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Article ; Online: Validation of prognostic stroke scores-comments on "Evaluation of FRESH scores in predicting outcome and quality of life after aneurysmal subarachnoid haemorrhage in a European patient cohort": Author's response.

Hofmann, Björn B / Kram, Rainer / Beseoglu, Kerim / Cornelius, Jan F

2024 Volume 166, Issue 1, Page(s) 161

MeSH term(s)	Humans ; Quality of Life ; Subarachnoid Hemorrhage/diagnosis ; Prognosis
Language	English
Publishing date	2024-04-02
Publishing country	Austria
Document type	Letter
ZDB-ID	80010-7
ISSN	0942-0940 ; 0001-6268
ISSN (online)	0942-0940
ISSN	0001-6268
DOI	10.1007/s00701-024-06048-4
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Article: CLR (C-Reactive Protein to Lymphocyte Ratio) Served as a Promising Predictive Biomarker for Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage (aSAH): A Retrospective Cohort Study.

Li, Ke / Khan, Dilaware / Fischer, Igor / Hänggi, Daniel / Cornelius, Jan F / Muhammad, Sajjad

Journal of clinical medicine

2024 Volume 13, Issue 4

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2024-02-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13040940
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Article ; Online: Photorealistic 3-Dimensional Models of the Anatomy and Neurosurgical Approaches to the V2, V3, and V4 Segments of the Vertebral Artery.

Spiriev, Toma / Nakov, Vladimir / Cornelius, Jan F

Operative neurosurgery (Hagerstown, Md.)

2023 Volume 25, Issue 1, Page(s) e15–e21

Abstract: Background: The vertebral artery (VA) has a tortuous course subdivided into 4 segments (V1-V4). For neurosurgeons, a thorough knowledge of the 3-dimensional (3D) anatomy at different segments is a prerequisite for safe surgery. New technologies allowing ...

Abstract	Background: The vertebral artery (VA) has a tortuous course subdivided into 4 segments (V1-V4). For neurosurgeons, a thorough knowledge of the 3-dimensional (3D) anatomy at different segments is a prerequisite for safe surgery. New technologies allowing creation of photorealistic 3D models may enhance the anatomic understanding of this complex region. Objective: To create photorealistic 3D models illustrating the anatomy and surgical steps needed for safe neurosurgical exposure of the VA. Methods: We dissected 2 latex injected cadaver heads. Anatomic layered dissections were performed on the first specimen. On the second specimen, the two classical approaches to the VA (far lateral and anterolateral) were realized. Every step of dissection was scanned using photogrammetry technology that allowed processing of 3D data from 2-dimensional photographs by a simplified algorithm mainly based on a dedicated mobile phone application and open-source 3D modeling software. For selected microscopic 3D anatomy, we used an operating microscope to generate 3D models. Results: Classic anatomic (n=17) and microsurgical (n=12) 3D photorealistic models based on cadaver dissections were created. The models allow observation of the spatial relations of each anatomic structure of interest and have an immersive view of the approaches to the V2-V4 segments of the VA. Once generated, these models may easily be shared on any digital device or web-based platforms for 3D visualization. Conclusions: Photorealistic 3D scanning technology is a promising tool to present complex anatomy in a more comprehensive way. These 3D models can be used for education, training, and potentially preoperative planning.
MeSH term(s)	Humans ; Vertebral Artery/surgery ; Vertebral Artery/anatomy & histology ; Neurosurgical Procedures/methods ; Software ; Cadaver
Language	English
Publishing date	2023-05-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2767575-0
ISSN	2332-4260 ; 2332-4252
ISSN (online)	2332-4260
ISSN	2332-4252
DOI	10.1227/ons.0000000000000701
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Book ; Thesis: Experimentelle Untersuchungen zum Einfluß der neuartigen Konservierungslösung Celsior auf die postischämische Organfunktion in einem extrakorporalen Rattenlungenmodell

Cornelius, Jan Frédérick

2001

Author's details	vorgelegt von Jan Frédérick Cornelius
Language	German
Size	107 Bl., Ill., graph. Darst., 30 cm
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Hannover, Med. Hochsch., Diss., 2001
HBZ-ID	HT013393228
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Evaluation of FRESH scores in predicting outcome and quality of life after aneurysmal subarachnoid haemorrhage in a European patient cohort.

Hofmann, Björn B / Gundlach, Evgenia P / Fischer, Igor / Muhammad, Sajjad / Kram, Rainer / Beseoglu, Kerim / Cornelius, Jan F

Acta neurochirurgica

2024 Volume 166, Issue 1, Page(s) 29

Abstract: Background: Despite aneurysmal subarachnoid haemorrhage (aSAH) patients often experiencing physical and mental disabilities impacting their quality of life (QoL), routine assessment of long-term QoL data and predictive tools are limited. This study ... ...

