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  1. Article ; Online: Progress in HNE Biology.

    Davies, Sean S / Forman, Henry J

    Archives of biochemistry and biophysics

    2023  Volume 735, Page(s) 109513

    MeSH term(s) Lipid Peroxidation ; Biology ; Aldehydes
    Chemical Substances Aldehydes
    Language English
    Publishing date 2023-01-14
    Publishing country United States
    Document type Editorial
    ZDB-ID 523-x
    ISSN 1096-0384 ; 0003-9861
    ISSN (online) 1096-0384
    ISSN 0003-9861
    DOI 10.1016/j.abb.2023.109513
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  2. Article ; Online: Transfer of the fittest: using preimplantation genetic testing for aneuploidy to select embryo(s) most likely to lead to live birth.

    Hynes, Jenna S / Forman, Eric J

    F&S science

    2023  Volume 4, Issue 2S, Page(s) 2–6

    Abstract: Preimplantation genetic testing for aneuploidy (PGT-A) was developed to identify euploid embryos from a cohort of embryos with unknown ploidy produced during an in vitro fertilization (IVF) cycle. In recent years, the ability of PGT-A to improve IVF ... ...

    Abstract Preimplantation genetic testing for aneuploidy (PGT-A) was developed to identify euploid embryos from a cohort of embryos with unknown ploidy produced during an in vitro fertilization (IVF) cycle. In recent years, the ability of PGT-A to improve IVF outcomes has come into question. The goal of this review was to summarize the major randomized controlled trials (RCTs) and nonselection studies evaluating the benefit of PGT-A to improve the live birth rates (LBRs). We argue that the LBR per transfer is more relevant to the individual patient than the cumulative LBR as a means to minimize the burden of IVF by reducing futile transfers, pregnancy losses, and ongoing aneuploidy. The early RCTs demonstrate improved implantation rates and LBRs with PGT-A for embryo selection vs. traditional morphology. However, these studies are limited by the small sample size and a bias toward good-prognosis patients. Further studies using next-generation sequencing found more variable results but did confirm an improvement in the LBRs per transfer in an older population with a higher baseline risk of aneuploidy. The largest RCT to date showed similar cumulative LBRs in the PGT-A and control groups after biopsy and sequential transfer of up to 3 blastocysts with a significant reduction in the cumulative clinical pregnancy loss rate in the PGT-A group. Nonselection studies evaluating pregnancy outcomes after transfer of euploid vs. aneuploid embryos demonstrate near-perfect negative predictive value for an aneuploid result to predict live birth. Putative mosaic embryos had similar LBRs compared with euploid embryos. The available RCTs and nonselection studies support the practice of using PGT-A to identify euploid embryos for transfer, especially in an older population, while simultaneously selecting against aneuploid embryos, without negative impact on the total reproductive potential of the cycle.
    MeSH term(s) Pregnancy ; Female ; Humans ; Live Birth ; Preimplantation Diagnosis/methods ; Genetic Testing/methods ; Pregnancy Outcome ; Abortion, Spontaneous/genetics ; Aneuploidy ; Seizures
    Language English
    Publishing date 2023-01-18
    Publishing country United States
    Document type Review ; Journal Article
    ISSN 2666-335X
    ISSN (online) 2666-335X
    DOI 10.1016/j.xfss.2022.12.005
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  3. Article ; Online: Does PGT-A affect cumulative live birth rate?

    Seckin, Serin / Forman, Eric J

    Current opinion in obstetrics & gynecology

    2023  Volume 35, Issue 3, Page(s) 216–223

    Abstract: Purpose of review: Preimplantation genetic testing for the purpose of aneuploidy screening (PGT-A) has increased in use over the last decade.: Recent findings: Whether PGT-A benefits all of the patients that choose to employ it has been a concern, as ...

