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Article ; Online: Life story templates in dementia care: Ambiguous direction and purpose.

Möllergren, Glenn / Harnett, Tove

2024 , Page(s) 14713012231224545

Abstract: Background: The use of life stories in dementia care has been described as a way of seeing every person as an individual, looking beyond their dementia. Life stories have become synonymous with high-quality care, while in Sweden their mere existence in ... ...

Abstract	Background: The use of life stories in dementia care has been described as a way of seeing every person as an individual, looking beyond their dementia. Life stories have become synonymous with high-quality care, while in Sweden their mere existence in dementia care settings is taken to indicate quality in national comparisons. Such life stories are often standardised, generated by a family member answering predetermined questions in a template. Aim and methods: Using a constructionist approach, this study will (1) chart what versions of a person's life story the templates produce, and (2) establish the intended purpose of such life stories, as communicated by the templates. This study departs from the assumption that life story templates communicate something about the conceptions of people living with dementia. The thematic analysis used data comprising 30 blank templates, totalling about 1,700 questions. Findings: The life story templates were found to generate two very different versions of the individual: (1) a person before symptoms of dementia or (2) a patient Discussion: Despite strong pressure on dementia care providers to collect life stories from residents, the life story templates they use are without clear direction, ideology, or purpose. The lack of direction is key given that life stories can be considered actants that shape assumptions about people with dementia and construct realities in dementia care settings. We highlight the need to develop ethical guidelines for life story template design, matched with guidelines for their intended use.
Language	English
Publishing date	2024-01-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2084045-7
ISSN	1741-2684 ; 1471-3012
ISSN (online)	1741-2684
ISSN	1471-3012
DOI	10.1177/14713012231224545
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Treatment of Community-Acquired Pneumonia: A Case Report and Current Treatment Dilemmas.

Harnett, Glenn

Case reports in emergency medicine

2017 Volume 2017, Page(s) 5045087

Abstract: Resistance to macrolides is rising in the USA and warrants careful consideration when confronted with a patient with suspected pneumonia in the urgent care clinic. This case study exemplifies the potentially serious consequences of treatment failure ... ...

Abstract	Resistance to macrolides is rising in the USA and warrants careful consideration when confronted with a patient with suspected pneumonia in the urgent care clinic. This case study exemplifies the potentially serious consequences of treatment failure following prescription of a macrolide for community-acquired bacterial pneumonia. Furthermore, the consequential treatment dilemmas currently faced by physicians are briefly discussed.
Language	English
Publishing date	2017-06-15
Publishing country	United States
Document type	Case Reports
ZDB-ID	2684646-9
ISSN	2090-6498 ; 2090-648X
ISSN (online)	2090-6498
ISSN	2090-648X
DOI	10.1155/2017/5045087
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Article ; Online: Exploring Workplace Testing with Real-Time Polymerase Chain Reaction SARS-CoV-2 Testing.

Fuentes, Lucas / Shah, Nigam / Kelly, Sara / Harnett, Glenn / Schulman, Kevin A

Journal of the American Board of Family Medicine : JABFM

2022 Volume 35, Issue 1, Page(s) 96–101

Abstract: Background: Molecular tests (ie, real-time polymerase chain reaction [RT-PCR]) and antigen tests are used to detect SARS-CoV-2. RT-PCR tests are generally considered to be the standard for clinical diagnosis of SARS-CoV-2 due to accuracy and reliability ...