Abstract	Background: Despite aneurysmal subarachnoid haemorrhage (aSAH) patients often experiencing physical and mental disabilities impacting their quality of life (QoL), routine assessment of long-term QoL data and predictive tools are limited. This study evaluates the newly developed "functional recovery expected after subarachnoid haemorrhage" (FRESH) scores with long-term outcomes and QoL in European aSAH patients. Methods: FRESH, FRESH-cog, and FRESH-quol scores were retrospectively obtained from aSAH patients. Patients were contacted, and the modified Rankin Scale (mRS), extended short form-36 (SF-36), and telephone interview for cognitive status (TICS) were collected and performed. The prognostic and empirical outcomes were compared. Results: Out of 374 patients, 171 patients (54.1%) completed the SF-36, and 154 patients completed the TICS. The SF-36 analysis showed that 32.7% had below-average physical component summary (PCS) scores, and 39.8% had below-average mental component summary (MCS) scores. There was no significant correlation between the FRESH score and PCS (p = 0.09736), MCS (p = 0.1796), TICS (p = 0.7484), or mRS 10-82 months (average 46 months) post bleeding (p = 0.024), respectively. There was also no significant correlation found for "FRESH-cog vs. TICS" (p = 0.0311), "FRESH-quol vs. PCS" (p = 0.0204), "FRESH-quol vs. MCS" (p = 0.1361) and "FRESH-quol vs. TICS" (p = 0.1608). Conclusions: This study found no correlation between FRESH scores and validated QoL tools in a European population of aSAH patients. The study highlights the complexity of reliable long-term QoL prognostication in aSAH patients and emphasises the need for further prospective research to also focus on QoL as an important outcome parameter.
MeSH term(s)	Humans ; Subarachnoid Hemorrhage/complications ; Subarachnoid Hemorrhage/diagnosis ; Quality of Life ; Retrospective Studies ; Patients ; Recovery of Function
Language	English
Publishing date	2024-01-23
Publishing country	Austria
Document type	Journal Article
ZDB-ID	80010-7
ISSN	0942-0940 ; 0001-6268
ISSN (online)	0942-0940
ISSN	0001-6268
DOI	10.1007/s00701-024-05909-2
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Article ; Online: Combined use of 3D printing and mixed reality technology for neurosurgical training: getting ready for brain surgery.

Jeising, Sebastian / Liu, Shufang / Blaszczyk, Timo / Rapp, Marion / Beez, Thomas / Cornelius, Jan F / Schwerter, Michael / Sabel, Michael

Neurosurgical focus

2024 Volume 56, Issue 1, Page(s) E12

Abstract: Objective: Learning surgical skills is an essential part of neurosurgical training. Ideally, these skills are acquired to a sufficient extent in an ex vivo setting. The authors previously described an in vitro brain tumor model, consisting of a ... ...

Abstract	Objective: Learning surgical skills is an essential part of neurosurgical training. Ideally, these skills are acquired to a sufficient extent in an ex vivo setting. The authors previously described an in vitro brain tumor model, consisting of a cadaveric animal brain injected with fluorescent agar-agar, for acquiring a wide range of basic neuro-oncological skills. This model focused on haptic skills such as safe tissue ablation technique and the training of fluorescence-based resection. As important didactical technologies such as mixed reality and 3D printing become more readily available, the authors developed a readily available training model that integrates the haptic aspects into a mixed reality setup. Methods: The anatomical structures of a brain tumor patient were segmented from medical imaging data to create a digital twin of the case. Bony structures were 3D printed and combined with the in vitro brain tumor model. The segmented structures were visualized in mixed reality headsets, and the congruence of the printed and the virtual objects allowed them to be spatially superimposed. In this way, users of the system were able to train on the entire treatment process from surgery planning to instrument preparation and execution of the surgery. Results: Mixed reality visualization in the joint model facilitated model (patient) positioning as well as craniotomy and the extent of resection planning respecting case-dependent specifications. The advanced physical model allowed brain tumor surgery training including skin incision; craniotomy; dural opening; fluorescence-guided tumor resection; and dura, bone, and skin closure. Conclusions: Combining mixed reality visualization with the corresponding 3D printed physical hands-on model allowed advanced training of sequential brain tumor resection skills. Three-dimensional printing technology facilitates the production of a precise, reproducible, and worldwide accessible brain tumor surgery model. The described model for brain tumor resection advanced regarding important aspects of skills training for neurosurgical residents (e.g., locating the lesion, head position planning, skull trepanation, dura opening, tissue ablation techniques, fluorescence-guided resection, and closure). Mixed reality enriches the model with important structures that are difficult to model (e.g., vessels and fiber tracts) and advanced interaction concepts (e.g., craniotomy simulations). Finally, this concept demonstrates a bridging technology toward intraoperative application of mixed reality.
MeSH term(s)	Humans ; Augmented Reality ; Agar ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/surgery ; Printing, Three-Dimensional ; Brain/diagnostic imaging ; Brain/surgery
Chemical Substances	Agar (9002-18-0)
Language	English
Publishing date	2024-01-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2026589-X
ISSN	1092-0684 ; 1092-0684
ISSN (online)	1092-0684
ISSN	1092-0684
DOI	10.3171/2023.10.FOCUS23611
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Book ; Online: Crizotinib

