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Article ; Online: Airway smooth muscle and long-term clinical efficacy following bronchial thermoplasty in severe asthma.

Wijsman, Pieta C / Goorsenberg, Annika W M / d'Hooghe, Julia N S / Ten Hacken, Nick H T / J T H Roelofs, Joris / Mauad, Thais / Weersink, Els J M / Shah, Pallav / Annema, Jouke T / Bonta, Peter I

Thorax

2024 Volume 79, Issue 4, Page(s) 359–362

Abstract: The mechanism of action of bronchial thermoplasty (BT) treatment for patients with severe asthma is incompletely understood. This study investigated the 2.5-year impact of BT on airway smooth muscle (ASM) mass and clinical parameters by paired data ... ...

Abstract	The mechanism of action of bronchial thermoplasty (BT) treatment for patients with severe asthma is incompletely understood. This study investigated the 2.5-year impact of BT on airway smooth muscle (ASM) mass and clinical parameters by paired data analysis in 22 patients. Our findings demonstrate the persistence of ASM mass reduction of >50% after 2.5 years. Furthermore, sustained improvement in asthma control, quality of life and exacerbation rates was found, which is in line with previous reports. An association was found between the remaining ASM and both the exacerbation rate (r=0.61, p=0.04 for desmin, r=0.85, p<0.01 for alpha smooth muscle actin (SMA)) and post-bronchodilator forced expiratory volume in 1 s predicted percentage (r=-0.69, p=0.03 for desmin, r=-0.58, p=0.08 for alpha SMA). This study provides new insight into the long-term impact of BT.
MeSH term(s)	Humans ; Bronchial Thermoplasty ; Bronchi/surgery ; Quality of Life ; Desmin/therapeutic use ; Asthma/drug therapy ; Treatment Outcome ; Muscle, Smooth
Chemical Substances	Desmin
Language	English
Publishing date	2024-03-15
Publishing country	England
Document type	Journal Article
ZDB-ID	204353-1
ISSN	1468-3296 ; 0040-6376
ISSN (online)	1468-3296
ISSN	0040-6376
DOI	10.1136/thorax-2023-220967
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Article ; Online: Cigarette smoking prior to blood sampling acutely affects serum levels of the chronic obstructive pulmonary disease biomarker surfactant protein D.

Klont, Frank / Horvatovich, Péter / Ten Hacken, Nick H T / Bischoff, Rainer

Clinical chemistry and laboratory medicine

2020 Volume 58, Issue 8, Page(s) e138–e141

MeSH term(s)	Adult ; Aged ; Artifacts ; Biomarkers/blood ; Cigarette Smoking/blood ; Female ; Humans ; Male ; Middle Aged ; Pulmonary Disease, Chronic Obstructive/blood ; Pulmonary Surfactant-Associated Protein D/blood ; Young Adult
Chemical Substances	Biomarkers ; Pulmonary Surfactant-Associated Protein D
Language	English
Publishing date	2020-03-06
Publishing country	Germany
Document type	Letter
ZDB-ID	1418007-8
ISSN	1437-4331 ; 1434-6621 ; 1437-8523
ISSN (online)	1437-4331
ISSN	1434-6621 ; 1437-8523
DOI	10.1515/cclm-2019-1246
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Article ; Online: The Decrease in Serum sRAGE Levels Upon Smoking is Associated with Activated Neutrophils.

Wiersma, Valerie R / Hoonhorst, Susan J M / Ten Hacken, Nick H T / van den Berge, Maarten / Slebos, Dirk-Jan / Pouwels, Simon D

Lung

2022 Volume 200, Issue 6, Page(s) 687–690

Abstract: The serum level of the soluble Receptor for Advanced Glycation End-products (sRAGE) is a promising blood biomarker for the development, severity, and progression of chronic obstructive pulmonary disease (COPD). However, cigarette smoking causes a nearly ... ...

