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  1. Article ; Online: Editorial: Molecular pathogenesis and control of viral infectious diseases in children.

    Cao, Jiali / Shen, Chenguang / He, Wanting

    Frontiers in cellular and infection microbiology

    2024  Volume 14, Page(s) 1368324

    MeSH term(s) Child ; Humans ; Communicable Diseases ; Diarrhea/pathology
    Language English
    Publishing date 2024-02-02
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2024.1368324
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Facile wound dressing replacement: Carbon dots for dissolving alginate hydrogels via competitive complexation.

    Li, Qian / Shen, Xin / Liu, Chenguang / Xing, Dongming

    International journal of biological macromolecules

    2023  Volume 240, Page(s) 124455

    Abstract: Dissolvable hydrogels have shown great potentials in removing the exudes and alleviating pain during wound dressing replacement. Herein, a series of carbon dots (CDs) composing high complexation ability with ... ...

    Abstract Dissolvable hydrogels have shown great potentials in removing the exudes and alleviating pain during wound dressing replacement. Herein, a series of carbon dots (CDs) composing high complexation ability with Cu
    MeSH term(s) Hydrogels ; Alginates ; Lysine ; Bandages ; Wound Healing
    Chemical Substances Hydrogels ; Alginates ; Lysine (K3Z4F929H6)
    Language English
    Publishing date 2023-04-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.124455
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Status and Developing Strategies for Neutralizing Monoclonal Antibody Therapy in the Omicron Era of COVID-19.

    Ren, Zuning / Shen, Chenguang / Peng, Jie

    Viruses

    2023  Volume 15, Issue 6

    Abstract: The monoclonal antibody (mAb)-based treatment is a highly valued therapy against COVID-19, especially for individuals who may not have strong immune responses to the vaccine. However, with the arrival of the Omicron variant and its evolving subvariants, ... ...

    Abstract The monoclonal antibody (mAb)-based treatment is a highly valued therapy against COVID-19, especially for individuals who may not have strong immune responses to the vaccine. However, with the arrival of the Omicron variant and its evolving subvariants, along with the occurrence of remarkable resistance of these SARS-CoV-2 variants to the neutralizing antibodies, mAbs are facing tough challenges. Future strategies for developing mAbs with improved resistance to viral evasion will involve optimizing the targeting epitopes on SARS-CoV-2, enhancing the affinity and potency of mAbs, exploring the use of non-neutralizing antibodies that bind to conserved epitopes on the S protein, as well as optimizing immunization regimens. These approaches can improve the viability of mAb therapy in the fight against the evolving threat of the coronavirus.
    MeSH term(s) Humans ; COVID-19/therapy ; SARS-CoV-2 ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Neutralizing/therapeutic use ; Epitopes ; Spike Glycoprotein, Coronavirus ; Antibodies, Viral/therapeutic use
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Neutralizing ; Epitopes ; Spike Glycoprotein, Coronavirus ; Antibodies, Viral ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2023-05-31
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15061297
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Seamless MEMS-INS/Geomagnetic Navigation System Based on Deep-Learning Strong Tracking Square-Root Cubature Kalman Filter.

    Zhao, Tianshang / Wang, Chenguang / Shen, Chong

    Micromachines

    2023  Volume 14, Issue 10

    Abstract: To suppress inertial navigation system drift and improve the seamless navigation capability of microelectromechanical system-inertial navigation systems/geomagnetic navigation systems (MEMS-INS/MNS) in geomagnetically unlocked environments, this paper ... ...

    Abstract To suppress inertial navigation system drift and improve the seamless navigation capability of microelectromechanical system-inertial navigation systems/geomagnetic navigation systems (MEMS-INS/MNS) in geomagnetically unlocked environments, this paper proposes a hybrid seamless MEMS-INS/MNS strategy combining a strongly tracked square-root cubature Kalman filter with deep self-learning (DSL-STSRCKF). The proposed DSL-STSRCKF method consists of two innovative steps: (i) The relationship between the deep Kalman filter gain and the optimal estimation is established. In this paper, combining the two auxiliary methods of strong tracking filtering and square-root filtering based on singular value decomposition, the heading accuracy error of ST-SRCKF can reach 1.29°, which improves the heading accuracy by 90.10% and 9.20% compared to the traditional single INS and the traditional integrated navigation algorithm and greatly improves the robustness and computational efficiency. (ii) Providing deep self-learning capability for the ST-SRCKF by introducing a nonlinear autoregressive neural network (NARX) with exogenous inputs, which means that the heading accuracy can still reach 1.33° even during the MNS lockout period, and the heading accuracy can be improved by 89.80% compared with the single INS, realizing the continuous high-precision navigation estimation.
    Language English
    Publishing date 2023-10-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi14101935
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Nighttime bionic compass based on a short-wave infrared polarization sensing system.

