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  1. Article: A 52-year-old woman with beading of intracranial arteries.

    Tan, Guan Zhong / Yu, Wai Yung / Chng, Soke Miang / Lee, Hwei Yee / Lin, Xuling

    Annals of the Academy of Medicine, Singapore

    2022  Volume 51, Issue 4, Page(s) 255–258

    MeSH term(s) Arteries ; Female ; Head ; Humans ; Middle Aged
    Language English
    Publishing date 2022-05-04
    Publishing country Singapore
    Document type Case Reports ; Journal Article
    ZDB-ID 604527-3
    ISSN 0304-4602
    ISSN 0304-4602
    DOI 10.47102/annals-acadmedsg.2021314
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2420: Show issues Location:
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  2. Article ; Online: Targeted Therapies for the Treatment of Glioblastoma in Adults.

    Chuang, Ding Fang / Lin, Xuling

    Current oncology reports

    2019  Volume 21, Issue 7, Page(s) 61

    Abstract: Purpose of review: Targeted therapies are part of biomarker-driven strategies that exploit actionable molecular targets and have gained traction following survival benefits demonstrated in various systemic malignancies. In glioblastoma, where ... ...

    Abstract Purpose of review: Targeted therapies are part of biomarker-driven strategies that exploit actionable molecular targets and have gained traction following survival benefits demonstrated in various systemic malignancies. In glioblastoma, where therapeutic options remain scarce and prognosis poor, targeted therapies offer an attractive treatment alternative and are actively examined in clinical trials. In this review, we summarize the targeted therapies, including traditional small molecule inhibitors and monoclonal antibodies as well as immunotherapeutic approaches that are examined in clinical trials, and discuss the challenges of using them for the treatment of glioblastoma.
    Recent findings: Despite initial speculations, phase II/III trials of targeted therapies in adult patients with glioblastoma have largely failed. Recent trials have focused on improving patient stratification, drug-tissue penetration, and target and compensatory pathway inhibition to optimize treatment response. In contrast to traditional small molecule and monoclonal antibody therapies, cancer immunotherapy may target specific molecular or immune checkpoint target(s) to trigger immune responses against glioblastoma. Early phase clinical trials of immunotherapy have shown encouraging results, and larger randomized trials are ongoing. Targeted therapies are being actively studied in clinical trials. Patients with glioblastoma should be prioritized for clinical trial participation.
    MeSH term(s) Adult ; Antineoplastic Agents, Immunological/therapeutic use ; Biomarkers, Tumor/metabolism ; Brain Neoplasms/drug therapy ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Glioblastoma/drug therapy ; Glioblastoma/metabolism ; Glioblastoma/pathology ; Humans ; Immunotherapy/methods ; Molecular Targeted Therapy/methods ; Prognosis
    Chemical Substances Antineoplastic Agents, Immunological ; Biomarkers, Tumor
    Language English
    Publishing date 2019-05-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057359-5
    ISSN 1534-6269 ; 1523-3790
    ISSN (online) 1534-6269
    ISSN 1523-3790
    DOI 10.1007/s11912-019-0807-1
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  3. Article ; Online: Studying an off-axis optical bench for future gravity missions from the perspective of carrier-to-noise ratio.

    Peng, Bo / Wu, Kailan / Yang, Yichao / Wu, Jingui / Guo, Zhongkai / Wang, Yun / Zheng, Yongchao / Lin, Xuling

    Optics express

    2023  Volume 31, Issue 9, Page(s) 13751–13762

    Abstract: The inter-satellite laser ranging heterodyne interferometer is vital for future gravity missions to achieve high ranging accuracy. This paper proposes a novel off-axis optical bench design which integrates merits of the off-axis optical bench design of ... ...

