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Book ; Online: From ORAN to Cell-Free RAN

Cao, Yang / Zhang, Ziyang / Xia, Xinjiang / Xin, Pengzhe / Liu, Dongjie / Zheng, Kang / Lou, Mengting / Jin, Jing / Wang, Qixing / Wang, Dongming / Huang, Yongming / You, Xiaohu / Wang, Jiangzhou

Architecture, Performance Analysis, Testbeds and Trials

2023

Abstract: ... RAN) of the fifth generation (5G) and beyond mobile communications. As a key technology ... Starting from scalable implementation of CF-mMIMO, we study a cell-free RAN (CF-RAN) under the ORAN ... of CF-RAN under ORAN architecture, including time-frequency synchronization and over-the-air reciprocity ...

Abstract	Open radio access network (ORAN) provides an open architecture to implement radio access network (RAN) of the fifth generation (5G) and beyond mobile communications. As a key technology for the evolution to the sixth generation (6G) systems, cell-free massive multiple-input multiple-output (CF-mMIMO) can effectively improve the spectrum efficiency, peak rate and reliability of wireless communication systems. Starting from scalable implementation of CF-mMIMO, we study a cell-free RAN (CF-RAN) under the ORAN architecture. Through theoretical analysis and numerical simulation, we investigate the uplink and downlink spectral efficiencies of CF-mMIMO with the new architecture. We then discuss the implementation issues of CF-RAN under ORAN architecture, including time-frequency synchronization and over-the-air reciprocity calibration, low layer splitting, deployment of ORAN radio units (O-RU), artificial intelligent based user associations. Finally, we present some representative experimental results for the uplink distributed reception and downlink coherent joint transmission of CF-RAN with commercial off-the-shelf O-RUs.
Keywords	Computer Science - Information Theory ; Electrical Engineering and Systems Science - Signal Processing
Publishing date	2023-01-30
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: RAN/RANBP2

Wang, Juxiang / Zhuo, Zhenjian / Chen, Min / Zhu, Jinhong / Zhao, Jie / Zhang, Jiao / Chen, Shanshan / He, Jing / Zhou, Haixia

Aging

2018 Volume 10, Issue 4, Page(s) 808–818

Abstract: The genetic etiology of sporadic neuroblastoma remains largely obscure. ...

Abstract	The genetic etiology of sporadic neuroblastoma remains largely obscure.
MeSH term(s)	Asian Continental Ancestry Group ; Case-Control Studies ; Child ; Female ; Genetic Predisposition to Disease/genetics ; Genotype ; Humans ; Male ; Molecular Chaperones/genetics ; Neuroblastoma/genetics ; Nuclear Pore Complex Proteins/genetics ; Odds Ratio ; Polymorphism, Single Nucleotide ; ran GTP-Binding Protein/genetics
Chemical Substances	Molecular Chaperones ; Nuclear Pore Complex Proteins ; RAN protein, human ; ran-binding protein 2 ; ran GTP-Binding Protein (EC 3.6.5.2)
Language	English
Publishing date	2018-04-20
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.101429
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Measuring Repeat-Associated Non-AUG (RAN) Translation.

Wang, Shaopeng / Sun, Shuying

Methods in molecular biology (Clifton, N.J.)

2022 Volume 2428, Page(s) 113–132

Abstract: ... associated non-AUG (RAN) translation in all the reading frames. Understanding how RAN translation occurs and ... disease pathogenesis. Using reporter systems to quantitatively measure RAN translation provides a platform ... we describe the dual-luciferase reporter system to measure RAN translation using C9ORF72 GGGGCC ...

Abstract	Expansions of short nucleotide repeats account for more than 50 neurological or neuromuscular diseases. Many repeat expansion-containing RNAs can generate toxic repeat proteins through repeat-associated non-AUG (RAN) translation in all the reading frames. Understanding how RAN translation occurs and what cellular factors regulate this process will help decipher the basic mechanism of the molecular process and disease pathogenesis. Using reporter systems to quantitatively measure RAN translation provides a platform to examine candidate genes/pathways and screen for modifiers of this non-canonical pathway. In this chapter, we describe the dual-luciferase reporter system to measure RAN translation using C9ORF72 GGGGCC
MeSH term(s)	Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/pathology ; C9orf72 Protein/genetics ; Frontotemporal Dementia/genetics ; Frontotemporal Dementia/pathology ; Humans ; Reading Frames
Chemical Substances	C9orf72 Protein
Language	English
Publishing date	2022-02-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-1975-9_8
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Article ; Online: Recent Advances in Machine Learning for Network Automation in the O-RAN.