    Abstract Purpose of review: Preimplantation genetic testing for the purpose of aneuploidy screening (PGT-A) has increased in use over the last decade.
    Recent findings: Whether PGT-A benefits all of the patients that choose to employ it has been a concern, as recent studies have highlighted a potential decrease in cumulative live birth rate (CLBR) for younger patients undergoing embryo transfer. However, there are limitations to many of these studies and the intended benefit of PGT-A, which is to aid as a selection tool, thus increasing the live birth rate per transfer, must not be ignored.
    Summary: PGT-A was never intended to increase CLBR. The purpose of PGT-A is to maximize the chance at live birth per transfer while minimizing the risk of clinical miscarriage, ongoing aneuploid pregnancy and futile transfers. However, if it harms CLBR in the process that has to be taken into consideration. This review will discuss PGT-A in terms of its benefits, risks, and how it has been shown to affect the cumulative live birth rate within in-vitro fertilization cycles.
    MeSH term(s) Pregnancy ; Female ; Humans ; Birth Rate ; Preimplantation Diagnosis ; Genetic Testing ; Fertilization in Vitro ; Abortion, Spontaneous ; Aneuploidy ; Pregnancy Rate ; Retrospective Studies
    Language English
    Publishing date 2023-03-20
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1049382-7
    ISSN 1473-656X ; 1040-872X
    ISSN (online) 1473-656X
    ISSN 1040-872X
    DOI 10.1097/GCO.0000000000000865
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    Zs.A 3048: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Inhibition of chromatin condensation disrupts planar cell migration.

    Forman, Jack / Hine, Briar / Kaonis, Samantha / Ghosh, Soham

    Nucleus (Austin, Tex.)

    2024  Volume 15, Issue 1, Page(s) 2325961

    Abstract: Cell migration involves the actin cytoskeleton, and recently recognized nuclear involvement. In this study, we explore the impact of chromatin remodeling on cell migration using NIH 3T3 cells and a scratch wound assay subjected to pharmacological ... ...

    Abstract Cell migration involves the actin cytoskeleton, and recently recognized nuclear involvement. In this study, we explore the impact of chromatin remodeling on cell migration using NIH 3T3 cells and a scratch wound assay subjected to pharmacological interventions. We inhibit histone deacetylases (HDACs) with Trichostatin A (TSA) and methyltransferase EZH2 with GSK126 to modulate chromatin compaction. Our results indicate that chromatin modifications impair wound closure efficiency, reduce individual cell migration speed, and disrupt migration persistence. Live-cell imaging reveals dynamic intranuclear chromatin remodeling and nuclear shape parameters during migration, influenced by both small- and large-scale chromatin remodeling. The altered nuclear shape is associated with disrupted cell and nuclear mechanics, suggesting a crucial interplay between chromatin remodeling, nuclear mechanics and migration. These findings shed light on the intricate connection between intranuclear chromatin dynamics, nuclear mechanics, and cell migration, providing a basis for further investigations into the molecular mechanisms governing these processes.
    MeSH term(s) Mice ; Animals ; Chromatin ; Chromatin Assembly and Disassembly ; Cell Movement
    Chemical Substances Chromatin
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2619626-8
    ISSN 1949-1042 ; 1949-1042
    ISSN (online) 1949-1042
    ISSN 1949-1042
    DOI 10.1080/19491034.2024.2325961
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  5. Article ; Online: High-Throughput Multiparametric Quantification of Mechanics Driven Heterogeneity in Mesenchymal Stromal Cell Population.

    Kaonis, Samantha / Aboellail, Zack / Forman, Jack / Ghosh, Soham

    Advanced biology

    2023  Volume 8, Issue 1, Page(s) e2300318

    Abstract: Mesenchymal stromal or stem cells (MSCs) are one of the most promising candidates for a myriad of cell therapy applications. Despite showing promise in numerous preclinical and clinical studies, MSC-based therapy is not yet a reality for regenerative ... ...

