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Article: George E. Brown, Jr.... California congressman shares views on Animal Welfare Act amendments, laboratory vandalism, APHIS funding. Interview by William M. Samuels.

Brown, G E

1986 Volume 29, Issue 3, Page(s) 35–37

MeSH term(s)	Animal Welfare ; Animals ; California ; Cats ; Dogs ; Politics ; United States
Language	English
Publishing date	1986-06
Publishing country	United States
Document type	Interview
ZDB-ID	208883-6
ISSN	1522-1202 ; 0031-9376
ISSN (online)	1522-1202
ISSN	0031-9376
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Zs.B 380: Show issues

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Article: Version or High Forceps, Which and When?

Brown, William M

Buffalo medical journal

2023 Volume 62, Issue 9, Page(s) 529–533

Language	English
Publishing date	2023-03-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	426473-3
ISSN	1040-3817
ISSN	1040-3817
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Article: Total Joint Arthroplasty in Patients With Lymphedema as Compared to a Propensity-Matched Control Cohort.

Cusma, William H / Brown, Nicholas M / Hopkinson, William J

Arthroplasty today

2023 Volume 25, Page(s) 101307

Abstract: Background: Lymphedema is rare in arthroplasty patients but has been associated with a higher complication rate. This study sought to determine the outcomes of total joint arthroplasty in patients with lymphedema as compared to a matched control cohort.! ...

Abstract	Background: Lymphedema is rare in arthroplasty patients but has been associated with a higher complication rate. This study sought to determine the outcomes of total joint arthroplasty in patients with lymphedema as compared to a matched control cohort. Methods: Treatment-control propensity matching was implemented on 335 patients following total knee or hip arthroplasty generating 5-patient sets of one patient with presurgery lymphedema (67 total) to 4 patients without presurgery lymphedema (268 total) and matched on age, sex, and surgery year. Body mass index and presence of diabetes were controlled using multivariable generalized estimating equations. Results: In the lymphedema cohort, 1 patient (1.5%) had a deep vein thrombosis within 90 days of their surgery, 36 (53.7%) were discharged to a rehabilitation center, 16 (23.9%) had a readmission, 14 (20.9%) were admitted to the emergency room within 90 days, 6 (9.0%) experienced infection, and 6 (9.0%) had a revision/reoperation. Lymphedema significantly increased emergency room admission within 90 days (odds ratio [OR] 4.56, Conclusions: Preoperative lymphedema is a significant risk factor for patients who are undergoing total joint arthroplasty. Preoperative and postoperative modalities should be utilized to help control lymphedema and mitigate these increased risks.
Language	English
Publishing date	2023-12-30
Publishing country	United States
Document type	Journal Article
ISSN	2352-3441
ISSN	2352-3441
DOI	10.1016/j.artd.2023.101307
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Article ; Online: Incidence and Risk Factors for Acid-fast Bacillus/Fungal Culture Positivity in Primary, Conversion, and Revision Hip and Knee Arthroplasty.

Oetojo, William / Feffer, Marina / Wesolowski, Michael / Hopkinson, William J / Brown, Nicholas M

The Journal of the American Academy of Orthopaedic Surgeons

2024

Abstract: Introduction: Previous literature has reported minimal incidences of positive fungal/AFB cultures, questioning the routine use of these tests. With growing concern for excessive use, predictive factors for patients at higher risk for intraoperative AFB/ ... ...