Abstract	Background: Molecular tests (ie, real-time polymerase chain reaction [RT-PCR]) and antigen tests are used to detect SARS-CoV-2. RT-PCR tests are generally considered to be the standard for clinical diagnosis of SARS-CoV-2 due to accuracy and reliability but can take longer to return results than antigen tests. Our aim was to examine if point-of-care (POC) testing for SARS-CoV-2 infection would provide a flexible resource to help achieve workplace safety. We compared test results and time-to-test results between a POC RT-PCR test and a send-out PCR test in a program implemented in summer 2020. Results: POC testing shortened the time to results to 110 minutes in the POC setting from the 754 minutes for send-out tests. The specificity of POC RT-PCR single POC testing was 98.7% compared with send-out RT-PCR testing and was confirmed at 99.8% in a validation analysis. The sensitivity of the POC testing was 100% compared with send-out RT-PCR, although in a validation analysis, sensitivity appeared as 0% because only the 12 positive or indeterminate samples on the first analysis were retested and the majority were false-positives that were correctly ruled out. Conclusions: POC testing for SARS-CoV-2 with RT-PCR technology is possible at reduced time compared with send-out PCR testing.
MeSH term(s)	COVID-19 ; COVID-19 Testing ; Humans ; Real-Time Polymerase Chain Reaction ; Reproducibility of Results ; SARS-CoV-2 ; Sensitivity and Specificity ; Workplace
Language	English
Publishing date	2022-01-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2239939-2
ISSN	1558-7118 ; 1557-2625
ISSN (online)	1558-7118
ISSN	1557-2625
DOI	10.3122/jabfm.2022.01.210284
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Article: It's about the patients: Practical antibiotic stewardship in outpatient settings in the United States.

Amin, Alpesh N / Dellinger, E Patchen / Harnett, Glenn / Kraft, Bryan D / LaPlante, Kerry L / LoVecchio, Frank / McKinnell, James A / Tillotson, Glenn / Valentine, Salisia

Frontiers in medicine

2022 Volume 9, Page(s) 901980

Abstract: Antibiotic-resistant pathogens cause over 35,000 preventable deaths in the United States every year, and multiple strategies could decrease morbidity and mortality. As antibiotic stewardship requirements are being deployed for the outpatient setting, ... ...

Abstract	Antibiotic-resistant pathogens cause over 35,000 preventable deaths in the United States every year, and multiple strategies could decrease morbidity and mortality. As antibiotic stewardship requirements are being deployed for the outpatient setting, community providers are facing systematic challenges in implementing stewardship programs. Given that the vast majority of antibiotics are prescribed in the outpatient setting, there are endless opportunities to make a smart and informed choice when prescribing and to move the needle on antibiotic stewardship. Antibiotic stewardship in the community, or "smart prescribing" as we suggest, should factor in antibiotic efficacy, safety, local resistance rates, and overall cost, in addition to patient-specific factors and disease presentation, to arrive at an appropriate therapy. Here, we discuss some of the challenges, such as patient/parent pressure to prescribe, lack of data or resources for implementation, and a disconnect between guidelines and real-world practice, among others. We have assembled an easy-to-use best practice guide for providers in the outpatient setting who lack the time or resources to develop a plan or consult lengthy guidelines. We provide specific suggestions for antibiotic prescribing that align real-world clinical practice with best practices for antibiotic stewardship for two of the most common bacterial infections seen in the outpatient setting: community-acquired pneumonia and skin and soft-tissue infection. In addition, we discuss many ways that community providers, payors, and regulatory bodies can make antibiotic stewardship easier to implement and more streamlined in the outpatient setting.
Language	English
Publishing date	2022-07-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2022.901980
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Article ; Online: Clinical Integration of a Highly Accurate Polymerase Chain Reaction Point-of-Care Test Can Inform Immediate Treatment Decisions for Chlamydia, Gonorrhea, and Trichomonas.

Dawkins, Megan / Bishop, Lisa / Walker, Paula / Otmaskin, Danielle / Ying, Julia / Schmidt, Ryan / Harnett, Glenn / Abraham, Teresa / Gaydos, Charlotte A / Schoolnik, Gary / DiBenedetto, Kevin

Sexually transmitted diseases

2023 Volume 49, Issue 4, Page(s) 262–267

Abstract: Background: Accurate same-day sexually transmitted infection (STI) diagnostic testing is generally unavailable, leading to syndromic management with high rates of overtreatment and undertreatment. We analyzed the ease of integration of the Visby STI ... ...

