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  1. Article ; Online: Resolving inflammation.

    Gilroy, Derek W

    Nature reviews. Immunology

    2021  Volume 21, Issue 10, Page(s) 620–621

    Language English
    Publishing date 2021-09-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-021-00597-w
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  2. Article ; Online: The translation potential of harnessing the resolution of inflammation.

    Collins, George / de Souza Carvalho, Jhonatan / Gilroy, Derek W

    The Journal of allergy and clinical immunology

    2023  Volume 152, Issue 2, Page(s) 356–358

    MeSH term(s) Humans ; Inflammation ; Phagocytosis ; Apoptosis
    Language English
    Publishing date 2023-06-21
    Publishing country United States
    Document type Editorial
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2023.06.008
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  3. Article ; Online: Dying cell-derived SAM switches off inflammation.

    De Maeyer, Roel P H / Gilroy, Derek W

    Nature metabolism

    2022  Volume 4, Issue 4, Page(s) 414–415

    MeSH term(s) Apoptosis ; Humans ; Inflammation
    Language English
    Publishing date 2022-03-31
    Publishing country Germany
    Document type Journal Article ; Comment
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-022-00556-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Fundamentals of inflammation

    Serhan, Charles N. / Ward, Peter A. / Gilroy, Derek W.

    2010  

    Author's details ed. by Charles N. Serhan ; Peter A. Ward ; Derek W. Gilroy
    Keywords Inflammation / immunology ; Immunity, Cellular / physiology
    Language English
    Size XIV, 473 S. : Ill., graph. Darst., 28 cm
    Publisher Cambridge Univ. Press
    Publishing place Cambridge
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT016443043
    ISBN 978-0-521-88729-8 ; 0-521-88729-1
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2010 A 3662 order for loan Magazin

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  5. Article ; Online: Aging immunity may exacerbate COVID-19.

    Akbar, Arne N / Gilroy, Derek W

    Science (New York, N.Y.)

    2020  Volume 369, Issue 6501, Page(s) 256–257

    MeSH term(s) Age Factors ; Aged ; Aging/immunology ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/physiopathology ; Cytokines/immunology ; Humans ; Immunosenescence ; Inflammation/immunology ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/physiopathology ; SARS-CoV-2 ; T-Lymphocytes/immunology
    Chemical Substances Cytokines
    Keywords covid19
    Language English
    Publishing date 2020-07-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abb0762
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Is Resolution the End of Inflammation?

    Feehan, Karen T / Gilroy, Derek W

    Trends in molecular medicine

    2019  Volume 25, Issue 3, Page(s) 198–214

    Abstract: Deciphering the origins of chronic inflammatory and autoimmune diseases remains elusive with reliance on therapies aimed at halting inflammation in its tracks. In recent years, an appreciation of targeting pathways by which inflammation is resolved has ... ...

    Abstract Deciphering the origins of chronic inflammatory and autoimmune diseases remains elusive with reliance on therapies aimed at halting inflammation in its tracks. In recent years, an appreciation of targeting pathways by which inflammation is resolved has begun to rouse interest. Resolution of inflammation is driven by a complex set of mediators that regulate cellular events required to clear inflammatory cells from sites of infection or injury to restore tissue function. However, recent studies suggest that resolution is not the end of innate mediated immune responses to infection/injury. There is further immunological activity occurring after the resolution cascade is complete that alters the immune physiology of tissues, redefining what was once termed restorative homeostasis as adapted homeostasis.
    MeSH term(s) Acute Disease ; Animals ; Biomarkers ; Chronic Disease ; Cytokines/metabolism ; Disease Susceptibility ; Humans ; Immunity ; Inflammation/drug therapy ; Inflammation/etiology ; Inflammation/metabolism ; Inflammation/pathology ; Inflammation Mediators/metabolism ; Signal Transduction
    Chemical Substances Biomarkers ; Cytokines ; Inflammation Mediators
    Language English
    Publishing date 2019-02-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2036490-8
    ISSN 1471-499X ; 1471-4914
    ISSN (online) 1471-499X
    ISSN 1471-4914
    DOI 10.1016/j.molmed.2019.01.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Home-built environment interventions and inflammation biomarkers: a systematic review and meta-analysis protocol.

    Hernandez-Garcia, Eva / Chrysikou, Evangelia / Nekhlyudov, Larissa / Gilroy, Derek W / Ordóñez-Mena, José M

    BJGP open

    2022  Volume 6, Issue 4

    Abstract: Background: Inflammation control is a fundamental part of chronic care in patients with a history of cancer and comorbidity. As the risk-benefit profile of anti-inflammatory drugs is unclear in survivors of cancer, GPs and patients could benefit from ... ...

