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  1. Article: COVID-19 Convalescent Plasma: from donation to treatment - A Systematic Review & Single Center Experience.

    Fabricius, Michela M / Dandachi, Dima

    Missouri medicine

    2021  Volume 118, Issue 1, Page(s) 74–80

    Abstract: Convalescent plasma is an old treatment for a new disease. The coronavirus disease 2019 (COVID-19) pandemic caused the analysis of convalescent plasma to reemerge as a possible treatment. First, a systematic review summarizes the available research ... ...

    Abstract Convalescent plasma is an old treatment for a new disease. The coronavirus disease 2019 (COVID-19) pandemic caused the analysis of convalescent plasma to reemerge as a possible treatment. First, a systematic review summarizes the available research examining the use of convalescent plasma for the treatment of patients with COVID-19. Second, we describe our experience in establishing a single-center convalescent plasma donation program.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Blood Donors/statistics & numerical data ; Blood Donors/supply & distribution ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/therapy ; COVID-19/virology ; Donor Selection/methods ; Female ; Humans ; Immunization, Passive/methods ; Male ; Middle Aged ; SARS-CoV-2/genetics ; SARS-CoV-2/isolation & purification ; Treatment Outcome
    Language English
    Publishing date 2021-02-08
    Publishing country United States
    Document type Journal Article ; Systematic Review
    ZDB-ID 427362-x
    ISSN 0026-6620
    ISSN 0026-6620
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Effects of HIV on the Tumor Microenvironment.

    Dandachi, Dima / Morón, Fanny

    Advances in experimental medicine and biology

    2020  Volume 1263, Page(s) 45–54

    Abstract: Oncomodulatory viruses can affect the tumor microenvironment (TME) by triggering inflammation, suppressing apoptosis, initiating angiogenesis, altering tumor metabolism, and stimulating tumor cell signaling pathways, leading to tumor growth, ... ...

    Abstract Oncomodulatory viruses can affect the tumor microenvironment (TME) by triggering inflammation, suppressing apoptosis, initiating angiogenesis, altering tumor metabolism, and stimulating tumor cell signaling pathways, leading to tumor growth, proliferation, and invasion. The higher incidence of malignancies among people with HIV (PWH), despite the widespread use of antiretroviral therapy (ART), suggests a more complex relation than HIV-associated immune deregulation. Viral cooperation can have synergistic effect on tumorigenesis. The most relevant oncogenes involved in viral cooperation include the HIV-1-related Tat and Vpu genes, EBV LMP-1 and EBNA-2 genes, and Kaposi's sarcoma herpesvirus (KSHV) KIE2, Rta, and LANA genes. The TME in HIV-related malignancies is highly angiogenic and characterized by high microvessel density compared to sporadic cases. Tat protein, found in patients with HIV infection regardless of their immune status, has been widely implicated in the increased angiogenesis and has been a target of interest for therapeutic strategies. Similarly, HIV-1 matrix protein p17 can be detected in the plasma and tissues of PWH, including those treated with ART. Studies have found that p17 can cause dysregulation of the biological activity of different immune cells, is involved in aberrant angiogenesis, and exhibits an IL8 chemokine activity, activating multiple intracellular signaling pathways, promoting angiogenic responses in endothelial cells, and forming capillary like structures. In addition, several studies have demonstrated difference in the cellular immune components within the TME in patients with or without HIV infection, as well as cases in pre- and post-ART era. In this chapter, we review the existing literature about the role tumor microenvironment plays in the pathogenesis of HIV-related malignancies. Understanding the functions of each component of the TME and determining how these cellular and noncellular components contribute to tumorigenesis will impact the advancement of interventions and treatment in clinical oncology among PWH.
    MeSH term(s) HIV/pathogenicity ; HIV Infections/virology ; Humans ; Oncogenes ; Sarcoma, Kaposi/virology ; Tumor Microenvironment
    Language English
    Publishing date 2020-06-25
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-44518-8_4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Infliximab Concentrations in Participants with Moderate to Severe COVID-19.

    Balevic, Stephen J / Dandachi, Dima / Dixon, Danielle / Hoetelmans, Richard M W / Bozzette, Sam / McCarthy, Matthew W

    Journal of clinical pharmacology

    2023  Volume 64, Issue 4, Page(s) 490–491

    MeSH term(s) Humans ; Infliximab ; COVID-19 ; Antibodies, Monoclonal ; Antirheumatic Agents ; Treatment Outcome
    Chemical Substances Infliximab (B72HH48FLU) ; Antibodies, Monoclonal ; Antirheumatic Agents
    Language English
    Publishing date 2023-12-14
    Publishing country England
    Document type Letter ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 188980-1
    ISSN 1552-4604 ; 0091-2700 ; 0021-9754
    ISSN (online) 1552-4604
    ISSN 0091-2700 ; 0021-9754
    DOI 10.1002/jcph.2388
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  4. Article: Acute Streptococcus constellatus Pyogenic Liver Abscess Due to an Atypical Presentation of Sigmoid Diverticulitis Complicated by Pericolonic Abscess.

