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  1. Article ; Online: Psychiatric emergency services and non-acute psychiatric services utilization during COVID-19 pandemic.

    Kolar, Dusan

    European archives of psychiatry and clinical neuroscience

    2020  Volume 271, Issue 2, Page(s) 391–392

    MeSH term(s) COVID-19 ; Emergency Services, Psychiatric ; Facilities and Services Utilization ; Humans ; Pandemics ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-08
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 1045583-8
    ISSN 1433-8491 ; 0175-758X ; 0940-1334
    ISSN (online) 1433-8491
    ISSN 0175-758X ; 0940-1334
    DOI 10.1007/s00406-020-01182-3
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  2. Article ; Online: Long-term treatment of depression with intranasal esketamine: Is it justified?

    Kolar, Dusan

    Asian journal of psychiatry

    2020  Volume 54, Page(s) 102232

    MeSH term(s) Administration, Intranasal ; Depression ; Depressive Disorder, Treatment-Resistant/drug therapy ; Humans ; Ketamine/therapeutic use
    Chemical Substances Esketamine (50LFG02TXD) ; Ketamine (690G0D6V8H)
    Language English
    Publishing date 2020-06-16
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2456678-0
    ISSN 1876-2026 ; 1876-2018
    ISSN (online) 1876-2026
    ISSN 1876-2018
    DOI 10.1016/j.ajp.2020.102232
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  4. Article ; Online: Psychiatric emergency services and non-acute psychiatric services utilization during COVID-19 pandemic

    Kolar, Dusan

    European Archives of Psychiatry and Clinical Neuroscience ; ISSN 0940-1334 1433-8491

    2020  

    Keywords Pharmacology (medical) ; Biological Psychiatry ; Psychiatry and Mental health ; General Medicine ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    DOI 10.1007/s00406-020-01182-3
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Addictive potential of novel treatments for refractory depression and anxiety.

    Kolar, Dusan

    Neuropsychiatric disease and treatment

    2018  Volume 14, Page(s) 1513–1519

    Abstract: Treatment-resistant mood disorders and anxiety disorders require intensive treatment, but treatment options should balance benefits and adverse effects or other potential detrimental effects on patients, including the risk of developing prescription ... ...

    Abstract Treatment-resistant mood disorders and anxiety disorders require intensive treatment, but treatment options should balance benefits and adverse effects or other potential detrimental effects on patients, including the risk of developing prescription medication addiction. Some of the newer treatment modalities for mood and anxiety disorders may have similar properties to benzodiazepines. The goal of this review was to identify the potential for developing dependence on the novel treatment approaches to treatment-resistant depression and refractory anxiety disorders. PubMed, MEDLINE, PsycINFO, Ovid, Cochrane Library, and Google Scholar were searched. Ketamine is effective in improving symptoms of major depressive disorder, but with no sustained benefits. Long-term use of oral or intranasal ketamine formulations may be associated with the risk of developing dependence. Augmentation of stimulant medication is usually effective for residual symptoms of depression, but the effects are usually short lasting and there is a potential for abuse. Synthetic cannabinoids and medicinal cannabis are increasingly being prescribed for a number of medical conditions, including anxiety disorders, without enough evidence about their efficacy and with the risk of patients developing dependence. In summary, benzodiazepines, ketamine, stimulant medications, and cannabinoids have some common characteristics, including short-lasting benefits and the risk of developing prescription medication addiction with longer use. All of these treatments may raise ethical dilemmas about the appropriateness of prescribing these medications in the long run for patients with depression and anxiety disorders.
    Language English
    Publishing date 2018-06-12
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2186503-6
    ISSN 1178-2021 ; 1176-6328
    ISSN (online) 1178-2021
    ISSN 1176-6328
    DOI 10.2147/NDT.S167538
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  6. Article ; Online: Current status of electroconvulsive therapy for mood disorders: a clinical review.

    Kolar, Dusan

    Evidence-based mental health

    2017  Volume 20, Issue 1, Page(s) 12–14

    Abstract: Electroconvulsive therapy (ECT) is an effective treatment for mood disorders and a viable treatment option especially when urgency of clinical situation requires a prompt treatment response. After acute series of ECT, the ECT long-term treatment may be ... ...

