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Article ; Online: Anterior Talofibular Ligament All-Inside Arthroscopic Reconstruction with InternalBrace™ for Chronic Lateral Ankle Instability.

Zeng, Guang-Long / Cai, Li-Min / Xie, QingXiang / Huang, Hao-Bo / Li, Yong-Cong / Su, Bo-Yuan

Medical science monitor : international medical journal of experimental and clinical research

2022 Volume 28, Page(s) e937699

Abstract: BACKGROUND Anterior talofibular ligament (ATFL) is the most easily injured or even broken of ankle sprain. Patients who fail to receive conservative treatment, resulting in persistent ankle swelling, painful and functional decline that it is so-called ... ...

Abstract	BACKGROUND Anterior talofibular ligament (ATFL) is the most easily injured or even broken of ankle sprain. Patients who fail to receive conservative treatment, resulting in persistent ankle swelling, painful and functional decline that it is so-called chronic lateral ankle instability (CLAI). It makes sense to investigate all-inside arthroscopic reconstruction of ATFL with InternalBrace™ for CLAI. MATERIAL AND METHODS We included 108 patients who underwent all-inside arthroscopic ATFL reconstruction with InternalBrace™ for CLAI from January 2018 to April 2020 through a retrospective study. Patients age ranged from 19 to 58 years (mean 35.6±8.7 years). Several elements are used to evaluate the clinical consequences of ankle function, including the American Orthopedic Foot and Ankle Society (AOFAS), Japanese Society for Surgery of the Foot Ankle-Hindfoot (JSSF), Kofoed, Tegner scores and complications, and the tilt angle of talus (TT) and the anterior displacement of talus (ADT) with stressing radiographs were taken to measure in follow-ups. RESULTS All 108 patients had all-inside arthroscopic procedures performed smoothly without serious complications. During the follow-up period (26.7±2.6 months on average), no recurrence of ankle instability and other serious complications happened. The AOFAS, JSSF, Kofoed, and Tegner scores significantly increased as time went by postoperatively, which proved statistically significant (P<0.01). Regarding stress-radiographic measurements, TT significantly decreased from (9.5±1.1)° preoperatively to (2.6±0.6)° at the latest follow-up (P<0.01), while ADT significantly decreased from (9.5±1.0) mm preoperatively to (2.6±0.6) mm at the latest examination (P<0.01). CONCLUSIONS All-inside arthroscopic ATFL reconstruction with the InternalBrace™ for CLAI is beneficial for ankle stability, allowing earlier return to activities.
MeSH term(s)	Adult ; Ankle ; Ankle Joint/surgery ; Arthroscopy/methods ; Humans ; Joint Instability/surgery ; Lateral Ligament, Ankle/surgery ; Middle Aged ; Retrospective Studies ; Young Adult
Language	English
Publishing date	2022-10-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	1439041-3
ISSN	1643-3750 ; 1234-1010
ISSN (online)	1643-3750
ISSN	1234-1010
DOI	10.12659/MSM.937699
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Zs.A 4924: Show issues

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Article ; Online: Scutellaria Baicalensis Georgi Stem and Leaf Flavonoids Ameliorate the Learning and Memory Impairment in Rats Induced by Okadaic Acid.

Ma, Shuai / Xu, Cong-Cong / Dong, Yong-Cai / Li, Cai-Xia / Shang, Ya-Zhen

Combinatorial chemistry & high throughput screening

2024

Abstract: Aim: The objective of this study is to explore the impact and underlying mechanism of Scutellaria baicalensis Georgi stem and leaf flavonoids (SSFs) on cognitive impairment caused by intracerebroventricular injection of okadaic acid (OA) in rats.: ... ...