    Navarrete, Daniela / Patil, Sachin / Dandachi, Dima

    Cureus

    2020  Volume 12, Issue 10, Page(s) e10940

    Abstract: Diverticulitis is a result of diverticulum inflammation that involves protrusion of the colonic wall. It is considered to be complicated when associated with an abscess, fistula, perforation of large bowel, or obstruction. The incidence of diverticulitis ...

    Abstract Diverticulitis is a result of diverticulum inflammation that involves protrusion of the colonic wall. It is considered to be complicated when associated with an abscess, fistula, perforation of large bowel, or obstruction. The incidence of diverticulitis increases with age, and it most commonly presents as constant abdominal pain in the left lower quadrant. We report a case of a 54-year-old male with a history of hypertension who was admitted to our hospital with systemic symptoms and right shoulder pain noted to have
    Language English
    Publishing date 2020-10-14
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.10940
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  5. Article ; Online: Antiretrovirals for People with HIV on Dialysis.

    Dandachi, Dima / Fabricius, Michela / Saad, Baraa / Sawkin, Mark T / Malhotra, Kunal

    AIDS patient care and STDs

    2022  Volume 36, Issue 3, Page(s) 86–96

    Abstract: In the era of widespread use of antiretroviral therapy (ART), people with HIV (PWH) have a near-normal life expectancy. However, PWH have high rates of kidney diseases and progression to end-stage renal disease at a younger age. PWH have multiple risks ... ...

    Abstract In the era of widespread use of antiretroviral therapy (ART), people with HIV (PWH) have a near-normal life expectancy. However, PWH have high rates of kidney diseases and progression to end-stage renal disease at a younger age. PWH have multiple risks for developing acute and chronic kidney diseases, including traditional risk factors such as diabetes, hypertension, and HIV-related factors such as HIV-associated nephropathy and increased susceptibility to infections and exposure to nephrotoxic medications. Despite an improvement in access to kidney transplant among PWH, the number of PWH on dialysis continues to increase. The expansion of the number of antiretrovirals (ARVs) and kidney replacement modalities, the absence of pharmacokinetic data, and therapeutic drug monitoring make it very challenging for providers to dose ARVs appropriately leading to medication errors, adverse events, and higher mortality. Most of the recommendations are either based on small sample size studies or extrapolated based on physiochemical characteristics of ART. We aim to review the most available and most current literature on ART in PWH with renal insufficiency and ART dosing recommendations on dialysis to ensure that PWH are provided with the safest and most effective ART regimen.
    MeSH term(s) Anti-Retroviral Agents/therapeutic use ; Female ; HIV Infections/complications ; HIV Infections/drug therapy ; Humans ; Kidney Transplantation ; Male ; Renal Dialysis ; Renal Insufficiency
    Chemical Substances Anti-Retroviral Agents
    Language English
    Publishing date 2022-03-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1326868-5
    ISSN 1557-7449 ; 0893-5068 ; 1087-2914
    ISSN (online) 1557-7449
    ISSN 0893-5068 ; 1087-2914
    DOI 10.1089/apc.2021.0173
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    Zs.A 2328: Show issues Location:
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  6. Article ; Online: Cancer immunotherapy in adult patients with HIV.

    Abu Khalaf, Suha / Dandachi, Dima / Granwehr, Bruno P / Rodriguez-Barradas, Maria C

    Journal of investigative medicine : the official publication of the American Federation for Clinical Research

    2022  Volume 70, Issue 4, Page(s) 883–891

    Abstract: The availability of antiretroviral therapy (ART) has increased the life expectancy of people with HIV (PWH) and reduced the incidence of AIDS-associated malignancies, yet PWH have a significantly increased incidence of malignancy and less favorable ... ...

    Abstract The availability of antiretroviral therapy (ART) has increased the life expectancy of people with HIV (PWH) and reduced the incidence of AIDS-associated malignancies, yet PWH have a significantly increased incidence of malignancy and less favorable outcomes of cancer treatment compared with the general population.Immunotherapy has revolutionized cancer therapy, becoming the standard of care for various malignancy treatments. However, PWH are an underserved population with limited access to clinical trials and cancer treatment.This review of the available evidence on different classes of cancer immunotherapy in PWH is mostly based on case reports, case series, but few prospective studies and clinical trials due to the exclusion of PWH from most oncologic clinical trials. The results of the available evidence support the safety of immunotherapy in PWH. Immunotherapy has similar effectiveness in PWH, an acceptable toxicity profile, and has no clinically significant impact on HIV viral load and CD4-T cell count. In addition, there is no reported change in the incidence of opportunistic infections and other complications for PWH with well-controlled viremia.This review aims to briefly summarize the current state of immunotherapy in cancer, guide clinicians in the management of immunotherapy in cancer PWH, and encourage the inclusion of PWH in clinical trials of cancer immunotherapy.
    MeSH term(s) Adult ; CD4 Lymphocyte Count ; HIV Infections/drug therapy ; HIV Infections/therapy ; Humans ; Immunotherapy ; Incidence ; Neoplasms/complications ; Neoplasms/therapy ; Prospective Studies
    Language English
    Publishing date 2022-01-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1217870-6
    ISSN 1708-8267 ; 0009-9279 ; 1081-5589
    ISSN (online) 1708-8267
    ISSN 0009-9279 ; 1081-5589
    DOI 10.1136/jim-2021-002205
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    Zs.A 307: Show issues Location:
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  7. Article ; Online: Recent advances in wearable sensors and data analytics for continuous monitoring and analysis of biomarkers and symptoms related to COVID-19.