Wörmann, Bernhard / Eberhardt, Wilfried E. E. / Griesinger, Frank / Stöhlmacher, Jan / Thomas, Michael / Waller, Cornelius

Stellungnahme zur Nutzenbewertung des IQWiG gemäß § 35a SGB V, Vorgangsnummer 2012-11-15-D-040, IQWiG Bericht Nr. 151, veröffentlicht am 15. Februar 2013

2013

Institution	Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie Deutschland / Gemeinsamer Bundesausschuss
Author's details	DGHO - Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie; Gemeinsamer Bundesausschuss ; die Stellungnahme wurde von Prof. Dr. Bernhard Wörmann in Kooperation mit Dr. Wilfried Eberhardt (Universitätsklinikum Essen, Westdeutsches Tumorzentrum, Innere Klinik und Poliklinik, Essen), Prof. Dr. Frank Griesinger (Cancer Center Oldenburg, Klinik für Hämatologie und Onkologie, Pius-Hospital Oldenburg), PD Dr. Jan Stöhlmacher-Williams (Universitätsklinikum Dresden, Medizinische Klinik I, Dresden), Prof. Dr. med. Michael Thomas (Thoraxklinik am Universitätsklinikum Heidelberg, Internistische Onkologie der Thoraxtumoren, Heidelberg) und Prof. Dr. Cornelius F. Waller (Abteilung Hämatologie/Onkologie, Medizinische Universitätsklinik Freiburg) erarbeitet
Subject code	610
Language	German
Size	1 Online-Ressource (7 Seiten)
Publisher	DGHO - Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie
Publishing place	Berlin
Publishing country	Germany
Document type	Book ; Online
Note	Open Access
HBZ-ID	HT020313838
Database	Repository for Life Sciences

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Article: Photogrammetry Applied to Neurosurgery: A Literature Review.

Trandzhiev, Martin / Vezirska, Donika I / Maslarski, Ivan / Milev, Milko D / Laleva, Lili / Nakov, Vladimir / Cornelius, Jan F / Spiriev, Toma

Cureus

2023 Volume 15, Issue 9, Page(s) e46251

Abstract: Photogrammetry refers to the process of creating 3D models and taking measurements through the use of photographs. Photogrammetry has many applications in neurosurgery, such as creating 3D anatomical models and diagnosing and evaluating head shape and ... ...

Abstract	Photogrammetry refers to the process of creating 3D models and taking measurements through the use of photographs. Photogrammetry has many applications in neurosurgery, such as creating 3D anatomical models and diagnosing and evaluating head shape and posture deformities. This review aims to summarize the uses of the technique in the neurosurgical practice and showcase the systems and software required for its implementation. A literature review was done in the online database PubMed. Papers were searched using the keywords "photogrammetry", "neurosurgery", "neuroanatomy", "craniosynostosis" and "scoliosis". The identified articles were later put through primary (abstracts and titles) and secondary (full text) screening for eligibility for inclusion. In total, 86 articles were included in the review from 315 papers identified. The review showed that the main uses of photogrammetry in the field of neurosurgery are related to the creation of 3D models of complex neuroanatomical structures and surgical approaches, accompanied by the uses for diagnosis and evaluation of patients with structural deformities of the head and trunk, such as craniosynostosis and scoliosis. Additionally, three instances of photogrammetry applied for more specific aims, namely, cervical spine surgery, skull-base surgery, and radiosurgery, were identified. Information was extracted on the software and systems used to execute the method. With the development of the photogrammetric method, it has become possible to create accurate 3D models of physical objects and analyze images with dedicated software. In the neurosurgical setting, this has translated into the creation of anatomical teaching models and surgical 3D models as well as the evaluation of head and spine deformities. Through those applications, the method has the potential to facilitate the education of residents and medical students and the diagnosis of patient pathologies.
Language	English
Publishing date	2023-09-30
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.46251
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Article: Initial Temporal Muscle Thickness and Area: Poor Predictors of Neurological Outcome in Aneurysmal Subarachnoid Hemorrhage in a Central European Patient Cohort.

