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Article ; Online: Management of brain metastasized non-small cell lung cancer (NSCLC) - From local treatment to new systemic therapies.

Tsakonas, G / De Petris, L / Ekman, S

2017 Volume 54, Page(s) 122–131

Abstract: Lung cancer has the highest frequency of brain dissemination compared to all other solid tumours. Classical treatment options such as brain irradiation have started to be questioned due to lack of survival benefit and risk for severe side effects. ... ...

Abstract	Lung cancer has the highest frequency of brain dissemination compared to all other solid tumours. Classical treatment options such as brain irradiation have started to be questioned due to lack of survival benefit and risk for severe side effects. Oncogenic driven tumours have the highest frequency of brain dissemination among NSCLC patients and available targeted therapies have shown activity both intra-and extracranially, with an acceptable toxicity profile. The recent approval of immune checkpoint inhibitors for the treatment of NSCLC has complicated treatment selection even more. Data regarding efficacy of immune therapy in the CNS are limited, though promising, and data from larger cohorts are eagerly expected. The purpose of this review is to summarize all available treatment options for brain metastatic NSCLC with an emphasis on oncogenic driven tumours. Treatment selection for brain metastasized NSCLC patients is challenging because of the detrimental effect of potential treatment related CNS side effects in patients' quality of life. Clinical decision making should be done in an individualised way, taking both clinical and molecular factors into consideration.
MeSH term(s)	Antineoplastic Agents/therapeutic use ; Brain Neoplasms/epidemiology ; Brain Neoplasms/secondary ; Brain Neoplasms/therapy ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/pathology ; Humans ; Immunotherapy/methods ; Lung Neoplasms/drug therapy ; Lung Neoplasms/pathology ; Mutation ; Protein Kinase Inhibitors/pharmacology ; Radiotherapy/adverse effects ; Radiotherapy/methods ; Receptor, Epidermal Growth Factor/antagonists & inhibitors ; Receptor, Epidermal Growth Factor/genetics
Chemical Substances	Antineoplastic Agents ; Protein Kinase Inhibitors ; EGFR protein, human (EC 2.7.10.1) ; Receptor, Epidermal Growth Factor (EC 2.7.10.1)
Language	English
Publishing date	2017-03
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	125102-8
ISSN	1532-1967 ; 0305-7372
ISSN (online)	1532-1967
ISSN	0305-7372
DOI	10.1016/j.ctrv.2017.02.004
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Zs.A 1022: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 611: Show issues

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Article: [Description générale des techniques biochimiques permettant d'identifier les virus animaux et d'établir leurs caractéristiques].

La Torre, J L / Parisi, J M / Tisminetzky, S G / De Petris, A

Revue scientifique et technique (International Office of Epizootics)

2017 Volume 3, Issue 2, Page(s) 271–289

Language	French
Publishing date	2017-12-13
Publishing country	France
Document type	Journal Article
ZDB-ID	792125-1
ISSN	1608-0637 ; 0253-1933
ISSN (online)	1608-0637
ISSN	0253-1933
DOI	10.20506/rst.3.2.166
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Zs.A 3513: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 291: Show issues

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Article: Drug-induced gastrointestinal injury (DIGI). Updates, reflections and key points.

De Petris, G / De Marco, L / López, J I

Pathologica

2017 Volume 109, Issue 2, Page(s) 97–109

Abstract: The goals of this short narrative review are 1) to provide an update in recent developments in the field of drug-induced gastrointestinal injury (DIGI), and 2) to distill few key points to approach with confidence a difficult and vast area of ... ...

Abstract	The goals of this short narrative review are 1) to provide an update in recent developments in the field of drug-induced gastrointestinal injury (DIGI), and 2) to distill few key points to approach with confidence a difficult and vast area of gastrointestinal pathology. DIGI is a challenging diagnosis as it can produce almost any pattern of the injury of the gastrointestinal tract. The recognition of a pattern and the knowledge of which drugs can produce that pattern, are the first step of the diagnostic process; communication with the clinical team and a high level of suspicion are then paramount. The pathologist can be the leading clinicians of the care team in few situations in which she/he can recognize the drug at the microscope. Knowledge of the most relevant differential diagnoses of DIGI is essential to avoid significant pitfalls. Finally, several DIGIs due to recently developed immunomodulators used in oncology have shown relevance given their sometimes fatal outcome and the accumulating evidence of a common morphological appearance among them.
MeSH term(s)	Diagnosis, Differential ; Gastrointestinal Diseases/chemically induced ; Gastrointestinal Tract/drug effects ; Humans
Language	English
Publishing date	2017-06
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	418229-7
ISSN	1591-951X ; 0031-2983
ISSN (online)	1591-951X
ISSN	0031-2983
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Zs.B 369: Show issues

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Article ; Online: Maternal vitamin D deficiency as a cause of hypocalcemic convulsions in a newborn from foreign parents: a re-emerging public health issue in Western countries?

