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  1. Article ; Online: Critical scaling of a two-orbital topological model with extended neighboring couplings.

    Kartik, Y R / Kumar, Ranjith R / Sarkar, Sujit

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 4504

    Abstract: Extended-range models are the interesting systems, which has been widely used to understand the non-local properties of the fermions at quantum scale. We aim to study the interplay between criticality and extended range couplings under various symmetry ... ...

    Abstract Extended-range models are the interesting systems, which has been widely used to understand the non-local properties of the fermions at quantum scale. We aim to study the interplay between criticality and extended range couplings under various symmetry constraints. Here, we consider a two orbital Bernevig-Hughes-Zhang model in one dimension with longer (finite neighbor) and long-range (infinite neighbor) couplings. We study the behavior of model using scaling laws and universality class for models with Hermitian, parity-time ([Formula: see text]) symmetric and broken time-reversal symmetries. We observe the interesting results on multi-criticalities, where the universality class of critical exponent is different than the normal criticalities. Also, the results can be generalized by considering the interplay between criticalities and different symmetry classes of Hamiltonian. Also, with the introduction of extended-range of coupling, there occurs different criticalities, and we provide the analogy to characterize their universality classes. We also show the violation of Lorentz invariance at multi-criticalities and evaluation of short-range limit in long-range models as the highlights of this work.
    Language English
    Publishing date 2024-02-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-54946-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Response.

    Kumar, Kartik / Loebinger, Michael R

    Chest

    2022  Volume 162, Issue 2, Page(s) e107

    Language English
    Publishing date 2022-08-04
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2022.04.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui III Zs.45: Show issues Location:
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    Zs.MO 349: Show issues

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  3. Article ; Online: A Spin-Frustrated Azide- and Alkoxide-Bridged Heterobimetallic Mixed-Valence Mn

    Kumar, Jayasree / Tarannum, Ibtesham / Singh, Saurabh Kumar / Mondal, Kartik Chandra

    ACS omega

    2024  Volume 9, Issue 5, Page(s) 5809–5818

    Abstract: Seven-membered homometallic ... ...

    Abstract Seven-membered homometallic Fe
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c08817
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  4. Article ; Online: Recent Trends in the Use of Small Extracellular Vesicles as Optimal Drug Delivery Vehicles in Oncology.

    Kumar, Sarwareddy Kartik / Sasidhar, Manda Venkata

    Molecular pharmaceutics

    2023  Volume 20, Issue 8, Page(s) 3829–3842

    Abstract: Small extracellular vesicles (sEVs) are produced by most cells and play an important role in cell-to-cell communication and maintaining cellular homeostasis. Their ability to transfer biological cargo to target cells makes them a promising tool for ... ...

    Abstract Small extracellular vesicles (sEVs) are produced by most cells and play an important role in cell-to-cell communication and maintaining cellular homeostasis. Their ability to transfer biological cargo to target cells makes them a promising tool for cancer drug delivery. Advances in sEV engineering, EV mimetics, and ligand-directed targeting have improved the efficacy of anticancer drug delivery and functionality. EV-based RNA interference and hybrid miRNA transfer have also been extensively used in various preclinical cancer models. Despite these developments, gaps still exist in our understanding of using sEVs to treat solid tumor malignancies effectively. This article provides an overview of the last five years of sEV research and its current status for the efficient and targeted elimination of cancer cells, which could advance cancer research and bring sEV formulations into clinical use.
    MeSH term(s) Medical Oncology ; Extracellular Vesicles ; Cell Communication ; Drug Delivery Systems ; Excipients
    Chemical Substances Excipients
    Language English
    Publishing date 2023-07-06
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2138405-8
    ISSN 1543-8392 ; 1543-8384
    ISSN (online) 1543-8392
    ISSN 1543-8384
    DOI 10.1021/acs.molpharmaceut.3c00363
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6250: Show issues Location:
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  5. Article ; Online: Decoding the ubiquitin language: Orchestrating transcription initiation and gene expression through chromatin remodelers and histones.

    Mandal, Kartik / Tomar, Shiva Kumar / Kumar Santra, Manas

    Gene

    2024  Volume 904, Page(s) 148218

    Abstract: Eukaryotic transcription is a finely orchestrated process and it is controlled by transcription factors as well as epigenetic regulators. Transcription factors and epigenetic regulators undergo different types of posttranslational modifications including ...

