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Article ; Online: Leadership of Black Women Faculty in Otolaryngology-More than A Rounding Error.

Flanary, Valerie / Jefferson, Gina D / Brown, David J / Arosarena, Oneida A / Brenner, Michael J / Cabrera-Muffly, Cristina / Cannon, Trinitia Y / Faucett, Erynne A / Francis, Carrie L / Harvey, Erin / Johnson, Romaine F / Loyo, Myriam / Nance, Melonie A / Vinson, Kimberly N / Thompson, Dana M

The Laryngoscope

2023 Volume 133, Issue 5, Page(s) E36–E37

MeSH term(s)	Female ; Humans ; Black People ; Faculty, Medical ; Leadership ; Minority Groups ; Otolaryngology
Language	English
Publishing date	2023-01-10
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1002/lary.30552
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Article ; Online: Considerations for Racial Diversity in the Cardiology Workforce in the United States of America.

Johnson, Amber E / Birru Talabi, Mehret / Bonifacino, Eliana / Culyba, Alison J / Jonassaint, Naudia L / Nance, Melonie A / Napoé, G Sarah / Olafiranye, Oladipupo / Owusu-Ansah, Sylvia / Suber, Tomeka L

Journal of the American College of Cardiology

2021 Volume 77, Issue 15, Page(s) 1934–1937

MeSH term(s)	Cardiology/statistics & numerical data ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/ethnology ; Cardiovascular Diseases/therapy ; Continental Population Groups/statistics & numerical data ; Cultural Competency ; Cultural Diversity ; Ethnic Groups/statistics & numerical data ; Health Workforce/statistics & numerical data ; Humans ; Population Groups/statistics & numerical data ; United States/epidemiology
Language	English
Publishing date	2021-04-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2021.02.043
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Zs.A 1846: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Response to Neoadjuvant Targeted Therapy in Operable Head and Neck Cancer Confers Survival Benefit.

Mascarella, Marco A / Olonisakin, Tolani F / Rumde, Purva / Vendra, Varun / Nance, Melonie A / Kim, Seungwon / Kubik, Mark W / Sridharan, Shaum S / Ferris, Robert L / Fenton, Moon J / Clayburgh, Daniel R / Ohr, James P / Joyce, Sonali C / Sen, Malabika / Herman, James G / Grandis, Jennifer R / Zandberg, Dan P / Duvvuri, Umamaheswar

Clinical cancer research : an official journal of the American Association for Cancer Research

2023 Volume 29, Issue 4, Page(s) 723–730

Abstract: Purpose: Neoadjuvant targeted therapy provides a brief, preoperative window of opportunity that can be exploited to individualize cancer care based on treatment response. We investigated whether response to neoadjuvant therapy during the preoperative ... ...

Abstract	Purpose: Neoadjuvant targeted therapy provides a brief, preoperative window of opportunity that can be exploited to individualize cancer care based on treatment response. We investigated whether response to neoadjuvant therapy during the preoperative window confers survival benefit in patients with operable head and neck squamous cell carcinoma (HNSCC). Patients and methods: A pooled analysis of treatment-naïve patients with operable HNSCC enrolled in one of three clinical trials from 2009 to 2020 (NCT00779389, NCT01218048, NCT02473731). Neoadjuvant regimens consisted of EGFR inhibitors (n = 83) or anti-ErbB3 antibody therapy (n = 9) within 28 days of surgery. Clinical to pathologic stage migration was compared with disease-free survival (DFS) and overall survival (OS) while adjusting for confounding factors using multivariable Cox regression. Circulating tumor markers validated in other solid tumor models were analyzed. Results: 92 of 118 patients were analyzed; all patients underwent surgery following neoadjuvant therapy. Clinical to pathologic downstaging was more frequent in patients undergoing neoadjuvant targeted therapy compared with control cohort (P = 0.048). Patients with pathologic downstage migration had the highest OS [89.5%; 95% confidence interval (CI), 75.7-100] compared with those with no stage change (58%; 95% CI, 46.2-69.8) or upstage (40%; 95% CI, 9.6-70.4; P = 0.003). Downstage migration remained a positive prognostic factor for OS (HR, 0.22; 95% CI, 0.05-0.90) while adjusting for measured confounders. Downstage migration correlated with decreased circulating tumor markers, SOX17 and TAC1 (P = 0.0078). Conclusions: Brief neoadjuvant therapy achieved pathologic downstaging in a subset of patients and was associated with significantly better DFS and OS as well as decreased circulating methylated SOX17 and TAC1.
MeSH term(s)	Humans ; Neoadjuvant Therapy ; Squamous Cell Carcinoma of Head and Neck/drug therapy ; Head and Neck Neoplasms/drug therapy ; Disease-Free Survival ; Biomarkers, Tumor
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2023-01-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1225457-5
ISSN	1557-3265 ; 1078-0432
ISSN (online)	1557-3265
ISSN	1078-0432
DOI	10.1158/1078-0432.CCR-22-1768
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Article ; Online: Feasibility of clinical evaluation of individuals with increased risk for HPV-associated oropharynx cancer.