    Abstract The inter-satellite laser ranging heterodyne interferometer is vital for future gravity missions to achieve high ranging accuracy. This paper proposes a novel off-axis optical bench design which integrates merits of the off-axis optical bench design of GRACE Follow-On mission and other on-axis designs. This design makes use of lens systems subtly to restrict the tilt-to-length coupling noise and takes advantage of the DWS feedback loop to maintain the transmitting beam and receiving beam anti-parallel. The critical parameters of the optical components are determined and the carrier-to-noise ratio for a single channel of the photoreceiver is calculated to be more than 100 dB-Hz for the high case. The off-axis optical bench design is a potential candidate for China's future gravity missions.
    Language English
    Publishing date 2023-05-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.485096
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  4. Article: Recent Advances in Alkali-Activated Materials with Seawater and Sea Sand.

    Sun, Zengqing / Li, Xiaoyu / Liu, Qingsong / Tang, Qingyu / Lin, Xiaochen / Fan, Xiaohui / Huang, Xiaoxian / Gan, Min / Chen, Xuling / Ji, Zhiyun

    Materials (Basel, Switzerland)

    2023  Volume 16, Issue 9

    Abstract: The development of sustainable cementitious materials is essential and urgent for the construction industry. Benefiting from excellent engineering properties and a reduced greenhouse gas footprint, alkali-activated materials (AAM) are among the robust ... ...

    Abstract The development of sustainable cementitious materials is essential and urgent for the construction industry. Benefiting from excellent engineering properties and a reduced greenhouse gas footprint, alkali-activated materials (AAM) are among the robust alternatives to Portland cement for civil infrastructure. Meanwhile, concrete production also accounts for around 20% of all industrial water consumption, and the global freshwater shortage is increasing. This review discusses recent investigations on seawater-mixed AAMs, including the effects of seawater on workability, reaction mechanism, shrinkage, short and long-term strength, binding of chloride and corrosion of steel reinforcement. Attention is also paid to the utilization of sea sand as aggregate, as well as discussions on the challenges and further research perspectives on the field application of AAMs with seawater and sea sand.
    Language English
    Publishing date 2023-05-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma16093571
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  5. Article ; Online: Deep Immunophenotyping of Human Whole Blood by Standardized Multi-parametric Flow Cytometry Analyses.

    Gao, Jian / Luo, Yali / Li, Helian / Zhao, Yiran / Zhao, Jialin / Han, Xuling / Han, Jingxuan / Lin, Huiqin / Qian, Feng

    Phenomics (Cham, Switzerland)

    2023  Volume 3, Issue 3, Page(s) 309–328

    Abstract: Immunophenotyping is proving crucial to understanding the role of the immune system in health and disease. High-throughput flow cytometry has been used extensively to reveal changes in immune cell composition and function at the single-cell level. Here, ... ...

    Abstract Immunophenotyping is proving crucial to understanding the role of the immune system in health and disease. High-throughput flow cytometry has been used extensively to reveal changes in immune cell composition and function at the single-cell level. Here, we describe six optimized 11-color flow cytometry panels for deep immunophenotyping of human whole blood. A total of 51 surface antibodies, which are readily available and validated, were selected to identify the key immune cell populations and evaluate their functional state in a single assay. The gating strategies for effective flow cytometry data analysis are included in the protocol. To ensure data reproducibility, we provide detailed procedures in three parts, including (1) instrument characterization and detector gain optimization, (2) antibody titration and sample staining, and (3) data acquisition and quality checks. This standardized approach has been applied to a variety of donors for a better understanding of the complexity of the human immune system.
    Supplementary information: The online version contains supplementary material available at 10.1007/s43657-022-00092-9.
    Language English
    Publishing date 2023-02-23
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2730-5848
    ISSN (online) 2730-5848
    DOI 10.1007/s43657-022-00092-9
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  6. Article ; Online: Organocatalytic Enantioselective 1,10-Addition of Alkynyl Indole Imine Methides with Thiazolones: An Access to Axially Chiral Tetrasubstituted Allenes.