Abstract	The serum level of the soluble Receptor for Advanced Glycation End-products (sRAGE) is a promising blood biomarker for the development, severity, and progression of chronic obstructive pulmonary disease (COPD). However, cigarette smoking causes a nearly instant drop in circulating sRAGE levels, strongly impacting on the variability in sRAGE levels. In the current study, we investigated the possible mechanism behind the sudden drop in sRAGE upon smoking. We showed that the number of activated neutrophils in blood significantly increases within two hours upon smoking three cigarettes within one hour. Furthermore, an increased expression of the leukocyte activation marker CD11b, which is a known ligand for RAGE, was observed upon smoking. Additionally, the in vitro activation of neutrophils increased their capacity to bind sRAGE. Together, these data indicate that smoking activates neutrophils in the circulation with concomitant upregulation of the RAGE ligand CD11b, leading to reduced levels of sRAGE in serum.
MeSH term(s)	Humans ; Receptor for Advanced Glycation End Products/metabolism ; Neutrophils/metabolism ; Ligands ; Receptors, Immunologic ; Biomarkers ; Smoking/adverse effects
Chemical Substances	Receptor for Advanced Glycation End Products ; Ligands ; Receptors, Immunologic ; Biomarkers
Language	English
Publishing date	2022-10-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	6165-7
ISSN	1432-1750 ; 0341-2040
ISSN (online)	1432-1750
ISSN	0341-2040
DOI	10.1007/s00408-022-00585-4
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Article ; Online: Patient Satisfaction and Attainment of Patient-Specific Goals after Endobronchial Valve Treatment.

Hartman, Jorine E / Klooster, Karin / Ten Hacken, Nick H T / van Dijk, Marlies / Slebos, Dirk-Jan

Annals of the American Thoracic Society

2020 Volume 18, Issue 1, Page(s) 68–74

Abstract: Rationale: ...

Abstract	Rationale:
MeSH term(s)	Bronchoscopy ; Forced Expiratory Volume ; Goals ; Humans ; Patient Satisfaction ; Pneumonectomy/psychology ; Pulmonary Emphysema/surgery ; Quality of Life ; Treatment Outcome
Language	English
Publishing date	2020-09-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2717461-X
ISSN	2325-6621 ; 1943-5665 ; 2325-6621
ISSN (online)	2325-6621 ; 1943-5665
ISSN	2325-6621
DOI	10.1513/AnnalsATS.202004-342OC
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Article: Single-nucleotide polymorphism rs2070600 regulates

Faiz, Alen / Rathnayake, Senani N H / Ten Hacken, Nick H T / Guryev, Victor / van den Berge, Maarten / Pouwels, Simon D

ERJ open research

2021 Volume 7, Issue 2

Abstract: The COPD susceptibility SNP rs2070600 affects the levels of the COPD biomarker sRAGE in sputum as well as splicing ... ...

Abstract	The COPD susceptibility SNP rs2070600 affects the levels of the COPD biomarker sRAGE in sputum as well as splicing of
Language	English
Publishing date	2021-06-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2827830-6
ISSN	2312-0541
ISSN	2312-0541
DOI	10.1183/23120541.00947-2020
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Article: Long-term follow-up after bronchoscopic lung volume reduction valve treatment for emphysema.

Hartman, Jorine E / Klooster, Karin / Koster, T David / Ten Hacken, Nick H T / van Dijk, Marlies / Slebos, Dirk-Jan

ERJ open research

2022 Volume 8, Issue 4

Abstract: Background: Multiple studies have shown that patients with severe emphysema can significantly benefit from bronchoscopic lung volume reduction endobronchial valve (EBV) treatment up to 1 year after treatment. However, hardly any data exist on longer ... ...

Abstract	Background: Multiple studies have shown that patients with severe emphysema can significantly benefit from bronchoscopic lung volume reduction endobronchial valve (EBV) treatment up to 1 year after treatment. However, hardly any data exist on longer term follow-up, especially on quality of life. Our aim was to investigate long-term follow-up after EBV treatment up to 3 years including quality of life in a real-life routine clinical setting. Methods: We retrospectively included patients who underwent EBV treatment in our hospital in the Netherlands at least 3 years prior. Patients were invited for annual visits to our hospital, and spirometry, body plethysmography, 6-min walk distance (6MWD) test and St George's Respiratory Questionnaire (SGRQ) were performed during these visits. Results: At 1-, 2- and 3-year follow-up, data were available from 189, 146 and 112 patients, respectively. Forced expiratory volume in 1 s, residual volume and SGRQ total score significantly improved up to 3 years after treatment compared with baseline, and 6MWD up to 2 years after treatment. In general, the magnitude of improvements gradually decreased over time. Conclusions: Our results show that patients can benefit at least up to 3 years after EBV treatment. For the first time we found that patients can also benefit in terms of quality of life in the long term, which is an important outcome for this group of patients with end-stage COPD.
Language	English
Publishing date	2022-11-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2827830-6
ISSN	2312-0541
ISSN	2312-0541
DOI	10.1183/23120541.00235-2022
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Article ; Online: Confounding Factors Affecting sRAGE as a Biomarker for Chronic Obstructive Pulmonary Disease.