Abstract	Background: Accurate same-day sexually transmitted infection (STI) diagnostic testing is generally unavailable, leading to syndromic management with high rates of overtreatment and undertreatment. We analyzed the ease of integration of the Visby STI Panel into clinical practice, studied acceptance by patients and clinic personnel, and assessed the potential to inform accurate treatment decisions. Methods: In a cross-sectional single-visit study of 55 women aged 18 to 56 years, women self-collected vaginal swab samples that were analyzed using the Visby STI Panel for Chlamydia trachomatis, Neisseria gonorrhoeae (NG), and Trichomonas vaginalis (TV). Results were compared with standard-of-care clinic results from send-out laboratory polymerase chain reaction tests. Surveys assessed patient and device operator experiences with the Visby STI Panel and clinicians' perceived need for and acceptance of the device. Time parameters were measured to evaluate the impact on clinical workflow, and syndromic treatment decisions were compared with anticipated treatment based on the Visby STI Panel results. Results: Patients strongly agreed that sample self-collection was easy, and operators reported the device easy to use. Clinicians valued the rapid return of results, and patients were comfortable waiting up to 30 minutes to receive them. In 13 of 15 cases, the Visby STI Panel correctly identified undertreated patients as infected and correctly identified all 33 incidences of overtreatment. Conclusions: Clinical adoption of the Visby STI Panel into primary care clinics and doctors' offices could reduce overtreatment and undertreatment of STIs. If integrated efficiently into the clinical workflow, the test would have minimal impact on staff time and visit duration for patients.
MeSH term(s)	Chlamydia Infections/diagnosis ; Chlamydia Infections/drug therapy ; Chlamydia Infections/epidemiology ; Chlamydia trachomatis/genetics ; Cross-Sectional Studies ; Female ; Gonorrhea/diagnosis ; Gonorrhea/drug therapy ; Gonorrhea/epidemiology ; Humans ; Male ; Neisseria gonorrhoeae/genetics ; Point-of-Care Testing ; Polymerase Chain Reaction ; Sexually Transmitted Diseases/diagnosis ; Sexually Transmitted Diseases/drug therapy ; Sexually Transmitted Diseases/epidemiology ; Trichomonas ; Trichomonas Infections/diagnosis ; Trichomonas Infections/drug therapy ; Trichomonas Infections/epidemiology ; Trichomonas vaginalis/genetics
Language	English
Publishing date	2023-07-28
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	435191-5
ISSN	1537-4521 ; 0148-5717
ISSN (online)	1537-4521
ISSN	0148-5717
DOI	10.1097/OLQ.0000000000001586
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Zs.A 1217: Show issues

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Article ; Online: Cepheid Xpert Xpress Flu/RSV evaluation performed by minimally trained non-laboratory operators in a CLIA-waived environment.

Shihabuddin, Bashar S / Faron, Matthew L / Relich, Ryan F / Van Heukelom, Paul / Mayne, Donna / Staat, Mary Allen / Selvarangan, Rangaraj / Hueschen, Leslie A / Wolk, Donna M / House, Stacey / Harnett, Glenn / McGann, Kevin / Steele, Mark T / Romero, Jose R / Arms, Joe / Lander, Owen / Loeffelholz, Michael / Strouts, Fiona / Cohen, Daniel

Diagnostic microbiology and infectious disease

2022 Volume 104, Issue 2, Page(s) 115764

Abstract: The COVID-19 pandemic highlighted the significance of readily available and easily performed viral testing for surveillance during future infectious pandemics. The objectives of this study were: to assess the performance of the Xpert Xpress Flu and/or ... ...

