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Article: Celiac disease is increased in esophageal squamous cell Carcinoma.

Poyrazoglu, Omer Bilgehan / Dulger, Ahmet Cumhur

2021 Volume 37, Issue 5, Page(s) 1445–1450

Abstract: Background and objective: The intercourse between Esophageal squamous cell carcinoma etc. (ESC) and Celiac disease (CD) is still a complicated subject. The purpose of this research was to define the relationship between CD and ESC, and the factors ... ...

Abstract	Background and objective: The intercourse between Esophageal squamous cell carcinoma etc. (ESC) and Celiac disease (CD) is still a complicated subject. The purpose of this research was to define the relationship between CD and ESC, and the factors associated with CD in patients with ESC. Methods: This research was conducted by Van University Medical Center in Turkey from 2012 to 2016.CD was identified by analyzing duodenal biopsy materials from 63 ESC patients via histopathologic examinations. Serum samples from the patients were also serologically tested to identify CD. A control group was selected from among subjects who underwent gastroduodenoscopy due to dyspepsia. Distinctions between case characteristics were evaluated with chi-square tests and t-tests for categorical and continuous factors, respectively. Results: Of the 63 study cases, 6 (9.5%) were both histological and serological positive for CD. Of the 290 control group, 8 (2.8%) had histopathological CD and tested positive for celiac antibodies. The patients with ESC had a significantly higher prevalence of CD compared to the dyspeptic patients (p<0.001). In addition, the mean creatinine levels of ESC patients with histopathological-proven CD were higher than those without CD (p=0.026). Furthermore, ESC patients who tested positive for tTg IgA had significantly higher levels of glucose and AST than those who were negative for tTg IgA (p=0.032) and (p=0.008), respectively. Conclusion: The present study demonstrated a statistically significant positive correlation between ESC and CD. Most remarkably, higher creatinine, glucose, and AST levels may predict CD in patients with ESC. These evidences may lead novel approaches for preventing ESC in patients with CD.
Language	English
Publishing date	2021-09-01
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	2032827-8
ISSN	1681-715X ; 1682-024X ; 1017-4699
ISSN (online)	1681-715X
ISSN	1682-024X ; 1017-4699
DOI	10.12669/pjms.37.5.2757
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Effect of Direct Oral Anticoagulants on Gastric Mucosa and Helicobacter Pylori Prevalence in Dyspeptic Patients: A Retrospective Cross-Sectional Study.

Issever, Kubilay / Kuloglu, Ersin / Muhtaroglu, Ali / Seker, Demet / Kotur, Osman / Dulger, Ahmet Cumhur

Cureus

2023 Volume 15, Issue 10, Page(s) e46477

Abstract: Background and aim Although direct oral anticoagulants (DOACs) are widely used and their side effects related to bleeding at various body sites have been well studied in the literature, less is known about their local impact on gastric mucosa. Some ... ...

Abstract	Background and aim Although direct oral anticoagulants (DOACs) are widely used and their side effects related to bleeding at various body sites have been well studied in the literature, less is known about their local impact on gastric mucosa. Some studies suggest that the higher risk of gastrointestinal (GI) bleeding associated with DOACs may be due to their direct local anticoagulant effects on the gastric mucosa. In this study, we aim to evaluate whether this potential local effect has a favorable outcome on the gastric mucosa and the prevalence of
Language	English
Publishing date	2023-10-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.46477
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Article: Helicobacter Pylori and Celiac Disease Antibody Positivity Have a Higher Prevalence in Patients With Distal Gastrectomy: A Cross-Sectional Retrospective Study.

Issever, Kubilay / Kuloglu, Ersin / Sengul, Demet / Muhtaroglu, Ali / Dulger, Ahmet Cumhur

Cureus

2023 Volume 15, Issue 8, Page(s) e42976

Abstract: Aims and objectives Distal gastrectomy was a widely used therapeutic option for peptic ulcer and gastroesophageal reflux disease until quite recently. The consequences of anatomical and physiological changes following surgery in the gastric mucosa have ... ...