    Abstract Electroconvulsive therapy (ECT) is an effective treatment for mood disorders and a viable treatment option especially when urgency of clinical situation requires a prompt treatment response. After acute series of ECT, the ECT long-term treatment may be considered, although this practice may vary significantly between countries or even within the same country, because there is no universal consensus about its indications, duration and frequency of administration. Continuation or maintenance ECT is common in routine clinical practice and clinicians should be aware of the risks of using ECT long term. Neuropsychological assessment should be an essential part of a good clinical practice in ECT services. Cognitive side effects of ECT are sometimes underestimated and may last much longer after completed treatment than it is usually expected. These cognitive impairments associated with ECT may cause significant functional difficulties and prevent patients to return to work. Cognitive assessment during ECT treatment is usually not comprehensive enough and is limited to bedside assessment. A more proactive approach to careful neuropsychological assessment and consideration of combined maintenance medication treatment after ECT are essential.
    MeSH term(s) Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/etiology ; Electroconvulsive Therapy/adverse effects ; Electroconvulsive Therapy/methods ; Electroconvulsive Therapy/standards ; Humans ; Mood Disorders/therapy
    Language English
    Publishing date 2017-01-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2009065-1
    ISSN 1468-960X ; 1362-0347
    ISSN (online) 1468-960X
    ISSN 1362-0347
    DOI 10.1136/eb-2016-102498
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    Zs.A 6383: Show issues Location:
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  7. Article ; Online: Gender differences in obstructive sleep apnea with comorbid treatment-resistant depression

    Emily Kasurak / Emily Hawken / Dusan Kolar / Ruzica Jokic

    Sleep Science and Practice, Vol 7, Iss 1, Pp 1-

    2023  Volume 9

    Abstract: Abstract Background A bidirectional relationship between major depression and obstructive sleep apnea (OSA) has been established, suggesting the possibility of overlapping and compounding disease processes. Depression, however, while more prevalent in ... ...

    Abstract Abstract Background A bidirectional relationship between major depression and obstructive sleep apnea (OSA) has been established, suggesting the possibility of overlapping and compounding disease processes. Depression, however, while more prevalent in women, is a highly heterogeneous disorder and can be difficult to treat regardless of gender. A common overlapping symptom of depression and OSA is fatigue. Gender differences in OSA symptomatology (and fatigue in particular) are also consistently observed. Here, we investigate OSA in specific relation to treatment-resistant depression. Methods A cross-sectional exploratory design was used to analyse data from 94 patients with treatment-resistant depression from a subspecialist mood disorders outpatient service who had no previous sleep assessment. Participants completed overnight polysomnography and a battery of rating scales assessing mood, sleep, and daytime functioning. Linear regression models determined whether presence of fatigue in treatment-resistant depression predicted OSA severity. Results There was a high prevalence (79%) of previously undiagnosed OSA in our sample of patients with treatment-resistant depression. Treatment-resistant depression was one factor to close the gap in obstructive sleep apnea prevalence between men and women in this group. Presence of OSA measured objectively by the Apnea Hypopnea Index was not associated with episode state (depressed vs. euthymic). Daytime sleepiness scores as measured by the Epworth Sleepiness Scale indicated higher than normal daytime sleepiness with no difference between genders. Men and women in our study reported similar amounts of fatigue as measured by the Profile of Mood States-Fatigue Subscale, however, daytime fatigue (but not sleepiness) predicted OSA severity in women only. Conclusions We argue that typical symptoms of treatment-resistant depression may overshadow key symptoms of undetected OSA. Specifically, we found that daytime fatigue may be one factor masking a potentially significant ...
    Keywords Obstructive sleep apnea ; Treatment-resistant depression ; Sleep disordered breathing ; Gender differences ; Fatigue ; Medicine ; R
    Subject code 150
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: CRITICAL REVIEW OF AVAILABLE TREATMENT OPTIONS FOR TREATMENT REFRACTORY DEPRESSION AND ANXIETY - CLINICAL AND ETHICAL DILEMMAS.

    Kolar, Dusan / Kolar, Michael V

    Medicinski pregled

    2018  Volume 69, Issue 5-6, Page(s) 171–176

    Abstract: Treatment-resistant mood and anxiety disorders require an intensive therapeutic approach, and it should balance benefits and adverse effects or other potential detrimental effects of medications. The goal of treatment is to provide consistent and lasting ...

    Abstract Treatment-resistant mood and anxiety disorders require an intensive therapeutic approach, and it should balance benefits and adverse effects or other potential detrimental effects of medications. The goal of treatment is to provide consistent and lasting improvement in symptoms of depression and anxiety. Beozodiazepines are effective for anxiety symptoms, but with no sustained treatment effects. Other medication treatment options for anxiety disorders are outlined. Ketamine is usually very effective in treating maior depressive disorder but without sustained benefits. Loog-term use may pose a signiticant risk of developing tolerance and dependence. Stimulant medication augmentation for treatment-resistant depression is effective for residual symptoms of depression, but effects are usually short-lasting and it sounds mor as an artificial way of improving energy, alertness and cognitive functioning. Synthetic cannabinoids and medical marijuana are increasingly prescribed for various medical conditions. but more recently also for patients with mood and anxiety disorders. All of these treatments may raise ethical dilemmas about appropriateness of prescribing these medications and a number of questions regarding the optimal treatment for patients with treatment-resistant depression and treatment refractory anxiety disorders.
    MeSH term(s) Anxiety Disorders/therapy ; Depressive Disorder, Treatment-Resistant/therapy ; Ethics ; Humans
    Language English
    Publishing date 2018-04-25
    Publishing country Serbia
    Document type Journal Article ; Review
    ZDB-ID 131108-6
    ISSN 0025-8105
    ISSN 0025-8105
    DOI 10.2298/mpns1606171k
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    Zs.B 878: Show issues Location:
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  9. Article: Long time-series ecological niche modelling using archaeological settlement data: Tracing the origins of present-day landscape

