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Article ; Online: Immune Reactivity of a 20-mer Peptide Representing the Zika E Glycan Loop Involves the Antigenic Determinants E-152/156/158.

Frumence, Etienne / Haddad, Juliano G / Vanwalscappel, Bénédicte / Andries, Jessica / Decotter, Jason / Viranaicken, Wildriss / Gadea, Gilles / Desprès, Philippe

Viruses

2020 Volume 12, Issue 11

Abstract: ... ZIKALIVax with African MR766-NIID strain as backbone and the envelope E protein of epidemic Brazilian ... BeH810915 strain. The MR766-NIID residues E-T152/I156/Y158 were introduced into BeH810915 E protein leading ... to a nonglycosylated ZIKALIVax. Recently, we reported that the residues E-152/156/158 that are part of ZIKV glycan loop ...

Abstract	Mosquito-borne Zika virus (ZIKV) causes a severe congenital syndrome and neurological disorders in humans. With the aim to develop a live-attenuated ZIKV strain, we generated a chimeric viral clone ZIKALIVax with African MR766-NIID strain as backbone and the envelope E protein of epidemic Brazilian BeH810915 strain. The MR766-NIID residues E-T152/I156/Y158 were introduced into BeH810915 E protein leading to a nonglycosylated ZIKALIVax. Recently, we reported that the residues E-152/156/158 that are part of ZIKV glycan loop (GL) region might have an impact on the availability of neutralizing antibody epitopes on ZIKV surface. In the present study, we evaluated the antigenic reactivity of a synthetic 20-mer peptide representing the ZIKALIVax GL region. The GL-related peptide was effective for the detection of GL-reactive antibody in mouse anti-ZIKALIVax immune serum. We showed that the residue E-158 influences the antigenic reactivity of GL-related peptide. The ZIKALIVax peptide was effective in generating mouse antibodies with reactivity against a recombinant E domain I that encompasses the GL region. The GL peptide-reactive antibodies revealed that antigenic reactivity of E-domain I may be impacted by both residues E-152 and E-156. In conclusion, we proposed a role for the residues E-152/156/158 as key antigenic determinants of ZIKV glycan loop region.
MeSH term(s)	Animals ; Antibodies, Neutralizing/blood ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Epitopes/immunology ; Mice ; Mice, Inbred BALB C ; Neutralization Tests ; Peptides/immunology ; Polysaccharides/immunology ; Zika Virus/genetics ; Zika Virus/immunology ; Zika Virus Infection/immunology
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; Epitopes ; Peptides ; Polysaccharides
Language	English
Publishing date	2020-11-05
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v12111258
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Unexpected high seroprevalence of hepatitis E virus in patients with alcohol-related cirrhosis.

Fantilli, Anabella C / Trinks, Julieta / Marciano, Sebastián / Zárate, Fabián / Balderramo, Domingo C / Wassaf, Maribel G Martínez / Haddad, Leila / Gadano, Adrián / Debes, José D / Pisano, María B / Ré, Viviana E

PloS one

2019 Volume 14, Issue 10, Page(s) e0224404

Abstract: Introduction: Little is known about hepatitis E virus (HEV) infection in patients with cirrhosis ...

Abstract	Introduction: Little is known about hepatitis E virus (HEV) infection in patients with cirrhosis. The aim of the present study was to describe the frequency of HEV infection and associated risk factors in patients with cirrhosis from Argentina. Materials and methods: We evaluated HEV seroprevalence (IgG anti-HEV) and acute infections (IgM and RNA) in patients with cirrhosis (n = 140) vs. healthy controls (n = 300). Additionally, we compared the same outcomes in individuals with alcohol-related cirrhosis (n = 43) vs. patients with alcohol use disorder (without cirrhosis, n = 72). Results: The overall HEV seroprevalence in the cohort of subjects with cirrhosis was 25% (35/140), compared to 4% in the healthy control group [12/300; OR = 8; (95% CI = 4-15.99); p<0.05]. HEV seropositivity was significantly higher in alcohol-related cirrhosis compared to other causes of cirrhosis [39.5% vs. 12.4%; OR = 4.71; (95% CI = 1.9-11.6); p<0.05] and to healthy controls [OR = 15.7; (95% CI = 6.8-36.4); p = 0.0001]. The HEV seroprevalence in alcoholic-related cirrhosis vs. with alcohol use disorder was 39.5% vs. 12.5% [OR = 4.58; (95% CI = 1.81-11.58); p<0.001]. Conclusion: We found a high seroprevalence of HEV in patients with cirrhosis and in individuals with alcohol use disorder. The simultaneous presence of both factors (cirrhosis + alcohol) showed more association to HEV infection. Larger studies with prospective follow up are needed to further clarify this interaction.
MeSH term(s)	Acute Disease ; Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; Cross-Sectional Studies ; Female ; Hepatitis E/complications ; Hepatitis E/epidemiology ; Humans ; Liver Cirrhosis, Alcoholic/complications ; Liver Cirrhosis, Alcoholic/virology ; Male ; Middle Aged ; Risk Factors ; Seroepidemiologic Studies ; Young Adult
Language	English
Publishing date	2019-10-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0224404
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Article ; Online: The burden of Hepatitis E virus in the Middle East and North Africa region: a systematic review.

