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  1. Article ; Online: To treat or not to treat:

    Gerding, Dale N

    Infection control and hospital epidemiology

    2023  Volume 44, Issue 9, Page(s) 1369–1370

    MeSH term(s) Humans ; Algorithms ; Clostridium Infections/diagnosis ; Clostridium Infections/drug therapy
    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0195-9417 ; 0899-823X
    ISSN (online) 1559-6834
    ISSN 0195-9417 ; 0899-823X
    DOI 10.1017/ice.2023.55
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1714: Show issues Location:
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  2. Article ; Online: Is the Healthcare Facility Level Sufficient for Assessing the Impact of 2-Step Clostridioides difficile Testing?

    Gerding, Dale N

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2023  Volume 77, Issue 7, Page(s) 1050–1052

    MeSH term(s) Humans ; Clostridioides difficile ; Delivery of Health Care
    Language English
    Publishing date 2023-06-04
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad332
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1505: Show issues Location:
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    Zs.MO 480: Show issues

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  3. Article ; Online: Incidence and Outcome of Clostridium difficile Infection-Beware of Strain Type and Diagnostic Tests.

    Gerding, Dale N

    JAMA network open

    2020  Volume 3, Issue 1, Page(s) e1918599

    MeSH term(s) Clostridium Infections ; Diagnostic Tests, Routine ; Enterocolitis, Pseudomembranous ; Humans ; Incidence
    Language English
    Publishing date 2020-01-03
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2019.18599
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Fidaxomicin and the evolving approach to the treatment of Clostridium difficile infection

    Gerding, Dale N. / Miller, Mark A.

    (Clinical infectious diseases ; 55, Suppl. 2)

    2012  

    Author's details guest ed.: Dale N. Gerding and Mark A. Miller
    Series title Clinical infectious diseases ; 55, Suppl. 2
    Collection
    Language English
    Size S. S65 - S169 : Ill., graph. Darst.
    Publisher Oxford Univ. Press
    Publishing place Cary, NC
    Publishing country United States
    Document type Book
    HBZ-ID HT017405297
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 1505 -55,Suppl.2- not available for loan Zeitschriften-Lesesaal

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  5. Article ; Online: Is pulsed dosing the answer to treatment of Clostridium difficile infection?

    Gerding, Dale N

    The Lancet. Infectious diseases

    2017  Volume 18, Issue 3, Page(s) 231–233

    MeSH term(s) Clostridium Infections ; Clostridium difficile ; Fidaxomicin ; Humans ; Vancomycin
    Chemical Substances Vancomycin (6Q205EH1VU) ; Fidaxomicin (Z5N076G8YQ)
    Language English
    Publishing date 2017-12-19
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(17)30750-8
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    Zs.A 5743: Show issues Location:
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  6. Article ; Online: Guideline Recommendations: Optimal Timing of Publication and Resulting Rate of Adoption.

    Gerding, Dale N / Johnson, Stuart

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 72, Issue 11, Page(s) 1950–1951

    MeSH term(s) Evidence-Based Medicine ; Guideline Adherence ; Humans
    Language English
    Publishing date 2020-04-28
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa485
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  7. Article ; Online: Treatment of Recurrent Clostridium difficile Infection.

    Johnson, Stuart / Gerding, Dale N

    JAMA

    2019  Volume 321, Issue 5, Page(s) 512–513

    MeSH term(s) Clostridium Infections ; Clostridium difficile ; Humans
    Language English
    Publishing date 2019-03-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2018.18993
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  8. Article ; Online: Editorial Commentary: Whole-Genome Sequencing of Clostridium difficile: Exquisitely Sensitive but Not Yet Optimally Applied.

    Gerding, Dale N

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2016  Volume 62, Issue 6, Page(s) 753–754

    MeSH term(s) Clostridium Infections ; Clostridium difficile/genetics ; Humans ; Ribotyping
    Language English
    Publishing date 2016-03-15
    Publishing country United States
    Document type Comment ; Editorial ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/civ1037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Absence of toxin gene transfer from Clostridioides difficile strain 630Δerm to nontoxigenic C. difficile strain NTCD-M3r in filter mating experiments.