Abstract	Aims and objectives Distal gastrectomy was a widely used therapeutic option for peptic ulcer and gastroesophageal reflux disease until quite recently. The consequences of anatomical and physiological changes following surgery in the gastric mucosa have been the object of interest for the scientist. In this study, we aimed to determine whether Helicobacter pylori (HP) infection and celiac disease were more common in patients with a history of distal gastrectomy. Materials and methods This is an observational retrospective study conducted at Giresun University Faculty of Medicine. The medical files of 35 patients with dyspepsia who had a history of distal gastrectomy for benign etiologies (antrectomy group) and 50 patients with dyspepsia (control group) were retrospectively analyzed. Results There were more males and older patients in the antrectomy group. Concerning the lab parameters, platelets, lymphocyte, and albumin levels were significantly lower, and urea, creatinine, anti-Endomisium Ig A (anti-EMA), and anti-tissue transglutaminase IgA (anti-tTGA) antibody positivity were significantly higher in the antrectomy group. Gastric biopsy results revealed a higher positivity of HP, atrophy, neutrophil, and lymphocytes in the antrectomy group. Correlation analysis revealed an inverse correlation between albumin and anti-EMA/atrophy positivity whereas a positive correlation between anti-EMA and HP/atrophy positivity. Conclusions HP infection and coeliac disease (CD) could be the problems that distal gastrectomy patients with dyspepsia can face during their follow-up. Concerning the pre-malignant potential of HP, its screening and eradication should be performed to prevent the malignant transformation of the remnant gastric tissue.
Language	English
Publishing date	2023-08-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.42976
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Article ; Online: Current Treatment Of Chronıc Hepatıtıs C Genotype 1

Mesut Aydın / Ahmet Cumhur Dülger

Van Tıp Dergisi, Vol 25, Iss 4, Pp 547-

2018 Volume 551

Abstract: Hepatitis C virus (HCV) causes both acute and chronic hepatitis. Following acute HCV infection, chronic infection develops in about of patients. In years, Chronic hepatitis C can progress to cirrhosis, hepatocellular carcinoma (HCC) or may result in ... ...

Abstract	Hepatitis C virus (HCV) causes both acute and chronic hepatitis. Following acute HCV infection, chronic infection develops in about of patients. In years, Chronic hepatitis C can progress to cirrhosis, hepatocellular carcinoma (HCC) or may result in liver transplantation. It is one of the most common causes of liver transplantion in the world. Recently, the treatment of CHC has dramatically improved. The success rate of over 90-95% with new developments in treatment, is promising for the future.
Keywords	direct acting antiviral ; hepatitis c virus ; chronic hepatitis c ; Medicine ; R
Language	English
Publishing date	2018-10-01T00:00:00Z
Publisher	Van Yuzuncu Yil University, School of Medicine
Document type	Article ; Online
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Article ; Online: Treatment of Crimean-Congo Haemorrhagic Fever by Favipiravir in a Patient with Novel Coronavirus Co-Infection.

Dülger, Ahmet Cumhur / Yakarişik, Mustafa / Uzun, Yusuf Emre / Şahin, Ahmet Melih

European journal of case reports in internal medicine

2020 Volume 7, Issue 12, Page(s) 2042

Abstract: Introduction: Crimean-Congo haemorrhagic fever (CCHF) is a lethal zoonotic disease caused by an RNA virus that is a member of the : Case description: A 65-year-old man was admitted to the emergency unit with dry cough, myalgia and fever. He was ... ...

Abstract	Introduction: Crimean-Congo haemorrhagic fever (CCHF) is a lethal zoonotic disease caused by an RNA virus that is a member of the Case description: A 65-year-old man was admitted to the emergency unit with dry cough, myalgia and fever. He was treated with favipiravir. He had disseminated intravascular coagulopathy with thrombocytopenia in the setting of COVID-19 infection. He tested positive for both COVID-19 and CCHF. By the end of the fifth day of treatment, his laboratory parameters and clinical symptoms had normalized. Conclusion: Favipiravir is currently on the market for treating COVID-19 infection worldwide. It has also been used to treat CCHF in laboratory animals. To the best of our knowledge this is the first report of CCHF successfully treated with favipiravir, which could be a key drug for treating human CCHF. Learning points: Clinicians should be alert for concomitant viral infections such as Crimean-Congo haemorrhagic fever, which share similar clinical and laboratory findings to COVID-19.The effectiveness of favipiravir for viral infections other than influenza and COVID-19, such as Crimean-Congo haemorrhagic fever, should be elucidated.
Language	English
Publishing date	2020-12-17
Publishing country	Italy
Document type	Journal Article
ISSN	2284-2594
ISSN (online)	2284-2594
DOI	10.12890/2020_002042
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Does enteral nutrition through a percutaneous endoscopic gastrostomy, attenuate Helicobacter pylori colonization?: is it worth mentioning?

Muhtaroglu, Ali / Sengul, Ilker / Sengul, Demet / Kesicioglu, Tugrul / Seker, Demet / Aydin, Muhammed / Dulger, Ahmet Cumhur

Revista da Associacao Medica Brasileira (1992)

2023 Volume 69, Issue 4, Page(s) e20221733

Abstract: Objective: In patients who experience difficulties in oral feeding, alimentary intake can be supported by creating direct access into the stomach through a percutaneous endoscopic gastrostomy. The present study purposed to compare naïve and exchanged ... ...

