
    ISSN 1532-5725 ; 1078-3903
    ISSN (online) 1532-5725
    ISSN 1078-3903
    DOI 10.1177/10783903231205495
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  6. Article ; Online: Multisystem inflammatory syndrome in children: Inputs of BNP, NT-proBNP and Galectin-3.

    Raynor, Alexandre / Vallée, Clarisse / Belkarfa, Anne-Laure / Lunte, Klara / Laney, Maude / Belhadjer, Zahra / Vicca, Stéphanie / Boutten, Anne / Bonnet, Damien / Nivet-Antoine, Valérie

    Clinica chimica acta; international journal of clinical chemistry

    2022  Volume 529, Page(s) 109–113

    Abstract: Background: Since the COVID-19 pandemic began, a cohort of Multisystem inflammatory syndrome in children (MIS-C) patients has been described. Cardiac involvement is found in 80-85% patients, typically with cardiac dysfunction with or without cardiogenic ...

    Abstract Background: Since the COVID-19 pandemic began, a cohort of Multisystem inflammatory syndrome in children (MIS-C) patients has been described. Cardiac involvement is found in 80-85% patients, typically with cardiac dysfunction with or without cardiogenic shock. Here, three cardiac biomarkers, BNP, NT-proBNP and Galectin-3 were compared for the first time in MIS-C in a unique cohort of hospitalized French children.
    Methods: Fourteen children with MIS-C hospitalized at Necker-Enfants Malades for cardiac management during the first three COVID-19 waves (March 2020-March 2021) were included. All had positive SARS-CoV-2 serology and proven cardiac involvement assessed by transthoracic echocardiography. NT-proBNP, BNP and Galectin-3 were measured at admission, discharge and first follow-up clinic.
    Results: All admission Galectin-3 measurements were comprised within the reference interval, both in patients with and without cardiogenic shock, and did not vary between admission, discharge and first follow-up clinic. Both median admission BNP and NT-proBNP were higher in children with cardiogenic shock than without. Median admission NT-proBNP was higher than its predictive positive value in heart failure in both groups of children, while median BNP was below its negative predictive value in children without cardiogenic shock but with cardiac dysfunction.
    Conclusions: Galectin-3 does not seem affected by MIS-C. NT-proBNP seems to increase more precociously than BNP possibly making it a more sensitive marker for screening of heart failure in MIS-C.
    MeSH term(s) Biomarkers ; COVID-19/complications ; Child ; Galectin 3 ; Heart Failure ; Humans ; Natriuretic Peptide, Brain ; Pandemics ; Peptide Fragments ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome
    Chemical Substances Biomarkers ; Galectin 3 ; Peptide Fragments ; pro-brain natriuretic peptide (1-76) ; Natriuretic Peptide, Brain (114471-18-0)
    Language English
    Publishing date 2022-02-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80228-1
    ISSN 1873-3492 ; 0009-8981
    ISSN (online) 1873-3492
    ISSN 0009-8981
    DOI 10.1016/j.cca.2022.02.011
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  7. Article ; Online: Associations between self-monitoring and weight change in behavioral weight loss interventions.

    Goldstein, Stephanie P / Goldstein, Carly M / Bond, Dale S / Raynor, Hollie A / Wing, Rena R / Thomas, J Graham

    Health psychology : official journal of the Division of Health Psychology, American Psychological Association

    2019  Volume 38, Issue 12, Page(s) 1128–1136

    Abstract: Objective: The current study is a secondary analysis of the Live SMART trial, a randomized controlled trial comparing a behavioral weight loss (BWL) condition delivered via smartphone (SMART) to a group-based BWL condition (GROUP) and a control ... ...

    Abstract Objective: The current study is a secondary analysis of the Live SMART trial, a randomized controlled trial comparing a behavioral weight loss (BWL) condition delivered via smartphone (SMART) to a group-based BWL condition (GROUP) and a control condition (CONTROL). Given the established importance of self-monitoring for weight loss, the aims were to evaluate bidirectional associations between adherence to self-monitoring and weight change and to examine the moderating effect of treatment condition on these associations.
    Method: Adults with overweight/obesity (n = 276; 83% women; 92.8% White; Mage = 55.1 years; Mbody mass index = 35.2 kg/m2) were instructed to self-monitor dietary intake, daily weight, and physical activity minutes via paper diaries in GROUP and CONTROL and via a smartphone application in SMART. All participants were weighed monthly at the research center. Adherence to self-monitoring was assessed via examination of self-monitoring records.
    Results: Generalized linear mixed models revealed that adherence to self-monitoring of dietary intake, self-weighing, and physical activity for each month was associated with weight change throughout that month, such that increased frequency of self-monitoring led to greater weight loss (ps < .001). For the GROUP condition only, poorer weight losses in 1 month were prospectively associated with poor adherence to self-monitoring the following month (ps ≤ .01).
    Conclusions: Results provide evidence of a bidirectional association between self-monitoring and weight change. Better self-monitoring was consistently associated with better weight loss across intervention and tracking modalities. Poorer weight loss was prospectively associated with poorer self-monitoring in group treatment, suggesting that social influences could drive adherence in this form of treatment. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
    MeSH term(s) Behavior Therapy/methods ; Exercise ; Female ; Humans ; Male ; Middle Aged ; Smartphone/instrumentation ; Weight Loss/physiology
    Language English
    Publishing date 2019-09-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 226369-5
    ISSN 1930-7810 ; 0278-6133
    ISSN (online) 1930-7810
    ISSN 0278-6133
    DOI 10.1037/hea0000800
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  8. Article: Prognostic significance of