Saade, Marie Christelle / Haddad, Gaëlle / El Hayek, Mario / Shaib, Yasser

Journal of infection in developing countries

2022 Volume 16, Issue 5, Page(s) 737–744

Abstract: Introduction: Hepatitis E virus is a leading cause of hepatitis in the Middle East and ... North Africa region. Although several countries in this area were shown to be endemic for hepatitis E, little ... the results of a systematic review addressing the seroprevalence of hepatitis E antibodies in the Middle East ...

Abstract	Introduction: Hepatitis E virus is a leading cause of hepatitis in the Middle East and North Africa region. Although several countries in this area were shown to be endemic for hepatitis E, little is known about the epidemiology and possible preventive measures. In this manuscript, we present the results of a systematic review addressing the seroprevalence of hepatitis E antibodies in the Middle East and North Africa region. Subsequently, we discuss the main prevention strategies for this virus. Methodology: We performed a literature review using the PubMed Database of all the Studies reporting data on hepatitis E seroprevalence (Anti-hepatitis E IgM and IgG) among the 20 countries of the Middle East and North Africa region from January 2000 to July 2021. Results: Eighty-nine articles were identified and included in our review. Ten of the MENA countries did not have any study that fits our criteria. Egypt and Iran were the countries with the highest IgG seroprevalence for hepatitis E reaching 85.1% and 68.6% respectively. Concerning acute hepatitis E presentations, Iraq and Egypt were shown to have the highest IgM seroprevalence reaching 38.1% and 35.3% respectively. Hemodialysis and poly-transfused patients as well as patients with concomitant hepatotropic viruses' infections were reported to have a higher seroprevalence than the general population. Conclusions: Hepatitis E is a major healthcare problem in the endemic Middle East and North Africa region. Even though no definite prevention strategy was described until today, implementing multiple minor precautionary approaches could help reduce the virus spread.
MeSH term(s)	Africa, Northern/epidemiology ; Hepatitis Antibodies ; Hepatitis E/epidemiology ; Hepatitis E virus ; Humans ; Immunoglobulin G ; Immunoglobulin M ; Middle East/epidemiology ; Seroepidemiologic Studies
Chemical Substances	Hepatitis Antibodies ; Immunoglobulin G ; Immunoglobulin M
Language	English
Publishing date	2022-05-30
Publishing country	Italy
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	2394024-4
ISSN	1972-2680 ; 2036-6590
ISSN (online)	1972-2680
ISSN	2036-6590
DOI	10.3855/jidc.15701
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Article ; Online: Declining prevalence of hepatitis A and silent circulation of hepatitis E virus infection in southeastern Brazil.

de Almeida E Araújo, Daniel Cardoso / de Oliveira, Jaqueline Mendes / Haddad, Simone Kashima / da Roza, Daiane Leite / Bottino, Fernanda de Oliveira / Faria, Sarah Beatriz Salvador Castro / Bellíssimo-Rodrigues, Fernando / Passos, Afonso Dinis Costa

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2020 Volume 101, Page(s) 17–23

Abstract: ... in low-income areas. In contrast, only a few human cases of hepatitis E have been reported. This study aimed ... to estimate the prevalence and potential risk factors of HAV and hepatitis E virus (HEV) infections ...