Ruffini, E / De Petris, L / Zorzi, G / Carlucci, A

Minerva pediatrica

2015 Volume 67, Issue 5, Page(s) 451–452

MeSH term(s)	Female ; Humans ; Hypocalcemia/complications ; Hypocalcemia/etiology ; Infant, Newborn ; Pregnancy ; Pregnancy Complications ; Public Health ; Seizures/etiology ; Vitamin D Deficiency/complications
Language	English
Publishing date	2015-10
Publishing country	Italy
Document type	Case Reports ; Letter
ZDB-ID	123571-0
ISSN	1827-1715 ; 0026-4946
ISSN (online)	1827-1715
ISSN	0026-4946
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Um IV Zs.161: Show issues

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Article ; Online: The importance of molecular markers for diagnosis and selection of targeted treatments in patients with cancer.

Tobin, N P / Foukakis, T / De Petris, L / Bergh, J

Journal of internal medicine

2015 Volume 278, Issue 6, Page(s) 545–570

Abstract: The past 30 years have seen the introduction of a number of cancer therapies with the aim of restricting the growth and spread of primary and metastatic tumours. A shared commonality among these therapies is their targeting of various aspects of the ... ...

Abstract	The past 30 years have seen the introduction of a number of cancer therapies with the aim of restricting the growth and spread of primary and metastatic tumours. A shared commonality among these therapies is their targeting of various aspects of the cancer hallmarks, that is traits that are essential to successful tumour propagation and dissemination. The evolution of molecular-scale technology has been central to the identification of new cancer targets, and it is not a coincidence that improved therapies have emerged at the same time as gene expression arrays and DNA sequencing have enhanced our understanding of cancer genetics. Modern tumour pathology is now viewed at the molecular level ranging from IHC biomarkers, to gene signature classifiers and gene mutations, all of which provide crucial information about which patients will respond to targeted therapy regimens. In this review, we briefly discuss the general types of targeted therapies used in a clinical setting and provide a short background on immunohistochemical, gene expression and DNA sequencing technologies, before focusing on three tumour types: breast, lung and colorectal cancers. For each of these cancer types, we provide a background to the disease along with an overview of the current standard therapies and then focus on the relevant targeted therapies and the pathways they inhibit. Finally, we highlight several strategies that are pivotal to the successful development of targeted anti-cancer drugs.
MeSH term(s)	Biomarkers, Tumor/analysis ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/therapy ; Female ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Lung Neoplasms/therapy ; Male ; Molecular Targeted Therapy/methods ; Neoplasm Metastasis ; Neoplasm Staging ; Patient Selection ; Pharmacogenetics ; Transcriptome
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2015-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	96274-0
ISSN	1365-2796 ; 0954-6820
ISSN (online)	1365-2796
ISSN	0954-6820
DOI	10.1111/joim.12429
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Article ; Online: Support systems to guide clinical decision-making in precision oncology: The Cancer Core Europe Molecular Tumor Board Portal.

Tamborero, David / Dienstmann, Rodrigo / Rachid, Maan Haj / Boekel, Jorrit / Baird, Richard / Braña, Irene / De Petris, Luigi / Yachnin, Jeffrey / Massard, Christophe / Opdam, Frans L / Schlenk, Richard / Vernieri, Claudio / Garralda, Elena / Masucci, Michele / Villalobos, Xenia / Chavarria, Elena / Calvo, Fabien / Fröhling, Stefan / Eggermont, Alexander /

Apolone, Giovanni / Voest, Emile E / Caldas, Carlos / Tabernero, Josep / Ernberg, Ingemar / Rodon, Jordi / Lehtiö, Janne

Nature medicine

2020 Volume 26, Issue 7, Page(s) 992–994

MeSH term(s)	Clinical Decision-Making ; Europe/epidemiology ; Humans ; Medical Oncology/trends ; Molecular Targeted Therapy ; Neoplasms/epidemiology ; Neoplasms/therapy ; Precision Medicine/trends
Language	English
Publishing date	2020-07-06
Publishing country	United States
Document type	Letter
ZDB-ID	1220066-9
ISSN	1546-170X ; 1078-8956
ISSN (online)	1546-170X
ISSN	1078-8956
DOI	10.1038/s41591-020-0969-2
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Zs.A 4212: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 39: Show issues

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Article ; Online: Roultella ornithinolytica infection in infancy: a case of febrile urinary tract infection.

