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  1. Article ; Online: Automation in the Thrombosis and Hemostasis Laboratory.

    Salazar, Eric / Higgins, Russell A

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2663, Page(s) 51–62

    Abstract: Automation continues to advance into hemostasis and thrombosis laboratories. Integration of hemostasis testing into an existing chemistry track systems and adoption of a separate hemostasis track systems are important considerations. Unique issues must ... ...

    Abstract Automation continues to advance into hemostasis and thrombosis laboratories. Integration of hemostasis testing into an existing chemistry track systems and adoption of a separate hemostasis track systems are important considerations. Unique issues must be addressed to maintain quality and efficiency when automation is introduced. Among other challenges, this chapter discusses centrifugation protocols, incorporation of specimen-check modules in the workflow, and inclusion of tests amenable to automation.
    MeSH term(s) Humans ; Laboratories ; Automation ; Hemostasis ; Thrombosis ; Centrifugation/methods ; Automation, Laboratory/methods
    Language English
    Publishing date 2023-05-19
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3175-1_3
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  2. Article: Challenges in the humanized mouse model for cancer: A commentary.

    Ramirez-Salazar, Eric / Herlyn, Meenhard / Somasundaram, Rajasekharan

    Journal of cancer biology

    2022  Volume 2, Issue 2, Page(s) 42–43

    Abstract: The complexity of the tumor microenvironment has been a challenge for understanding the mechanisms of therapy resistance. The development of improved animal models that closely mimic human disease is key for understanding and treating diseases. Recently, ...

    Abstract The complexity of the tumor microenvironment has been a challenge for understanding the mechanisms of therapy resistance. The development of improved animal models that closely mimic human disease is key for understanding and treating diseases. Recently, a new humanized mouse model has been developed that enables the study of human immune cells in tumor host-cell interactions. In this commentary we highlight the critical aspects of mast cells in immune therapy resistance. These mast cells release cytokines that downmodulate HLA class I on the malignant cells making them inaccessible the cytotoxic activity of T cells.
    Language English
    Publishing date 2022-09-26
    Publishing country United States
    Document type Journal Article ; Comment
    DOI 10.46439/cancerbiology.2.022
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  3. Article: Uncertainty quantification for predictions of atomistic neural networks.

    Vazquez-Salazar, Luis Itza / Boittier, Eric D / Meuwly, Markus

    Chemical science

    2022  Volume 13, Issue 44, Page(s) 13068–13084

    Abstract: The value of uncertainty quantification on predictions for trained neural networks (NNs) on quantum chemical reference data is quantitatively explored. For this, the architecture of the PhysNet NN was suitably modified and the resulting model (PhysNet- ... ...

    Abstract The value of uncertainty quantification on predictions for trained neural networks (NNs) on quantum chemical reference data is quantitatively explored. For this, the architecture of the PhysNet NN was suitably modified and the resulting model (PhysNet-DER) was evaluated with different metrics to quantify its calibration, the quality of its predictions, and whether prediction error and the predicted uncertainty can be correlated. Training on the QM9 database and evaluating data in the test set within and outside the distribution indicate that error and uncertainty are not linearly related. However, the observed variance provides insight into the quality of the data used for training. Additionally, the influence of the chemical space covered by the training data set was studied by using a biased database. The results clarify that noise and redundancy complicate property prediction for molecules even in cases for which changes - such as double bond migration in two otherwise identical molecules - are small. The model was also applied to a real database of tautomerization reactions. Analysis of the distance between members in feature space in combination with other parameters shows that redundant information in the training dataset can lead to large variances and small errors whereas the presence of similar but unspecific information returns large errors but small variances. This was,
    Language English
    Publishing date 2022-10-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d2sc04056e
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  4. Article: New and noteworthy species of the genus

    Arista, Jessy Patricia / Hágsater, Eric / Santiago, Elizabeth / Edquén, José D / Pariente, Elí / Oliva, Manuel / Salazar, Gerardo A

    PhytoKeys

    2023  Volume 227, Page(s) 43–87

    Abstract: Fourteen species of the ... ...

    Abstract Fourteen species of the genus
    Language English
    Publishing date 2023-06-01
    Publishing country Bulgaria
    Document type Journal Article
    ZDB-ID 2579891-1
    ISSN 1314-2003 ; 1314-2011
    ISSN (online) 1314-2003
    ISSN 1314-2011
    DOI 10.3897/phytokeys.227.101907
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  5. Article ; Online: Visual-functional impact of people affected by severe ocular trauma during social protests in Chile in 2019.

    Varas, Joaquín / Campos, Miguel Ángel / Tapia, Eric / Sanhueza, José Luis / Salazar, Claudia / Vergara, Nayadet / Tapia, Nicole / Mantero, Gianinna / Bustamante, Patricio

    International ophthalmology

    2024  Volume 44, Issue 1, Page(s) 77

    Abstract: Purpose: To determine the impact on the functionality associated with visual loss (VFIP) in people with severe ocular trauma (SOT) caused by kinetic impact projectiles used in police crowd control through a prioritization tool in people admitted to a ... ...