    Lu, Yiming / Liu, Xiaojie / Cao, Huiliang / Wang, Chenguang / Shen, Chong / Tang, Jun / Liu, Jun

    Applied optics

    2024  Volume 63, Issue 2, Page(s) 525–534

    Abstract: Sky-bionic polar co-ordinate navigation is an effective means of providing navigational information in the absence of a priori information. Polar co-ordinate navigation during clear daytime conditions has been studied, but there has been a lack of ... ...

    Abstract Sky-bionic polar co-ordinate navigation is an effective means of providing navigational information in the absence of a priori information. Polar co-ordinate navigation during clear daytime conditions has been studied, but there has been a lack of research of it at night due to problems with noise. Therefore, in this paper, a short-wave infrared polarimetric sensor system is designed, which is capable of acquiring atmospheric polarimetric information in low illumination environments at night, compared with traditional visible band sensors. Additionally, based on the statistics of polarization angle information, an algorithm for removing noise and starlight is proposed to solve the influence of starlight and noise on the polarization information at night. After many outdoor experiments, we found that the method can output the heading angle stably and accurately, and its standard deviation is controlled to be 0.42° in a clear night.
    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4522
    ISSN (online) 1539-4522
    DOI 10.1364/AO.511496
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Seamless Micro-Electro-Mechanical System-Inertial Navigation System/Polarization Compass Navigation Method with Data and Model Dual-Driven Approach.

    Zhao, Huijun / Shen, Chong / Cao, Huiliang / Chen, Xuemei / Wang, Chenguang / Huang, Haoqian / Li, Jie

    Micromachines

    2024  Volume 15, Issue 2

    Abstract: The integration of micro-electro-mechanical system-inertial navigation systems (MEMS-INSs) with other autonomous navigation sensors, such as polarization compasses (PCs) and geomagnetic compasses, has been widely used to improve the navigation accuracy ... ...

    Abstract The integration of micro-electro-mechanical system-inertial navigation systems (MEMS-INSs) with other autonomous navigation sensors, such as polarization compasses (PCs) and geomagnetic compasses, has been widely used to improve the navigation accuracy and reliability of vehicles in Internet of Things (IoT) applications. However, a MEMS-INS/PC integrated navigation system suffers from cumulative errors and time-varying measurement noise covariance in unknown, complex occlusion, and dynamic environments. To overcome these problems and improve the integrated navigation system's performance, a dual data- and model-driven MEMS-INS/PC seamless navigation method is proposed. This system uses a nonlinear autoregressive neural network (NARX) based on the Gauss-Newton Bayesian regularization training algorithm to model the relationship between the MEMS-INS outputs composed of the specific force and angular velocity data and the PC heading's angular increment, and to fit the integrated navigation system's dynamic characteristics, thus realizing data-driven operation. In the model-driven part, a nonlinear MEMS-INS/PC loosely coupled navigation model is established, the variational Bayesian method is used to estimate the time-varying measurement noise covariance, and the cubature Kalman filter method is then used to solve the nonlinear problem in the model. The robustness and effectiveness of the proposed method are verified experimentally. The experimental results show that the proposed method can provide high-precision heading information stably in complex, occluded, and dynamic environments.
    Language English
    Publishing date 2024-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi15020237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The regulation of lncRNAs and miRNAs in SARS-CoV-2 infection.

    Lin, Yuhao / Sun, Qiqi / Zhang, Bao / Zhao, Wei / Shen, Chenguang

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1229393

    Abstract: The coronavirus disease 2019 (COVID-19) was a global endemic that continues to cause a large number of severe illnesses and fatalities. There is increasing evidence that non-coding RNAs (ncRNAs) are crucial regulators of viral infection and antiviral ... ...