Scott-Wittenborn, Nicholas / D'Souza, Gypsyamber / Aygun, Nafi / Tewari, Sakshi R / Azadi, Javad / Vosler, Peter / Gooi, Zhen / Mehta, Vikas / Mydlarz, Wojciech / Nance, Melonie / Mlot, Stefan / Patel, Mihir R / Tan, Marietta / Miles, Brett A / Troy, Tanya / Fakhry, Carole

Head & neck

2022 Volume 45, Issue 1, Page(s) 95–102

Abstract: Background: Human papillomavirus-associated oropharynx squamous cell carcinoma (HPV-OPSCC) has no known pre-malignant lesion. While vaccination offers future primary prevention, there is current interest in secondary prevention. The feasibility of ... ...

Abstract	Background: Human papillomavirus-associated oropharynx squamous cell carcinoma (HPV-OPSCC) has no known pre-malignant lesion. While vaccination offers future primary prevention, there is current interest in secondary prevention. The feasibility of clinical evaluation of individuals at increased risk for HPV-OPSCC is unclear. Methods: Individuals with risk factors for HPV-OPSCC were enrolled in a prospective study (MOUTH). Participants positive for biomarkers associated with HPV-OPSCC were eligible for a clinical evaluation which comprised a head and neck examination and imaging with ultrasound and/or magnetic resonance imaging (MRI). This study was designed to evaluate feasibility of clinical evaluation in a screening study. Results: Three hundred and eighty-four participants were eligible for clinical evaluation. Of the 384, 204 (53%) completed a head and neck examination or imaging. Of these, 66 (32%) completed MRI (n = 51) and/or ultrasound (n = 64) studies. Conclusions: Clinical evaluations, including head and neck examination and imaging, are feasible in the context of a screening study for HPV-OPSCC.
MeSH term(s)	Humans ; Papillomavirus Infections/complications ; Papillomaviridae ; Prospective Studies ; Carcinoma, Squamous Cell/pathology ; Oropharyngeal Neoplasms/pathology ; Squamous Cell Carcinoma of Head and Neck/complications ; Head and Neck Neoplasms/diagnostic imaging ; Head and Neck Neoplasms/complications ; Human Papillomavirus Viruses
Language	English
Publishing date	2022-10-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	645165-2
ISSN	1097-0347 ; 0148-6403 ; 1043-3074
ISSN (online)	1097-0347
ISSN	0148-6403 ; 1043-3074
DOI	10.1002/hed.27212
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Article ; Online: The ATR inhibitor ceralasertib potentiates cancer checkpoint immunotherapy by regulating the tumor microenvironment.