    Abstract Purpose: To determine the impact on the functionality associated with visual loss (VFIP) in people with severe ocular trauma (SOT) caused by kinetic impact projectiles used in police crowd control through a prioritization tool in people admitted to a rehabilitation program in Santiago de Chile from December 02, 2019, to November 13, 2020.
    Methods: A cross-sectional descriptive study of SOT victims (N = 85), average age 31.4 ± 11.9. The data were recorded through a new 9-item screening instrument for assessment and prioritization of rehabilitation created for this emergency scenario.
    Results: The impact of the use of kinetic weapons resulted in monocular blindness in the majority of those affected (n = 68; 80.0%). The highest VFIP observed was among young men from lower social strata. There were extreme difficulties in the performance of productive tasks (occupational and/or educational) (n = 42; 49.4%) and the pursuit of hobbies and pastimes (n = 23; 27.1%), as well as a high difficulty in adapting to changes in brightness (n = 29; 34.1%) and handling objects accurately (n = 22; 25.9%).
    Conclusion: The use of kinetic weapons for crowd control resulted in high and extreme VFIP and, in most cases, monocular blindness, causing major difficulties in work, study, and development of hobbies and pastimes in the affected population, highlighting the urgent need for effective rehabilitative care, which requires special attention in order to generate an adequate rehabilitation program. The use of kinetic weapons for crowd control contravenes international goals, policies, and plans set by the WHO and the International Agency for the Prevention of Blindness on strategies to prevent avoidable blindness worldwide until 2020. It is essential to ban the use of these weapons in Chile and worldwide, as well as to revise police protocols for crowd control.
    MeSH term(s) Male ; Humans ; Young Adult ; Adult ; Cross-Sectional Studies ; Chile/epidemiology ; Blindness/epidemiology ; Blindness/etiology ; Eye Injuries/complications ; Eye Injuries/epidemiology ; Hospitalization
    Language English
    Publishing date 2024-02-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 800087-6
    ISSN 1573-2630 ; 0165-5701
    ISSN (online) 1573-2630
    ISSN 0165-5701
    DOI 10.1007/s10792-024-02969-2
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    Zs.A 1479: Show issues Location:
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  6. Article ; Online: Bradycardia May Decrease Cardiorespiratory Coupling in Preterm Infants.

    Porta-García, Miguel Ángel / Quiroz-Salazar, Alberto / Abarca-Castro, Eric Alonso / Reyes-Lagos, José Javier

    Entropy (Basel, Switzerland)

    2023  Volume 25, Issue 12

    Abstract: Bradycardia, frequently observed in preterm infants, presents significant risks due to the immaturity of their autonomic nervous system (ANS) and respiratory systems. These infants may face cardiorespiratory events, leading to severe complications like ... ...

    Abstract Bradycardia, frequently observed in preterm infants, presents significant risks due to the immaturity of their autonomic nervous system (ANS) and respiratory systems. These infants may face cardiorespiratory events, leading to severe complications like hypoxemia and neurodevelopmental disorders. Although neonatal care has advanced, the influence of bradycardia on cardiorespiratory coupling (CRC) remains elusive. This exploratory study delves into CRC in preterm infants, emphasizing disparities between events with and without bradycardia. Using the Preterm Infant Cardio-Respiratory Signals (PICS) database, we analyzed interbeat (R-R) and inter-breath intervals (IBI) from 10 preterm infants. The time series were segmented into bradycardic (B) and non-bradycardic (NB) segments. Employing information theory measures, we quantified the irregularity of cardiac and respiratory time series. Notably, B segments had significantly lower entropy values for R-R and IBI than NB segments, while mutual information was higher in NB segments. This could imply a reduction in the complexity of respiratory and cardiac dynamics during bradycardic events, potentially indicating weaker CRC. Building on these insights, this research highlights the distinctive physiological characteristics of preterm infants and underscores the potential of emerging non-invasive diagnostic tools.
    Language English
    Publishing date 2023-12-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2014734-X
    ISSN 1099-4300 ; 1099-4300
    ISSN (online) 1099-4300
    ISSN 1099-4300
    DOI 10.3390/e25121616
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  7. Article ; Online: Review of Technologies and Materials Used in High-Voltage Film Capacitors.

    Gnonhoue, Olatoundji Georges / Velazquez-Salazar, Amanda / David, Éric / Preda, Ioana

    Polymers

    2021  Volume 13, Issue 5

    Abstract: High-voltage capacitors are key components for circuit breakers and monitoring and protection devices, and are important elements used to improve the efficiency and reliability of the grid. Different technologies are used in high-voltage capacitor ... ...

    Abstract High-voltage capacitors are key components for circuit breakers and monitoring and protection devices, and are important elements used to improve the efficiency and reliability of the grid. Different technologies are used in high-voltage capacitor manufacturing process, and at all stages of this process polymeric films must be used, along with an encapsulating material, which can be either liquid, solid or gaseous. These materials play major roles in the lifespan and reliability of components. In this paper, we present a review of the different technologies used to manufacture high-voltage capacitors, as well as the different materials used in fabricating high-voltage film capacitors, with a view to establishing a bibliographic database that will allow a comparison of the different technologies.
    Language English
    Publishing date 2021-02-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym13050766
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  8. Article ; Online: Review of Technologies and Materials Used in High-Voltage Film Capacitors

    Olatoundji Georges Gnonhoue / Amanda Velazquez-Salazar / Éric David / Ioana Preda

    Polymers, Vol 13, Iss 5, p

    2021  Volume 766

    Abstract: High-voltage capacitors are key components for circuit breakers and monitoring and protection devices, and are important elements used to improve the efficiency and reliability of the grid. Different technologies are used in high-voltage capacitor ... ...