Abstract	Objective: In patients who experience difficulties in oral feeding, alimentary intake can be supported by creating direct access into the stomach through a percutaneous endoscopic gastrostomy. The present study purposed to compare naïve and exchanged percutaneous endoscopic gastrostomy tubes in terms of Helicobacter pylori infection and other clinical characteristics. Methods: A total of 96 cases who underwent naïve or exchanged percutaneous endoscopic gastrostomy procedures with various indications were incorporated into the study. The patients' demographic data, such as age and gender, etiology of percutaneous endoscopic gastrostomy, anti-HBs status, Helicobacter pylori status, the presence of atrophy and intestinal metaplasia, biochemical parameters, and lipid profiles, had been analyzed. In addition, the anti-HCV and anti-HIV statuses had also been evaluated. Results: The most common indication for percutaneous endoscopic gastrostomy placement was dementia in 26 (27.08%) cases (p=0.033). The presence of Helicobacter pylori positivity was significantly lower in the exchange group compared to the naïve group (p=0.022). Total protein, albumin, and lymphocyte levels were significantly higher in the exchange group compared to the naïve group (both p=0.001), and the mean calcium, hemoglobin, and hematocrit levels were statistically significantly higher in the exchange group (p<0.001). Conclusion: Preliminary outcomes of the present study revealed that enteral nutrition attenuates the incidence of Helicobacter pylori infection. Considering the acute-phase reactant, the significantly lower ferritin values in the exchange group suggest that there is no active inflammatory process in the patients and that immunity is sufficient.
MeSH term(s)	Humans ; Enteral Nutrition/methods ; Gastrostomy/methods ; Helicobacter pylori ; Helicobacter Infections/therapy
Language	English
Publishing date	2023-04-21
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	731969-1
ISSN	1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
ISSN (online)	1806-9282
ISSN	0104-4230 ; 0004-5241 ; 0102-843X
DOI	10.1590/1806-9282.20221733
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Article ; Online: Prevalance of Celiac Disease in Subjects With Diverticular Disease Of The Colon

Mesut Aydın / Serhat Özer / Yaren Dirik / Elif Tuğba Tuncel / Ahmet Cumhur Dülger

Van Tip Dergisi, Vol 28, Iss 3, Pp 400-

2021 Volume 403

Abstract: INTRODUCTION: Celiac disease (CD) is a small bowel malabsorption syndrome that is caused by hypersensitivity to wheat in subjects who have positive HLA haplotypes DQ2 and DQ8. Diverticular disease of the colon (DDC) is saccular dilatations of colon, ... ...

Abstract	INTRODUCTION: Celiac disease (CD) is a small bowel malabsorption syndrome that is caused by hypersensitivity to wheat in subjects who have positive HLA haplotypes DQ2 and DQ8. Diverticular disease of the colon (DDC) is saccular dilatations of colon, which is seen mostly in adults older than 40. In this study, we tried to see whether CD is protective for DDC. METHODS: We identified 114 (57 female; the mean age 58+-4.1 years) patients with DDC during the 7-month period from January to October 2018. Age-matched control group (100 subjects; 50 female; the mean age 59+-3.4 years) was selected from subjects without DDC. RESULTS: Among subjects with DDC, only one tested positive for CD serologically (Tissue Transglutaminase - tTTG IgA and G). In control subjects with dyspepsia, 2.8% of subjects tested positive for celiac antibodies. There was a robust difference between groups in terms of TTG Ig A seropositivity (P<0.005, respectively). DISCUSSION AND CONCLUSION: The results indicate an inverse relationship between DDC and CD. These data support that lack of celiac antibodies may have a preventive role for developing DDC. The mechanism of presented finding is still unclear. Further research is needed.
Keywords	celiac disease ; diverticuls of colon ; diarrhea ; Medicine ; R
Subject code	150
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	Van Yuzuncu Yil University, School of Medicine
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Treatment of Crimean-Congo Haemorrhagic Fever by Favipiravir in a Patient with Novel Coronavirus Co-Infection

Ahmet Cumhur Dülger / Mustafa Yakarişik / Yusuf Emre Uzun / Ahmet Melih Şahin

European Journal of Case Reports in Internal Medicine (2020)

2020

Abstract: Introduction: Crimean-Congo haemorrhagic fever (CCHF) is a lethal zoonotic disease caused by an RNA virus that is a member of the Nairovirus genus in the Bunyaviridae family from the arbovirus group. CCHF is transmitted by Hyalomma ticks through direct ... ...