Hardaker, Elizabeth L / Sanseviero, Emilio / Karmokar, Ankur / Taylor, Devon / Milo, Marta / Michaloglou, Chrysis / Hughes, Adina / Mai, Mimi / King, Matthew / Solanki, Anisha / Magiera, Lukasz / Miragaia, Ricardo / Kar, Gozde / Standifer, Nathan / Surace, Michael / Gill, Shaan / Peter, Alison / Talbot, Sara / Tohumeken, Sehmus /

Fryer, Henderson / Mostafa, Ali / Mulgrew, Kathy / Lam, Carolyn / Hoffmann, Scott / Sutton, Daniel / Carnevalli, Larissa / Calero-Nieto, Fernando J / Jones, Gemma N / Pierce, Andrew J / Wilson, Zena / Campbell, David / Nyoni, Lynet / Martins, Carla P / Baker, Tamara / Serrano de Almeida, Gilberto / Ramlaoui, Zainab / Bidar, Abdel / Phillips, Benjamin / Boland, Joseph / Iyer, Sonia / Barrett, J Carl / Loembé, Arsene-Bienvenu / Fuchs, Serge Y / Duvvuri, Umamaheswar / Lou, Pei-Jen / Nance, Melonie A / Gomez Roca, Carlos Alberto / Cadogan, Elaine / Critichlow, Susan E / Fawell, Steven / Cobbold, Mark / Dean, Emma / Valge-Archer, Viia / Lau, Alan / Gabrilovich, Dmitry I / Barry, Simon T

Nature communications

2024 Volume 15, Issue 1, Page(s) 1700

Abstract: The Ataxia telangiectasia and Rad3-related (ATR) inhibitor ceralasertib in combination with the PD-L1 antibody durvalumab demonstrated encouraging clinical benefit in melanoma and lung cancer patients who progressed on immunotherapy. Here we show that ... ...

Abstract	The Ataxia telangiectasia and Rad3-related (ATR) inhibitor ceralasertib in combination with the PD-L1 antibody durvalumab demonstrated encouraging clinical benefit in melanoma and lung cancer patients who progressed on immunotherapy. Here we show that modelling of intermittent ceralasertib treatment in mouse tumor models reveals CD8
MeSH term(s)	Humans ; Animals ; Mice ; CD8-Positive T-Lymphocytes ; B7-H1 Antigen ; Tumor Microenvironment ; Cell Line, Tumor ; Immunotherapy ; Disease Models, Animal ; Neoplasms ; Ataxia Telangiectasia Mutated Proteins ; Indoles ; Morpholines ; Pyrimidines ; Sulfonamides
Chemical Substances	ceralasertib (85RE35306Z) ; B7-H1 Antigen ; ATR protein, human (EC 2.7.11.1) ; Ataxia Telangiectasia Mutated Proteins (EC 2.7.11.1) ; Indoles ; Morpholines ; Pyrimidines ; Sulfonamides
Language	English
Publishing date	2024-02-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-45996-4
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Article ; Online: Racial Diversity Among American Cardiologists: Implications for the Past, Present, and Future.

Johnson, Amber E / Talabi, Mehret Birru / Bonifacino, Eliana / Culyba, Alison J / Davis, Esa M / Davis, Paula K / De Castro, Laura M / Essien, Utibe R / Maria Gonzaga, Alda / Hogan, MaCalus V / James, Alaina J / Jonassaint, Charles R / Jonassaint, Naudia L / Matheo, Loreta / Nance, Melonie A / Napoé, G Sarah / Olafiranye, Oladipupo / Owusu-Ansah, Sylvia / Pierson-Brown, Tomar N /

Conrad Smith, A J / Suber, Tomeka L / Torres, Orquidia / Tripp, Rickquel / Ufomata, Eloho / Wilson, J Deanna / South-Paul, Jeannette E

Circulation

2021 Volume 143, Issue 24, Page(s) 2395–2405

Abstract: In the United States, race-based disparities in cardiovascular disease care have proven to be pervasive, deadly, and expensive. African American/Black, Hispanic/Latinx, and Native/Indigenous American individuals are at an increased risk of cardiovascular ...