Abstract	Introduction: Previous literature has reported minimal incidences of positive fungal/AFB cultures, questioning the routine use of these tests. With growing concern for excessive use, predictive factors for patients at higher risk for intraoperative AFB/fungal infections would help surgeons limit unnecessary testing. This study evaluates the positivity rate and predictive factors of positive fungal and/or acid-fast bacillus (AFB) cultures after primary, conversion, or revision hip and knee arthroplasty. Method: Two hundred thirty-eight knee and hip procedures were done between January 2007 and 2022 where intraoperative AFB/fungal cultures were obtained. Procedures included primary total knee arthroplasty, primary total hip arthroplasty, conversion, first of two-stage, second of two-stage, irrigation and débridement polyexchange, and aseptic revision. Positivity rates of intraoperative AFB/fungal cultures were calculated as binomial exact proportions with 95% confidence intervals and are displayed as percentages. Univariable generalized linear mixed models estimated the unadjusted effects of demographics, individual comorbid conditions, and procedural characteristics on the logit of positive AFB/fungal cultures. Results: Two hundred thirty-eight knee and hip procedures recorded an overall positivity rate of 5.8% for intraoperative AFB/fungal cultures. Aseptic revisions showed the lowest rates of positivity at 3.6%, while conversions showed the highest rates of positivity at 14.3%. The positivity rates are highest among patients who are male (9.0%), of Hispanic origin (12.0%), with body mass index <30 (6.4%), and a Charlson Comorbidity Index <5 (6.1%). History of a prior infection in the same surgical joint showed statistically significant influence of odds of culture positivity with an odds ratio of 3.47 (P-value: 0.039). Other demographic factors that we investigated including age, sex, race, ethnicity, body mass index, and Charlson Comorbidity Index did not show any notable influence on AFB/fungal positivity rates. Conclusion: These results suggest utility in obtaining routine intraoperative AFB/fungal cultures, given the relatively high positivity and poor predictive factors.
Language	English
Publishing date	2024-04-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1200524-1
ISSN	1940-5480 ; 1067-151X
ISSN (online)	1940-5480
ISSN	1067-151X
DOI	10.5435/JAAOS-D-23-00980
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Zs.A 4048: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 274: Show issues

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Article: A synthetic biology approach for the treatment of pollutants with microalgae.

Webster, Luke J / Villa-Gomez, Denys / Brown, Reuben / Clarke, William / Schenk, Peer M

Frontiers in bioengineering and biotechnology

2024 Volume 12, Page(s) 1379301

Abstract: The increase in global population and industrial development has led to a significant release of organic and inorganic pollutants into water streams, threatening human health and ecosystems. Microalgae, encompassing eukaryotic protists and prokaryotic ... ...

Abstract	The increase in global population and industrial development has led to a significant release of organic and inorganic pollutants into water streams, threatening human health and ecosystems. Microalgae, encompassing eukaryotic protists and prokaryotic cyanobacteria, have emerged as a sustainable and cost-effective solution for removing these pollutants and mitigating carbon emissions. Various microalgae species, such as
Language	English
Publishing date	2024-04-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2024.1379301
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Article ; Online: Assessing Evidence-Based Practice Knowledge, Self-Efficacy, and Use Among Respiratory Therapists.

Clark, Kimberly M / Brown, Pamela / Gill, Diane / Karper, William

Respiratory care

2024

Abstract: Background: Evidence-based practice is at the forefront of providing quality patient care by using the best available evidence and clinical expertise, while also considering patient needs and preferences for clinical decisions. However, evidence-based ... ...

Abstract	Background: Evidence-based practice is at the forefront of providing quality patient care by using the best available evidence and clinical expertise, while also considering patient needs and preferences for clinical decisions. However, evidence-based practice may not be consistently used even when the evidence supports the therapy. The purpose of this study was to assess the factors associated with the use of evidence-based practice among respiratory therapy faculty teaching in a large community college system and post-professional students enrolled in a university-based, respiratory therapy baccalaureate degree-advancement program. Methods: A non-probability, descriptive survey research design was used to develop and administer an online questionnaire. Results: All respondents demonstrated sufficient knowledge and understanding of introductory concepts of evidence-based practice but knowledge of specific components of the evidence-based practice process was not as strong. Self-efficacy in knowledge and the use of evidence-based practice among faculty and degree-advancement students varied. Faculty and students rated their self-efficacy high in assessing patients' needs, values, and treatment preferences but ratings were lower for using the PICO (patient/population/problem, intervention, comparison, outcome) technique and interpreting common statistical tests. Students viewed their previous evidence-based practice learning experiences more favorably compared with faculty ( Conclusions: Analysis of the results suggested that respiratory therapy faculty and students were knowledgeable and confident with regard to evidence-based practice but their use of evidence-based practice in clinical decisions was limited. Although the evidence-based practice knowledge, self-efficacy, and learning experiences had minimal influence on the use of evidence-based practice, the results of the study provide a foundation for future research.
Language	English
Publishing date	2024-04-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	603252-7
ISSN	1943-3654 ; 0098-9142 ; 0020-1324
ISSN (online)	1943-3654
ISSN	0098-9142 ; 0020-1324
DOI	10.4187/respcare.10327
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Zs.B 2285: Show issues

