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  1. Book: Cushing's disease

    Swearingen, Brooke / Biller, Beverly M. K.

    (Endocrine updates ; [31] ; Internal medicine)

    2011  

    Author's details Brooke, Swearingen, Beverly M. K. Biller (ed.)
    Series title Endocrine updates ; [31]
    Internal medicine
    Collection
    Language English
    Size XI, 264 S. : Ill., graf. Darst.
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT016958221
    ISBN 978-1-4614-0010-3 ; 9781461400110 ; 1-4614-0010-4 ; 1461400112
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2011 A 3393 order for loan Magazin

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  2. Book: A case based consideration of current practice in Cushing's disease and acromegaly

    Biller, Beverly M. K.

    (Best practice & research : Clinical endocrinology & metabolism ; 23, Suppl. 1)

    2009  

    Title variant A case-based consideration of current practice in Cushing's disease and acromegaly
    Author's details B. M. K. Biller ..., guest ed
    Series title Best practice & research : Clinical endocrinology & metabolism ; 23, Suppl. 1
    Best practice & research
    Best practice & research ; Clinical endocrinology & metabolism
    Collection Best practice & research
    Best practice & research ; Clinical endocrinology & metabolism
    Language English
    Size S39 S. : Ill., graph. Darst.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT016291847
    Database Catalogue ZB MED Medicine, Health

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    Se 1075 -23,Suppl.1- verfügbar in Königswinter Königswinter

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  3. Article ; Online: Long-term Effectiveness and Safety of GH Replacement Therapy in Adults ≥60 Years: Data From NordiNet® IOS and ANSWER.

    Biller, Beverly M K / Höybye, Charlotte / Ferran, Jean-Marc / Kelepouris, Nicky / Nedjatian, Navid / Olsen, Anne Helene / Weber, Matthias M / Gordon, Murray B

    Journal of the Endocrine Society

    2023  Volume 7, Issue 6, Page(s) bvad054

    Abstract: Context: Effectiveness and safety data on GH replacement therapy (GHRT) in older adults with adult GH deficiency (AGHD) are limited.: Objective: To compare GHRT safety and clinical outcomes in older (≥60 years and, for some outcomes, ≥75 years) and ... ...

    Abstract Context: Effectiveness and safety data on GH replacement therapy (GHRT) in older adults with adult GH deficiency (AGHD) are limited.
    Objective: To compare GHRT safety and clinical outcomes in older (≥60 years and, for some outcomes, ≥75 years) and middle-aged (35-<60 years) patients with AGHD.
    Design/setting: Ten-year follow-up, real-world data from 2 large noninterventional studies-NordiNet® International Outcome Study (IOS) and the American Norditropin® Studies: Web-Enabled Research (ANSWER) Program-were analyzed.
    Patients: GH-naïve and non-naïve patients with AGHD.
    Intervention: Norditropin® (somatropin).
    Main outcome measures: Outcomes included GH exposure, IGF-I standard deviation scores (SDS), body mass index (BMI), glycated hemoglobin (HbA
    Results: The effectiveness analysis set comprised 545 middle-aged and 214 older patients (19 aged ≥75 years) from NordiNet® IOS. The full analysis set comprised 1696 middle-aged and 652 older patients (59 aged ≥75 years) from both studies. Mean GH doses were higher in middle-aged vs older patients. For both age groups and sexes, mean IGF-I SDS increased following GHRT, while BMI and HbA
    Conclusion: Clinical outcomes of GHRT in AGHD were similar in middle-aged and older patients, with no significantly increased risk of GHRT-related adverse reactions in older patients.
    Language English
    Publishing date 2023-04-26
    Publishing country United States
    Document type Journal Article
    ISSN 2472-1972
    ISSN (online) 2472-1972
    DOI 10.1210/jendso/bvad054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Current management of Cushing's disease.

    Tritos, N A / Biller, B M K

    Journal of internal medicine

    2019  Volume 286, Issue 5, Page(s) 526–541

    Abstract: Cushing's disease (CD) is caused by a pituitary tumour that secretes adrenocorticotropin (ACTH) autonomously, leading to excess cortisol secretion from the adrenal glands. The condition is associated with increased morbidity and mortality that can be ... ...

