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Article: Local photo-mechanical stiffness revealed in gold nanoparticles supracrystals by ultrafast small-angle electron diffraction.

Mancini, Giulia Fulvia / Pennacchio, Francesco / Latychevskaia, Tatiana / Reguera, Javier / Stellacci, Francesco / Carbone, Fabrizio

Structural dynamics (Melville, N.Y.)

2019 Volume 6, Issue 2, Page(s) 24304

Abstract: We demonstrate that highly ordered two-dimensional crystals of ligand-capped gold nanoparticles display a local photo-mechanical stiffness as high as that of solids such as graphite. In out-of-equilibrium electron diffraction experiments, a strong ... ...

Abstract	We demonstrate that highly ordered two-dimensional crystals of ligand-capped gold nanoparticles display a local photo-mechanical stiffness as high as that of solids such as graphite. In out-of-equilibrium electron diffraction experiments, a strong temperature jump is induced in a thin film with a femtosecond laser pulse. The initial electronic excitation transfers energy to the underlying structural degrees of freedom, with a rate generally proportional to the stiffness of the material. Using femtosecond small-angle electron diffraction, we observe the temporal evolution of the diffraction feature associated with the nearest-neighbor nanoparticle distance. The Debye-Waller decay for the octanethiol-capped nanoparticle supracrystal, in particular, is found to be unexpectedly fast, almost as fast as the stiffest solid known and observed by the same technique, i.e., graphite. Our observations unravel that local stiffness in a dense supramolecular assembly can be created by van der Waals interactions up to a level comparable to crystalline systems characterized by covalent bonding.
Language	English
Publishing date	2019-04-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2758684-4
ISSN	2329-7778
ISSN	2329-7778
DOI	10.1063/1.5091858
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Article ; Online: Role of HIV-1 Tat Protein Interactions with Host Receptors in HIV Infection and Pathogenesis.

Cafaro, Aurelio / Schietroma, Ivan / Sernicola, Leonardo / Belli, Roberto / Campagna, Massimo / Mancini, Flavia / Farcomeni, Stefania / Pavone-Cossut, Maria Rosaria / Borsetti, Alessandra / Monini, Paolo / Ensoli, Barbara

International journal of molecular sciences

2024 Volume 25, Issue 3

Abstract: ... antiretroviral therapy (ART), the transactivator of viral transcription Tat is one of the first HIV-1 protein ... of the Tat protein exits infected cells, accumulates in the extracellular matrix and exerts profound effects ... extracellular Tat contributes to the acquisition of infection, spreading and progression to AIDS in untreated ...

Abstract	Each time the virus starts a new round of expression/replication, even under effective antiretroviral therapy (ART), the transactivator of viral transcription Tat is one of the first HIV-1 protein to be produced, as it is strictly required for HIV replication and spreading. At this stage, most of the Tat protein exits infected cells, accumulates in the extracellular matrix and exerts profound effects on both the virus and neighbor cells, mostly of the innate and adaptive immune systems. Through these effects, extracellular Tat contributes to the acquisition of infection, spreading and progression to AIDS in untreated patients, or to non-AIDS co-morbidities in ART-treated individuals, who experience inflammation and immune activation despite virus suppression. Here, we review the role of extracellular Tat in both the virus life cycle and on cells of the innate and adaptive immune system, and we provide epidemiological and experimental evidence of the importance of targeting Tat to block residual HIV expression and replication. Finally, we briefly review vaccine studies showing that a therapeutic Tat vaccine intensifies ART, while its inclusion in a preventative vaccine may blunt escape from neutralizing antibodies and block early events in HIV acquisition.
MeSH term(s)	Humans ; HIV Infections ; HIV-1/metabolism ; tat Gene Products, Human Immunodeficiency Virus/metabolism ; Antibodies, Neutralizing ; Vaccines/therapeutic use
Chemical Substances	tat Gene Products, Human Immunodeficiency Virus ; Antibodies, Neutralizing ; Vaccines
Language	English
Publishing date	2024-01-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25031704
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Article: Vestibulocochlear Delineation for Vestibular Schwannoma Treated With Radiation Therapy.