    Abstract Mesenchymal stromal or stem cells (MSCs) are one of the most promising candidates for a myriad of cell therapy applications. Despite showing promise in numerous preclinical and clinical studies, MSC-based therapy is not yet a reality for regenerative medicine due to its suboptimal outcome at the clinical endpoint. The mechanical environment is a critical determinant of MSC gene expression and function. This study reports that MSC population becomes phenotypically heterogenous and commits to an unwanted osteoprogenitor pathway when it experiences an abnormal mechanically stiff environment, compared to its native softer environment. A method is developed to measure the heterogeneity using nuclear shape, chromatin state, and CD73 marker. Heterogeneity is shown to be associated with a larger spread in the nuclear shape parameters and a smaller spread in the chromatin openness. Subsequently, intervention strategies are investigated to create a more homogeneous MSC population. Culturing MSCs on soft surfaces or inhibiting actomyosin on stiff surfaces can make them more homogeneous, while inhibiting YAP, Runx2, and actin polymerization helps maintain but does not fully homogenize them. This study offers insights for cell and tissue engineers, aiding in the design of optimal conditions and materials for MSC culture, ultimately enhancing their therapeutic potential.
    MeSH term(s) Mesenchymal Stem Cells/metabolism ; Tissue Engineering ; Regenerative Medicine ; Chromatin/metabolism
    Chemical Substances Chromatin
    Language English
    Publishing date 2023-10-15
    Publishing country Germany
    Document type Journal Article
    ISSN 2701-0198
    ISSN (online) 2701-0198
    DOI 10.1002/adbi.202300318
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  6. Book ; Online ; E-Book: Thomas' hematopoietic cell transplantation

    Appelbaum, Frederick R. / Forman, Stephen J. / Negrin, Robert S. / Antin, Joseph H.

    stem cell transplantation

    2016  

    Title variant Hematopoietic cell transplantation
    Author's details edited by Frederick R. Appelbaum, Stephen J. Forman, Robert S. Negrin, Joseph H. Antin
    Keywords Hematopoietic Stem Cell Transplantation ; Transplantation Immunology
    Language English
    Dates of publication 2016-9999
    Size 1 Online-Ressource (xxxi, 1342 Seiten)
    Edition Fifth edition
    Publisher Wiley-Blackwell
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Note 2 bibliografische Bände in einer Online-Ressource
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT018975694
    ISBN 978-1-118-41612-9 ; 9781118416006 ; 1-118-41612-0 ; 1118416007
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  7. Article ; Online: Feasibility and preliminary efficacy of the Balance Program to reduce pain-related disability in pediatric sickle cell disease.

    Connolly, Megan E / Forman, Sydney / Sharkey, Christina M / Merwin, Stephanie / Darbari, Deepika S / Hardy, Steven J

    Pediatric blood & cancer

    2023  Volume 70, Issue 12, Page(s) e30667

    Abstract: Background: Sickle cell disease (SCD) pain is associated with functional impairment, and treatment is often limited to pharmacological approaches with unwanted side effects. Although behavioral interventions exist for non-SCD pain populations, ... ...

    Abstract Background: Sickle cell disease (SCD) pain is associated with functional impairment, and treatment is often limited to pharmacological approaches with unwanted side effects. Although behavioral interventions exist for non-SCD pain populations, interventions designed to address pain-related impairment in SCD are lacking.
    Methods: Twenty youth (9-17 years) with SCD completed a four-week telemedicine pain intervention (NCT04388241). Participants and caregivers completed baseline and post-intervention PROMIS pain measures and the Treatment Evaluation Inventory-Short Form (TEI-SF). Descriptive analyses assessed feasibility and acceptability. Reliable Change Index analyses assessed for significant post-intervention changes in pain functioning. Paired t test analyses compared baseline and post-intervention opioid prescription fills.
    Results: All participants completed at least one treatment session. Eighteen (90%) youth completed all sessions. Youth (100%) and caregivers (94%) rated the intervention as moderately or highly acceptable on the TEI-SF. Forty-seven percent of caregivers and 44% of youth reported reliably significant improvements in pain interference after the intervention (median T-score differences: 24.8 and 23.5, respectively). Sixty-five percent of caregivers (T-score improvement difference: 19.3) and 31% of youth (T-score improvement difference: 32) reported improvements in pain behaviors. There was no significant difference in opioid prescription fills pre- and post-intervention (P > 0.05).
    Conclusions: The Balance Program is feasible, highly acceptable, and can be delivered remotely to reduce barriers to care. Approximately half of youth and caregivers reported significant declines in pain interference following the intervention, with substantial improvements in functioning for treatment responders. Behavioral pain interventions are important adjunctive treatments to uniquely address functional impairment associated with acute and chronic pain in SCD.
    Language English
    Publishing date 2023-09-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.30667
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    Zs.A 1131: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: Development and Validation of an Automated Robotic System for Preparation of Embryo Culture Dishes.