Hamdan, Mutasem Q / Lee, Haeyoung / Triantafyllopoulou, Dionysia / Borralho, Rúben / Kose, Abdulkadir / Amiri, Esmaeil / Mulvey, David / Yu, Wenjuan / Zitouni, Rafik / Pozza, Riccardo / Hunt, Bernie / Bagheri, Hamidreza / Foh, Chuan Heng / Heliot, Fabien / Chen, Gaojie / Xiao, Pei / Wang, Ning / Tafazolli, Rahim

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 21

Abstract: ... networks, with the Open Radio Access Network (O-RAN) architecture emerging as a promising solution. O-RAN ... interoperable solutions. However, managing and automating the complex O-RAN ecosystem presents numerous ... years, offering promising avenues for network automation in O-RAN. This paper presents a comprehensive ...

Abstract	The evolution of network technologies has witnessed a paradigm shift toward open and intelligent networks, with the Open Radio Access Network (O-RAN) architecture emerging as a promising solution. O-RAN introduces disaggregation and virtualization, enabling network operators to deploy multi-vendor and interoperable solutions. However, managing and automating the complex O-RAN ecosystem presents numerous challenges. To address this, machine learning (ML) techniques have gained considerable attention in recent years, offering promising avenues for network automation in O-RAN. This paper presents a comprehensive survey of the current research efforts on network automation usingML in O-RAN.We begin by providing an overview of the O-RAN architecture and its key components, highlighting the need for automation. Subsequently, we delve into O-RAN support forML techniques. The survey then explores challenges in network automation usingML within the O-RAN environment, followed by the existing research studies discussing application of ML algorithms and frameworks for network automation in O-RAN. The survey further discusses the research opportunities by identifying important aspects whereML techniques can benefit.
Language	English
Publishing date	2023-10-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23218792
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Article ; Online: Fucoxanthin inhibits gastric cancer lymphangiogenesis and metastasis by regulating Ran expression.

Wang, Jia / Dong, Xue / Li, Dandan / Fang, Zhiyao / Wan, Xianyao / Liu, Jing

Phytomedicine : international journal of phytotherapy and phytopharmacology

2023 Volume 118, Page(s) 154926

Abstract: ... showed that Ran was highly expressed in metastatic lymph nodes and has some predictive value ... of Ran via hydrogen bonds. Mechanistically, fucoxanthin inhibits the nuclear transport of NF-κB ... by downregulating protein expression of Ran and importinβ, thereby inhibiting VEGF-C secretion, and ultimately ...

Abstract	Background: Lymph node metastasis is a key mechanism in gastric cancer (GC) metastasis and lymphangiogenesis is a vital step in the process of lymph node metastasis. Currently, there are no drugs which can treat lymph node metastasis in GC. Previous studies using the drug fucoxanthin have mainly focused on cell cycle arrest, induction of apoptosis, or inhibition of angiogenesis in GC. However, the effects of fucoxanthin on lymphangiogenesis and metastasis in GC have not been studied. Methods: Cell counting kit 8 and transwell experiments were used to evaluate the inhibitory effect of fucoxanthin on cell proliferation, migration and invasion. HGC-27 and HLEC cells were co-cultured in a transwell chamber and the footpad metastasis model was established to evaluate lymphangiogenesis and lymph node metastasis. The possible regulatory targets of fucoxanthin in GC were analyzed using human tissue microarrays, bioinformatics analysis, and molecular docking. The regulatory pathway of fucoxanthin was verified using confocal laser microscopy, adenovirus transfection and western blotting. Results: Tissue microarray and bioinformatics analyses showed that Ran was highly expressed in metastatic lymph nodes and has some predictive value for metastasis in GC. Molecular docking results revealed that fucoxanthin interacted with Met189 and Lys167 of Ran via hydrogen bonds. Mechanistically, fucoxanthin inhibits the nuclear transport of NF-κB by downregulating protein expression of Ran and importinβ, thereby inhibiting VEGF-C secretion, and ultimately inhibiting tumor lymphangiogenesis and lymph node metastasis in vivo and in vitro. Conclusions: Fucoxanthin suppressed GC-induced lymphangiogenesis and metastasis in vitro and in vivo by regulating Ran expression via the importinβ/NF-κB/VEGF-C nuclear transport signaling pathway. These novel findings provide the basis for the research and development of novel treatments using traditional Chinese medicine in treatment of lymph node metastasis, which has important theoretical significance and clinical value.
MeSH term(s)	Humans ; Lymphangiogenesis ; Lymphatic Metastasis ; NF-kappa B/metabolism ; Vascular Endothelial Growth Factor C/metabolism ; Stomach Neoplasms/drug therapy ; Molecular Docking Simulation ; Cell Line, Tumor
Chemical Substances	NF-kappa B ; Vascular Endothelial Growth Factor C ; fucoxanthin (06O0TC0VSM)
Language	English
Publishing date	2023-06-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2023.154926
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Article ; Online: Effects on the crystallization behavior and biocompatibility of poly(LLA-ran-PDO-ran-GA) with poly(d-lactide) as nucleating agents.