Abstract	In the United States, race-based disparities in cardiovascular disease care have proven to be pervasive, deadly, and expensive. African American/Black, Hispanic/Latinx, and Native/Indigenous American individuals are at an increased risk of cardiovascular disease and are less likely to receive high-quality, evidence-based medical care as compared with their White American counterparts. Although the United States population is diverse, the cardiovascular workforce that provides its much-needed care lacks diversity. The available data show that care provided by physicians from racially diverse backgrounds is associated with better quality, both for minoritized patients and for majority patients. Not only is cardiovascular workforce diversity associated with improvements in health care quality, but racial diversity among academic teams and research scientists is linked with research quality. We outline documented barriers to achieving workforce diversity and suggest evidence-based strategies to overcome these barriers. Key strategies to enhance racial diversity in cardiology include improving recruitment and retention of racially diverse members of the cardiology workforce and focusing on cardiovascular health equity for patients. This review draws attention to academic institutions, but the implications should be considered relevant for nonacademic and community settings as well.
MeSH term(s)	Cardiologists/statistics & numerical data ; Female ; Health Equity ; Humans ; Male ; Racial Groups ; United States ; Workforce
Language	English
Publishing date	2021-06-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	80099-5
ISSN	1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
ISSN (online)	1524-4539
ISSN	0009-7322 ; 0069-4193 ; 0065-8499
DOI	10.1161/CIRCULATIONAHA.121.053566
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Article ; Online: A new paradigm for the diagnosis and management of unknown primary tumors of the head and neck: a role for transoral robotic surgery.

Mehta, Vikas / Johnson, Paul / Tassler, Andrew / Kim, Seungwon / Ferris, Robert L / Nance, Melonie / Johnson, Jonas T / Duvvuri, Umamaheswar

The Laryngoscope

2013 Volume 123, Issue 1, Page(s) 146–151

Abstract: Objectives/hypothesis: In 2% to 3% of patients with cancer metastatic to cervical lymph nodes, a primary tumor will not be found despite exhaustive diagnostic efforts. The treatment for these patients includes cervical lymphadenectomy followed by ... ...

Abstract	Objectives/hypothesis: In 2% to 3% of patients with cancer metastatic to cervical lymph nodes, a primary tumor will not be found despite exhaustive diagnostic efforts. The treatment for these patients includes cervical lymphadenectomy followed by radiation to areas with increased risk of harboring a mucosal primary. Wide-field radiation therapy increases the incidence of xerostomia and dysphagia. Localizing a primary tumor has thus both therapeutic and quality-of-life implications, allowing possible complete surgical excision, concentrated radiation therapy, and potential deintensification of adjuvant therapy. With improved visualization and freedom of motion, transoral robotic surgery (TORS) is an innovative surgical modality that allows resection of oropharyngeal subsites with minimal morbidity. Study design: Retrospective chart review. Methods: Ten patients with unknown primary tumors of the head and neck were identified. All patients underwent a cervical biopsy, positron-emission tomography/computed tomography, formal endoscopy, and bilateral tonsillectomy. When the initial endoscopy and biopsies did not localize a primary tumor, all patients underwent transoral robotic base of tongue resection. Results: Evaluation of the patients' oropharyngeal mucosa using the robot did not reveal an obvious lesion and no palpable tumors were appreciated in the resected specimens. In 9/10 (90%) patients, pathologic examination revealed invasive squamous cell carcinoma (SCCA) with a mean diameter of 0.9 cm. Conclusions: Unknown primary SCCA presents a diagnostic challenge to the head and neck surgeon. We present a small series of tumors that would have been treated as unknown primaries under traditional diagnostic and therapeutic algorithms. TORS base of tongue resection identified primary tumors in 90% patients with minimal morbidity.
MeSH term(s)	Adult ; Aged ; Biopsy ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/surgery ; Combined Modality Therapy ; Female ; Head and Neck Neoplasms/diagnosis ; Head and Neck Neoplasms/pathology ; Head and Neck Neoplasms/surgery ; Humans ; Lymph Nodes/pathology ; Lymph Nodes/surgery ; Lymphatic Metastasis/pathology ; Male ; Middle Aged ; Multimodal Imaging ; Neoplasms, Unknown Primary/diagnosis ; Neoplasms, Unknown Primary/pathology ; Neoplasms, Unknown Primary/surgery ; Positron-Emission Tomography ; Retrospective Studies ; Robotics/methods ; Tomography, X-Ray Computed ; Tongue/surgery
Language	English
Publishing date	2013-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1002/lary.23562
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Article ; Online: Characteristics of participants in a free oral, head and neck cancer screening program.