Abstract	Objectives: Hepatitis A virus (HAV) infection is considered highly endemic in Brazil, especially in low-income areas. In contrast, only a few human cases of hepatitis E have been reported. This study aimed to estimate the prevalence and potential risk factors of HAV and hepatitis E virus (HEV) infections in an adult population from a rural township of southeastern Brazil. Methods: We conducted a cross-sectional survey using serum samples from urban and rural residents of Cássia dos Coqueiros, São Paulo state. A total of 990 samples were tested for anti-HAV IgG by chemiluminescent microparticle immunoassay, and a subset of 248 samples tested for anti-HEV IgG, using two commercial ELISA. Variables associated with anti-HAV and anti-HEV positivity were assessed by a multivariate analysis using a binomial logistic regression model. Results: Seroprevalence of HAV and HEV was 89.1% and 20.7%, respectively. Age was significantly associated with HAV infection. Wantai and Mikrogen ELISA yielded comparable HEV seroprevalence results. Conclusions: Anti-HAV seroprevalence has declined and correlates with age, whereas anti-HEV was significantly higher than that found in previous population-based studies. These results indicate a need for further investigations of the magnitude of HEV infection in Brazil using the currently available, more sensitive diagnostic methods.
MeSH term(s)	Adolescent ; Adult ; Brazil/epidemiology ; Cross-Sectional Studies ; Enzyme-Linked Immunosorbent Assay ; Female ; Hepatitis A/epidemiology ; Hepatitis A virus/immunology ; Hepatitis Antibodies/blood ; Hepatitis E/epidemiology ; Hepatitis E virus/immunology ; Humans ; Male ; Middle Aged ; Models, Statistical ; Prevalence ; Risk Factors ; Rural Population ; Seroepidemiologic Studies ; Young Adult
Chemical Substances	Hepatitis Antibodies
Language	English
Publishing date	2020-09-16
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2020.09.024
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Article: Regulation of Soluble E-Cadherin Signaling in Non-Small-Cell Lung Cancer Cells by Nicotine, BDNF, and β-Adrenergic Receptor Ligands.

Ray, Ravel / Goel, Stuti / Al Khashali, Hind / Darweesh, Ban / Haddad, Ben / Wozniak, Caroline / Ranzenberger, Robert / Khalil, Jeneen / Guthrie, Jeffrey / Heyl, Deborah / Evans, Hedeel Guy

Biomedicines

2023 Volume 11, Issue 9

Abstract: The ectodomain of the transmembrane protein E-cadherin can be cleaved and released in a soluble ... form referred to as soluble E-cadherin, or sE-cad, accounting for decreased E-cadherin levels ... including MMP9. Opposite functions have been reported for full-length E-cadherin and sE-cad. In this study ...

Abstract	The ectodomain of the transmembrane protein E-cadherin can be cleaved and released in a soluble form referred to as soluble E-cadherin, or sE-cad, accounting for decreased E-cadherin levels at the cell surface. Among the proteases implicated in this cleavage are matrix metalloproteases (MMP), including MMP9. Opposite functions have been reported for full-length E-cadherin and sE-cad. In this study, we found increased MMP9 levels in the media of two non-small cell lung cancer (NSCLC) cell lines, A549 and H1299, treated with BDNF, nicotine, or epinephrine that were decreased upon cell treatment with the β-adrenergic receptor blocker propranolol. Increased MMP9 levels correlated with increased sE-cad levels in A549 cell media, and knockdown of MMP9 in A549 cells led to downregulation of sE-cad levels in the media. Previously, we reported that A549 and H1299 cell viability increased with nicotine and/or BDNF treatment and decreased upon treatment with propranolol. In investigating the function of sE-cad, we found that immunodepletion of sE-cad from the media of A549 cells untreated or treated with BDNF, nicotine, or epinephrine reduced activation of EGFR and IGF-1R, decreased PI3K and ERK1/2 activities, increased p53 activation, decreased cell viability, and increased apoptosis, while no effects were found using H1299 cells under all conditions tested.
Language	English
Publishing date	2023-09-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11092555
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Article ; Online: Hepatitis E infection is an infrequent cause of acute hepatitis in the metropolitan area of Buenos Aires.

Mendizabal, Manuel / Haddad, Leila / Marciano, Sebastián / Ganem, Federico Orozco / Paz, Silvina / Gruz, Fernando / Ridruejo, Ezequiel / Lurbet, María Fernanda / Fernandez, Nora / Descalzi, Valeria / Anders, Margarita / Gadano, Adrián / Martínez, Alfredo / Silva, Y Marcelo

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

2020 Volume 126, Page(s) 104309

Abstract: Background Argentina is considered a region of low seroprevalence of hepatitis E virus (HEV ...