Restini, Felipe Cicci Farinha / Brito, Leticia Hernandes / Yoshimoto, Fernanda Hayashida / Pereira, Ana Paula Alves / Neto, David Rodrigues Ferreira / Gomes, Vitor Cunha / Nascimento, Beatriz Cunha / Mancini, Anselmo / Alves, Tatiana Midori Martins Telles / Starling, Maria Thereza Mansur / Chaves, Guilherme Wilson Otaviano Garcia / Passos, Ula Lindoso / Marta, Gustavo Nader / Hanna, Samir Abdallah

Advances in radiation oncology

2023 Volume 8, Issue 4, Page(s) 101171

Abstract: Purpose: To develop a specialist-based consensus of cochlear contouring to be used in patients undergoing stereotactic radiosurgery (SRS) treatment for vestibular schwannoma.: Methods and materials: Representative computed tomography (CT) and ... ...

Abstract	Purpose: To develop a specialist-based consensus of cochlear contouring to be used in patients undergoing stereotactic radiosurgery (SRS) treatment for vestibular schwannoma. Methods and materials: Representative computed tomography (CT) and magnetic resonance imaging (MRI) were used for cochlear contouring. The semicircles, cochlea, vestibule, and internal acoustic meatus were delineated by 7 radiation oncology department physicians and reviewed by neuroradiologists. A total of 12 cases accrued from a single academic institution were studied for a similarity analysis by the Dice coefficient. Results: The suggested guideline is an easily reproductive tool that allows radiation oncologists to accurately contour the vestibulocochlear system to avoid toxicity due to inadequate dosimetry of organs at risk. This could be a useful tool even for non-vestibular schwannoma radiation therapy. The Dice coefficient suggests reproducible results as long as the following contouring recommendations are observed. Conclusions: The template for vestibulocochlear delineation may be useful for an adequate organs at risk definition. Future studies are required to find specific constraints for each segment of the vestibulocochlear system, and to mitigate interobserver variations.
Language	English
Publishing date	2023-01-06
Publishing country	United States
Document type	Journal Article
ISSN	2452-1094
ISSN	2452-1094
DOI	10.1016/j.adro.2022.101171
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Article ; Online: The science we need for the beaches we want

Guilherme Nascimento Corte / Yasmina Shah Esmaeili / Tatiana Fabricio Maria / Leonardo Lopes Costa / Gustavo Mattos / Helio Herminio Checon / Nicole Malinconico / Paulo Cesar Paiva / Paula Debiasi / Tatiana Cabrini / Victor Corrêa Seixas / Eduardo Bulhões / José Souto Rosa Filho / Leonir André Colling / Leonardo Cruz da Rosa / Leonardo Querobim Yokoyama / Ricardo Cardoso / Maíra Pombo / Patricia Luciano Mancini /

Luciana Yokoyama Xavier / Thuareag Santos / Marcelo Petracco / Ligia Salgado Bechara / Ivan Rodrigo Abrão Laurino / Maikon Di Domenico / Clarisse Odebrecht / Antonio Henrique da Fontoura Klein / Cristina de Almeida Rocha Barreira / Abilio Soares-Gomes / Ilana Rosental Zalmon / Antonia Cecilia Zacagnini Amaral / Alexander Turra / Carlos Alberto de Moura Barboza

Frontiers in Marine Science, Vol

frontiers of the flourishing Brazilian ecological sandy beach research

2023 Volume 10

Keywords	anthropocene ; biodiversity ; socio-ecological systems ; conservation ; management ; ecosystem-based management ; Science ; Q ; General. Including nature conservation ; geographical distribution ; QH1-199.5
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Endoplasmic Reticulum Stress and Autophagy Markers in Soleus Muscle Disuse-Induced Atrophy of Rats Treated with Fish Oil.

Marzuca-Nassr, Gabriel Nasri / Kuwabara, Wilson Mitsuo Tatagiba / Vitzel, Kaio Fernando / Murata, Gilson Masahiro / Torres, Rosângela Pavan / Mancini-Filho, Jorge / Alba-Loureiro, Tatiana Carolina / Curi, Rui

Nutrients

2021 Volume 13, Issue 7

Abstract: Endoplasmic reticulum stress (ERS) and autophagy pathways are implicated in disuse muscle atrophy. The effects of high eicosapentaenoic (EPA) or high docosahexaenoic (DHA) fish oils on soleus muscle ERS and autophagy markers were investigated in a rat ... ...

Abstract	Endoplasmic reticulum stress (ERS) and autophagy pathways are implicated in disuse muscle atrophy. The effects of high eicosapentaenoic (EPA) or high docosahexaenoic (DHA) fish oils on soleus muscle ERS and autophagy markers were investigated in a rat hindlimb suspension (HS) atrophy model. Adult Wistar male rats received daily by gavage supplementation (0.3 mL per 100 g b.w.) of mineral oil or high EPA or high DHA fish oils (FOs) for two weeks. Afterward, the rats were subjected to HS and the respective treatments concomitantly for an additional two-week period. After four weeks, we evaluated ERS and autophagy markers in the soleus muscle. Results were analyzed using two-way analysis of variance (ANOVA) and Bonferroni post hoc test. Gastrocnemius muscle ω-6/ω-3 fatty acids (FAs) ratio was decreased by both FOs indicating the tissue incorporation of omega-3 fatty acids. HS altered (
MeSH term(s)	Animals ; Autophagy/drug effects ; Biomarkers/metabolism ; Disease Models, Animal ; Docosahexaenoic Acids/pharmacology ; Eicosapentaenoic Acid/pharmacology ; Endoplasmic Reticulum Stress/drug effects ; Fish Oils/pharmacology ; Hindlimb Suspension ; Male ; Muscle, Skeletal/metabolism ; Muscular Atrophy/etiology ; Muscular Atrophy/metabolism ; Muscular Atrophy/therapy ; Rats ; Rats, Wistar
Chemical Substances	Biomarkers ; Fish Oils ; Docosahexaenoic Acids (25167-62-8) ; Eicosapentaenoic Acid (AAN7QOV9EA)
Language	English
Publishing date	2021-07-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13072298
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Article ; Online: Assessing self-efficacy in type 2 diabetes management: validation of the Italian version of the Diabetes Management Self-Efficacy Scale (IT-DMSES).

Messina, Rossella / Rucci, Paola / Sturt, Jackie / Mancini, Tatiana / Fantini, Maria Pia

Health and quality of life outcomes

2018 Volume 16, Issue 1, Page(s) 71

Abstract: Background: Being highly self-efficacious is a key factor in successful chronic disease self-management. In the context of measuring self-efficacy in type 2 diabetes management, the Diabetes Management Self-Efficacy Scale (DMSES) is the most widely used ...

Abstract	Background: Being highly self-efficacious is a key factor in successful chronic disease self-management. In the context of measuring self-efficacy in type 2 diabetes management, the Diabetes Management Self-Efficacy Scale (DMSES) is the most widely used scale. The aim of this study was to adapt the English version of the scale to Italian and to evaluate the psychometric properties of the Italian version of DMSES in type 2 diabetes (IT-DMSES). Methods: We conducted a cross-sectional study of people with type 2 diabetes attending the Endocrine-Metabolic Disease Care Unit of the Internal Medicine Department of San Marino State Hospital between October 2016 and February 2017. Patients completed a socio-demographic and clinical data form, the IT-DMSES and 3 self-report questionnaires measuring diabetes distress (PAID-5), psychological well-being (WHO-5) and depression (PHQ-9). Psychometric testing included construct validity (principal component analysis), internal consistency (Cronbach's α coefficient) and convergent/discriminant validity (Spearman's correlation coefficient). Decision tree analysis was performed to classify patients into homogeneous subgroups of self-efficacy based on their demographic and clinical characteristics. Results: Participants were 110 males and 55 females, mean age of 65.2 years (SD ± 9), 56.9% had been diagnosed for 1-15 years, 63% had HbA1c level > 53 mmol/mol. Two main factors underlain the construct of self-efficacy in diabetes management: 'Disease Management' and "Lifestyles Management". Disease Management had a good reliability (α = .849) and Lifestyle Management had an excellent reliability (α = .902) indicating that the instrument is internally consistent. A negative and weak correlation was found between Lifestyle management, PAID-5 (r = - 0.258, p = < 0.01) and PHQ-9 (r = - 0.274, p = < 0.01) and a positive one with WHO-5 (r = 0.325, p < 0.01) supporting convergent validity. Disease management was uncorrelated with PAID-5 (r = - 0.142, p = 0.083), PHQ-9 (r = - 0.145, p = 0.076) and weekly correlated with WHO-5 (r = 0.170, p = 0.037) confirming discriminant validity. Higher levels of self-efficacy in lifestyle management were found in patients diagnosed for at least 1 year up to 15 years and aged > 65 years and the poorest self-efficacy was found in males < 65 years. Conclusions: Results support the validity and reliability of IT-DMSES. The scale can be used in research and clinical practice to monitor type 2 diabetes self-management over time.
MeSH term(s)	Adult ; Aged ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/prevention & control ; Diabetes Mellitus, Type 2/psychology ; Diagnostic Self Evaluation ; Female ; Humans ; Italy ; Male ; Middle Aged ; Principal Component Analysis ; Psychometrics ; Quality of Life/psychology ; Reproducibility of Results ; Self Efficacy ; Self Report ; Self-Assessment ; Surveys and Questionnaires/standards ; Translations
Language	English
Publishing date	2018-04-23
Publishing country	England
Document type	Journal Article ; Validation Studies
ISSN	1477-7525
ISSN (online)	1477-7525
DOI	10.1186/s12955-018-0901-3
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Article ; Online: Does self-efficacy in diabetes management differ by type of diabetes and gender? Results from network analysis.

Rucci, Paola / Messina, Rossella / Ubiali, Andrea / Rochira, Andrea / van der Bijl, Jaap / Mancini, Tatiana / Fantini, Maria Pia / Pagotto, Uberto

Journal of health psychology

2018 Volume 26, Issue 1, Page(s) 156–167

Abstract: This study aims to analyze the correlations and relevance of self-efficacy items in 411 patients with diabetes using network analysis. We found that the self-efficacy items structure is consistent between genders and types of diabetes. However, the ... ...

Abstract	This study aims to analyze the correlations and relevance of self-efficacy items in 411 patients with diabetes using network analysis. We found that the self-efficacy items structure is consistent between genders and types of diabetes. However, the strength of item correlations was significantly higher in type 2 diabetes. The items central to the network were
MeSH term(s)	Diabetes Mellitus, Type 2/therapy ; Female ; Humans ; Male ; Self Care ; Self Efficacy ; Sex Factors ; Surveys and Questionnaires
Language	English
Publishing date	2018-10-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2021897-7
ISSN	1461-7277 ; 1359-1053
ISSN (online)	1461-7277
ISSN	1359-1053
DOI	10.1177/1359105318804866
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Article ; Online: Assessing self-efficacy in type 2 diabetes management

Rossella Messina / Paola Rucci / Jackie Sturt / Tatiana Mancini / Maria Pia Fantini

Health and Quality of Life Outcomes, Vol 16, Iss 1, Pp 1-

validation of the Italian version of the Diabetes Management Self-Efficacy Scale (IT-DMSES)

2018 Volume 9

Abstract: Abstract Background Being highly self-efficacious is a key factor in successful chronic disease self-management. In the context of measuring self-efficacy in type 2 diabetes management, the Diabetes Management Self-Efficacy Scale (DMSES) is the most ... ...

Abstract	Abstract Background Being highly self-efficacious is a key factor in successful chronic disease self-management. In the context of measuring self-efficacy in type 2 diabetes management, the Diabetes Management Self-Efficacy Scale (DMSES) is the most widely used scale. The aim of this study was to adapt the English version of the scale to Italian and to evaluate the psychometric properties of the Italian version of DMSES in type 2 diabetes (IT-DMSES). Methods We conducted a cross-sectional study of people with type 2 diabetes attending the Endocrine-Metabolic Disease Care Unit of the Internal Medicine Department of San Marino State Hospital between October 2016 and February 2017. Patients completed a socio-demographic and clinical data form, the IT-DMSES and 3 self-report questionnaires measuring diabetes distress (PAID-5), psychological well-being (WHO-5) and depression (PHQ-9). Psychometric testing included construct validity (principal component analysis), internal consistency (Cronbach’s α coefficient) and convergent/discriminant validity (Spearman’s correlation coefficient). Decision tree analysis was performed to classify patients into homogeneous subgroups of self-efficacy based on their demographic and clinical characteristics. Results Participants were 110 males and 55 females, mean age of 65.2 years (SD ± 9), 56.9% had been diagnosed for 1–15 years, 63% had HbA1c level > 53 mmol/mol. Two main factors underlain the construct of self-efficacy in diabetes management: ‘Disease Management’ and “Lifestyles Management”. Disease Management had a good reliability (α = .849) and Lifestyle Management had an excellent reliability (α = .902) indicating that the instrument is internally consistent. A negative and weak correlation was found between Lifestyle management, PAID-5 (r = − 0.258, p = < 0.01) and PHQ-9 (r = − 0.274, p = < 0.01) and a positive one with WHO-5 (r = 0.325, p < 0.01) supporting convergent validity. Disease management was uncorrelated with PAID-5 (r = − 0.142, p = 0.083), PHQ-9 (r = − ...
Keywords	Self-efficacy ; Self-management ; Type 2 diabetes ; Psychometric properties ; Questionnaire ; Psychosocial aspects of diabetes ; Computer applications to medicine. Medical informatics ; R858-859.7
Subject code	150
Language	English
Publishing date	2018-04-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Order/Disorder Dynamics in a Dodecanethiol-Capped Gold Nanoparticles Supracrystal by Small-Angle Ultrafast Electron Diffraction.