Gourin, Christine G / Kaboli, Kavon C / Blume, Erin J / Nance, Melonie A / Koch, Wayne M

The Laryngoscope

2009 Volume 119, Issue 4, Page(s) 679–682

Abstract: Objective: Early detection of head and neck cancer is associated with improved survival. It is unclear if screening programs successfully target high-risk populations. We sought to determine the characteristics of participants presenting for a free oral, ...

Abstract	Objective: Early detection of head and neck cancer is associated with improved survival. It is unclear if screening programs successfully target high-risk populations. We sought to determine the characteristics of participants presenting for a free oral, head and neck cancer screening. Materials and methods: Prospective analysis of 89 participants in a one-day, free oral, head, and neck cancer screening. Results: The majority of participants were female (57%) and not tobacco users (71%) with a mean age of 56 years (range, 23-83). Symptoms associated with head and neck cancer were reported by 59 participants (66%), but only 31 (35%) were aware of an association between symptoms and head and neck cancer. There was no correlation between symptom prevalence and exam findings (r = 0.1161). Ten participants (11%) had findings concerning for neoplasia and were referred for immediate consultation. Demographically, 64 (72%) of participants had attended college and 51 (57%) earned an annual income greater then $30,000. The majority of participants (85%) believed that screening increased their awareness and knowledge of oral and head and neck cancer. Conclusions: Free oral, head and neck cancer screenings increase awareness of oral and head and neck cancer and identify a subset of individuals requiring further evaluation. However, participants do not share characteristics of the population at greatest risk for the development of head and neck cancer based on risk factors and socioeconomic status. These findings suggest that early detection efforts need to be designed to target high-risk populations.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Alcohol Drinking/epidemiology ; Communications Media ; Comorbidity ; Early Detection of Cancer ; Educational Status ; Female ; Head and Neck Neoplasms/diagnosis ; Head and Neck Neoplasms/epidemiology ; Head and Neck Neoplasms/prevention & control ; Health Knowledge, Attitudes, Practice ; Health Promotion/methods ; Health Promotion/organization & administration ; Humans ; Male ; Mass Screening/statistics & numerical data ; Middle Aged ; Patient Selection ; Prevalence ; Program Development ; Program Evaluation ; Prospective Studies ; Risk Assessment ; Sex Distribution ; Smoking/epidemiology ; Socioeconomic Factors ; United States/epidemiology
Language	English
Publishing date	2009-04
Publishing country	United States
Document type	Evaluation Studies ; Journal Article
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1002/lary.20093
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Article ; Online: Molecular (SNP) analyses of overlapping hemizygous deletions of 10q25.3 to 10qter in four patients: evidence for HMX2 and HMX3 as candidate genes in hearing and vestibular function.

Miller, Nathaniel D / Nance, Melonie A / Wohler, Elizabeth S / Hoover-Fong, Julie E / Lisi, Emily / Thomas, George H / Pevsner, Jonathan

American journal of medical genetics. Part A

2009 Volume 149A, Issue 4, Page(s) 669–680

Abstract: We report on the analyses of four unrelated patients with de novo, overlapping, hemizygous deletions of the long arm of chromosome 10. These include two small terminal deletions (10q26.2 to 10qter), a larger terminal deletion (10q26.12 to 10qter), and an ...