Abstract	The COVID-19 pandemic highlighted the significance of readily available and easily performed viral testing for surveillance during future infectious pandemics. The objectives of this study were: to assess the performance of the Xpert Xpress Flu and/or RSV test, a multiplex PCR assay for detecting influenza A and B virus and respiratory syncytial virus nucleic acids in respiratory tract specimens, relative to the Quidel Lyra Influenza A+B assay and the Prodesse ProFlu+ assay, and the system's ease of use by minimally trained operators. Overall, the Xpert Xpress Flu/RSV test demonstrated a high positive and negative percent agreement with the comparator assays, and was easy to use and interpret results, based on the operators' feedback. We concluded that the Xpert Xpress Flu/RSV test is sensitive, specific, and easy to use for the diagnosis of influenza and RSV by minimally trained operators and can be a valuable tool in future infectious clusters or pandemics.
MeSH term(s)	COVID-19/diagnosis ; Humans ; Influenza A virus/genetics ; Influenza B virus/genetics ; Influenza, Human/diagnosis ; Molecular Diagnostic Techniques/methods ; Nasopharynx ; Pandemics ; Real-Time Polymerase Chain Reaction/methods ; Respiratory Syncytial Virus Infections/diagnosis ; Respiratory Syncytial Virus, Human/genetics ; Sensitivity and Specificity
Language	English
Publishing date	2022-07-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	604920-5
ISSN	1879-0070 ; 0732-8893
ISSN (online)	1879-0070
ISSN	0732-8893
DOI	10.1016/j.diagmicrobio.2022.115764
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Zs.A 1845: Show issues

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Article ; Online: Accurate PCR Detection of Influenza A/B and Respiratory Syncytial Viruses by Use of Cepheid Xpert Flu+RSV Xpress Assay in Point-of-Care Settings: Comparison to Prodesse ProFlu.

Cohen, Daniel M / Kline, Jennifer / May, Larissa S / Harnett, Glenn Eric / Gibson, Jane / Liang, Stephen Y / Rafique, Zubaid / Rodriguez, Carina A / McGann, Kevin M / Gaydos, Charlotte A / Mayne, Donna / Phillips, David / Cohen, Jason

Journal of clinical microbiology

2018 Volume 56, Issue 2

Abstract: The Xpert Flu+RSV Xpress Assay is a fast, ... ...

Abstract	The Xpert Flu+RSV Xpress Assay is a fast, automated
MeSH term(s)	Automation, Laboratory ; DNA, Viral/genetics ; Humans ; Influenza A virus/genetics ; Influenza A virus/isolation & purification ; Influenza B virus/genetics ; Influenza B virus/isolation & purification ; Influenza, Human/diagnosis ; Influenza, Human/virology ; Molecular Diagnostic Techniques/methods ; Molecular Diagnostic Techniques/standards ; Nasopharynx/virology ; Point-of-Care Systems ; Real-Time Polymerase Chain Reaction ; Respiratory Syncytial Virus Infections/diagnosis ; Respiratory Syncytial Virus Infections/virology ; Respiratory Syncytial Virus, Human/genetics ; Respiratory Syncytial Virus, Human/isolation & purification ; Sensitivity and Specificity ; Time Factors
Chemical Substances	DNA, Viral
Language	English
Publishing date	2018-01-24
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	390499-4
ISSN	1098-660X ; 0095-1137
ISSN (online)	1098-660X
ISSN	0095-1137
DOI	10.1128/JCM.01237-17
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Zs.A 1188: Show issues

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Article ; Online: The impact of respiratory syncytial virus infection on endothelin receptor function and release in sheep bronchial explants.

Fernandes, Lynette B / D'Aprile, Angela C / Self, Glenn J / Harnett, Gerald B / Goldie, Roy G

Journal of cardiovascular pharmacology

2004 Volume 44 Suppl 1, Page(s) S202–6

Abstract: We investigated the impact of respiratory syncytial virus (RSV) infection, an important asthma precipitant, on endothelin receptor function and release in sheep bronchial explants. RSV infection was confirmed using polymerase chain reaction and ... ...