    Zadeh, Mahdi Zirakchian / Seraj, Siavash Mehdizadeh / Østergaard, Brian / Mimms, Stephanie / Raynor, William Y / Aly, Mahmoud / Borja, Austin J / Arani, Leila S / Gerke, Oke / Werner, Thomas J / Zhuang, Hongming / Revheim, Mona-Elisabeth / Abildgaard, Niels / Høilund-Carlsen, Poul Flemming / Alavi, Abass

    American journal of nuclear medicine and molecular imaging

    2020  Volume 10, Issue 4, Page(s) 151–160

    Abstract: Focal bone lesions and fractures due to weakened bone are associated with higher morbidity and mortality of multiple myeloma (MM) patients. ...

    Abstract Focal bone lesions and fractures due to weakened bone are associated with higher morbidity and mortality of multiple myeloma (MM) patients.
    Language English
    Publishing date 2020-08-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2623515-8
    ISSN 2160-8407
    ISSN 2160-8407
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  9. Article ; Online: Comparison of the Harms, Advantages, and Costs Associated With Alternative Guidelines for the Evaluation of Hematuria.

    Georgieva, Mihaela V / Wheeler, Stephanie B / Erim, Daniel / Smith-Bindman, Rebecca / Loo, Ronald / Ng, Casey / Garg, Tullika / Raynor, Mathew / Nielsen, Matthew E

    JAMA internal medicine

    2019  Volume 179, Issue 10, Page(s) 1352–1362

    Abstract: Importance: Existing recommendations for the diagnostic testing of hematuria range from uniform evaluation of varying intensity to patient-level risk stratification. Concerns have been raised about not only the costs and advantages of computed ... ...

    Abstract Importance: Existing recommendations for the diagnostic testing of hematuria range from uniform evaluation of varying intensity to patient-level risk stratification. Concerns have been raised about not only the costs and advantages of computed tomography (CT) scans but also the potential harms of CT radiation exposure.
    Objective: To compare the advantages, harms, and costs associated with 5 guidelines for hematuria evaluation.
    Design, setting, and participants: A microsimulation model was developed to assess each of the following guidelines (listed in order of increasing intensity) for initial evaluation of hematuria: Dutch, Canadian Urological Association (CUA), Kaiser Permanente (KP), Hematuria Risk Index (HRI), and American Urological Association (AUA). Participants comprised a hypothetical cohort of patients (n = 100 000) with hematuria aged 35 years or older. This study was conducted from August 2017 through November 2018.
    Exposures: Under the Dutch and CUA guidelines, patients received cystoscopy and ultrasonography if they were 50 years or older (Dutch) or 40 years or older (CUA). Under the KP and HRI guidelines, patients received different combinations of cystoscopy, ultrasonography, and CT urography or no evaluation on the basis of risk factors. Under the AUA guidelines, all patients 35 years or older received cystoscopy and CT urography.
    Main outcomes and measures: Urinary tract cancer detection rates, radiation-induced secondary cancers (from CT radiation exposure), procedural complications, false-positive rates per 100 000 patients, and incremental cost per additional urinary tract cancer detected.
    Results: The simulated cohort included 100 000 patients with hematuria, aged 35 years or older. A total of 3514 patients had urinary tract cancers (estimated prevalence, 3.5%; 95% CI, 3.0%-4.0%). The AUA guidelines missed detection for the fewest number of cancers (82 [2.3%]) compared with the detection rate of the HRI (116 [3.3%]) and KP (130 [3.7%]) guidelines. However, the simulation model projected 108 (95% CI, 34-201) radiation-induced cancers under the KP guidelines, 136 (95% CI, 62-229) under the HRI guidelines, and 575 (95% CI, 184-1069) under the AUA guidelines per 100 000 patients. The CUA and Dutch guidelines missed detection for a larger number of cancers (172 [4.9%] and 251 [7.1%]) but had 0 radiation-induced secondary cancers. The AUA guidelines cost approximately double the other 4 guidelines ($939/person vs $443/person for Dutch guidelines), with an incremental cost of $1 034 374 per urinary tract cancer detected compared with that of the HRI guidelines.
    Conclusions and relevance: In this simulation study, uniform CT imaging for patients with hematuria was associated with increased costs and harms of secondary cancers, procedural complications, and false positives, with only a marginal increase in cancer detection. Risk stratification may optimize the balance of advantages, harms, and costs of CT.
    Language English
    Publishing date 2019-08-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2019.2280
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  10. Article ; Online: Eating disorders in weight-related therapy (EDIT): Protocol for a systematic review with individual participant data meta-analysis of eating disorder risk in behavioural weight management.

