Article ; Online: Sarcomatoid variant of Xp11 translocation renal cell carcinoma: A rare case report in an adult female.
Indian journal of pathology & microbiology
2024 Volume 67, Issue 1, Page(s) 178–181
Abstract: Xp11 translocation renal cell carcinoma (XPTRCC) is a very rare kidney neoplasm, which has been predominantly reported in young patients. Sarcomatoid transformation in renal cell carcinomas is known. However, its occurrence in XPTRCC is unreported so far ...
Abstract | Xp11 translocation renal cell carcinoma (XPTRCC) is a very rare kidney neoplasm, which has been predominantly reported in young patients. Sarcomatoid transformation in renal cell carcinomas is known. However, its occurrence in XPTRCC is unreported so far in the literature. We report a unique case of sarcomatoid transformation in a XPTRCC in a 23-year-old female, who presented with a huge right-sided renal mass and had metastatic deposits in lungs. Morphologically, clear cell morphology with papillary architecture along with foci of sarcomatoid transformation and rhabdoid differentiation were noted. Immunohistochemistry showed Pax-8 and TFE-3 expression in all components including the sarcomatous areas, whereas CK and EMA were expressed in conventional clear cell component. We present an extremely rare case of sarcomatous transformation in XPTRCC and discuss the case as determined by histopathology and immunocytochemistry. To our knowledge, this is the first case of sarcomatoid transformation XPTRCC being reported in the world literature. |
---|---|
MeSH term(s) | Adult ; Humans ; Female ; Young Adult ; Carcinoma, Renal Cell/diagnosis ; Carcinoma, Renal Cell/genetics ; Kidney Neoplasms/diagnosis ; Kidney Neoplasms/genetics ; Kidney/pathology ; Sarcoma ; Cell Differentiation ; Translocation, Genetic |
Language | English |
Publishing date | 2024-02-12 |
Publishing country | India |
Document type | Case Reports |
ZDB-ID | 197621-7 |
ISSN | 0974-5130 ; 0377-4929 |
ISSN (online) | 0974-5130 |
ISSN | 0377-4929 |
DOI | 10.4103/ijpm.ijpm_1159_21 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
Zs.B 862: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.