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  1. Article: Erythromelalgia: A Child With V400M Mutation in the

    Nwebube, Chineze / Bulancea, Sabrina / Marchidann, Adrian / Bello-Espinosa, Lourdes / Treidler, Simona

    Neurology. Genetics

    2021  Volume 7, Issue 2, Page(s) e570

    Language English
    Publishing date 2021-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2818607-2
    ISSN 2376-7839
    ISSN 2376-7839
    DOI 10.1212/NXG.0000000000000570
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Expansion of Intravenous Tissue Plasminogen Activator Eligibility Beyond National Institute of Neurological Disorders and Stroke and European Cooperative Acute Stroke Study III Criteria.

    Marchidann, Adrian / Balucani, Clotilde / Levine, Steven R

    Neurologic clinics

    2015  Volume 33, Issue 2, Page(s) 381–400

    Abstract: Intravenous tPA is the standard treatment for acute ischemic stroke. Multiple contraindications for thrombolysis developed during the design of the clinical trials may be overly cautious and limit the number of patients who may be eligible and ... ...

    Abstract Intravenous tPA is the standard treatment for acute ischemic stroke. Multiple contraindications for thrombolysis developed during the design of the clinical trials may be overly cautious and limit the number of patients who may be eligible and potentially benefit from treatment. As clinicians have become more comfortable with off-label use of tPA, new data on the safety of thrombolysis have become available and shaped the current guidelines. This article updates our knowledge on the evidence available for these contraindications to help guide the clinician in choosing the optimal approach to some of the most commonly encountered clinical scenarios.
    MeSH term(s) Clinical Trials as Topic ; Fibrinolytic Agents/therapeutic use ; Humans ; National Institute of Neurological Disorders and Stroke (U.S.) ; Stroke/drug therapy ; Tissue Plasminogen Activator/therapeutic use ; United States
    Chemical Substances Fibrinolytic Agents ; Tissue Plasminogen Activator (EC 3.4.21.68)
    Language English
    Publishing date 2015-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1013148-6
    ISSN 1557-9875 ; 0733-8619
    ISSN (online) 1557-9875
    ISSN 0733-8619
    DOI 10.1016/j.ncl.2015.01.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Treatment of carotid artery disease: endarterectomy or angioplasty?

    Marchidann, Adrian / Marshall, Randolph S

    Current neurology and neuroscience reports

    2010  Volume 11, Issue 1, Page(s) 61–66

    Abstract: The management of carotid stenosis has enjoyed renewed interest in the neurological community in recent years due to the advent of endovascular approaches. In concert, progress in medical treatment of these patients has rekindled the debate regarding the ...

    Abstract The management of carotid stenosis has enjoyed renewed interest in the neurological community in recent years due to the advent of endovascular approaches. In concert, progress in medical treatment of these patients has rekindled the debate regarding the best management of carotid stenosis overall, both for symptomatic and asymptomatic disease. For symptomatic carotid stenosis, the major decision required is choosing the type of intervention best suited for individual patients: carotid endarterectomy versus carotid artery stenting. For patients with asymptomatic carotid stenosis, intensive medical management has evolved significantly over the past decade to decrease the risk of ischemic stroke to match surgical intervention under most circumstances. This review will examine the supporting evidence for each intervention, and discuss the recent advances in medical and endovascular therapy that provide the data for a new era in clinical decision making.
    MeSH term(s) Angioplasty/methods ; Carotid Arteries/pathology ; Carotid Arteries/surgery ; Carotid Artery Diseases/complications ; Carotid Artery Diseases/surgery ; Carotid Stenosis/complications ; Carotid Stenosis/surgery ; Clinical Trials as Topic ; Decision Making ; Endarterectomy, Carotid/methods ; Humans ; Stents ; Stroke/etiology ; Stroke/prevention & control ; Treatment Outcome
    Language English
    Publishing date 2010-10-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057363-7
    ISSN 1534-6293 ; 1528-4042
    ISSN (online) 1534-6293
    ISSN 1528-4042
    DOI 10.1007/s11910-010-0153-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5549: Show issues Location:
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  4. Article ; Online: Association of low ejection fraction with impaired verbal memory in older patients with heart failure.

    Festa, Joanne R / Jia, Xiaoyu / Cheung, Ken / Marchidann, Adrian / Schmidt, Michael / Shapiro, Peter A / Mancini, Donna M / Naka, Yoshifumi / Deng, Mario / Lantz, Emily R / Marshall, Randolph S / Lazar, Ronald M

    Archives of neurology

    2011  Volume 68, Issue 8, Page(s) 1021–1026

    Abstract: Background: Cognitive dysfunction has a major role in health outcomes for cardiac patients. The association of cognitive dysfunction with heart failure is well established, but the cardiac variables that contribute to cognition are not well understood.!# ...