De Petris, Laura / Ruffini, Ermanno

CEN case reports

2018 Volume 7, Issue 2, Page(s) 234–236

Abstract: Raoultella ornithinolytica is a Gram-negative, non-motile, encapsulated, aerobic bacillus belonging to the Enterobacteriaceae family. R. ornithinolytica is a not very common, but emergent causal agent of human infection, and its expression of beta- ... ...

Abstract	Raoultella ornithinolytica is a Gram-negative, non-motile, encapsulated, aerobic bacillus belonging to the Enterobacteriaceae family. R. ornithinolytica is a not very common, but emergent causal agent of human infection, and its expression of beta-lactamase provides resistance to commonly used antibiotics. The pathogenetic potential of R. ornithinolytica isolates in human disease has become increasingly important. Several cases of hospital-acquired infection, mostly associated with invasive procedures, or in patients with co-morbidity caused by R. ornithinolytica, have been previously reported in the adult population. In pediatric population, two cases in immunocompromised children, one case in an infant with visceral heterotaxy and one case of catheter-related bacteraemia are described. Here, we present the first case of febrile urinary tract infection due to R. ornithinolytica in an 8-month-old infant, recovered from a previous febrile UTI caused by E. coli and without co-morbidity. The empiric therapy with ceftriaxone, followed by cefpodoxime proxetil, resolved symptoms: the clinical condition of the infant improved rapidly and the treatment eradicated urine from the R. ornithinolytica infection. Since other pathogens rather than R. ornithinolytica are usually identified in children with urinary tract infections, including Escherichia coli, Proteus, Klebsiella and Pseudomonas, the identification of this microorganism in our patient's urine was also unexpected.
MeSH term(s)	Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/therapeutic use ; Ceftizoxime/administration & dosage ; Ceftizoxime/analogs & derivatives ; Ceftizoxime/therapeutic use ; Female ; Fever/diagnosis ; Fever/etiology ; Humans ; Infant ; Klebsiella/classification ; Klebsiella/isolation & purification ; Klebsiella Infections/diagnosis ; Klebsiella Infections/drug therapy ; Klebsiella Infections/microbiology ; Treatment Outcome ; Urinary Tract Infections/diagnosis ; Urinary Tract Infections/drug therapy ; Urinary Tract Infections/microbiology ; Vesico-Ureteral Reflux/complications ; Vesico-Ureteral Reflux/diagnostic imaging ; Vesico-Ureteral Reflux/pathology ; Cefpodoxime Proxetil
Chemical Substances	Anti-Bacterial Agents ; Ceftizoxime (C43C467DPE)
Language	English
Publishing date	2018-05-02
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	2660492-9
ISSN	2192-4449 ; 2192-4449
ISSN (online)	2192-4449
ISSN	2192-4449
DOI	10.1007/s13730-018-0333-2
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Article: Two cases of neonatal adrenal hemorrhage presenting with persistent jaundice.

Ruffini, E / De Petris, L / Zorzi, G / Paoletti, P / Mambelli, G / Carlucci, A

La Pediatria medica e chirurgica : Medical and surgical pediatrics

2013 Volume 35, Issue 6, Page(s) 285–287

Abstract: The adrenal hemorrhage is a relatively rare event in newborns but must be considered in the presence of a persistent unexplained jaundice, especially in presence of predisposing factors. Serial ultrasonography is the modality of choice for initial ... ...