    Lin, Xiao / Shen, Boming / Wang, Ziyang / Cheng, Yuyu / Chen, Xuling / Li, Pengfei / Yu, Peiyuan / Li, Wenjun

    Organic letters

    2022  Volume 24, Issue 27, Page(s) 4914–4918

    Abstract: An asymmetric organocatalytic remote 1,10-addition of alkynyl indole imine methides ... ...

    Abstract An asymmetric organocatalytic remote 1,10-addition of alkynyl indole imine methides generated
    Language English
    Publishing date 2022-06-30
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.2c01794
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  7. Article ; Online: Recurrent Multi-territorial Acute Ischemic Stroke due to Cardiac Angiosarcoma.

    Lim, Gareth Zigui / Chua, Hsieh En / Aung, Ei Mon / Seet, Ying Hao Christopher / Lin, Xuling / Chng, Soke Miang / Tan, Louis C S

    Neurology

    2022  Volume 98, Issue 18, Page(s) 765–766

    MeSH term(s) Brain Ischemia/complications ; Brain Ischemia/diagnostic imaging ; Heart Neoplasms/complications ; Heart Neoplasms/diagnostic imaging ; Hemangiosarcoma/complications ; Hemangiosarcoma/diagnostic imaging ; Humans ; Ischemic Stroke ; Recurrence ; Risk Factors ; Stroke/diagnostic imaging ; Stroke/etiology
    Language English
    Publishing date 2022-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000200342
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    Ui II Zs.153: Show issues Location:
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    Zs.MO 374: Show issues

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  8. Article ; Online: A Deep Learning Model for Detecting Rhegmatogenous Retinal Detachment Using Ophthalmologic Ultrasound Images.

    Wang, Huihang / Chen, Xuling / Miao, Xiaocui / Tang, Shumin / Lin, Yijun / Zhang, Xiaojuan / Chen, Yingying / Zhu, Yihua

    Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde

    2023  Volume 247, Issue 1, Page(s) 8–18

    Abstract: Introduction: Rhegmatogenous retinal detachment (RRD) is one of the most common fundus diseases. Many rural areas of China have few ophthalmologists, and ophthalmologic ultrasound examination is of great significance for remote diagnosis of RRD. ... ...

    Abstract Introduction: Rhegmatogenous retinal detachment (RRD) is one of the most common fundus diseases. Many rural areas of China have few ophthalmologists, and ophthalmologic ultrasound examination is of great significance for remote diagnosis of RRD. Therefore, this study aimed to develop and evaluate a deep learning (DL) model, to be used for automated RRD diagnosis based on ophthalmologic ultrasound images, in order to support timely diagnosis of RRD in rural and remote areas.
    Methods: A total of 6,000 ophthalmologic ultrasound images from 1,645 participants were used to train and verify the DL model. A total of 5,000 images were used for training and validating DL models, and an independent testing set of 1,000 images was used to test the performance of eight DL models trained using four different DL model architectures (fully connected neural network, LeNet5, AlexNet, and VGG16) and two preprocessing techniques (original, original image augmented). Receiver operating characteristic (ROC) curves were used to analyze their performance. Heatmaps were generated to visualize the process of the best DL model in the identification of RRD. Finally, five ophthalmologists were invited to diagnose RRD independently on the same test set of 1,000 images for performance comparison with the best DL model.
    Results: The best DL model for identifying RRD achieved an area under the ROC curve (AUC) of 0.998 with a sensitivity and specificity of 99.2% and 99.8%, respectively. The best preprocessing method in each model architecture was the application of original image augmentation (average AUC = 0.982). The best model architecture in each preprocessing method was VGG16 (average AUC = 0.998).
    Conclusion: The best DL model determined in this study has higher accuracy, sensitivity, and specificity than the ophthalmologists' diagnosis in identifying RRD based on ophthalmologic ultrasound images. This model may provide support for timely diagnosis in locations without access to ophthalmologic care.
    MeSH term(s) Humans ; Retinal Detachment/diagnosis ; Deep Learning ; Neural Networks, Computer ; Fundus Oculi ; ROC Curve
    Language English
    Publishing date 2023-12-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 209735-7
    ISSN 1423-0267 ; 0030-3755
    ISSN (online) 1423-0267
    ISSN 0030-3755
    DOI 10.1159/000535798
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  9. Article: Organocatalytic Enantioselective 1,10-Addition of Alkynyl Indole Imine Methides with Thiazolones: An Access to Axially Chiral Tetrasubstituted Allenes