    Abstract Eukaryotic transcription is a finely orchestrated process and it is controlled by transcription factors as well as epigenetic regulators. Transcription factors and epigenetic regulators undergo different types of posttranslational modifications including ubiquitination to control transcription process. Ubiquitination, traditionally associated with protein degradation, has emerged as a crucial contributor to the regulation of chromatin structure through ubiquitination of histone and chromatin remodelers. Ubiquitination introduces new layers of intricacy to the regulation of transcription initiation through controlling the equilibrium between euchromatin and heterochromatin states. Nucleosome, the fundamental units of chromatin, spacing in euchromatin and heterochromatin states are regulated by histone modification and chromatin remodeling complexes. Chromatin remodeling complexes actively sculpt the chromatin architecture and thereby influence the transcriptional states of genes. Therefore, understanding the dynamic behavior of nucleosome spacing is critical as it impacts various cellular functions through controlling gene expression profiles. In this comprehensive review, we discussed the intricate interplay between ubiquitination and transcription initiation, and illuminated the underlying molecular mechanisms that occur in a variety of biological contexts. This exploration sheds light on the complex regulatory networks that govern eukaryotic transcription, providing important insights into the fine orchestration of gene expression and chromatin dynamics.
    MeSH term(s) Histones/genetics ; Histones/metabolism ; Chromatin/genetics ; Nucleosomes/genetics ; Euchromatin ; Heterochromatin ; Ubiquitin/genetics ; Ubiquitin/metabolism ; Ubiquitination ; Transcription Factors/genetics ; Gene Expression
    Chemical Substances Histones ; Chromatin ; Nucleosomes ; Euchromatin ; Heterochromatin ; Ubiquitin ; Transcription Factors
    Language English
    Publishing date 2024-02-01
    Publishing country Netherlands
    Document type Review ; Journal Article
    ZDB-ID 391792-7
    ISSN 1879-0038 ; 0378-1119
    ISSN (online) 1879-0038
    ISSN 0378-1119
    DOI 10.1016/j.gene.2024.148218
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1357: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article ; Online: Proinflammatory signaling mechanism of endocan in macrophages: Involvement of TLR2 mediated MAPK-NFkB pathways.

    Kumar, Sarwareddy Kartik / Mani, Krishna Priya

    Cytokine

    2023  Volume 175, Page(s) 156482

    Abstract: Endocan is an endothelial cell-specific proteoglycan that contributes to vascular dysfunction by impairing endothelial function and inducing vascular smooth muscle cell migration. However, its role in regulating macrophage inflammation, a key ... ...

    Abstract Endocan is an endothelial cell-specific proteoglycan that contributes to vascular dysfunction by impairing endothelial function and inducing vascular smooth muscle cell migration. However, its role in regulating macrophage inflammation, a key pathological feature of vascular dysfunction, is not well understood. In this study, we investigated the effect of endocan on macrophage inflammation to better understand its contribution to vascular dysfunction. We found that endocan upregulated pro-inflammatory cytokines including IL-1β, IL-6 and TNF-α in RAW 264.7 cells and activated MAPK/NFkB signaling pathways. Inhibiting these pathways reduced endocan-induced cytokine levels, while inhibiting TLR2 compromised the MAPK/NFkB regulation. Additionally, LPS-induced HUVEC conditioned medium stimulated cytokine levels in RAW 264.7 cells, which were reduced by endocan siRNA treatment in HUVEC. These results suggest that endocan positively regulates pro-inflammation in macrophages through the TLR2-MAPK-NFkB axis, highlighting the potential of targeting endocan to reduce inflammation in vascular dysfunction.
    MeSH term(s) Animals ; Mice ; Cytokines/metabolism ; Inflammation/metabolism ; Lipopolysaccharides/pharmacology ; Lipopolysaccharides/metabolism ; Macrophages/metabolism ; NF-kappa B/metabolism ; Signal Transduction ; Toll-Like Receptor 2/genetics ; Toll-Like Receptor 2/metabolism
    Chemical Substances Cytokines ; Lipopolysaccharides ; NF-kappa B ; Tlr2 protein, mouse ; Toll-Like Receptor 2
    Language English
    Publishing date 2023-12-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1018055-2
    ISSN 1096-0023 ; 1043-4666
    ISSN (online) 1096-0023
    ISSN 1043-4666
    DOI 10.1016/j.cyto.2023.156482
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    Zs.A 2840: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Determining Cryogenic Temperatures in Specimens by using EELS.