    Abstract Background: Inflammation control is a fundamental part of chronic care in patients with a history of cancer and comorbidity. As the risk-benefit profile of anti-inflammatory drugs is unclear in survivors of cancer, GPs and patients could benefit from alternative non-pharmacological treatment options for dysregulated inflammation. There is a potential for home-built environment (H-BE) interventions to modulate inflammation; however, discrepancies exist between studies.
    Aim: To evaluate the effectiveness of H-BE interventions on cancer-associated inflammation biomarkers.
    Design & setting: A systematic review and meta-analysis of randomised and non-randomised trials in community-dwelling adults.
    Method: PubMed and MEDLINE, Embase, Web of Science, and Google Scholar will be searched for clinical trials published in January 2000 onwards. The study will include H-BE interventions modifying air quality, thermal comfort, non-ionising radiation, noise, nature, and water. No restrictions to study population will be applied to allow deriving expectations for effects of the interventions in cancer survivors from available source populations. Outcome measures will be inflammatory biomarkers clinically and physiologically relevant to cancer. The first reviewer will independently screen articles together with GPs and extract data that will be verified by a second reviewer. The quality of studies will be assessed using the Cochrane risk-of-bias tools. Depending on the clinical and methodological homogeneity of populations, interventions, and outcomes, a meta-analysis will be conducted using random-effects models.
    Conclusion: Findings will determine the effectiveness of H-BE interventions on inflammatory parameters, guide future directions for its provision in community-dwelling survivors of cancer and support GPs with safer anti-inflammatory treatment options in high-risk patients for clinical complications.
    Language English
    Publishing date 2022-12-20
    Publishing country England
    Document type Journal Article
    ISSN 2398-3795
    ISSN (online) 2398-3795
    DOI 10.3399/BJGPO.2022.0104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Home-built environment interventions and inflammation biomarkers

    Eva Hernandez-Garcia / Evangelia Chrysikou / Larissa Nekhlyudov / Derek W Gilroy / José M Ordóñez-Mena

    BJGP Open, Vol 6, Iss

    a systematic review and meta-analysis protocol

    2022  Volume 4

    Abstract: Background: Inflammation control is a fundamental part of chronic care in patients with a history of cancer and comorbidity. As the risk–benefit profile of anti-inflammatory drugs is unclear in survivors of cancer, GPs and patients could benefit from ... ...

    Abstract Background: Inflammation control is a fundamental part of chronic care in patients with a history of cancer and comorbidity. As the risk–benefit profile of anti-inflammatory drugs is unclear in survivors of cancer, GPs and patients could benefit from alternative non-pharmacological treatment options for dysregulated inflammation. There is a potential for home-built environment (H-BE) interventions to modulate inflammation; however, discrepancies exist between studies. Aim: To evaluate the effectiveness of H-BE interventions on cancer-associated inflammation biomarkers. Design & setting: A systematic review and meta-analysis of randomised and non-randomised trials in community-dwelling adults. Method: PubMed and MEDLINE, Embase, Web of Science, and Google Scholar will be searched for clinical trials published in January 2000 onwards. The study will include H-BE interventions modifying air quality, thermal comfort, non-ionising radiation, noise, nature, and water. No restrictions to study population will be applied to allow deriving expectations for effects of the interventions in cancer survivors from available source populations. Outcome measures will be inflammatory biomarkers clinically and physiologically relevant to cancer. The first reviewer will independently screen articles together with GPs and extract data that will be verified by a second reviewer. The quality of studies will be assessed using the Cochrane risk-of-bias tools. Depending on the clinical and methodological homogeneity of populations, interventions, and outcomes, a meta-analysis will be conducted using random-effects models. Conclusion: Findings will determine the effectiveness of H-BE interventions on inflammatory parameters, guide future directions for its provision in community-dwelling survivors of cancer and support GPs with safer anti-inflammatory treatment options in high-risk patients for clinical complications.
    Keywords housing ; home-built environment ; biomarkers ; inflammation ; cancer survivor ; comorbidity ; chronic disease ; general practice ; community care ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher Royal College of General Practitioners
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Lipid mediators in immune regulation and resolution.

    Gilroy, Derek W / Bishop-Bailey, David

    British journal of pharmacology

    2019  Volume 176, Issue 8, Page(s) 1009–1023

    Abstract: We are all too familiar with the events that follow a bee sting-heat, redness, swelling, and pain. These are Celsus' four cardinal signs of inflammation that are driven by very well-defined signals and hormones. In fact, targeting the factors that drive ... ...

    Abstract We are all too familiar with the events that follow a bee sting-heat, redness, swelling, and pain. These are Celsus' four cardinal signs of inflammation that are driven by very well-defined signals and hormones. In fact, targeting the factors that drive this onset phase is the basis upon which most current anti-inflammatory therapies were developed. We are also very well aware that within a few hours, these cardinal signs normally disappear. In other words, inflammation resolves. When it does not, inflammation persists, resulting in damaging chronic conditions. While inflammatory onset is actively driven, so also is its resolution-years of research have identified novel internal counter-regulatory signals that work together to switch off inflammation. Among these signals, lipids are potent signalling molecules that regulate an array of immune responses including vascular hyper reactivity and pain, as well as leukocyte trafficking and clearance, so-called resolution. Here, we collate bioactive lipid research to date and summarize the major pathways involved in their biosynthesis and their role in inflammation, as well as resolution. LINKED ARTICLES: This article is part of a themed section on Eicosanoids 35 years from the 1982 Nobel: where are we now? To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.8/issuetoc.
    MeSH term(s) Animals ; Cytochrome P-450 Enzyme System/metabolism ; Humans ; Inflammation/enzymology ; Inflammation/immunology ; Lipids/biosynthesis ; Lipids/immunology ; Prostaglandin-Endoperoxide Synthases/metabolism
    Chemical Substances Lipids ; Cytochrome P-450 Enzyme System (9035-51-2) ; Prostaglandin-Endoperoxide Synthases (EC 1.14.99.1)
    Language English
    Publishing date 2019-03-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.14587
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