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  1. Article ; Online: Treatment of Nonhealing Ulcers with an Allograft/Xenograft Substitute: A Case Series.

    Sivlér, Tobias / Sivlér, Petter / Skog, Mårten / Conti, Luca / Aili, Daniel

    Advances in skin & wound care

    2018  Volume 31, Issue 7, Page(s) 306–309

    Abstract: Objective: Wound dressings that use biosynthetic cellulose may be a good alternative to dressings currently used to treat chronic and acute ulcers because their nanostructure is similar to collagen. The objective of this study was to evaluate a wound ... ...

    Abstract Objective: Wound dressings that use biosynthetic cellulose may be a good alternative to dressings currently used to treat chronic and acute ulcers because their nanostructure is similar to collagen. The objective of this study was to evaluate a wound dressing created with a new material that is composed of a fibrillary network of biosynthetic cellulose.
    Methods: A case series of 8 patients in primary healthcare centers in Östergötland county council, Sweden, with chronic and acute lower limb wounds were treated with a wound dressing based on eiratex (S2Medical AB, Linköping, Sweden). The dressing was applied to traumatic (n = 5) and venous ulcers (n = 3). All ulcers were considered healed at the end of the treatment.
    Main outcome measure: The wounds were examined at regular intervals by a physician to determine healing time, number of dressing changes, and number of visits.
    Main results: Mean healing time was 43 ± 6 days after the first application of the dressing. The mean number of visits was 5.7 ± 0.6, and the mean number of dressings used per patient was 1.7 ± 0.2.
    Conclusions: These results demonstrate the efficacy of a wound dressing made of eiratex to heal chronic and acute ulcers. The data show that the number of dressings used and dressing changes needed to heal the ulcers are lower than what have been reported in the literature for other dressing materials.
    MeSH term(s) Aged ; Aged, 80 and over ; Bandages, Hydrocolloid ; Cellulose/administration & dosage ; Female ; Foot Ulcer/therapy ; Humans ; Lower Extremity ; Male ; Middle Aged ; Skin Absorption/physiology ; Sweden ; Varicose Ulcer/therapy ; Wound Healing/physiology
    Chemical Substances Cellulose (9004-34-6)
    Language English
    Publishing date 2018-06-28
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 2012792-3
    ISSN 1538-8654 ; 1527-7941
    ISSN (online) 1538-8654
    ISSN 1527-7941
    DOI 10.1097/01.ASW.0000534701.57785.cd
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3164: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Integrative genomics reveals frequent somatic NF1 mutations in sporadic pheochromocytomas.

    Welander, Jenny / Larsson, Catharina / Bäckdahl, Martin / Hareni, Niyaz / Sivlér, Tobias / Brauckhoff, Michael / Söderkvist, Peter / Gimm, Oliver

    Human molecular genetics

    2012  Volume 21, Issue 26, Page(s) 5406–5416

    Abstract: Pheochromocytomas are neuroendocrine tumors of the adrenal medulla which can occur either sporadically or in the context of hereditary tumor syndromes. Whereas the genetic background of hereditary pheochromocytomas is becoming rather well-defined, very ... ...

    Abstract Pheochromocytomas are neuroendocrine tumors of the adrenal medulla which can occur either sporadically or in the context of hereditary tumor syndromes. Whereas the genetic background of hereditary pheochromocytomas is becoming rather well-defined, very little is known about the more common sporadic form of the disease which constitutes ∼70% of all cases. In this study, we elucidate some of the molecular mechanisms behind sporadic pheochromocytoma by performing a comprehensive analysis of copy number alterations, gene expression, promoter methylation and somatic mutations in the genes RET, VHL, NF1, SDHA, SDHB, SDHC, SDHD, SDHAF2, KIF1Bβ, TMEM127 and MAX, which have been associated with hereditary pheochromocytoma or paraganglioma. Our genomic and genetic analyses of 42 sporadic pheochromocytomas reveal that a large proportion (83%) has an altered copy number in at least one of the known susceptibility genes, often in association with an altered messenger RNA (mRNA) expression. Specifically, 11 sporadic tumors (26%) displayed a loss of one allele of the NF1 gene, which significantly correlated with a reduced NF1 mRNA expression. Subsequent sequencing of NF1 mRNA, followed by confirmation in the corresponding genomic DNA (gDNA), revealed somatic truncating mutations in 10 of the 11 tumors with NF1 loss. Our results thus suggest that the NF1 gene constitutes the most frequent (24%) target of somatic mutations so far known in sporadic pheochromocytomas.
    MeSH term(s) Alleles ; DNA Copy Number Variations ; DNA Mutational Analysis ; Gene Deletion ; Gene Expression Regulation, Neoplastic ; Genes, Neurofibromatosis 1 ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Germ-Line Mutation ; Heterozygote ; Humans ; Immunohistochemistry ; Microarray Analysis/methods ; Pheochromocytoma/genetics ; Pheochromocytoma/pathology ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
    Chemical Substances RNA, Messenger
    Language English
    Publishing date 2012-12-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1108742-0
    ISSN 1460-2083 ; 0964-6906
    ISSN (online) 1460-2083
    ISSN 0964-6906
    DOI 10.1093/hmg/dds402
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3469: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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