Abstract	Aim: The objective of this study is to explore the impact and underlying mechanism of Scutellaria baicalensis Georgi stem and leaf flavonoids (SSFs) on cognitive impairment caused by intracerebroventricular injection of okadaic acid (OA) in rats. Methods: An experimental model of Alzheimer's disease (AD) was induced in rats by intracerebroventricular injection of OA, resulting in memory impairment. The Morris water maze test was employed to confirm the successful establishment of the memory impairment model. The rats that exhibited significant memory impairment were randomly divided into different groups, including a model group, three SSFs dose groups (25, 50, and 100 mg/kg), and a positive control group treated with Ginkgo biloba tablets (GLT) at a dose of 200 mg/kg. To evaluate the learning and memory abilities of the rats, the Morris water maze test was conducted. Hematoxylin-eosin (HE) staining was used to observe any morphological changes in neurons. Immunohistochemistry (IHC) was performed to measure the expression of choline acetyltransferase (ChAT) protein. Western blotting (WB) was utilized to assess the phosphorylation levels of tau protein at Ser262 and Ser396. The activities of inducible nitric oxide synthase (iNOS) and constitutive nitric oxide synthase (cNOS) were quantified using ultraviolet spectrophotometry. The levels of inflammatory factors, including interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6), were measured using ELISA. Results: In rats, the administration of OA via intracerebroventricular injection resulted in cognitive impairment, neuropathological changes, and alterations in protein expression and activity levels. Specifically, the protein expression of ChAT was significantly reduced (P<0.01), while the phosphorylation levels of tau protein at Ser262 and Ser396 were significantly increased (P<0.01). Moreover, iNOS activity in the hippocampus and cerebral cortex exhibited a significant increase (P<0.01), whereas cNOS activity showed a decrease (P<0.05). Furthermore, the levels of IL-1β and TNF-α in the cerebral cortex were elevated (P<0.01), while the level of IL-6 was decreased (P<0.05). The administration of three doses of SSFs and GLT to rats exhibited varying degrees of improvement in the aforementioned pathological alterations induced by OA. Conclusion: SSFs demonstrated the ability to enhance cognitive function and mitigate memory deficits in rats following intracerebroventricular injection of OA. This beneficial effect may be attributed to the modulation of ChAT protein expression, tau hyperphosphorylation, NOS activity, and inflammatory cytokine levels by SSFs.
Language	English
Publishing date	2024-01-09
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2064785-2
ISSN	1875-5402 ; 1386-2073
ISSN (online)	1875-5402
ISSN	1386-2073
DOI	10.2174/0113862073265060231127054325
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Zs.A 5577: Show issues

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Article ; Online: Photocatalytic Generation of H

Ren, Hai-Tao / Cai, Chao-Chen / Zhu, Peng-Yue / Wang, Cong / Wu, Song-Hai / Liu, Yong / Han, Xu

Langmuir : the ACS journal of surfaces and colloids

2024 Volume 40, Issue 14, Page(s) 7384–7394

Abstract: Photocatalytic technology is a popular research area for converting solar energy into environmentally friendly chemicals and is considered the greenest approach for producing ... ...

Abstract	Photocatalytic technology is a popular research area for converting solar energy into environmentally friendly chemicals and is considered the greenest approach for producing H
Language	English
Publishing date	2024-03-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021/acs.langmuir.3c03651
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Article ; Online: Role of Platelet/Lymphocyte, Neutrophil/Lymphocyte, and Interleukin-37/Interleukin-17 Ratios in the Occurrence and Treatment of Rheumatoid Arthritis.

Meng, Yan / Cai, Xuan-Lin / Cong, Shan / Sun, Jiao / Hu, Yong-Wei / Gu, Yan-Qin / Ma, Xiu-Min / Luo, Li

Immunological investigations

2024 Volume 53, Issue 3, Page(s) 464–474

Abstract: This study was designed to investigate the correlation of neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and interleukin (IL)-37/IL-17 ratio with the incidence/treatment of rheumatoid arthritis (RA). Firstly, fifty-eight patients ... ...

Abstract	This study was designed to investigate the correlation of neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and interleukin (IL)-37/IL-17 ratio with the incidence/treatment of rheumatoid arthritis (RA). Firstly, fifty-eight patients with RA treated at the first affiliated hospital of Xinjiang Medical University from January 2018 to January 2019 were selected as the RA group; forty-nine healthy volunteers were enrolled in the control group. RA patients were treated with disease-modifying anti-rheumatic drugs (DMARDs). Next, the NLR, PLR, IL-37, IL-17 and 28-joint disease activity score using erythrocyte sedimentation rate (DAS28-ESR) were deleted in two groups. Subsequently, Spearman correlation analysis was adopted for the correlations of various indicators before and after treatment in two groups. According to the analysis results, the levels of NLR, PLR, IL-37, and IL-17 before treatment in the RA group were higher than those in the control group (
MeSH term(s)	Humans ; Interleukin-17/metabolism ; Neutrophils ; Arthritis, Rheumatoid ; Lymphocytes/metabolism ; Blood Platelets/chemistry ; Antirheumatic Agents/therapeutic use ; C-Reactive Protein/metabolism ; Retrospective Studies
Chemical Substances	Interleukin-17 ; Antirheumatic Agents ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2024-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	632565-8
ISSN	1532-4311 ; 0882-0139
ISSN (online)	1532-4311
ISSN	0882-0139
DOI	10.1080/08820139.2023.2299687
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Zs.A 988: Show issues

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Article ; Online: Identification of undescribed key impurities of homoharringtonine bulk drug.

Yu, Yang / Wu, Jing / Yue, Cong-Yong / Zhang, Tao / Cai, Xiang-Hai

Natural product research

2023 , Page(s) 1–8

Abstract: The knowledge of impurities is an important issue and the base of quality control in modern drugs. To date, the quality control of the antitumor drug homoharringtonine (HHT) is still not sufficiently solved and needs to be improved. Six main impurities, ... ...