    Lin, Xiao / Shen, Boming / Wang, Ziyang / Cheng, Yuyu / Chen, Xuling / Li, Pengfei / Yu, Peiyuan / Li, Wenjun

    Organic letters. 2022 June 30, v. 24, no. 27

    2022  

    Abstract: An asymmetric organocatalytic remote 1,10-addition of alkynyl indole imine methides generated in situ from α-(6-indolyl) propargylic alcohols with thiazolones has been developed for the first time, affording axially chiral tetrasubstituted allenes ... ...

    Abstract An asymmetric organocatalytic remote 1,10-addition of alkynyl indole imine methides generated in situ from α-(6-indolyl) propargylic alcohols with thiazolones has been developed for the first time, affording axially chiral tetrasubstituted allenes featuring vicinal sulfur-containing quaternary carbon stereocenters in high yields with excellent stereoselectivities. The representative scale-up reaction and transformations of the 1,10-adduct were examined. The reaction mechanism was expounded by control experiments and DFT calculations.
    Keywords carbon ; catalytic activity ; enantioselectivity ; imines ; indoles ; reaction mechanisms
    Language English
    Dates of publication 2022-0630
    Size p. 4914-4918.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1523-7052
    DOI 10.1021/acs.orglett.2c01794
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Effect of tumor-associated macrophages on the pyroptosis of breast cancer tumor cells.

    Ji, XuLing / Huang, Xiaoxia / Li, Chao / Guan, Ningning / Pan, Tingting / Dong, Jing / Li, Lin

    Cell communication and signaling : CCS

    2023  Volume 21, Issue 1, Page(s) 197

    Abstract: Macrophages are immune cells with high plasticity that are widely distributed in all tissues and organs of the body. Under the influence of the immune microenvironment of breast tumors, macrophages differentiate into various germline lineages. They exert ...

    Abstract Macrophages are immune cells with high plasticity that are widely distributed in all tissues and organs of the body. Under the influence of the immune microenvironment of breast tumors, macrophages differentiate into various germline lineages. They exert pro-tumor or tumor-suppressive effects by secreting various cytokines. Pyroptosis is mediated by Gasdermin family proteins, which form holes in cell membranes and cause a violent inflammatory response and cell death. This is an important way for the body to fight off infections. Tumor cell pyroptosis can activate anti-tumor immunity and inhibit tumor growth. At the same time, it releases inflammatory mediators and recruits tumor-associated macrophages (TAMs) for accumulation. Macrophages act as "mediators" of cytokine interactions and indirectly influence the pyroptosis pathway. This paper describes the mechanism of action on the part of TAM in affecting the pyroptosis process of breast tumor cells, as well as its key role in the tumor microenvironment. Additionally, it provides the basis for in-depth research on how to use immune cells to affect breast tumors and guide anti-tumor trends, with important implications for the prevention and treatment of breast tumors. Video Abstract.
    MeSH term(s) Humans ; Female ; Pyroptosis ; Tumor-Associated Macrophages/metabolism ; Breast Neoplasms/pathology ; Macrophages/metabolism ; Cytokines/metabolism ; Tumor Microenvironment
    Chemical Substances Cytokines
    Language English
    Publishing date 2023-08-04
    Publishing country England
    Document type Video-Audio Media ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2126315-2
    ISSN 1478-811X ; 1478-811X
    ISSN (online) 1478-811X
    ISSN 1478-811X
    DOI 10.1186/s12964-023-01208-y
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