Karadag, Cihat / Kamp, Marcel A / Fischer, Igor / Boogaarts, Hieronymus D / Beseoglu, Kerim / Muhammad, Sajjad / Cornelius, Jan F / Hofmann, Björn B

Journal of clinical medicine

2023 Volume 12, Issue 16

Abstract: The temporalis muscle area (TMA) has been proclaimed as a surrogate parameter for estimating skeletal muscle mass. Pilot studies in Asian populations suggested temporal muscle thickness (TMT) and TMA as prognostic factors for neurological outcomes in ... ...

Abstract	The temporalis muscle area (TMA) has been proclaimed as a surrogate parameter for estimating skeletal muscle mass. Pilot studies in Asian populations suggested temporal muscle thickness (TMT) and TMA as prognostic factors for neurological outcomes in aneurysmal subarachnoid hemorrhage (aSAH) patients. This study aimed to validate these findings in a larger European patient cohort. We retrospectively analyzed age, sex, aneurysm location, treatment, World Federation of Neurosurgical Societies (WFNS) grade, Fisher score, and modified Rankin Score (mRS) at six months in patients with aSAH. TMT and TMA measurements were obtained from initial native CT scans. Logistic regression with the dichotomized six-month mRS as the outcome incorporating TMT, weighted average of TMT, or TMA as predictors was performed. Of the included 478 patients, 66% were female, the mean age was 56, and 48% of patients had an mRS of three to six after six months. The mean TMT at the level of the Sylvian fissure was 5.9 (±1.7) mm in males and 4.8 (±1.8) mm in females. The mean TMA was 234.5 (±107.9) mm
Language	English
Publishing date	2023-08-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12165210
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Article ; Online: Clinical Outcome Prediction of Early Brain Injury in Aneurysmal Subarachnoid Hemorrhage: the SHELTER-Score.

Hofmann, Björn B / Donaldson, Daniel M / Neyazi, Milad / Abusabha, Yousef / Beseoglu, Kerim / Hänggi, Daniel / Cornelius, Jan F / Fischer, Igor / Muhammad, Sajjad

Neurocritical care

2023 Volume 40, Issue 2, Page(s) 438–447

Abstract: Background: Despite intensive research on preventing and treating vasospasm and delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage (aSAH), mortality and morbidity rates remain high. Early brain injury (EBI) has emerged as possibly the major ...

Abstract	Background: Despite intensive research on preventing and treating vasospasm and delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage (aSAH), mortality and morbidity rates remain high. Early brain injury (EBI) has emerged as possibly the major significant factor in aSAH pathophysiology, emphasizing the need to investigate EBI-associated clinical events for improved patient management and decision-making. This study aimed to identify early clinical and radiological events within 72 h after aSAH to develop a conclusive predictive EBI score for clinical practice. Methods: This retrospective analysis included 561 consecutive patients with aSAH admitted to our neurovascular center between 01/2014 and 09/2022. Fourteen potential predictors occurring within the initial 72 h after hemorrhage were analyzed. The modified Rankin Scale (mRS) score at 6 months, discretized to three levels (0-2, favorable; 3-5, poor; 6, dead), was used as the outcome variable. Univariate ordinal regression ranked predictors by significance, and forward selection with McFadden's pseudo-R Results: The analysis resulted in the Subarachnoid Hemorrhage Associated Early Brain Injury Outcome Prediction score (SHELTER-score), comprising seven clinical and radiological events: age (0-4 points), World Federation of Neurosurgical Societies (0-2.5 points), cardiopulmonary resuscitation (CPR) (2 points), mydriasis (1-2 points), midline shift (0.5-1 points), early deterioration (1 point), and early ischemic lesion (2 points). McFadden's pseudo-R Conclusions: The novel SHELTER-score, incorporating seven clinical and radiological features of EBI, demonstrated strong predictive performance in determining clinical outcomes. This scoring system serves as a valuable tool for neurointensivists to identify patients with poor outcomes and guide treatment decisions, reflecting the great impact of EBI on the overall outcome of patients with aSAH.
MeSH term(s)	Humans ; Subarachnoid Hemorrhage/complications ; Subarachnoid Hemorrhage/therapy ; Retrospective Studies ; Prognosis ; Brain Ischemia/etiology ; Brain Ischemia/therapy ; Brain Injuries ; Treatment Outcome
Language	English
Publishing date	2023-11-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2381896-7
ISSN	1556-0961 ; 1541-6933
ISSN (online)	1556-0961
ISSN	1541-6933
DOI	10.1007/s12028-023-01879-y
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