Abstract	Background Argentina is considered a region of low seroprevalence of hepatitis E virus (HEV), however; no studies have evaluated its burden among acute hepatitis cases. Objectives: We aimed to estimate the proportion of acute HEV and outcome in a cohort of patients with acute hepatitis from 6 liver units in the Metropolitan area of Buenos Aires (MABA). Study design: We performed a prospective cohort study including patients ≥18 years with acute hepatitis (increase in transaminases x 5 ULN) fromJuly 2016 to May 2018. Severe hepatitis was defined as acute hepatitis + INR> 1.5 and acute liver failure as severe hepatitis + encephalopathy. In patients in whom other etiologies were excluded, HEV tests were performed: anti-HEV IgM/G and HEV-RNA in serum and feces. Results: Overall, 268 patients with acute hepatitis were included in the study. The most frequent etiologies of acute hepatitis were hepatitis B (67patients, 25 %), hepatotoxicity (65, 24 %) and autoimmune hepatitis (26, 10 %). Acute HEV infection was confirmed in 8 (2.98 %; 95 %CI 1.25-5.63) patients who tested positive for anti-HEV IgM. A total of 63 (23.5 %) patients were hospitalized and 9 (3.3 %) patients died. Overall, 48 (18 %) patients developed severe hepatitis, 6 (2.2 %) have acute liver failure, 6 (1.9 %) underwent liver transplantation and 9 (3.4 %) patients died. Conclusions: the proportion of acute HEV in MABA was low during the period studied. We believe our findings will aid physicians prioritize other etiologies of acute hepatitis over HEV in order to optimize diagnostic resources and offer better care to their patients.
MeSH term(s)	Acute Disease/epidemiology ; Adult ; Argentina/epidemiology ; Cities/epidemiology ; Female ; Genotype ; Hepatitis Antibodies/blood ; Hepatitis E/epidemiology ; Hepatitis E virus/genetics ; Hepatitis, Viral, Human/epidemiology ; Humans ; Immunoglobulin G/blood ; Immunoglobulin M/blood ; Liver Failure, Acute/epidemiology ; Liver Failure, Acute/virology ; Male ; Middle Aged ; Prospective Studies ; RNA, Viral/blood ; Seroepidemiologic Studies
Chemical Substances	Hepatitis Antibodies ; Immunoglobulin G ; Immunoglobulin M ; RNA, Viral
Language	English
Publishing date	2020-03-06
Publishing country	Netherlands
Document type	Journal Article ; Multicenter Study
ZDB-ID	1446080-4
ISSN	1873-5967 ; 1386-6532
ISSN (online)	1873-5967
ISSN	1386-6532
DOI	10.1016/j.jcv.2020.104309
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 3790: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Immune Reactivity of a 20-mer Peptide Representing the Zika E Glycan Loop Involves the Antigenic Determinants E-152/156/158

Frumence, Etienne / Haddad, Juliano G / Vanwalscappel, Bénédicte / Andries, Jessica / Decotter, Jason / Viranaicken, Wildriss / Gadea, Gilles / Desprès, Philippe

Viruses. 2020 Nov. 05, v. 12, no. 11

2020

Abstract	Mosquito-borne Zika virus (ZIKV) causes a severe congenital syndrome and neurological disorders in humans. With the aim to develop a live-attenuated ZIKV strain, we generated a chimeric viral clone ZIKALIVax with African MR766-NIID strain as backbone and the envelope E protein of epidemic Brazilian BeH810915 strain. The MR766-NIID residues E-T152/I156/Y158 were introduced into BeH810915 E protein leading to a nonglycosylated ZIKALIVax. Recently, we reported that the residues E-152/156/158 that are part of ZIKV glycan loop (GL) region might have an impact on the availability of neutralizing antibody epitopes on ZIKV surface. In the present study, we evaluated the antigenic reactivity of a synthetic 20-mer peptide representing the ZIKALIVax GL region. The GL-related peptide was effective for the detection of GL-reactive antibody in mouse anti-ZIKALIVax immune serum. We showed that the residue E-158 influences the antigenic reactivity of GL-related peptide. The ZIKALIVax peptide was effective in generating mouse antibodies with reactivity against a recombinant E domain I that encompasses the GL region. The GL peptide-reactive antibodies revealed that antigenic reactivity of E-domain I may be impacted by both residues E-152 and E-156. In conclusion, we proposed a role for the residues E-152/156/158 as key antigenic determinants of ZIKV glycan loop region.
Keywords	Zika virus ; antiserum ; epitopes ; human diseases ; immune response ; live vaccines ; mice ; nervous system diseases ; neutralizing antibodies ; peptides
Language	English
Dates of publication	2020-1105
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2516098-9
ISSN	1999-4915
ISSN	1999-4915
DOI	10.3390/v12111258
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Inhibition Effect of Solid Products and DC Breakdown Characteristics of the HFO1234Ze(E)-N

Liu, Heng / Li, Qingmin / Wang, Jingrui / Jiang, Yuheng / Haddad, A Manu

ACS omega

2021 Volume 6, Issue 36, Page(s) 23281–23292

Abstract: HFO1234ze(E) is an environmentally friendly SF ...