    Abstract High-voltage capacitors are key components for circuit breakers and monitoring and protection devices, and are important elements used to improve the efficiency and reliability of the grid. Different technologies are used in high-voltage capacitor manufacturing process, and at all stages of this process polymeric films must be used, along with an encapsulating material, which can be either liquid, solid or gaseous. These materials play major roles in the lifespan and reliability of components. In this paper, we present a review of the different technologies used to manufacture high-voltage capacitors, as well as the different materials used in fabricating high-voltage film capacitors, with a view to establishing a bibliographic database that will allow a comparison of the different technologies
    Keywords high-voltage capacitors ; resin ; dielectric film ; Organic chemistry ; QD241-441
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  9. Article ; Online: Corrigendum to "Sex differences on multikinase inhibitors toxicity in patients with advanced gastroenteropancreatic neuroendocrine tumours" [Eur J Cancer 188 (2023) 39-48].

    Hernando, Jorge / Roca-Herrera, Maria / García-Álvarez, Alejandro / Raymond, Eric / Ruszniewski, Philippe / Kulke, Matthew H / Grande, Enrique / Carbonero, Rocío García / Castellano, Daniel / Salazar, Ramón / Ibrahim, Toni / Teule, Alex / Alonso, Vicente / Fazio, Nicola / Valle, Juan W / Tafuto, Salvatore / Carmona, Ana / Navarro, Victor / Capdevila, Jaume

    European journal of cancer (Oxford, England : 1990)

    2024  , Page(s) 114061

    Language English
    Publishing date 2024-04-11
    Publishing country England
    Document type Published Erratum
    ZDB-ID 82061-1
    ISSN 1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
    ISSN (online) 1879-0852
    ISSN 0277-5379 ; 0959-8049 ; 0964-1947
    DOI 10.1016/j.ejca.2024.114061
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 456: Show issues Location:
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    Zs.MO 583: Show issues

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  10. Article ; Online: Evaluation of outcomes with apixaban use for venous thromboembolism in hospitalized patients with end-stage renal disease receiving renal replacement therapy.

    Chen, Jingshi / Nguyen, Steffany / Ruegger, Melanie / Samuel, Leena / Salazar, Eric / Dunne, Ian

    Journal of thrombosis and thrombolysis

    2022  Volume 54, Issue 2, Page(s) 260–267

    Abstract: While direct oral anticoagulants (DOACs) received expanded labeling for use in atrial fibrillation (AF) for end-stage renal disease (ESRD) based on pharmacokinetic trials, little data exist regarding the use of DOACs for venous thromboembolism (VTE) in ... ...

    Abstract While direct oral anticoagulants (DOACs) received expanded labeling for use in atrial fibrillation (AF) for end-stage renal disease (ESRD) based on pharmacokinetic trials, little data exist regarding the use of DOACs for venous thromboembolism (VTE) in ESRD patients requiring renal replacement therapy (RRT). This retrospective, descriptive cohort study evaluated adult patients with a diagnosis of ESRD on RRT and with a VTE diagnosis receiving apixaban therapy prior to or during admission. The primary outcome was to identify major bleeding events within 72 h of last apixaban dose administration. Secondary outcomes included new VTE while on apixaban, appropriateness of anticoagulation regimen with regards to FDA labeled dosing and frequency, anticoagulation regimen adjustments, and factor Xa inhibitor-specific anti-Xa levels if available. A total of 68 patients met criteria for inclusion in the final analysis. Major bleeding events occurred in 13.2% of patients receiving apixaban within the last 72 h. Recurrent thrombosis occurred in 7.4% of patients. The use of apixaban for VTE in patients with ESRD on RRT led to a higher risk of bleeding compared to that of landmark trials. Therefore, apixaban use should occur following shared decision making especially if there is no contraindication to warfarin.
    MeSH term(s) Administration, Oral ; Adult ; Anticoagulants/adverse effects ; Cohort Studies ; Hemorrhage/chemically induced ; Hemorrhage/drug therapy ; Humans ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/therapy ; Pyrazoles ; Pyridones/adverse effects ; Renal Replacement Therapy ; Retrospective Studies ; Venous Thromboembolism/chemically induced ; Venous Thromboembolism/drug therapy
    Chemical Substances Anticoagulants ; Pyrazoles ; Pyridones ; apixaban (3Z9Y7UWC1J)
    Language English
    Publishing date 2022-04-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1230645-9
    ISSN 1573-742X ; 0929-5305
    ISSN (online) 1573-742X
    ISSN 0929-5305
    DOI 10.1007/s11239-022-02650-4
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