    Jebeile, Hiba / Lister, Natalie B / Libesman, Sol / Hunter, Kylie E / McMaster, Caitlin M / Johnson, Brittany J / Baur, Louise A / Paxton, Susan J / Garnett, Sarah P / Ahern, Amy L / Wilfley, Denise E / Maguire, Sarah / Sainsbury, Amanda / Steinbeck, Katharine / Askie, Lisa / Braet, Caroline / Hill, Andrew J / Nicholls, Dasha / Jones, Rebecca A /
    Dammery, Genevieve / Grunseit, Alicia M / Cooper, Kelly / Kyle, Theodore K / Heeren, Faith A / Quigley, Fiona / Barnes, Rachel D / Bean, Melanie K / Beaulieu, Kristine / Bonham, Maxine / Boutelle, Kerri N / Branco, Braulio Henrique Magnani / Calugi, Simona / Cardel, Michelle I / Carpenter, Kelly / Cheng, Hoi Lun / Dalle Grave, Riccardo / Danielsen, Yngvild S / Demarzo, Marcelo / Dordevic, Aimee / Eichen, Dawn M / Goldschmidt, Andrea B / Hilbert, Anja / Houben, Katrijn / Lofrano do Prado, Mara / Martin, Corby K / McTiernan, Anne / Mensinger, Janell L / Pacanowski, Carly / do Prado, Wagner Luiz / Ramalho, Sofia M / Raynor, Hollie A / Rieger, Elizabeth / Robinson, Eric / Salvo, Vera / Sherwood, Nancy E / Simpson, Sharon A / Skjakodegard, Hanna F / Smith, Evelyn / Partridge, Stephanie / Tanofsky-Kraff, Marian / Taylor, Rachael W / Van Eyck, Annelies / Varady, Krista A / Vidmar, Alaina P / Whitelock, Victoria / Yanovski, Jack / Seidler, Anna L

    PloS one

    2023  Volume 18, Issue 7, Page(s) e0282401

    Abstract: The Eating Disorders In weight-related Therapy (EDIT) Collaboration brings together data from randomised controlled trials of behavioural weight management interventions to identify individual participant risk factors and intervention strategies that ... ...

    Abstract The Eating Disorders In weight-related Therapy (EDIT) Collaboration brings together data from randomised controlled trials of behavioural weight management interventions to identify individual participant risk factors and intervention strategies that contribute to eating disorder risk. We present a protocol for a systematic review and individual participant data (IPD) meta-analysis which aims to identify participants at risk of developing eating disorders, or related symptoms, during or after weight management interventions conducted in adolescents or adults with overweight or obesity. We systematically searched four databases up to March 2022 and clinical trials registries to May 2022 to identify randomised controlled trials of weight management interventions conducted in adolescents or adults with overweight or obesity that measured eating disorder risk at pre- and post-intervention or follow-up. Authors from eligible trials have been invited to share their deidentified IPD. Two IPD meta-analyses will be conducted. The first IPD meta-analysis aims to examine participant level factors associated with a change in eating disorder scores during and following a weight management intervention. To do this we will examine baseline variables that predict change in eating disorder risk within intervention arms. The second IPD meta-analysis aims to assess whether there are participant level factors that predict whether participation in an intervention is more or less likely than no intervention to lead to a change in eating disorder risk. To do this, we will examine if there are differences in predictors of eating disorder risk between intervention and no-treatment control arms. The primary outcome will be a standardised mean difference in global eating disorder score from baseline to immediately post-intervention and at 6- and 12- months follow-up. Identifying participant level risk factors predicting eating disorder risk will inform screening and monitoring protocols to allow early identification and intervention for those at risk.
    MeSH term(s) Adult ; Adolescent ; Humans ; Overweight/complications ; Overweight/therapy ; Obesity ; Feeding and Eating Disorders/therapy ; Behavior Therapy ; Systematic Reviews as Topic ; Meta-Analysis as Topic
    Language English
    Publishing date 2023-07-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0282401
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