    Li, Huijie / Yuan, Jianhe / Fennell, Gavin / Abdulla, Vagif / Nistala, Ravi / Dandachi, Dima / Ho, Dominic K C / Zhang, Yi

    Biophysics reviews

    2023  Volume 4, Issue 3, Page(s) 31302

    Abstract: The COVID-19 pandemic has changed the lives of many people around the world. Based on the available data and published reports, most people diagnosed with COVID-19 exhibit no or mild symptoms and could be discharged home for self-isolation. Considering ... ...

    Abstract The COVID-19 pandemic has changed the lives of many people around the world. Based on the available data and published reports, most people diagnosed with COVID-19 exhibit no or mild symptoms and could be discharged home for self-isolation. Considering that a substantial portion of them will progress to a severe disease requiring hospitalization and medical management, including respiratory and circulatory support in the form of supplemental oxygen therapy, mechanical ventilation, vasopressors, etc. The continuous monitoring of patient conditions at home for patients with COVID-19 will allow early determination of disease severity and medical intervention to reduce morbidity and mortality. In addition, this will allow early and safe hospital discharge and free hospital beds for patients who are in need of admission. In this review, we focus on the recent developments in next-generation wearable sensors capable of continuous monitoring of disease symptoms, particularly those associated with COVID-19. These include wearable non/minimally invasive biophysical (temperature, respiratory rate, oxygen saturation, heart rate, and heart rate variability) and biochemical (cytokines, cortisol, and electrolytes) sensors, sensor data analytics, and machine learning-enabled early detection and medical intervention techniques. Together, we aim to inspire the future development of wearable sensors integrated with data analytics, which serve as a foundation for disease diagnostics, health monitoring and predictions, and medical interventions.
    Language English
    Publishing date 2023-07-19
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2688-4089
    ISSN (online) 2688-4089
    DOI 10.1063/5.0140900
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  8. Article: Staphylococcus lugdunensis

    Khalaf, Suha Abu / Mansour, Abdallah / Perveze, Isma / Fender, Belinda / Walker, Daniel R / Dandachi, Dima

    Missouri medicine

    2021  Volume 118, Issue 6, Page(s) 552–555

    Abstract: Staphylococcus ... ...

    Abstract Staphylococcus lugdunensis
    MeSH term(s) Aged ; Bacteremia ; Female ; Humans ; Pericarditis/diagnosis ; Staphylococcal Infections/complications ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/drug therapy ; Staphylococcus aureus ; Staphylococcus lugdunensis
    Language English
    Publishing date 2021-12-15
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 427362-x
    ISSN 0026-6620
    ISSN 0026-6620
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  9. Article ; Online: It is Time to Include Telehealth in Our Measure of Patient Retention in HIV Care.

    Dandachi, Dima / Freytag, Jennifer / Giordano, Thomas P / Dang, Bich N

    AIDS and behavior

    2019  Volume 24, Issue 9, Page(s) 2463–2465

    Keywords covid19
    Language English
    Publishing date 2019-02-08
    Publishing country United States
    Document type Editorial
    ZDB-ID 1339885-4
    ISSN 1573-3254 ; 1090-7165
    ISSN (online) 1573-3254
    ISSN 1090-7165
    DOI 10.1007/s10461-020-02880-8
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  10. Article: Are We Prescribing Enough HIV Pre-Exposure Prophylaxis in Missouri?: A Cross-Sectional Study at University of Missouri Health Care.

    Abu-Khalaf, Suha / Dent, James / Teti, Michelle / Dandachi, Dima

    Missouri medicine

    2020  Volume 117, Issue 6, Page(s) 563–568

    Abstract: Despite the proven efficacy and safety of HIV pre-exposure prophylaxis (PrEP), it remains underutilized. PrEP use among Missouri providers has increased as the rate of new HIV infections grows statewide, but remains lower than the Midwest and United ... ...

    Abstract Despite the proven efficacy and safety of HIV pre-exposure prophylaxis (PrEP), it remains underutilized. PrEP use among Missouri providers has increased as the rate of new HIV infections grows statewide, but remains lower than the Midwest and United States (U.S.) averages. Because the Centers for Disease Control and Prevention (CDC) identify Missouri as at-risk for an HIV outbreak, we seek to characterize HIV testing practices and PrEP knowledge and use among Missouri healthcare providers.
    MeSH term(s) Cross-Sectional Studies ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; Health Knowledge, Attitudes, Practice ; Humans ; Missouri/epidemiology ; Practice Patterns, Physicians' ; Pre-Exposure Prophylaxis ; United States
    Language English
    Publishing date 2020-12-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 427362-x
    ISSN 0026-6620
    ISSN 0026-6620
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