Pouwels, Simon D / Klont, Frank / Bischoff, Rainer / Ten Hacken, Nick H T

American journal of respiratory and critical care medicine

2019 Volume 200, Issue 1, Page(s) 114

MeSH term(s)	Biomarkers ; Humans ; Pulmonary Disease, Chronic Obstructive
Chemical Substances	Biomarkers
Language	English
Publishing date	2019-03-19
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.201902-0356LE
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Article ; Online: Gene expression profiles in mesenchymal stromal cells from bone marrow, adipose tissue and lung tissue of COPD patients and controls.

Kruk, Dennis / Yeung, Anna C Y / Faiz, Alen / Ten Hacken, Nick H T / Timens, Wim / van Kuppevelt, Toin H / Daamen, Willeke / Hof, Danique / Harmsen, Martin C / Rojas, Mauricio / Heijink, Irene H

Respiratory research

2023 Volume 24, Issue 1, Page(s) 22

Abstract: Background: Chronic obstructive pulmonary disease (COPD) is characterized by irreversible lung tissue damage. Novel regenerative strategies are urgently awaited. Cultured mesenchymal stem/stromal cells (MSCs) have shown promising results in experimental ...

Abstract	Background: Chronic obstructive pulmonary disease (COPD) is characterized by irreversible lung tissue damage. Novel regenerative strategies are urgently awaited. Cultured mesenchymal stem/stromal cells (MSCs) have shown promising results in experimental models of COPD, but differences between sources may impact on their potential use in therapeutic strategies in patients. Aim: To assess the transcriptome of lung-derived MSCs (LMSCs), bone marrow-derived MSCs (BM-MSC) and adipose-derived MSCs (AD-MSCs) from COPD patients and non-COPD controls. Methods: We studied differences in gene expression profiles between the MSC-subtypes, as well as between COPD and control using RNA sequencing (RNA-seq). Results: We show that besides heterogeneity between donors, MSCs from different sources have strongly divergent gene signatures. The growth factors FGF10 and HGF were predominantly expressed in LMSCs. MSCs from all sources displayed altered expression profiles in COPD, with most pronounced significantly up- and downregulated genes in MSCs from adipose tissue. Pathway analysis revealed that the most differentially expressed genes in COPD-derived AD-MSCs are involved in extracellular matrix (ECM) binding and expression. In LMSCs, the gene that differed most strongly between COPD and control was CSGALNACT1, an ECM modulating gene. Conclusion: Autologous MSCs from COPD patients display abnormalities with respect to their transcriptome, which were surprisingly most profound in MSCs from extrapulmonary sources. LMSCs may be optimally equipped for lung tissue repair because of the expression of specific growth factor genes.
MeSH term(s)	Humans ; Transcriptome ; Bone Marrow ; Adipose Tissue ; Lung ; Pulmonary Disease, Chronic Obstructive/genetics ; Pulmonary Disease, Chronic Obstructive/metabolism ; Mesenchymal Stem Cells/metabolism ; Bone Marrow Cells/metabolism ; Cells, Cultured ; Cell Differentiation
Language	English
Publishing date	2023-01-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2041675-1
ISSN	1465-993X ; 1465-993X
ISSN (online)	1465-993X
ISSN	1465-993X
DOI	10.1186/s12931-023-02314-8
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Article ; Online: Change in Dynamic Hyperinflation After Bronchoscopic Lung Volume Reduction in Patients with Emphysema.

van Dijk, Marlies / Klooster, Karin / Hartman, Jorine E / Ten Hacken, Nick H T / Slebos, Dirk-Jan

Lung

2020 Volume 198, Issue 5, Page(s) 795–801

Abstract: Background and purpose: In patients with severe emphysema, dynamic hyperinflation is superimposed on top of already existing static hyperinflation. Static hyperinflation reduces significantly after bronchoscopic lung volume reduction (BLVR). In this ... ...