    Abstract Cushing's disease (CD) is caused by a pituitary tumour that secretes adrenocorticotropin (ACTH) autonomously, leading to excess cortisol secretion from the adrenal glands. The condition is associated with increased morbidity and mortality that can be mitigated by treatments that result in sustained endocrine remission. Transsphenoidal pituitary surgery (TSS) remains the mainstay of treatment for CD but requires considerable neurosurgical expertise and experience in order to optimize patient outcomes. Up to 90% of patients with microadenomas (tumour below 1 cm in largest diameter) and 65% of patients with macroadenomas (tumour at or above 1 cm in greatest diameter) achieve endocrine remission after TSS by an experienced surgeon. Patients who are not in remission postoperatively or those who relapse may benefit from undergoing a second pituitary operation. Alternatively, radiation therapy to the sella with interim medical therapy, or bilateral adrenalectomy, can be effective as definitive treatments of CD. Medical therapy is currently adjunctive in most patients with CD and is generally prescribed to patients who are about to receive radiation therapy and will be awaiting its salutary effects to occur. Available treatment options include steroidogenesis inhibitors, centrally acting agents and glucocorticoid receptor antagonists. Several novel agents are in clinical trials and may eventually constitute additional treatment options for this serious condition.
    MeSH term(s) Humans ; Pituitary ACTH Hypersecretion/diagnosis ; Pituitary ACTH Hypersecretion/therapy
    Language English
    Publishing date 2019-10-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 96274-0
    ISSN 1365-2796 ; 0954-6820
    ISSN (online) 1365-2796
    ISSN 0954-6820
    DOI 10.1111/joim.12975
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Reduced CV risk with long-term GH replacement in AGHD: data from two large observational studies.

    Hoybye, Charlotte / Biller, Beverly M K / Ferran, Jean-Marc / Gordon, Murray B / Kelepouris, Nicky / Nedjatian, Navid / Olsen, Anne H / Weber, Matthias M

    Endocrine connections

    2022  

    Abstract: Adult growth hormone deficiency (AGHD) is associated with an increased risk for cardiovascular (CV) disease. Long-term growth hormone (GH) treatment could improve CV outcomes. The objective of this study was to evaluate CV disease risk in patients with ... ...

    Abstract Adult growth hormone deficiency (AGHD) is associated with an increased risk for cardiovascular (CV) disease. Long-term growth hormone (GH) treatment could improve CV outcomes. The objective of this study was to evaluate CV disease risk in patients with AGHD who received GH replacement therapy for up to 10 years as part of NordiNet® IOS (NCT00960128) and the ANSWER Program (NCT01009905). The studies were observational, non-interventional, multicentre, monitoring long-term effectiveness and safety of GH treatment. NordiNet® IOS involved 23 countries (469 sites) across Europe and the Middle East. The ANSWER Program was conducted in the USA (207 sites). This analysis included patients aged 18-75 years who were GH-naïve at study entry, who had ≤10 years of GH treatment data, and who could be assessed for CV risk for at least one follow-up year. Main outcome measure was risk of CV disease by age 75 years, as calculated with the Multinational Cardiovascular Risk Consortium model (Brunner score) using non-high-density lipoprotein cholesterol adjusted for age, sex and CV risk factors. The results of this analysis showed that CV risk decreased gradually over the 10-year period for GH-treated patients. The risk was lower for patients treated for 2 and 7 years versus age- and sex-matched control groups (not yet started treatment) (14.51% vs 16.15%; P = 0.0105 and 13.53% vs 16.81%; P = 0.0001, respectively). This suggests that GH treatment in people with AGHD may reduce the risk of CV disease by age 75 years compared with matched controls.
    Language English
    Publishing date 2022-11-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2668428-7
    ISSN 2049-3614
    ISSN 2049-3614
    DOI 10.1530/EC-22-0267
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: COVID-19 and Cushing's syndrome: recommendations for a special population with endogenous glucocorticoid excess.

    Pivonello, Rosario / Ferrigno, Rosario / Isidori, Andrea M / Biller, Beverly M K / Grossman, Ashley B / Colao, Annamaria

    The lancet. Diabetes & endocrinology

    2020  Volume 8, Issue 8, Page(s) 654–656

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Cushing Syndrome/complications ; Cushing Syndrome/immunology ; Glucocorticoids/physiology ; Humans ; Pandemics ; Pneumonia, Viral/complications ; SARS-CoV-2
    Chemical Substances Glucocorticoids
    Keywords covid19
    Language English
    Publishing date 2020-06-09
    Publishing country England
    Document type Journal Article
    ISSN 2213-8595
    ISSN (online) 2213-8595
    DOI 10.1016/S2213-8587(20)30215-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online: Diagnosis and Management of Pituitary Disorders

    Swearingen, Brooke / Biller, Beverly M. K.