Abstract	The adrenal hemorrhage is a relatively rare event in newborns but must be considered in the presence of a persistent unexplained jaundice, especially in presence of predisposing factors. Serial ultrasonography is the modality of choice for initial diagnosis and follow-up of neonatal adrenal hemorrhage. We report two cases of neonatal adrenal hemorrhage presenting with persistent jaundice. The causes of the neonatal adrenal hemorrhages were a difficult vaginal delivery in macrosomic infant and a neonatal infection.
MeSH term(s)	Adrenal Gland Diseases/complications ; Adrenal Gland Diseases/diagnosis ; Adrenal Gland Diseases/diagnostic imaging ; Adrenal Gland Diseases/etiology ; Adrenal Gland Diseases/therapy ; Adult ; Anti-Bacterial Agents/therapeutic use ; Clavicle/injuries ; Diagnosis, Differential ; Female ; Fetal Macrosomia/complications ; Follow-Up Studies ; Fractures, Bone/etiology ; Hemorrhage/complications ; Hemorrhage/diagnosis ; Hemorrhage/diagnostic imaging ; Hemorrhage/etiology ; Hemorrhage/therapy ; Humans ; Infant, Newborn ; Jaundice, Neonatal/diagnosis ; Jaundice, Neonatal/etiology ; Jaundice, Neonatal/therapy ; Male ; Obstetric Labor Complications ; Phototherapy/methods ; Pregnancy ; Treatment Outcome ; Ultrasonography
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2013-11
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	605942-9
ISSN	2420-7748 ; 0391-5387
ISSN (online)	2420-7748
ISSN	0391-5387
DOI	10.4081/pmc.2013.26
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Zs.A 2022: Show issues

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Article ; Online: Application of Process Mining for Modelling Small Cell Lung Cancer Prognosis.

Marzano, Luca / Meijer, Sebastiaan / Dan, Asaf / Tendler, Salomon / De Petris, Luigi / Lewensohn, Rolf / Raghothama, Jayanth / Darwich, Adam S

Studies in health technology and informatics

2023 Volume 302, Page(s) 18–22

Abstract: Process mining is a relatively new method that connects data science and process modelling. In the past years a series of applications with health care production data have been presented in process discovery, conformance check and system enhancement. In ...

Abstract	Process mining is a relatively new method that connects data science and process modelling. In the past years a series of applications with health care production data have been presented in process discovery, conformance check and system enhancement. In this paper we apply process mining on clinical oncological data with the purpose of studying survival outcomes and chemotherapy treatment decision in a real-world cohort of small cell lung cancer patients treated at Karolinska University Hospital (Stockholm, Sweden). The results highlighted the potential role of process mining in oncology to study prognosis and survival outcomes with longitudinal models directly extracted from clinical data derived from healthcare.
MeSH term(s)	Humans ; Small Cell Lung Carcinoma/therapy ; Prognosis ; Delivery of Health Care ; Lung Neoplasms ; Sweden
Language	English
Publishing date	2023-05-19
Publishing country	Netherlands
Document type	Journal Article
ISSN	1879-8365
ISSN (online)	1879-8365
DOI	10.3233/SHTI230056
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Article: Lung abscess in a child secondary to Mycoplasma pneumoniae infection.

Ruffini, E / De Petris, L / Candelotti, P / Tulli, M / Sabatini, M R / Luciani, L / Carlucci, A

La Pediatria medica e chirurgica : Medical and surgical pediatrics

2014 Volume 36, Issue 2, Page(s) 87–89

Abstract: We present a case of a lung abscess in a child 6-year-old admitted with a history of right hemithorax pain lasting for 15 days and the onset of mild fever in the last two days. Etiological research showed positivity of IgM antibodies to Mycoplasma ... ...

Abstract	We present a case of a lung abscess in a child 6-year-old admitted with a history of right hemithorax pain lasting for 15 days and the onset of mild fever in the last two days. Etiological research showed positivity of IgM antibodies to Mycoplasma pneumoniae after seven days of admission. The child has been successfully treated with antibiotic therapy, without the use of macrolides, for a duration of 4 weeks. Our study suggests that the Mycoplasma pneumoniae infection may predispose to severe infections, such as lung abscess, caused by typical respiratory pathogens. The reported case of lung abscess is one of the few reported in the literature in the modern antibiotic era and is the first preceded by Mycoplasma pneumoniae infection.
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Child ; Humans ; Immunoglobulin M/immunology ; Lung Abscess/drug therapy ; Lung Abscess/etiology ; Lung Abscess/microbiology ; Male ; Mycoplasma pneumoniae/isolation & purification ; Pneumonia, Mycoplasma/complications ; Pneumonia, Mycoplasma/drug therapy
Chemical Substances	Anti-Bacterial Agents ; Immunoglobulin M
Language	English
Publishing date	2014-03
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	605942-9
ISSN	2420-7748 ; 0391-5387
ISSN (online)	2420-7748
ISSN	0391-5387
DOI	10.4081/pmc.2014.17
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