Abstract	We report on the analyses of four unrelated patients with de novo, overlapping, hemizygous deletions of the long arm of chromosome 10. These include two small terminal deletions (10q26.2 to 10qter), a larger terminal deletion (10q26.12 to 10qter), and an interstitial deletion (10q25.3q26.13). Single nucleotide polymorphism (SNP) studies (Illumina 550 K) established that these deletions resulted in the hemizygous loss of approximately 6.1, approximately 6.1, approximately 12.5, and approximately 7.0 Mb respectively. Additionally, these data establish that Patients 1, 2, and 3 share common, distal, hemizygous deleted regions of 6.09 Mb containing 37 RefSeq genes. Patients 3 and 4 share a 2.52 Mb deleted region corresponding to the proximal deleted region of Patient 3 and the distal deleted region of Patient 4. This common, hemizygous region contains 20 RefSeq genes including two H6 family homeobox genes (HMX2 and HMX3). Based on previous reports that Hmx2/Hmx3 knockout mice have vestibular anomalies, we propose that hemizygous deletions of HMX2 and HMX3 are responsible for the inner ear malformations observed from CT images, vestibular dysfunction, and congenital sensorineural hearing loss found in Patients 3 and 4.
MeSH term(s)	Child, Preschool ; Chromosome Deletion ; Chromosomes, Human, Pair 10/genetics ; Ear, Inner/abnormalities ; Ear, Inner/diagnostic imaging ; Female ; Genes, Homeobox ; Hearing Loss, Sensorineural/genetics ; Hearing Loss, Sensorineural/pathology ; Hearing Loss, Sensorineural/physiopathology ; Humans ; In Situ Hybridization, Fluorescence ; Infant ; Karyotyping ; Male ; Polymorphism, Single Nucleotide ; Tomography, X-Ray Computed ; Vestibule, Labyrinth/physiopathology
Language	English
Publishing date	2009-02-27
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2108614-X
ISSN	1552-4833 ; 0148-7299 ; 1552-4825
ISSN (online)	1552-4833
ISSN	0148-7299 ; 1552-4825
DOI	10.1002/ajmg.a.32705
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Article: Treatment and survival outcomes based on histologic grading in patients with head and neck mucoepidermoid carcinoma.

Nance, Melonie A / Seethala, Raja R / Wang, Yun / Chiosea, Simion I / Myers, Eugene N / Johnson, Jonas T / Lai, Stephen Y

Cancer

2008 Volume 113, Issue 8, Page(s) 2082–2089

Abstract: Background: Histopathologic grade of mucoepidermoid carcinoma (MEC) is an established predictor of prognosis and affects treatment protocol. Tumor behavior is more aggressive in high-grade than in low-grade MEC, leading to a more intensive treatment ... ...

Abstract	Background: Histopathologic grade of mucoepidermoid carcinoma (MEC) is an established predictor of prognosis and affects treatment protocol. Tumor behavior is more aggressive in high-grade than in low-grade MEC, leading to a more intensive treatment protocol. Outcomes for patients with intermediate-grade MEC are less clear; therefore, the optimal treatment protocol for this group is not well defined. The treatment protocol and survival outcomes of patients treated for MEC of the head and neck was investigated. Methods: A retrospective clinical review and prospective review of histopathologic grading were undertaken using the most recently established grading system of 50 patients with MEC of the head and neck from 1983 through 2004. Results: As histologic grade increased from low to intermediate to high, overall survival (P < .0001) and disease-free survival (P < .001) were significantly decreased. Overall and disease-free survival were significantly better for patients with intermediate-grade MEC than those with high-grade disease. Overall and disease-free survival were similar for patients with low-grade and intermediate-grade MEC. There was a low rate of disease recurrence in patients with intermediate-grade MEC, but this did not lead to death from disease. Although no patients with low-grade or intermediate-grade MEC died of disease, 52% of patients with high-grade MEC died of disease. Multivariate analysis revealed that histologic grade, age, and surgical margin status significantly predicted prognosis. Conclusions: These findings suggest that, under the current histopathologic classification system, the behavior of intermediate-grade MEC is comparable to that of low-grade MEC and different from high-grade MEC, allowing for the establishment of an evidence-based treatment protocol.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Carcinoma, Mucoepidermoid/mortality ; Carcinoma, Mucoepidermoid/pathology ; Carcinoma, Mucoepidermoid/therapy ; Combined Modality Therapy ; Disease-Free Survival ; Female ; Head and Neck Neoplasms/mortality ; Head and Neck Neoplasms/pathology ; Head and Neck Neoplasms/therapy ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Prognosis ; Radiotherapy ; Retrospective Studies ; Surgical Procedures, Operative
Language	English
Publishing date	2008-08-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1429-1
ISSN	1097-0142 ; 0008-543X ; 1934-662X
ISSN (online)	1097-0142
ISSN	0008-543X ; 1934-662X
DOI	10.1002/cncr.23825
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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito