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  1. Article ; Online: Developments in Gastroesophageal Reflux Disease over the Last 40 Years.

    Vakil, Nimish

    Digestive diseases (Basel, Switzerland)

    2023  Volume 42, Issue 2, Page(s) 127–136

    Abstract: Background: The last 40 years have seen a remarkable change in our understanding of reflux disease.: Summary: These changes encompass disease definition and impact, pathophysiology, diagnostic testing, regulatory oversight of clinical trials, ... ...

    Abstract Background: The last 40 years have seen a remarkable change in our understanding of reflux disease.
    Summary: These changes encompass disease definition and impact, pathophysiology, diagnostic testing, regulatory oversight of clinical trials, pharmacotherapy, endoscopic, and surgical treatment. We have also seen a number of promising therapies fail.
    Key messages: The future holds the promise of further advances. Adaptive artificial intelligence will take over diagnostics in manometry and pH impedance testing and patient-driven outcomes may be changed by interactions with artificial intelligence rather than humans. Changes in chip technology will allow higher resolution chips to be carried on smaller devices making extra-esophageal areas where reflux may play a role more accessible to prolonged observation and testing.
    MeSH term(s) Humans ; Fundoplication ; Artificial Intelligence ; Esophageal pH Monitoring ; Gastroesophageal Reflux/diagnosis ; Gastroesophageal Reflux/therapy ; Endoscopy ; Manometry ; Proton Pump Inhibitors/therapeutic use
    Chemical Substances Proton Pump Inhibitors
    Language English
    Publishing date 2023-09-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 632798-9
    ISSN 1421-9875 ; 0257-2753
    ISSN (online) 1421-9875
    ISSN 0257-2753
    DOI 10.1159/000533901
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1853: Show issues Location:
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  2. Article ; Online: Endoscopic Diagnosis, Grading, and Treatment of Bleeding Peptic Ulcer Disease.

    Vakil, Nimish

    Gastrointestinal endoscopy clinics of North America

    2023  Volume 34, Issue 2, Page(s) 217–229

    Abstract: Peptic ulcer bleeding is a major cause for hospital admissions and has a significant mortality. Endoscopic interventions reduce the risk of rebleeding in high-risk patients and several options are available including injection therapies, thermal ... ...

    Abstract Peptic ulcer bleeding is a major cause for hospital admissions and has a significant mortality. Endoscopic interventions reduce the risk of rebleeding in high-risk patients and several options are available including injection therapies, thermal therapies, mechanical clips, hemostatic sprays, and endoscopic suturing. Proton-pump inhibitors and Helicobacter pylori treatment are important adjuncts to endoscopic therapy. Endoscopic therapy is indicated in Forrest 1a, 1b, and 2a lesions. Patients with Forrest 2b lesions may do well with proton-pump inhibitor therapy alone but can also be managed by removal of the clot and targeting endoscopic therapy to the underlying lesion.
    MeSH term(s) Humans ; Hemostasis, Endoscopic ; Peptic Ulcer Hemorrhage/diagnosis ; Peptic Ulcer Hemorrhage/etiology ; Peptic Ulcer Hemorrhage/therapy ; Peptic Ulcer/complications ; Peptic Ulcer/diagnosis ; Peptic Ulcer/therapy ; Endoscopy ; Proton Pump Inhibitors/therapeutic use
    Chemical Substances Proton Pump Inhibitors
    Language English
    Publishing date 2023-09-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1313994-0
    ISSN 1558-1950 ; 1052-5157
    ISSN (online) 1558-1950
    ISSN 1052-5157
    DOI 10.1016/j.giec.2023.09.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Commentary: tegaserod and IBS, two decades on.

    Vakil, Nimish

    Alimentary pharmacology & therapeutics

    2019  Volume 51, Issue 1, Page(s) 200–201

    MeSH term(s) Abdominal Pain ; Constipation ; Humans ; Indoles ; Irritable Bowel Syndrome ; Serotonin
    Chemical Substances Indoles ; Serotonin (333DO1RDJY) ; tegaserod (458VC51857)
    Language English
    Publishing date 2019-12-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.15516
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Editorial: population-based testing for Helicobacter pylori in Western countries.

    Vakil, Nimish

    Alimentary pharmacology & therapeutics

    2019  Volume 49, Issue 10, Page(s) 1360

    MeSH term(s) Cost-Benefit Analysis ; Follow-Up Studies ; Helicobacter Infections ; Helicobacter pylori ; Humans ; Mass Screening
    Language English
    Publishing date 2019-04-23
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.15224
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Editorial: functional dyspepsia-a disorder of duodenal permeability?

    Vakil, N

    Alimentary pharmacology & therapeutics

    2017  Volume 46, Issue 1, Page(s) 70–71

    Language English
    Publishing date 2017-07
    Publishing country England
    Document type Editorial
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.14096
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Dietary Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols (FODMAPs) and Gastrointestinal Disease.

    Vakil, Nimish

    Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition

    2018  Volume 33, Issue 4, Page(s) 468–475

    Abstract: FODMAP is an acronym for fermentable oligosaccharides, disaccharides, monosaccharides, and polyols. Dietary modification of FODMAPs has been shown to have significant effects on the physiology of the gastrointestinal tract and improves symptoms of ... ...

    Abstract FODMAP is an acronym for fermentable oligosaccharides, disaccharides, monosaccharides, and polyols. Dietary modification of FODMAPs has been shown to have significant effects on the physiology of the gastrointestinal tract and improves symptoms of abdominal pain, distention, and bloating in patients with irritable bowel syndrome. Structured withdrawal and reintroduction of FODMAPs supervised by a dietitian is the optimal practice for dietary FODMAP modification in irritable bowel syndrome. FODMAPs are present in enteral feeding formulas and may have a role in diarrhea and bloating in tube-fed patients. Emerging areas of research include the effects of dietary modification of FODMAPs on the microbiome, micronutrient absorption, and caloric intake. FODMAP dietary modification is an emerging area in other gastrointestinal disorders and is of relevance to all practicing dietitians.
    MeSH term(s) Diet ; Dietary Carbohydrates ; Disaccharides/adverse effects ; Energy Intake/drug effects ; Enteral Nutrition ; Feeding Behavior ; Fermentation ; Gastrointestinal Diseases/diet therapy ; Gastrointestinal Diseases/pathology ; Gastrointestinal Microbiome/drug effects ; Humans ; Intestinal Absorption/drug effects ; Irritable Bowel Syndrome/diet therapy ; Irritable Bowel Syndrome/pathology ; Monosaccharides/adverse effects ; Oligosaccharides/adverse effects ; Polymers/adverse effects
    Chemical Substances Dietary Carbohydrates ; Disaccharides ; Monosaccharides ; Oligosaccharides ; Polymers ; polyol
    Language English
    Publishing date 2018-06-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645074-x
    ISSN 1941-2452 ; 0884-5336
    ISSN (online) 1941-2452
    ISSN 0884-5336
    DOI 10.1002/ncp.10108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2451: Show issues Location:
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  7. Article ; Online: Scratch…Descriptive epidemiologic study of billiards-related injuries.

    Bhardwaj, Namita / Vakil, Haris / Chavez, Michael C / Lee, Wei-Chen / Villasante-Tezanos, Alejandro

    Medicine

    2024  Volume 103, Issue 13, Page(s) e37661

    Abstract: ... total of 78,524 (n = 1214) estimated patients, had emergency department visits after incurring billiards ... related injuries as a sample. The mean age was 24.9 years. Most injuries occurred in males, 54,915 (n ... 851, 69.9%). More injuries appeared to be soft-tissue contusions and abrasions, 19,000 (24.2%, n = 280 ...

    Abstract The purpose of this descriptive epidemiological study is to identify billiards-related injuries that presented to the United States emergency departments from 2000 to 2020. This is a study using secondary data from emergency departments from 2000 to 2020 and presented with billiards-related injuries. No applicable intervention, but the main outcome measure was a description of injuries sustained due to participation in billiards. Billiards-related injury was captured by the National Electronic Injury Surveillance System - All Injury Program database. We extracted information on age, gender, injury, and disposition. A collective total of 78,524 (n = 1214) estimated patients, had emergency department visits after incurring billiards-related injuries as a sample. The mean age was 24.9 years. Most injuries occurred in males, 54,915 (n = 851, 69.9%). More injuries appeared to be soft-tissue contusions and abrasions, 19,000 (24.2%, n = 280), followed by lacerations, 17,520 (22.3%, n = 269). The most common cause of injury was being struck by a ball or cue, 39,705 (51.1%, n = 643). While the majority of injured patients were discharged home after evaluation, 2527 (3.2%, n = 45) of them required hospitalization. While a small number of billiards-related injuries presented to the emergency department in comparison to other sports-related injuries, some required more intensive treatment or hospitalization.
    MeSH term(s) Male ; Humans ; United States/epidemiology ; Young Adult ; Adult ; Athletic Injuries/epidemiology ; Emergency Service, Hospital ; Lacerations ; Hospitalization ; Contusions
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000037661
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Editorial: selective serotonin receptor inhibitors and gastrointestinal bleeding-managing the risk.

    Vakil, Nimish

    Alimentary pharmacology & therapeutics

    2017  Volume 46, Issue 5, Page(s) 552–553

    Language English
    Publishing date 2017-09
    Publishing country England
    Document type Editorial
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.14199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The Global Burden of Pleural Diseases.

    Vakil, Erik / Taghizadeh, Niloofar / Tremblay, Alain

    Seminars in respiratory and critical care medicine

    2023  Volume 44, Issue 4, Page(s) 417–425

    Abstract: Pleural diseases include a spectrum of disorders broadly categorized into pneumothorax and pleural effusion. They often cause pain, breathlessness, cough, and reduced quality of life. The global burden of diseases reflects regional differences in ... ...

    Abstract Pleural diseases include a spectrum of disorders broadly categorized into pneumothorax and pleural effusion. They often cause pain, breathlessness, cough, and reduced quality of life. The global burden of diseases reflects regional differences in conditions and exposures associated with pleural disease, such as smoking, pneumonia, tuberculosis, asbestos, cancer, and organ failure. Disease burden in high-income countries is overrepresented given the availability of data and disease burden in lower-income countries is likely underestimated. In the United States, in 2016, there were 42,215 treat-and-discharge visits to the emergency room for pleural diseases and an additional 361,270 hospitalizations, resulting in a national cost of $10.1 billion.
    MeSH term(s) Humans ; Quality of Life ; Cost of Illness ; Pleural Effusion ; Pneumothorax ; Hospitalization ; Pleural Diseases/epidemiology ; Pleural Diseases/therapy
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0043-1769614
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Closure of a Gastropleural Fistula Using Advanced Endoscopy.

    Vakil, Deep P / Palacio, Jennifer / Motta, Monique / Shatawi, Zaineb N / Colvin, Juliana L / Llaguna, Omar H

    The American surgeon

    2024  , Page(s) 31348241248697

    Abstract: Gastropleural fistulas are rare complications with significant mortality and morbidity. There are limited reports on the successful management of gastropleural fistulas with advanced endoscopic procedures. The following case of a 75-year-old woman with a ...

    Abstract Gastropleural fistulas are rare complications with significant mortality and morbidity. There are limited reports on the successful management of gastropleural fistulas with advanced endoscopic procedures. The following case of a 75-year-old woman with a history of recurrent pseudomyxoma peritonei secondary to ruptured low-grade appendiceal mucinous neoplasm status post cytoreductive surgery highlights the successful treatment of a gastropleural fistula with endoscopic suturing.
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 202465-2
    ISSN 1555-9823 ; 0003-1348
    ISSN (online) 1555-9823
    ISSN 0003-1348
    DOI 10.1177/00031348241248697
    Database MEDical Literature Analysis and Retrieval System OnLINE

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