    Abstract Background: Cognitive dysfunction has a major role in health outcomes for cardiac patients. The association of cognitive dysfunction with heart failure is well established, but the cardiac variables that contribute to cognition are not well understood.
    Objectives: To investigate the relationships among age, memory, and left ventricular ejection fraction (EF) in patients with heart failure.
    Design: Retrospective study.
    Setting: Academic medical center.
    Participants: A total of 207 patients with heart failure underwent neuropsychological assessment of memory on standardized tests.
    Main outcome measures: Patients were grouped by age quartiles, and memory function was compared in those with an EF below 30% vs those with an EF of 30% or higher.
    Results: Demographic, cognitive, and medical variables having a significant association with a memory composite score were identified in a univariate linear regression analysis. In a multivariate linear model that adjusted for significant covariates, there was a significant interaction between age and EF for memory function. Patients younger than 63 years maintained stable memory function across EF levels, but patients 63 years or older showed a significant decline in memory performance when EF dropped below 30% (P < .02). Post hoc multivariate analysis showed that verbal delayed recall and recognition were the components of memory most affected by low EF.
    Conclusion: The effect of EF on memory differs by age such that older patients with lower EFs have significantly reduced verbal memory function.
    MeSH term(s) Adolescent ; Adult ; Age Factors ; Aged ; Cognition Disorders/diagnosis ; Cognition Disorders/physiopathology ; Comorbidity ; Female ; Heart Failure/diagnosis ; Heart Failure/physiopathology ; Humans ; Male ; Memory Disorders/diagnosis ; Memory Disorders/physiopathology ; Middle Aged ; Retrospective Studies ; Stroke Volume/physiology ; Young Adult
    Language English
    Publishing date 2011-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80049-1
    ISSN 1538-3687 ; 0003-9942
    ISSN (online) 1538-3687
    ISSN 0003-9942
    DOI 10.1001/archneurol.2011.163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui II Zs.191: Show issues Location:
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  5. Article ; Online: Too good to treat? Outcomes in patients not receiving thrombolysis due to mild deficits or rapidly improving symptoms.

    Willey, Joshua Z / Stillman, Joshua / Rivolta, Juan A / Vieira, Julio / Doyle, Margaret M / Linares, Guillermo / Marchidann, Adrian / Elkind, Mitchell S V / Boden-Albala, Bernadette / Marshall, Randolph S

    International journal of stroke : official journal of the International Stroke Society

    2011  Volume 7, Issue 3, Page(s) 202–206

    Abstract: Introduction: Among ischemic stroke patients arriving within the treatment window, rapidly improving symptoms or having a mild deficit (i.e. too good to treat) is a common reason for exclusion. Several studies have reported poor outcomes in this group. ... ...

    Abstract Introduction: Among ischemic stroke patients arriving within the treatment window, rapidly improving symptoms or having a mild deficit (i.e. too good to treat) is a common reason for exclusion. Several studies have reported poor outcomes in this group. We addressed the question of early neurological deterioration in too good to treat patients in a larger prospective cohort study.
    Methods: Admission and discharge information were collected prospectively in acute stroke patients who presented to the emergency room within three-hours from onset. The primary outcome measure was change in the National Institutes of Health Stroke Scale from baseline to discharge. Secondary outcomes were discharge National Institutes of Health Stroke Scale >4, not being discharged home, and discharge modified Rankin scale.
    Results: Of 355 patients who presented within three-hours, 127 (35·8%) had too good to treat listed as the only reason for not receiving thrombolysis, with median admission National Institutes of Health Stroke Scale = 1 (range = 0 to 19). At discharge, seven (5·5%) showed a worsening of National Institutes of Health Stroke Scale ≥1, and nine (7·1%) had a National Institutes of Health Stroke Scale >4. When excluding prior stroke (remaining n = 97), discharge status was even more benign: only five (5·2%) had a discharge National Institutes of Health Stroke Scale >4, and two (2·1%) patients were not discharged home.
    Conclusion: We found that a small proportion of patients deemed too good to treat will have early neurological deterioration, in contrast to other studies. Decisions about whether to treat mild stroke patients depend on the outcome measure chosen, particularly when considering discharge disposition among patients who have had prior stroke. The decision to thrombolyze may ultimately rest on the nature of the presentation and deficit.
    MeSH term(s) Aged ; Aged, 80 and over ; Brain Ischemia/diagnosis ; Brain Ischemia/epidemiology ; Brain Ischemia/therapy ; Female ; Humans ; Male ; Middle Aged ; Nervous System Diseases/diagnosis ; Nervous System Diseases/epidemiology ; Nervous System Diseases/therapy ; Prospective Studies ; Stroke/diagnosis ; Stroke/epidemiology ; Stroke/therapy ; Thrombolytic Therapy/methods ; Time Factors ; Treatment Outcome
    Language English
    Publishing date 2011-11-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2303728-3
    ISSN 1747-4949 ; 1747-4930
    ISSN (online) 1747-4949
    ISSN 1747-4930
    DOI 10.1111/j.1747-4949.2011.00696.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6582: Show issues Location:
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