Fan, Tiantang / Qin, Jingwen / Dong, Fen / Meng, Xiao / Li, Yanqi / Wang, Ying / Liu, Qing / Wang, Guannan

RSC advances

2022 Volume 12, Issue 17, Page(s) 10711–10724

Abstract: The blends of poly(l-lactide acid- ...

Abstract	The blends of poly(l-lactide acid-
Language	English
Publishing date	2022-04-06
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d2ra00525e
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Article ; Online: Phonological awareness and RAN contribute to Chinese reading and arithmetic for different reasons.

Yang, Xiujie / Star, Jon R / Zhu, Xiangyi / Wang, Rong / Zhang, Yan / Tong, Jiajin / He, Zhonghui

Cognitive processing

2024

Abstract: ... RAN), simultaneously contributed to Chinese reading and arithmetic fluency. Specifically, we proposed ... a new hypothesized mechanism that processing speed would mediate the relations of RAN with Chinese ... revealed that phonological awareness and RAN were uniquely related to character reading and arithmetic ...

Abstract	The present study investigated how phonological awareness and rapid automatized naming (hereafter, RAN), simultaneously contributed to Chinese reading and arithmetic fluency. Specifically, we proposed a new hypothesized mechanism that processing speed would mediate the relations of RAN with Chinese reading and arithmetic fluency. One hundred and forty-five Chinese children at the fifth grade were administered with a battery of measures, including three phonological processing measures, character reading, and whole number computation, as well as nonverbal IQ, and vocabulary knowledge. Path analyses revealed that phonological awareness and RAN were uniquely related to character reading and arithmetic fluency, while phonological memory was not significantly correlated to either character reading or arithmetic fluency, after controlling for age, nonverbal IQ, and vocabulary knowledge. Further analysis indicated that processing speed demonstrated a mediating effect on the importance of RAN in character reading, rather than in arithmetic fluency. Results underscore the potential importance of phonological awareness and RAN in character reading and arithmetic fluency, and the mediating role of processing speed in RAN to promote Chinese character reading fluency.
Language	English
Publishing date	2024-03-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2075054-7
ISSN	1612-4790 ; 1612-4782
ISSN (online)	1612-4790
ISSN	1612-4782
DOI	10.1007/s10339-024-01184-2
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Article: Prognostic potential of the small GTPase Ran and its methylation in hepatocellular carcinoma.

Liu, Hui-Hui / Wang, Ju / Zhang, Ying / Fan, Yu-Chen / Wang, Kai

Hepatobiliary & pancreatic diseases international : HBPD INT

2022 Volume 21, Issue 3, Page(s) 248–256

Abstract: ... The prognostic significance of Ran, a member of Ras superfamily, remains unclear in HCC patients.: Methods ... we analyzed the correlations among Ran expression, promoter methylation and immune cell infiltration. We also ... investigated the Ran expression levels in HCC tissues and normal tissues by using quantitative real-time PCR ...