Abstract	The knowledge of impurities is an important issue and the base of quality control in modern drugs. To date, the quality control of the antitumor drug homoharringtonine (HHT) is still not sufficiently solved and needs to be improved. Six main impurities, drupacine, cephalotaxine, desmethylcephalotaxinone, harringtonine, 3-
Language	English
Publishing date	2023-02-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2023.2175358
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Article: 不同培肥模式对辽西北沙化草地土壤改良与植被恢复的影响.

Zhang, Xiu-Ying / Cai, Jiang-Ping / Wang, Cong / Jiang, Zhi-Yang / Li, Hui / Wang, Zheng-Wen / Jiang, Yong / Zhang, Yu-Ge

Ying yong sheng tai xue bao = The journal of applied ecology

2024 Volume 35, Issue 1, Page(s) 55–61

Abstract: Improving soil fertility is one of the key approaches for ecological restoration of the wind-sand area in northwest Liaoning Province. Taking wind-sand area in northwest Liaoning Province as test object, we conducted a fertilization experiment with ... ...

Title translation	Effects of different fertilization patterns on soil improvement and vegetation restoration of desertified grassland in northwest Liaoning Province, China.
Abstract	Improving soil fertility is one of the key approaches for ecological restoration of the wind-sand area in northwest Liaoning Province. Taking wind-sand area in northwest Liaoning Province as test object, we conducted a fertilization experiment with treatments of inorganic fertilizer (nitrogen, phosphorus and potassium fertilizers), organic fertilizer, combined application of organic and inorganic fertilizers, and organic fertilizer combined with a biologically organic matrix (γ-polyglutamic acid), and no fertilizer as control. We measured soil organic matter content and extractable cations concentrations, vegetation coverage, and biomass under different fertilization treatments and determine the suitable fertilization mode. The results showed that compared to the control, inorganic fertilizer rapidly increased vegetation coverage and biomass, but high levels of inorganic fertilizer (150 kg N·hm
MeSH term(s)	Soil ; Agriculture/methods ; Fertilizers ; Sand ; Grassland ; Polyglutamic Acid ; China ; Nitrogen/analysis ; Fertilization
Chemical Substances	Soil ; Fertilizers ; Sand ; Polyglutamic Acid (25513-46-6) ; Nitrogen (N762921K75)
Language	Chinese
Publishing date	2024-03-21
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2881809-X
ISSN	1001-9332
ISSN	1001-9332
DOI	10.13287/j.1001-9332.202401.016
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Article ; Online: The non-causative role of abnormal serum uric acid in intervertebral disc degeneration: A Mendelian randomization study.

Cai, Yang-Ting / Li, Yong-Xian / Wang, Li-Ren / Mo, Ling / Li, Ying / Zhang, Shun-Cong

JOR spine

2023 Volume 7, Issue 1, Page(s) e1283

Abstract: Background: Intervertebral disc degeneration (IDD) is a common musculoskeletal disorder that contributes significantly to disability and healthcare costs. Serum urate concentration has been implicated in the development of various musculoskeletal ... ...

Abstract	Background: Intervertebral disc degeneration (IDD) is a common musculoskeletal disorder that contributes significantly to disability and healthcare costs. Serum urate concentration has been implicated in the development of various musculoskeletal conditions. While previous observational studies have suggested an association between the two conditions, it might confound the effect of serum urate concentrations on IDD. This Mendelian randomization (MR) study aimed to investigate the causal relationship between serum urate concentration and IDD. Methods: We performed a two-sample MR analysis using summary-level data from genome-wide association studies (GWAS) of serum urate concentration ( Results: In the primary IVW analysis, genetically predicted serum urate concentration was unrelated associated with IDD (odds ratio [OR] = 1.00, 95% confidence interval (CI): 1.00-1.00, Conclusions: This MR study provides evidence that there is no causal relationship between serum urate concentration and IDD. It suggests previous observational associations may be confounded. Serum urate levels are unlikely to be an important contributor to IDD.
Language	English
Publishing date	2023-09-29
Publishing country	United States
Document type	Journal Article
ISSN	2572-1143
ISSN (online)	2572-1143
DOI	10.1002/jsp2.1283
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Article ; Online: Modular catalytic activity of nonribosomal peptide synthetases depends on the dynamic interaction between adenylation and condensation domains.

Peng, Ye-Jun / Chen, Yuxing / Zhou, Cong-Zhao / Miao, Wei / Jiang, Yong-Liang / Zeng, Xiaoli / Zhang, Cheng-Cai

Structure (London, England : 1993)

2024 Volume 32, Issue 4, Page(s) 440–452.e4

Abstract: Nonribosomal peptide synthetases (NRPSs) are large multidomain enzymes for the synthesis of a variety of bioactive peptides in a modular and pipelined fashion. Here, we investigated how the condensation (C) domain and the adenylation (A) domain cooperate ...