    Lattin, Miriam Temmeh / Djandji, Alexandre S / Kronfeld, Matan T / Samsel, Tara / Ling, Ruifeng / Ciskanik, Martin / Sadowy, Sasha / Forman, Eric J / Williams, Zev

    Fertility and sterility

    2024  

    Abstract: Objective: To study the development and clinical validation of the ART Pipetting Robot for the IVF Laboratory (APRIL), a liquid-handling robot customized for the precise preparation of microdroplet culture dishes in the field of in vitro fertilization ( ... ...

    Abstract Objective: To study the development and clinical validation of the ART Pipetting Robot for the IVF Laboratory (APRIL), a liquid-handling robot customized for the precise preparation of microdroplet culture dishes in the field of in vitro fertilization (IVF).
    Design: A prospective randomized study conducted at an academic IVF center comparing mouse and human embryo outcomes and quantitative measures of accuracy in embryo dishes prepared using APRIL compared with standard manual preparation.
    Subjects: The study involved the assessment of the automated culture dish preparation system, APRIL, compared to manual preparation methods in the context of IVF.
    Exposure: APRIL, an enclosed liquid-handling robot equipped with custom 3D-printed adapters and designed to dispense embryo culture media and mineral oil into microdroplet culture dishes.
    Main outcome measures: The study evaluated the precision and consistency of APRIL in culture dish preparation looking at droplet mass, pH of prepared media droplets, and mouse and human embryo development rates. Clinical implementation was assessed by comparing embryo development and outcomes in dishes prepared by APRIL and human embryologists.
    Results: Compared with embryo culture dishes prepared using standard manual procedures, embryo culture dishes prepared using APRIL demonstrated a greater than ten-fold improvement in consistence (CV 0.46% vs. 6-7%), maintained optimal pH levels (pH range 7.281-7.33 vs 7.275-7.311), and had a greater mouse embryo blastocyst rate (100% vs 90-91%). Human embryos cultured in dishes prepared by APRIL had a higher rate of development to Day 3 (92.4% vs. 82.6%, p<0.05) and Day 5 (19.75% vs. 15.57%) and a total number of usable embryos (50.3% vs. 46.1%) compared with manually prepared dishes, though the last two outcomes did not reach statistical significance.
    Conclusion: The results suggest that the use of an automated robotic system for preparation of embryo culture dishes may improve accuracy and outcome measures while reducing the need for trained laboratory personnel to manually prepare the dishes.
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80133-1
    ISSN 1556-5653 ; 0015-0282
    ISSN (online) 1556-5653
    ISSN 0015-0282
    DOI 10.1016/j.fertnstert.2024.04.016
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  9. Article ; Online: An ounce of preimplantation prevention.

    Karipcin, Sinem / Forman, Eric J

    Fertility and sterility

    2020  Volume 114, Issue 4, Page(s) 759

    MeSH term(s) Genetic Testing ; Humans
    Language English
    Publishing date 2020-10-12
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80133-1
    ISSN 1556-5653 ; 0015-0282
    ISSN (online) 1556-5653
    ISSN 0015-0282
    DOI 10.1016/j.fertnstert.2020.08.1403
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  10. Article ; Online: Mentoring from the diverse lens of epidemiologists reveals a dynamic and mutually rewarding relationship.

    Forman, M R / Wright, J L / Waring, S C / Liese, A D

    Annals of epidemiology

    2021  Volume 60, Page(s) 28–30

    MeSH term(s) Career Choice ; Epidemiologists ; Humans ; Mentoring ; Mentors
    Language English
    Publishing date 2021-05-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1074355-8
    ISSN 1873-2585 ; 1047-2797
    ISSN (online) 1873-2585
    ISSN 1047-2797
    DOI 10.1016/j.annepidem.2021.04.013
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