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Article ; Online: Primary aldosteronism: molecular medicine meets public health.

Azizan, Elena A B / Drake, William M / Brown, Morris J

Nature reviews. Nephrology

2023 Volume 19, Issue 12, Page(s) 788–806

Abstract: Primary aldosteronism is the most common single cause of hypertension and is potentially curable when only one adrenal gland is the culprit. The importance of primary aldosteronism to public health derives from its high prevalence but huge under- ... ...

Abstract	Primary aldosteronism is the most common single cause of hypertension and is potentially curable when only one adrenal gland is the culprit. The importance of primary aldosteronism to public health derives from its high prevalence but huge under-diagnosis (estimated to be <1% of all affected individuals), despite the consequences of poor blood pressure control by conventional therapy and enhanced cardiovascular risk. This state of affairs is attributable to the fact that the tools used for diagnosis or treatment are still those that originated in the 1970-1990s. Conversely, molecular discoveries have transformed our understanding of adrenal physiology and pathology. Many molecules and processes associated with constant adrenocortical renewal and interzonal metamorphosis also feature in aldosterone-producing adenomas and aldosterone-producing micronodules. The adrenal gland has one of the most significant rates of non-silent somatic mutations, with frequent selection of those driving autonomous aldosterone production, and distinct clinical presentations and outcomes for most genotypes. The disappearance of aldosterone synthesis and cells from most of the adult human zona glomerulosa is the likely driver of the mutational success that causes aldosterone-producing adenomas, but insights into the pathways that lead to constitutive aldosterone production and cell survival may open up opportunities for novel therapies.
MeSH term(s)	Adult ; Humans ; Aldosterone/metabolism ; Hyperaldosteronism/diagnosis ; Hyperaldosteronism/genetics ; Hyperaldosteronism/therapy ; Public Health ; Molecular Medicine ; Adenoma/complications ; Adenoma/metabolism
Chemical Substances	Aldosterone (4964P6T9RB)
Language	English
Publishing date	2023-08-23
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2490366-8
ISSN	1759-507X ; 1759-5061
ISSN (online)	1759-507X
ISSN	1759-5061
DOI	10.1038/s41581-023-00753-6
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Zs.A 6334: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 107: Show issues

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Article ; Online: Relationship Between Resuscitation Team Members' Self-Efficacy and Team Competence During In-Hospital Cardiac Arrest.

Hooper, Gabriel A / Butler, Allison M / Guidry, David / Kumar, Naresh / Brown, Katie / Beninati, William / Brown, Samuel M / Peltan, Ithan D

Critical care explorations

2024 Volume 6, Issue 1, Page(s) e1029

Abstract: Objectives: Inadequate self-efficacy of resuscitation team members may impair team performance, but high self-efficacy does not guarantee competence. We evaluated the relationship between individual self-efficacy and resuscitation team competence.: ... ...