Abstract	Nonribosomal peptide synthetases (NRPSs) are large multidomain enzymes for the synthesis of a variety of bioactive peptides in a modular and pipelined fashion. Here, we investigated how the condensation (C) domain and the adenylation (A) domain cooperate with each other for the efficient catalytic activity in microcystin NRPS modules. We solved two crystal structures of the microcystin NRPS modules, representing two different conformations in the NRPS catalytic cycle. Our data reveal that the dynamic interaction between the C and the A domains in these modules is mediated by the conserved "RXGR" motif, and this interaction is important for the adenylation activity. Furthermore, the "RXGR" motif-mediated dynamic interaction and its functional regulation are prevalent in different NRPSs modules possessing both the A and the C domains. This study provides new insights into the catalytic mechanism of NRPSs and their engineering strategy for synthetic peptides with different structures and properties.
MeSH term(s)	Microcystins ; Peptide Synthases/chemistry ; Molecular Conformation ; Peptides
Chemical Substances	non-ribosomal peptide synthase (EC 6.3.2.-) ; Microcystins ; Peptide Synthases (EC 6.3.2.-) ; Peptides
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1213087-4
ISSN	1878-4186 ; 0969-2126
ISSN (online)	1878-4186
ISSN	0969-2126
DOI	10.1016/j.str.2024.01.010
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Zs.A 4141: Show issues

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Article ; Online: A Real-Time Strategy for Chiroptical Sensing and Enantiomeric Excess Determination of Primary Amines via an Acid-Base Reaction.

Wu, Datong / Wang, Fangqin / Ma, Cong / Tan, Lilan / Cai, Wenrong / Li, Junyao / Kong, Yong

Organic letters

2022 Volume 24, Issue 28, Page(s) 5226–5229

Abstract: Two achiral aromatic carboxylic acids that included the 1,8-naphthalimide group and an imidazolium cation were synthesized and exploited as chiroptical sensors. These compounds showed the real-time discrimination and enantiomeric excess determination of ... ...

Abstract	Two achiral aromatic carboxylic acids that included the 1,8-naphthalimide group and an imidazolium cation were synthesized and exploited as chiroptical sensors. These compounds showed the real-time discrimination and enantiomeric excess determination of chiral amines and amino alcohols via an acid-base interaction, especially for UV-silent chiral compounds.
Language	English
Publishing date	2022-07-13
Publishing country	United States
Document type	Journal Article
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.2c02246
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Article ; Online: Treating head and neck tumors during the SARS-CoV-2 epidemic, 2019 to 2020: Sichuan Cancer Hospital.

Cai, Yong-Cong / Wang, Wei / Li, Chao / Zeng, Din-Fen / Zhou, Yu-Qiu / Sun, Rong-Hao / Jiang, Hua / Guo, Hui / Wang, Shao-Xin / Jiang, Jian

Head & neck

2020 Volume 42, Issue 6, Page(s) 1153–1158

Abstract: Since December 2019, a number of patients with novel coronavirus pneumonia (NCP) have been identified in Wuhan, Hubei Province, China. NCP has rapidly spread to other provinces and cities in China and other countries in the world. Due to the rapid ... ...

Abstract	Since December 2019, a number of patients with novel coronavirus pneumonia (NCP) have been identified in Wuhan, Hubei Province, China. NCP has rapidly spread to other provinces and cities in China and other countries in the world. Due to the rapid increase in reported cases in China and around the world, on January 30, 2020, the World Health Organization (WHO) Emergency Committee announced that NCP is a Public Health Emergency of International Concern (PHEIC). However, there are relatively few suggestions and measures for tumor patients, especially patients with head and neck tumors. This article summarizes the prevention and control of disease in our medical institution to provide a reference for front-line head and neck surgeons.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Cancer Care Facilities/organization & administration ; China ; Communicable Disease Control/organization & administration ; Communicable Diseases/transmission ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Delivery of Health Care/organization & administration ; Emergencies/epidemiology ; Emergency Service, Hospital/organization & administration ; Female ; Head and Neck Neoplasms/diagnosis ; Head and Neck Neoplasms/epidemiology ; Head and Neck Neoplasms/therapy ; Hospitals, Special/organization & administration ; Humans ; Male ; Pandemics/prevention & control ; Patient Safety ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; SARS-CoV-2 ; Triage
Keywords	covid19
Language	English
Publishing date	2020-05-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	645165-2
ISSN	1097-0347 ; 0148-6403 ; 1043-3074
ISSN (online)	1097-0347
ISSN	0148-6403 ; 1043-3074
DOI	10.1002/hed.26161
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