    Demján, Peter / Dreslerová, Dagmar / Kolář, Jan / Chuman, Tomáš / Romportl, Dušan / Trnka, Miroslav / Lieskovský, Tibor

    Applied geography. 2022 Apr., v. 141

    2022  

    Abstract: Human activities have shaped the environment since long before the advent of agriculture and resulted in anthropogenic landscapes, which are sometimes perceived as natural, but are clearly shaped by dozens of previous generations. This study is the first ...

    Abstract Human activities have shaped the environment since long before the advent of agriculture and resulted in anthropogenic landscapes, which are sometimes perceived as natural, but are clearly shaped by dozens of previous generations. This study is the first to apply ecological niche modelling on a long time-series of archaeological data to illuminate the development of the landscape from the perspective of settlement behaviour and its dependence on environmental conditions. Using a large dataset of evidence of prehistoric settlement activities covering the area of the Czech Republic and spanning 6600 years from the beginning of agricultural prehistory, we analyse to what degree settlement was related to environmental parameters. We quantified the strength of this relation in terms of the predictive power of ecological niche models generated with the MaxEnt method. We observed a significant variability of settlement behaviour over time, but also landscape occupation, which has retained similar general characteristics to now. This shows that settlement strategies were remarkably stable and the presence of previous settlement was beneficial for subsequent land-use. Comparison of prehistoric settlement with contemporary landscape typology also points to a long-term legacy pre-dating historical periods, which makes the landscape our largest and most important heritage monument.
    Keywords archaeology ; data collection ; geography ; humans ; land use ; landscapes ; monuments ; niches ; occupations ; time series analysis ; Czech Republic
    Language English
    Dates of publication 2022-04
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 0143-6228
    DOI 10.1016/j.apgeog.2022.102669
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Critical review of available treatment options for treatment refractory depression and anxiety - clinical and ethical dilemmas

    Kolar Dušan / Kolar Michael V.

    Medicinski Pregled, Vol 69, Iss 5-6, Pp 171-

    2016  Volume 176

    Abstract: Treatment-resistant mood and anxiety disorders require an intensive therapeutic approach, and it should balance benefits and adverse effects or other potential detrimental effects of medications. The goal of treatment is to provide consistent and lasting ...

    Abstract Treatment-resistant mood and anxiety disorders require an intensive therapeutic approach, and it should balance benefits and adverse effects or other potential detrimental effects of medications. The goal of treatment is to provide consistent and lasting improvement in symptoms of depression and anxiety. Benzodiazepines are effective for anxiety symptoms, but with no sustained treatment effects. Other medication treatment options for anxiety disorders are outlined. Ketamine is usually very effective in treating major depressive disorder but without sustained benefits. Long-term use may pose a significant risk of developing tolerance and dependence. Stimulant medication augmentation for treatment-resistant depression is effective for residual symptoms of depression, but effects are usually short-lasting and it sounds more as an artificial way of improving energy, alertness and cognitive functioning. Synthetic cannabinoids and medical marijuana are increasingly prescribed for various medical conditions, but more recently also for patients with mood and anxiety disorders. All of these treatments may raise ethical dilemmas about appropri­ateness of prescribing these medications and a number of questions regarding the optimal treatment for patients with treatment-resistant depression and treatment refractory anxiety disorders.
    Keywords Depressive Disorder ; Treatment-Resistant ; Anxiety Disorders ; Depression ; Treatment Outcome ; Risk Factors ; Benzo­diazepines ; Ketamine ; Pregabalin ; Central Nervous System Stimulants ; Cannabinoids ; Prescription Drug Overuse ; Drug-Related Side Effects and Adverse Reactions ; Medicine (General) ; R5-920 ; Medicine ; R
    Subject code 150
    Language Serbian
    Publishing date 2016-01-01T00:00:00Z
    Publisher Serbian Medical Society, Society of Physicians of Vojvodina, Novi Sad
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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