Abstract	We investigated the impact of respiratory syncytial virus (RSV) infection, an important asthma precipitant, on endothelin receptor function and release in sheep bronchial explants. RSV infection was confirmed using polymerase chain reaction and immunohistochemistry. Since sheep airway smooth muscle contains only endothelin-A receptors, sarafotoxin (Stx) S6c did not cause airway contraction. In contrast, sarafotoxin S6c (300 nM) caused contraction in RSV-infected bronchial explants (8 +/- 3% carbachol Emax). However, we could not detect airway smooth muscle endothelin-B receptors in explants using autoradiography. RSV infection per se did not alter the release of immunoreactive endothelin from sheep bronchial explants (control = 11.6 +/- 0.9 pg versus RSV = 12.1 +/- 0.9 pg). Interestingly, dexamethasone (1 microM) alone increased endothelin release in both control (17.9 +/- 2.0 pg) and RSV-infected tissue (18.3 +/- 3.1 pg). The combined presence of protease-activated receptor-2 (PAR-2) ligand (100 microM) and dexamethasone (1 microM) also increased endothelin release from control tissue (17.3 +/- 1.4 pg), but endothelin release was suppressed by PAR-2 ligand in RSV-infected tissue (10.3 +/- 0.8 pg), probably because PAR-2 expression was increased by RSV. In summary, the novel expression of endothelin-B receptors triggered by RSV might be relevant to RSV-associated asthma. Furthermore, activation of airway PAR-2 may be protective in asthma where endothelin levels are elevated in part via endothelin release suppression.
MeSH term(s)	Animals ; Bronchi/drug effects ; Bronchi/metabolism ; Bronchi/physiopathology ; Bronchi/virology ; Culture Media, Conditioned/metabolism ; Dexamethasone/metabolism ; Dinoprostone/metabolism ; Dose-Response Relationship, Drug ; Endothelin-1/metabolism ; Enzyme-Linked Immunosorbent Assay ; Female ; Indomethacin/pharmacology ; Male ; Muscle Contraction/drug effects ; Muscle, Smooth/drug effects ; Muscle, Smooth/metabolism ; Muscle, Smooth/physiopathology ; Muscle, Smooth/virology ; Oligopeptides/pharmacology ; Peptides, Cyclic/pharmacology ; Piperidines/pharmacology ; Receptor, Endothelin A/metabolism ; Receptor, Endothelin B/drug effects ; Receptor, Endothelin B/metabolism ; Receptor, PAR-2/metabolism ; Respiratory Syncytial Virus Infections/metabolism ; Respiratory Syncytial Virus Infections/physiopathology ; Sheep ; Time Factors ; Tissue Culture Techniques ; Viper Venoms/pharmacology
Chemical Substances	Culture Media, Conditioned ; Endothelin-1 ; Oligopeptides ; Peptides, Cyclic ; Piperidines ; Receptor, Endothelin A ; Receptor, Endothelin B ; Receptor, PAR-2 ; Viper Venoms ; sarafotoxins s6 ; BQ 788 (44OLL8XEJ4) ; Dexamethasone (7S5I7G3JQL) ; Dinoprostone (K7Q1JQR04M) ; cyclo(Trp-Asp-Pro-Val-Leu) (S2A8YZM151) ; Indomethacin (XXE1CET956)
Language	English
Publishing date	2004-06-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	391970-5
ISSN	1533-4023 ; 0160-2446
ISSN (online)	1533-4023
ISSN	0160-2446
DOI	10.1097/01.fjc.0000166236.57077.9f
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Article ; Online: Life story templates in dementia care: Ambiguous direction and purpose.

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Article: Treatment of Community-Acquired Pneumonia: A Case Report and Current Treatment Dilemmas.

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Article ; Online: Exploring Workplace Testing with Real-Time Polymerase Chain Reaction SARS-CoV-2 Testing.

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Article: It's about the patients: Practical antibiotic stewardship in outpatient settings in the United States.

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Article ; Online: Clinical Integration of a Highly Accurate Polymerase Chain Reaction Point-of-Care Test Can Inform Immediate Treatment Decisions for Chlamydia, Gonorrhea, and Trichomonas.

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Article ; Online: Cepheid Xpert Xpress Flu/RSV evaluation performed by minimally trained non-laboratory operators in a CLIA-waived environment.

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Article ; Online: Accurate PCR Detection of Influenza A/B and Respiratory Syncytial Viruses by Use of Cepheid Xpert Flu+RSV Xpress Assay in Point-of-Care Settings: Comparison to Prodesse ProFlu.

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Article ; Online: The impact of respiratory syncytial virus infection on endothelin receptor function and release in sheep bronchial explants.

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