Abstract	HFO1234ze(E) is an environmentally friendly SF
Language	English
Publishing date	2021-08-31
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.1c03020
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Article: Machine Learning-Based Nicotine Addiction Prediction Models for Youth E-Cigarette and Waterpipe (Hookah) Users.

Choi, Jeeyae / Jung, Hee-Tae / Ferrell, Anastasiya / Woo, Seoyoon / Haddad, Linda

Journal of clinical medicine

2021 Volume 10, Issue 5

Abstract: Despite the harmful effect on health, e-cigarette and hookah smoking in youth in the U.S. has ... increased. Developing tailored e-cigarette and hookah cessation programs for youth is imperative. The aim ... that cause nicotine addiction in youth e-cigarette or hookah users and build nicotine addiction ...

Abstract	Despite the harmful effect on health, e-cigarette and hookah smoking in youth in the U.S. has increased. Developing tailored e-cigarette and hookah cessation programs for youth is imperative. The aim of this study was to identify predictor variables such as social, mental, and environmental determinants that cause nicotine addiction in youth e-cigarette or hookah users and build nicotine addiction prediction models using machine learning algorithms. A total of 6511 participants were identified as ever having used e-cigarettes or hookah from the National Youth Tobacco Survey (2019) datasets. Prediction models were built by Random Forest with ReliefF and Least Absolute Shrinkage and Selection Operator (LASSO). ReliefF identified important predictor variables, and the Davies-Bouldin clustering evaluation index selected the optimal number of predictors for Random Forest. A total of 193 predictor variables were included in the final analysis. Performance of prediction models was measured by Root Mean Square Error (RMSE) and Confusion Matrix. The results suggested high performance of prediction. Identified predictor variables were aligned with previous research. The noble predictors found, such as 'witnessed e-cigarette use in their household' and 'perception of their tobacco use', could be used in public awareness or targeted e-cigarette and hookah youth education and for policymakers.
Language	English
Publishing date	2021-03-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10050972
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Article ; Online: Unexpected high seroprevalence of hepatitis E virus in patients with alcohol-related cirrhosis.

Anabella C Fantilli / Julieta Trinks / Sebastián Marciano / Fabián Zárate / Domingo C Balderramo / Maribel G Martínez Wassaf / Leila Haddad / Adrián Gadano / José D Debes / María B Pisano / Viviana E Ré

PLoS ONE, Vol 14, Iss 10, p e

2019 Volume 0224404

Abstract: INTRODUCTION:Little is known about hepatitis E virus (HEV) infection in patients with cirrhosis ...

Abstract	INTRODUCTION:Little is known about hepatitis E virus (HEV) infection in patients with cirrhosis. The aim of the present study was to describe the frequency of HEV infection and associated risk factors in patients with cirrhosis from Argentina. MATERIALS AND METHODS:We evaluated HEV seroprevalence (IgG anti-HEV) and acute infections (IgM and RNA) in patients with cirrhosis (n = 140) vs. healthy controls (n = 300). Additionally, we compared the same outcomes in individuals with alcohol-related cirrhosis (n = 43) vs. patients with alcohol use disorder (without cirrhosis, n = 72). RESULTS:The overall HEV seroprevalence in the cohort of subjects with cirrhosis was 25% (35/140), compared to 4% in the healthy control group [12/300; OR = 8; (95% CI = 4-15.99); p<0.05]. HEV seropositivity was significantly higher in alcohol-related cirrhosis compared to other causes of cirrhosis [39.5% vs. 12.4%; OR = 4.71; (95% CI = 1.9-11.6); p<0.05] and to healthy controls [OR = 15.7; (95% CI = 6.8-36.4); p = 0.0001]. The HEV seroprevalence in alcoholic-related cirrhosis vs. with alcohol use disorder was 39.5% vs. 12.5% [OR = 4.58; (95% CI = 1.81-11.58); p<0.001]. CONCLUSION:We found a high seroprevalence of HEV in patients with cirrhosis and in individuals with alcohol use disorder. The simultaneous presence of both factors (cirrhosis + alcohol) showed more association to HEV infection. Larger studies with prospective follow up are needed to further clarify this interaction.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
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