Abstract	Background: Hepatocellular carcinoma (HCC) is a common malignant tumor with high mortality. The prognostic significance of Ran, a member of Ras superfamily, remains unclear in HCC patients. Methods: Based on The Cancer Genome Atlas (TCGA) database and Tumor Immune Estimation Resource (TIMER), we analyzed the correlations among Ran expression, promoter methylation and immune cell infiltration. We also investigated the Ran expression levels in HCC tissues and normal tissues by using quantitative real-time PCR. Results: Ran mRNA expression was significantly increased in HCC tissues compared with the normal tissues (P < 0.001). Time-dependent receiver operating characteristic (ROC) curves showed that Ran expression had predictive value of the 1-, 3- and 5-year overall survival for HCC patients, and the areas under the curves (AUC) were 0.747, 0.634 and 0.704, respectively. Cox regression analysis showed that Ran expression was an independent prognostic factor for HCC patients (HR = 1.492, 95% CI: 1.129-1.971, P = 0.005). We also found a negative relationship between Ran mRNA expression and its promoter methylation (r = -0.36, P < 0.001). High Ran expression and promoter hypomethylation predicted worse overall survival and progression-free survival (P < 0.05) and were involved in the progression of HCC. Ran expression exhibited significant correlations with immune infiltrates and prognostic immune-related genes. Conclusions: The present study provides further insight into the prognosis of HCC, and Ran could serve as a biomarker for predicting the survival of HCC patients.
MeSH term(s)	Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Carcinoma, Hepatocellular/pathology ; DNA Methylation ; Humans ; Liver Neoplasms/pathology ; Monomeric GTP-Binding Proteins/genetics ; Monomeric GTP-Binding Proteins/metabolism ; Prognosis ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
Chemical Substances	Biomarkers, Tumor ; RNA, Messenger ; Monomeric GTP-Binding Proteins (EC 3.6.5.2)
Language	English
Publishing date	2022-03-22
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2241386-8
ISSN	1499-3872
ISSN	1499-3872
DOI	10.1016/j.hbpd.2022.03.011
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Article ; Online: Residual Aligner-based Network (RAN): Motion-separable structure for coarse-to-fine discontinuous deformable registration.

Zheng, Jian-Qing / Wang, Ziyang / Huang, Baoru / Lim, Ngee Han / Papież, Bartłomiej W

Medical image analysis

2023 Volume 91, Page(s) 103038

Abstract: ... Network (RAN), on abdominal Computed Tomography (CT) scans and it has shown to achieve one of the most ... to state-of-the-art methods. Furthermore, when applied to lung CT, the RAN achieves comparable results ...

Abstract	Deformable image registration, the estimation of the spatial transformation between different images, is an important task in medical imaging. Deep learning techniques have been shown to perform 3D image registration efficiently. However, current registration strategies often only focus on the deformation smoothness, which leads to the ignorance of complicated motion patterns (e.g., separate or sliding motions), especially for the intersection of organs. Thus, the performance when dealing with the discontinuous motions of multiple nearby objects is limited, causing undesired predictive outcomes in clinical usage, such as misidentification and mislocalization of lesions or other abnormalities. Consequently, we proposed a novel registration method to address this issue: a new Motion Separable backbone is exploited to capture the separate motion, with a theoretical analysis of the upper bound of the motions' discontinuity provided. In addition, a novel Residual Aligner module was used to disentangle and refine the predicted motions across the multiple neighboring objects/organs. We evaluate our method, Residual Aligner-based Network (RAN), on abdominal Computed Tomography (CT) scans and it has shown to achieve one of the most accurate unsupervised inter-subject registration for the 9 organs, with the highest-ranked registration of the veins (Dice Similarity Coefficient (%)/Average surface distance (mm): 62%/4.9mm for the vena cava and 34%/7.9mm for the portal and splenic vein), with a smaller model structure and less computation compared to state-of-the-art methods. Furthermore, when applied to lung CT, the RAN achieves comparable results to the best-ranked networks (94%/3.0mm), also with fewer parameters and less computation.
MeSH term(s)	Humans ; Algorithms ; Tomography, X-Ray Computed/methods ; Motion ; Lung/diagnostic imaging ; Imaging, Three-Dimensional ; Image Processing, Computer-Assisted/methods
Language	English
Publishing date	2023-11-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1356436-5
ISSN	1361-8423 ; 1361-8431 ; 1361-8415
ISSN (online)	1361-8423 ; 1361-8431
ISSN	1361-8415
DOI	10.1016/j.media.2023.103038
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Article: Rapid and inexpensive bedside diagnosis of RAN binding protein 2-associated acute necrotizing encephalopathy.

Gouy, Benoît / Decorsière, Adrien / Desgraupes, Sophie / Duan, Wenming / Ouyang, Hong / Wang, Yifan E / Yeh, E Ann / Palazzo, Alexander F / Moraes, Theo J / Nisole, Sébastien / Arhel, Nathalie J

Frontiers in neurology

2023 Volume 14, Page(s) 1282059

Abstract: Acute necrotizing encephalopathy 1 (ANE1) is a very rare disorder associated with a dominant heterozygous mutation in the : Systematic review registration: The protocol was registered in the international prospective register of systematic reviews ( ... ...

Abstract	Acute necrotizing encephalopathy 1 (ANE1) is a very rare disorder associated with a dominant heterozygous mutation in the Systematic review registration: The protocol was registered in the international prospective register of systematic reviews (PROSPERO- CRD42023443257).
Language	English
Publishing date	2023-11-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2023.1282059
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