Mancini, Giulia Fulvia / Latychevskaia, Tatiana / Pennacchio, Francesco / Reguera, Javier / Stellacci, Francesco / Carbone, Fabrizio

Nano letters

2016 Volume 16, Issue 4, Page(s) 2705–2713

Abstract: The design and the characterization of functionalized gold nanoparticles supracrystals require atomically resolved information on both the metallic core and the external organic ligand shell. At present, there is no known approach to characterize ... ...

Abstract	The design and the characterization of functionalized gold nanoparticles supracrystals require atomically resolved information on both the metallic core and the external organic ligand shell. At present, there is no known approach to characterize simultaneously the static local order of the ligands and of the nanoparticles, nor their dynamical evolution. In this work, we apply femtosecond small-angle electron diffraction combined with angular cross-correlation analysis, to retrieve the local arrangement from nanometer to interatomic scales in glassy aggregates. With this technique we study a two-dimensional distribution of functionalized gold nanoparticles deposited on amorphous carbon. We show that the dodecanethiol ligand chains, coating the gold cores, order in a preferential orientation on the nanoparticle surface and throughout the supracrystal. Furthermore, we retrieve the dynamics of the supracrystal upon excitation with light and show that the positional disorder is induced by light pulses, while its overall homogeneity is surprisingly found to transiently increase. This new technique will enable the systematic investigation of the static and dynamical structural properties of nanoassembled materials containing light elements, relevant for several applications including signal processing and biology.
Language	English
Publishing date	2016-03-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1530-6992
ISSN (online)	1530-6992
DOI	10.1021/acs.nanolett.6b00355
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Book ; Online: Local photo-mechanical stiffness revealed in gold nanoparticles supracrystals by ultrafast small-angle electron diffraction

Mancini, Giulia Fulvia / Pennacchio, Francesco / Latychevskaia, Tatiana / Reguera, Javier / Stellacci, Francesco / Carbone, Fabrizio

2018

Abstract: We demonstrate that highly-ordered two-dimensional crystals of ligand-capped gold nanoparticles display a local photo-mechanical stiffness as high as that of solids such as graphite. In out-of equilibrium electron diffraction experiments, a strong ... ...

Abstract	We demonstrate that highly-ordered two-dimensional crystals of ligand-capped gold nanoparticles display a local photo-mechanical stiffness as high as that of solids such as graphite. In out-of equilibrium electron diffraction experiments, a strong temperature jump is induced in a thin film with a femtosecond laser pulse. The initial electronic excitation transfers energy to the underlying structural degrees of freedom, with a rate generally proportional to the stiffness of the material. With femtosecond small-angle electron diffraction, we observe the temporal evolution of the diffraction feature associated to the nearest-neighbor nanoparticle distance. The Debye-Waller decay for the octanethiol-capped nanoparticles supracrystal, in particular, is found to be unexpectedly fast, almost as fast as the stiffest solid known and observed by the same technique, i.e. graphite. Our observations unravel that local stiffness in a dense supramolecular assembly can be created by Van der Waals interactions up to a level comparable to crystalline systems characterized by covalent bonding.
Keywords	Condensed Matter - Mesoscale and Nanoscale Physics ; Condensed Matter - Disordered Systems and Neural Networks ; Condensed Matter - Materials Science ; Condensed Matter - Soft Condensed Matter ; Physics - Instrumentation and Detectors
Subject code	530
Publishing date	2018-08-16
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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