    Abstract The coronavirus disease 2019 (COVID-19) was a global endemic that continues to cause a large number of severe illnesses and fatalities. There is increasing evidence that non-coding RNAs (ncRNAs) are crucial regulators of viral infection and antiviral immune response and the role of non-coding RNAs in SARS-CoV-2 infection has now become the focus of scholarly inquiry. After SARS-CoV-2 infection, some ncRNAs' expression levels are regulated to indirectly control the expression of antiviral genes and viral gene replication. However, some other ncRNAs are hijacked by SARS-CoV-2 in order to help the virus evade the immune system by suppressing the expression of type I interferon (IFN-1) and controlling cytokine levels. In this review, we summarize the recent findings of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) among non-coding RNAs in SARS-CoV-2 infection and antiviral response, discuss the potential mechanisms of actions, and prospects for the detection, treatment, prevention and future directions of SARS-CoV-2 infection research.
    Language English
    Publishing date 2023-07-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1229393
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Various mpox recombinant subunits induce broadly reactive antibodies against orthopoxvirus in mice.

    Jiang, Yushan / Ren, Zuning / Yang, Yang / Chen, Jiayin / Zhao, Wei / Peng, Jie / Shen, Chenguang

    Journal of medical virology

    2023  Volume 95, Issue 8, Page(s) e28983

    MeSH term(s) Animals ; Mice ; Orthopoxvirus/genetics ; Mpox (monkeypox) ; Communicable Diseases ; Antibodies, Viral
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2023-07-28
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.28983
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
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  9. Article ; Online: Multispectral silicon-based photodetector with stacked PN junctions.

    Wang, Chenguang / Zhao, Jiangting / Cao, Huiliang / Shen, Chong / Tang, Jun / Liu, Jun

    Optics express

    2023  Volume 31, Issue 21, Page(s) 33776–33786

    Abstract: A multispectral silicon-based photodetector structure with stacked PN junctions is proposed in this study. The substrate layer of the proposed photodetector consists of four vertically stacked PN junction structures that contain four photodiodes. The ... ...

    Abstract A multispectral silicon-based photodetector structure with stacked PN junctions is proposed in this study. The substrate layer of the proposed photodetector consists of four vertically stacked PN junction structures that contain four photodiodes. The designed structure achieves quantum efficiency of up to 70% and a response time of 5.1 × 10
    Language English
    Publishing date 2023-10-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.495874
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Facile wound dressing replacement: Carbon dots for dissolving alginate hydrogels via competitive complexation

    Li, Qian / Shen, Xin / Liu, Chenguang / Xing, Dongming

    International Journal of Biological Macromolecules. 2023 June, v. 240 p.124455-

    2023  

    Abstract: Dissolvable hydrogels have shown great potentials in removing the exudes and alleviating pain during wound dressing replacement. Herein, a series of carbon dots (CDs) composing high complexation ability with Cu²⁺ were prepared for capturing Cu²⁺ from Cu²⁺ ...

    Abstract Dissolvable hydrogels have shown great potentials in removing the exudes and alleviating pain during wound dressing replacement. Herein, a series of carbon dots (CDs) composing high complexation ability with Cu²⁺ were prepared for capturing Cu²⁺ from Cu²⁺-alginate hydrogels. CDs were prepared using biocompatible lysine as the main starting material, while ethylenediamine was chosen as the other starting material for its extremely high complexation ability with Cu²⁺. The complexation ability increased with the increasing amount of ethylenediamine, while the cell viability decreased. When the mass ratio of ethylenediamine to lysine in CDs was above 1/4, six-coordinate copper centers could be formed. CD₁/₄ at the concentration of 90 mg/mL could dissolve Cu²⁺-alginate hydrogels within 16 min, which was about twice faster than lysine. In vivo results showed the replaced hydrogels could ameliorate hypoxic conditions, alleviate local inflammatory reactions and promote the healing speed of burn wounds. Thus, the above results suggested the competitive complexation of CDs with Cu²⁺ could effectively dissolve Cu²⁺-alginate hydrogels, which have much potential in realizing facile wound dressing replacement.
    Keywords alginates ; carbon ; cell viability ; ethylenediamines ; hydrogels ; lysine ; pain ; Carbon dots ; Alginate ; Dissolvable hydrogel
    Language English
    Dates of publication 2023-06
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.124455
    Database NAL-Catalogue (AGRICOLA)

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