    Sambol, Susan P / Johnson, Stuart / Cheknis, Adam / Gerding, Dale N

    PloS one

    2022  Volume 17, Issue 6, Page(s) e0270119

    Abstract: Nontoxigenic Clostridioides difficile strain M3 (NTCD-M3) protects hamsters and humans against C. difficile infection. Transfer in vitro of the pathogenicity locus (PaLoc) to nontoxigenic strain CD37 has been reported. We repeated these conjugations ... ...

    Abstract Nontoxigenic Clostridioides difficile strain M3 (NTCD-M3) protects hamsters and humans against C. difficile infection. Transfer in vitro of the pathogenicity locus (PaLoc) to nontoxigenic strain CD37 has been reported. We repeated these conjugations using toxigenic strain 630Δerm as donor and NTCD-M3 and CD37 as recipients. In order to conduct these matings we induced rifampin resistance (50ug/ml) in NTCD-M3 by serial passage on rifampin-containing media to obtain strain NTCD-M3r. 630Δerm/CD37 matings produced 21 PaLoc transconjugants in 5.5 x 109 recipient CFUs; a frequency of 3.8 x 10-9. All transconjugants carried the tcdB gene and produced toxin. 630Δerm/NTCD-M3r matings produced no transconjugants in 5 assays with a total of 9.4 x 109 NTCD-M3r recipient cells. Toxin gene transfer to NTCD-M3r could not be demonstrated under conditions that demonstrated transfer to strain CD37.
    MeSH term(s) Animals ; Bacterial Proteins/genetics ; Bacterial Toxins/genetics ; Cell Communication ; Clostridioides ; Clostridioides difficile/genetics ; Cricetinae ; Humans ; Rifampin
    Chemical Substances Bacterial Proteins ; Bacterial Toxins ; Rifampin (VJT6J7R4TR)
    Language English
    Publishing date 2022-06-29
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0270119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Current and future trends in clostridioides (clostridium) difficile infection management.

    Khanna, Sahil / Gerding, Dale N

    Anaerobe

    2019  Volume 58, Page(s) 95–102

    Abstract: Current and future management of Clostridioides difficile infection (CDI) including antibiotic treatment is increasingly focused on preventive strategies, either prevention of recurrent CDI (rCDI) or primary prevention of CDI. In addition to newer narrow ...

    Abstract Current and future management of Clostridioides difficile infection (CDI) including antibiotic treatment is increasingly focused on preventive strategies, either prevention of recurrent CDI (rCDI) or primary prevention of CDI. In addition to newer narrow spectrum antibiotics and pulse dosing of antibiotic treatment, multiple widely differing approaches to prevention of CDI and rCDI are under clinical development or recently approved for clinical use. They include immunologics, both passive monoclonal antibodies and active vaccines targeted at C. difficile toxins, approaches to reduce antibiotic dysbiosis in the gut, microbiome restoration using fecal microbiome transplants (FMT) or biotherapeutic bacterial derivatives, and substitution of non-toxigenic C. difficile (NTCD) for toxigenic C. difficile. Newer antibiotics, monoclonal antibodies, and FMT are targeted at reducing rCDI whereas vaccines and reduction of antibiotic dysbiosis in the gut are targeted at prevention of primary CDI. Biotherapeutics may be used for prevention of either primary CDI or rCDI. Approaches such as monoclonal antibodies, FMT, and biotherapeutics provide rapid but transient preventive benefits, whereas vaccines require weeks to months to be effective, but will presumably provide long term prevention. More rapid but transient prevention strategies such as FMT and biotherapeutics could be used in combination with vaccines to provide both rapid and durable CDI prevention.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Clostridium Infections/therapy ; Disease Management ; Fecal Microbiota Transplantation/methods ; Humans ; Immunologic Factors/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Immunologic Factors
    Language English
    Publishing date 2019-05-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1237621-8
    ISSN 1095-8274 ; 1075-9964
    ISSN (online) 1095-8274
    ISSN 1075-9964
    DOI 10.1016/j.anaerobe.2019.04.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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