    Kumar, Abinash / Venkatraman, Kartik / Hachtel, Jordan / Chi, Miaofang

    Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

    2023  Volume 29, Issue Supplement_1, Page(s) 1706

    Language English
    Publishing date 2023-08-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1385710-1
    ISSN 1435-8115 ; 1431-9276
    ISSN (online) 1435-8115
    ISSN 1431-9276
    DOI 10.1093/micmic/ozad067.880
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  8. Article ; Online: The Coexisting Neuromyelitis Optica Spectrum Disorder and Systemic Lupus Erythematosus: A Therapeutic Challenge.

    Kumar, Abhishek / Gupta, Anirban / Gupta, Preeti / Vasdev, Vivek / Kartik, S

    Mediterranean journal of rheumatology

    2023  Volume 34, Issue 3, Page(s) 372–376

    Abstract: Neuromyelitis Optica (NMO), or Devic's disease, is an immune-mediated, usually relapsing, central nervous system (CNS) demyelination disorder associated with optic neuritis and transverse myelitis. It is characterised by the presence of longitudinally ... ...

    Abstract Neuromyelitis Optica (NMO), or Devic's disease, is an immune-mediated, usually relapsing, central nervous system (CNS) demyelination disorder associated with optic neuritis and transverse myelitis. It is characterised by the presence of longitudinally extensive transverse myelitis (LETM) and antibodies against water channel aquaporin-4 (AQP4-immunoglobulin G [IgG]). The term NMO spectrum disorder (NMOSD) includes patients with limited forms of NMO who are at risk of recurrence. Often patients with NMO or NMOSD have an associated systemic autoimmune disease, most commonly systemic lupus erythematosus (SLE) or Sjogren syndrome (SS) or a related profile of non-organ-specific autoantibodies. The intriguing aspect of coexisting NMOSD and SLE is whether they are independent diseases that can coexist with each other or the serological findings specific to both diseases in a patient is a non-specific finding of no prognostic or therapeutic concern. We have presented two cases of NMOSD coexisting with SLE and based upon the existing evidence in the literature we present that the two conditions are independent of each other, and, at times, it can throw a therapeutic challenge to any clinician.
    Language English
    Publishing date 2023-08-08
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 3019943-8
    ISSN 2529-198X ; 2459-3516
    ISSN (online) 2529-198X
    ISSN 2459-3516
    DOI 10.31138/mjr.20230808.tc
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  9. Article: Revisiting Porcine Circovirus Infection: Recent Insights and Its Significance in the Piggery Sector.

    Maity, Hemanta Kumar / Samanta, Kartik / Deb, Rajib / Gupta, Vivek Kumar

    Vaccines

    2023  Volume 11, Issue 8

    Abstract: Porcine circovirus (PCV), a member of ... ...

    Abstract Porcine circovirus (PCV), a member of the
    Language English
    Publishing date 2023-07-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11081308
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  10. Article ; Online: Tocilizumab for refractory post-COVID-19 pansclerotic morphea.

    Saraswat, Neerja / Tripathy, Durga Madhab / Mishra, Abhishek / Kumar, Abhishek / Kartik, Sivasami / Gopal, Manoj M

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2023  Volume 38, Issue 5, Page(s) e364–e365

    MeSH term(s) Humans ; Antibodies, Monoclonal, Humanized/therapeutic use ; COVID-19/complications ; Scleroderma, Localized/drug therapy ; Female ; Middle Aged ; Male ; SARS-CoV-2
    Chemical Substances Antibodies, Monoclonal, Humanized ; tocilizumab (I031V2H011)
    Language English
    Publishing date 2023-12-11
    Publishing country England
    Document type Letter ; Case Reports
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.19692
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    Zs.A 3492: Show issues Location:
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    Zs.MO 413: Show issues

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