    2008  

    Author's details edited by Brooke Swearingen, Beverly M. K. Biller
    Keywords Endocrinology ; Neurosurgery ; Oncology
    Language English
    Publisher Humana Press, Totowa, NJ
    Publishing place Totowa, NJ
    Document type Book ; Online
    HBZ-ID TT050387194
    ISBN 978-1-588-29922-2 ; 978-1-597-45264-9 ; 1-588-29922-8 ; 1-597-45264-5
    DOI 10.1007/978-1-59745-264-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Article ; Online: Pregnancy outcomes in women receiving growth hormone replacement therapy enrolled in the NordiNet® International Outcome Study (IOS) and the American Norditropin® Studies: Web-Enabled Research (ANSWER) Program.

    Biller, Beverly M K / Höybye, Charlotte / Carroll, Paul / Gordon, Murray B / Birkegård, Anna Camilla / Kelepouris, Nicky / Nedjatian, Navid / Weber, Matthias M

    Pituitary

    2021  Volume 24, Issue 4, Page(s) 611–621

    Abstract: Purpose: Data on the safety of growth hormone (GH) replacement therapy during pregnancy are limited. We report a combined analysis of data from pregnant women treated with GH while enrolled in two non-interventional, multicenter studies: NordiNet® ... ...

    Abstract Purpose: Data on the safety of growth hormone (GH) replacement therapy during pregnancy are limited. We report a combined analysis of data from pregnant women treated with GH while enrolled in two non-interventional, multicenter studies: NordiNet® International Outcome Study (IOS) and the American Norditropin® Studies: Web-Enabled Research (ANSWER) Program.
    Methods: Pregnancy data were pooled from NordiNet® IOS and the ANSWER Program. Data were collected during routine clinic visits by participating physicians using a web-based system. Patients exposed to GH replacement therapy during pregnancy were included in the analysis.
    Results: The study population included 40 female patients with typical causes of adult GH deficiency (GHD). Overall, there were 54 pregnancies. Of these, 47 were exposed to GH between conception and delivery. In 48.9% of pregnancies exposed to GH, the dose was > 0.6 mg/day. GH was continued past conception and then stopped during the first, second, and third trimester, in 27.7%, 17.0%, and 2.1% of pregnancies, respectively. In 29.8%, GH was continued throughout pregnancy, with an unchanged dose in most cases. Of the 47 GH-exposed pregnancies, 37 (78.7%) progressed to normal delivery. There were three adverse events reported in two pregnancies.
    Conclusion: These real-world data suggest that there were no new safety signals related to GH exposure in women with GHD during pregnancy. These results are consistent with findings from previous studies reporting data in pregnancies exposed to GH at conception or throughout pregnancy. This observational study in additional pregnancies provides further evidence that GH exposure does not adversely affect pregnancy outcome.
    Clinical trial registration: ClinicalTrials.gov NCT00960128 (date of registration: August 13, 2009) and NCT01009905 (date of registration: November 5, 2009).
    MeSH term(s) Dwarfism, Pituitary ; Female ; Growth Hormone/therapeutic use ; Hormone Replacement Therapy ; Human Growth Hormone/therapeutic use ; Humans ; Insulin-Like Growth Factor I ; Outcome Assessment, Health Care ; Pregnancy ; Pregnancy Outcome ; United States
    Chemical Substances Human Growth Hormone (12629-01-5) ; Insulin-Like Growth Factor I (67763-96-6) ; Growth Hormone (9002-72-6)
    Language English
    Publishing date 2021-03-12
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 1385151-2
    ISSN 1573-7403 ; 1386-341X
    ISSN (online) 1573-7403
    ISSN 1386-341X
    DOI 10.1007/s11102-021-01138-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6139: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article: COVID-19 and Cushing's syndrome: recommendations for a special population with endogenous glucocorticoid excess

    Pivonello, Rosario / Ferrigno, Rosario / Isidori, Andrea M / Biller, Beverly M K / Grossman, Ashley B / Colao, Annamaria

    Lancet Diabetes Endocrinol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #591498
    Database COVID19

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  10. Article ; Online: COVID-19 and Cushing's syndrome

    Pivonello, Rosario / Ferrigno, Rosario / Isidori, Andrea M / Biller, Beverly M K / Grossman, Ashley B / Colao, Annamaria

    The Lancet Diabetes & Endocrinology

    recommendations for a special population with endogenous glucocorticoid excess

    2020  Volume 8, Issue 8, Page(s) 654–656

    Keywords Internal Medicine ; Endocrinology, Diabetes and Metabolism ; Endocrinology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2213-8587
    DOI 10.1016/s2213-8587(20)30215-1
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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