Abstract	Objectives: Inadequate self-efficacy of resuscitation team members may impair team performance, but high self-efficacy does not guarantee competence. We evaluated the relationship between individual self-efficacy and resuscitation team competence. Design: Secondary analysis of a randomized controlled trial. Setting: High-fidelity in situ in-hospital cardiac arrest simulations at seven hospitals in Utah. Subjects: Multidisciplinary cardiac arrest resuscitation team members. Interventions: None. Measurements and main results: Resuscitation team members completed surveys evaluating resuscitation self-efficacy (confidence in resuscitation role, difficulty thinking clearly, and concerns about committing errors) after each simulation. The primary outcome was event-level chest compression hands-on fraction greater than 75%. Secondary outcomes included other measures of resuscitation quality, advanced cardiac life support protocol adherence, and nontechnical team performance. Analyses employed the Datta-Satten rank-sum method to account for response clustering within simulation events. Of 923 participants in 76 analyzable simulations, 612 (66%) submitted complete surveys and 33 (43%) resuscitation teams achieved hands-on fraction greater than 75%. Event-level chest compression hands-on fraction greater than 75% versus less than or equal to 75% was not associated with the percentage of resuscitation team members reporting confidence in their team role ( Conclusions: Team members' self-efficacy was not associated with most team-level competence metrics during simulated cardiac arrest resuscitation. These data suggest that self-efficacy should have a limited role for evaluation of resuscitation training programs and for initial certification and monitoring of individual resuscitation team members' competence.
Language	English
Publishing date	2024-01-19
Publishing country	United States
Document type	Journal Article
ISSN	2639-8028
ISSN (online)	2639-8028
DOI	10.1097/CCE.0000000000001029
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Low Incidence of New Intracranial Aneurysms in Adults With Coarctation of Aorta on Serial Brain Imaging.

Egbe, Alexander C / Miranda, William R / Jain, C Charles / Burchill, Luke J / Jokhadar, Maan / Brown, Robert D / Connolly, Heidi M

The American journal of cardiology

2024 Volume 216, Page(s) 46–47

MeSH term(s)	Adult ; Humans ; Aortic Coarctation/complications ; Aortic Coarctation/diagnostic imaging ; Aortic Coarctation/epidemiology ; Intracranial Aneurysm/complications ; Intracranial Aneurysm/diagnostic imaging ; Intracranial Aneurysm/epidemiology ; Incidence ; Aorta ; Neuroimaging/adverse effects
Language	English
Publishing date	2024-02-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2024.01.031
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Article ; Online: Decreasing Post-Operative Narcotic Usage Following Total Knee Arthroplasty Requires More than Simple Education: A Blinded Randomized Controlled Trial.

Cusma, William H / Davis, Benjamin J / Mak, Ryan A / Brown, Nicholas M

The Orthopedic clinics of North America

2023 Volume 54, Issue 4, Page(s) 377–382

Abstract: The purpose of this study was to understand if including a patient opioid education document would decrease opioid consumption following TKA. Patients were balanced between the control and intervention group based on age, sex, and date of surgery. At 5 ... ...

Abstract	The purpose of this study was to understand if including a patient opioid education document would decrease opioid consumption following TKA. Patients were balanced between the control and intervention group based on age, sex, and date of surgery. At 5 weeks following surgery, there were significantly fewer patients driving in the education cohort as compared to the control cohort. There was not a significant difference in mean 2-week post-operative VAS pain score, mean 5 weeks post-operative VAS pain score, mean number of dispensed pills. Reducing post-operative narcotic usage likely requires a more comprehensive strategy.
MeSH term(s)	Humans ; Analgesics, Opioid/therapeutic use ; Arthroplasty, Replacement, Knee/adverse effects ; Narcotics ; Pain, Postoperative/drug therapy ; Pain, Postoperative/prevention & control ; Postoperative Period ; Male ; Female
Chemical Substances	Analgesics, Opioid ; Narcotics
Language	English
Publishing date	2023-07-21
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	417389-2
ISSN	1558-1373 ; 0030-5898
ISSN (online)	1558-1373
ISSN	0030-5898
DOI	10.1016/j.ocl.2023.06.001
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