Article: Treatment Options for HIV-Associated Tuberculosis.
The Journal of infectious diseases
2007 Volume 196 Suppl 1, Page(s) S35–45
Abstract: The vicious interaction between the human immunodeficiency virus (HIV) infection and tuberculosis (TB) pandemics poses special challenges to national control programs and individual physicians. Although recommendations for the treatment of TB in HIV- ... ...
| Abstract | The vicious interaction between the human immunodeficiency virus (HIV) infection and tuberculosis (TB) pandemics poses special challenges to national control programs and individual physicians. Although recommendations for the treatment of TB in HIV-infected patients do not significantly differ from those for HIV-uninfected patients, the appropriate management of HIV-associated TB is complicated by health system issues, diagnostic difficulties, adherence concerns, overlapping adverse-effect profiles and drug interactions, and the occurrence of paradoxical reactions after the initiation of effective antiretroviral therapy. In this article, recommended treatment strategies and novel approaches to the management of HIV-associated TB are reviewed, including adjuvant treatment and options for treatment simplification. A focused research agenda is proposed in the context of the limitations of the current knowledge framework. |
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| MeSH term(s) | AIDS-Related Opportunistic Infections/drug therapy ; Anti-HIV Agents/administration & dosage ; Anti-HIV Agents/therapeutic use ; Anti-Infective Agents/therapeutic use ; Antitubercular Agents/administration & dosage ; Antitubercular Agents/therapeutic use ; Biomedical Research ; Clinical Trials as Topic ; Drug Administration Schedule ; HIV ; HIV Infections/complications ; HIV Infections/drug therapy ; Humans ; Immunologic Factors/therapeutic use ; Micronutrients/therapeutic use ; Trimethoprim, Sulfamethoxazole Drug Combination/therapeutic use ; Tuberculosis/complications ; Tuberculosis/drug therapy |
| Chemical Substances | Anti-HIV Agents ; Anti-Infective Agents ; Antitubercular Agents ; Immunologic Factors ; Micronutrients ; Trimethoprim, Sulfamethoxazole Drug Combination (8064-90-2) |
| Language | English |
| Publishing date | 2007-08-29 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review |
| ZDB-ID | 3019-3 |
| ISSN | 1537-6613 ; 0022-1899 |
| ISSN (online) | 1537-6613 |
| ISSN | 0022-1899 |
| DOI | 10.1086/518657 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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