Abstract	Background and purpose: In patients with severe emphysema, dynamic hyperinflation is superimposed on top of already existing static hyperinflation. Static hyperinflation reduces significantly after bronchoscopic lung volume reduction (BLVR). In this study, we investigated the effect of BLVR compared to standard of care (SoC) on dynamic hyperinflation. Methods: Dynamic hyperinflation was induced by a manually paced tachypnea test (MPT) and was defined by change in inspiratory capacity (IC) measured before and after MPT. Static and dynamic hyperinflation measurements were performed both at baseline and 6 months after BLVR with endobronchial valves or coils (treatment group) or SoC (control group). Results: Eighteen patients underwent BLVR (78% female, 57 (43-67) years, FEV Conclusion: Bronchoscopic lung volume reduction increases the ability for dynamic hyperinflation in patients with severe emphysema. We propose this is a consequence of improved static hyperinflation.
MeSH term(s)	Female ; Humans ; Lung/diagnostic imaging ; Lung/physiopathology ; Lung Volume Measurements/methods ; Male ; Middle Aged ; Netherlands ; Outcome Assessment, Health Care/methods ; Pneumonectomy/adverse effects ; Pneumonectomy/methods ; Pulmonary Emphysema/diagnosis ; Pulmonary Emphysema/physiopathology ; Pulmonary Emphysema/surgery ; Residual Volume ; Respiratory Function Tests/methods ; Respiratory Function Tests/statistics & numerical data ; Severity of Illness Index ; Tomography, X-Ray Computed/methods ; Walk Test/methods
Language	English
Publishing date	2020-07-24
Publishing country	United States
Document type	Clinical Trial ; Journal Article
ZDB-ID	6165-7
ISSN	1432-1750 ; 0341-2040
ISSN (online)	1432-1750
ISSN	0341-2040
DOI	10.1007/s00408-020-00382-x
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Article ; Online: Endobronchial valve therapy for severe emphysema: an overview of valve-related complications and its management.

Koster, T David / Klooster, Karin / Ten Hacken, Nick H T / van Dijk, Marlies / Slebos, Dirk-Jan

Expert review of respiratory medicine

2020 Volume 14, Issue 12, Page(s) 1235–1247

Abstract: Introduction: Bronchoscopic lung volume reduction treatment with one-way valves is an effective guideline treatment option for patients with severe emphysema. However, important challenges and adverse reactions may occur after treatment.: Areas ... ...

Abstract	Introduction: Bronchoscopic lung volume reduction treatment with one-way valves is an effective guideline treatment option for patients with severe emphysema. However, important challenges and adverse reactions may occur after treatment. Areas covered: This review summarizes the complications after endobronchial and intrabronchial valve treatment that have been described by the currently published randomized controlled trials and other relevant papers regarding the complications and its management. In case there was no relevant literature regarding these subjects, recommendations are based on expert opinion. Complications include pneumothorax, post-obstruction pneumonia and hemoptysis. Also, the treatment may not be effective due to the presence of collateral ventilation or misplaced valves. Furthermore, an initial beneficial effect may vanish due to granulation tissue formation, valve dysfunction or valve migration. Careful follow-up after treatment with valves is important. Evaluation with a CT-scan and/or bronchoscopy is needed if there is no improvement after treatment, loss of benefit, or occurrence of important adverse events during follow-up. Expert opinion: Treating severe emphysema patients with one-way valves requires continuous dedication and expertise, especially to achieve an optimal outcome and elegantly deal with the various complications after treatment.
MeSH term(s)	Bronchoscopy/adverse effects ; Bronchoscopy/methods ; Heart Valve Diseases/diagnosis ; Heart Valve Diseases/etiology ; Heart Valve Diseases/therapy ; Hemoptysis/diagnosis ; Hemoptysis/etiology ; Hemoptysis/therapy ; Humans ; Pneumonectomy/adverse effects ; Pneumonia/diagnosis ; Pneumonia/etiology ; Pneumonia/therapy ; Pneumothorax/diagnosis ; Pneumothorax/etiology ; Pneumothorax/therapy ; Postoperative Complications/diagnosis ; Postoperative Complications/etiology ; Postoperative Complications/therapy ; Prostheses and Implants/adverse effects ; Pulmonary Emphysema/diagnosis ; Pulmonary Emphysema/pathology ; Pulmonary Emphysema/surgery ; Pulmonary Valve/pathology ; Pulmonary Valve/surgery ; Tomography, X-Ray Computed ; Treatment Outcome
Language	English
Publishing date	2020-08-31
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2479146-5
ISSN	1747-6356 ; 1747-6348
ISSN (online)	1747-6356
ISSN	1747-6348
DOI	10.1080/17476348.2020.1813571
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