Abstract	Introduction: Crimean-Congo haemorrhagic fever (CCHF) is a lethal zoonotic disease caused by an RNA virus that is a member of the Nairovirus genus in the Bunyaviridae family from the arbovirus group. CCHF is transmitted by Hyalomma ticks through direct contact with the blood and other bodily fluids of patients or infected animals. Case description: A 65-year-old man was admitted to the emergency unit with dry cough, myalgia and fever. He was treated with favipiravir. He had disseminated intravascular coagulopathy with thrombocytopenia in the setting of COVID-19 infection. He tested positive for both COVID-19 and CCHF. By the end of the fifth day of treatment, his laboratory parameters and clinical symptoms had normalized. Conclusion: Favipiravir is currently on the market for treating COVID-19 infection worldwide. It has also been used to treat CCHF in laboratory animals. To the best of our knowledge this is the first report of CCHF successfully treated with favipiravir, which could be a key drug for treating human CCHF.
Keywords	crimean-congo haemorrhagic fever ; covid-19 ; favipiravir ; Medicine ; R
Subject code	616 ; 630
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	SMC MEDIA SRL
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Helicobacter Pylori

Aydın, Mesut / Tolunay, Harun Egemen / Varlı, Erol Nadi / Boza, Barış / Şahin, Özgür / Özer, Serhat / Dülger, Ahmet Cumhur

The Yale journal of biology and medicine

2020 Volume 93, Issue 4, Page(s) 487–493

Abstract: ... ...

Abstract	Objectives
MeSH term(s)	Amniotic Fluid ; Female ; Helicobacter Infections/complications ; Helicobacter Infections/diagnosis ; Helicobacter pylori ; Humans ; Hyperemesis Gravidarum ; Pregnancy ; Pregnancy Complications, Infectious ; Prospective Studies
Language	English
Publishing date	2020-09-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	200515-3
ISSN	1551-4056 ; 0044-0086
ISSN (online)	1551-4056
ISSN	0044-0086
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Article ; Online: Aspartate-aminotransferase to platelet ratio index score for predicting HELLP syndrome.

Şaşmaz, Muhammed İkbal / Ayvaz, Muhammed Ali / Dülger, Ahmet Cumhur / Kuday Kaykısız, Eylem Kuday / Güven, Ramazan

The American journal of emergency medicine

2019 Volume 38, Issue 3, Page(s) 459–462

Abstract: Introduction: HELLP (hemolysis, elevated liver enzyme levels, low platelet counts)-syndrome is a rare but dramatic pregnancy-related illness. The difficult part of this syndrome is the lack of standardised diagnostic criterias and tests to be used to ... ...

Abstract	Introduction: HELLP (hemolysis, elevated liver enzyme levels, low platelet counts)-syndrome is a rare but dramatic pregnancy-related illness. The difficult part of this syndrome is the lack of standardised diagnostic criterias and tests to be used to predict it. The aim of this study is determining the role of APRI score in the diagnosis of HELLP syndrome. Material and methods: In this cross sectional, retrospective study, patients with HELLP syndrome as case group and age-matched healthy pregnants at the similar pregnancy trimester as control group were included between January 12,017 and May 31, 2018. Data including sex, age, laboratory values, prognosis were recorded from the computerized system of the hospital. The p-value <0.05 was considered statistically significant. Results: 40 patients with HELLP syndrome and 124 age-matched healthy pregnants included in the study. There was a statistically significant difference between control group and HELLP patients in terms of the mean urinary protein, platelet count, ALT, AST, creatinin, D dimer levels and also the mean APRI score. In the multivariate regression analysis, APRI score was found a better predictor than AST and both were in a good significant in predicting HELLP. On the ROC curve in order to distinguish the patients with HELLP from the control group for AST and APRI score, the sensitivity was found to be 71.7% and 82.6%, specificity to be 91.2% and 87.6% respectively. Maternal mortality rate of HELLP syndrome was 10%. Conclusion: We concluded that the APRI score was robustly predicted HELLP syndrome than AST alone in this study. Further studies are needed to support our data with prospective, multicentre, larger patient groups.
MeSH term(s)	Adult ; Aspartate Aminotransferases/blood ; Biomarkers/blood ; Case-Control Studies ; Cross-Sectional Studies ; Female ; HELLP Syndrome/blood ; HELLP Syndrome/diagnosis ; HELLP Syndrome/mortality ; Humans ; Platelet Count ; Predictive Value of Tests ; Pregnancy ; Proteinuria ; Reference Standards ; Retrospective Studies
Chemical Substances	Biomarkers ; Aspartate Aminotransferases (EC 2.6.1.1)
Language	English
Publishing date	2019-02-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	605890-5
ISSN	1532-8171 ; 0735-6757
ISSN (online)	1532-8171
ISSN	0735-6757
DOI	10.1016/j.ajem.2019.02.014
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