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  1. Article ; Online: Complicated Sinusitis in Children: Should We Increase Awareness After the Pandemic?

    Fusani, Lara / Venturini, Elisabetta / Indolfi, Giuseppe / Scagnet, Mirko / Trabalzini, Franco / Chiappini, Elena / Galli, Luisa

    The Pediatric infectious disease journal

    2024  

    Language English
    Publishing date 2024-04-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000004357
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cat scratch disease in childhood: a 10-year experience of an Italian tertiary care children's hospital.

    Fusani, Lara / Venturini, Elisabetta / Chiappini, Elena / Galli, Luisa

    World journal of pediatrics : WJP

    2022  Volume 19, Issue 2, Page(s) 189–193

    MeSH term(s) Child ; Humans ; Cat-Scratch Disease/diagnosis ; Cat-Scratch Disease/epidemiology ; Tertiary Healthcare ; Hospitals, Pediatric ; Italy/epidemiology
    Language English
    Publishing date 2022-09-13
    Publishing country Switzerland
    Document type Letter
    ZDB-ID 2236681-7
    ISSN 1867-0687 ; 1708-8569
    ISSN (online) 1867-0687
    ISSN 1708-8569
    DOI 10.1007/s12519-022-00616-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Hearing Outcome and Virologic Characteristics of Children With Congenital Cytomegalovirus Infection in Relation to Antiviral Therapy: A Retrospective Cohort Study.

    Venturini, Elisabetta / Impagnatiello, Luisa / Chiappini, Elena / Galli, Luisa

    The Pediatric infectious disease journal

    2022  Volume 42, Issue 1, Page(s) 52–58

    Abstract: Background: Congenital cytomegalovirus infection is one of the leading causes of nongenetic sensorineural hearing loss. The aim of our retrospective cohort study was to describe the changes in hearing in relation to antiviral therapy and the trend in ... ...

    Abstract Background: Congenital cytomegalovirus infection is one of the leading causes of nongenetic sensorineural hearing loss. The aim of our retrospective cohort study was to describe the changes in hearing in relation to antiviral therapy and the trend in viremia and viruria in children with congenital cytomegalovirus infection.
    Methods: In the present study, data were collected from infants treated with valganciclovir for 6 weeks or 6 months or untreated, seen between 2000 and 2021 at the Infectious Diseases Unit, Meyer Children's University Hospital, Florence, Italy. Hearing deterioration was studied using Kaplan-Meier survival curves and risk factors for the outcome "deterioration" with Cox analysis.
    Results: Ninety-eight children were enrolled. Three children developed late hearing loss (2 children treated with valganciclovir for 6 weeks and 1 untreated). Kaplan-Meier survival curves of children treated for 6 weeks and 6 months overlapped until 36 months of life, after then 2 children of the 6-week group showed a worsening of hearing function (P = 0.609). Cox analysis did not show a significant impact of analyzed variables (group of therapy, viruria and viremia) on the outcome. The resolution of detectable viruria and viremia was significantly faster in the 6-month group (P = 0.011, <0.001, respectively).
    Conclusions: Our study is the first that reports audiological characteristics at follow-up after 24 months of life in treated and untreated children with congenital cytomegalovirus infection. In our population, 6 months therapy may prevent the development of late hearing loss, although the different regimens did not differ in influencing the progression of congenital deafness.
    MeSH term(s) Child ; Humans ; Retrospective Studies ; Hearing ; Cytomegalovirus Infections/drug therapy ; Hearing Loss ; Antiviral Agents/therapeutic use
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2022-09-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000003727
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Discomfort relief after paracetamol administration in febrile children admitted to a third level paediatric emergency department.

    Chiappini, Elena / Bestetti, Matilde / Masi, Stefano / Paba, Teresa / Venturini, Elisabetta / Galli, Luisa

    Frontiers in pediatrics

    2023  Volume 11, Page(s) 1075449

    Abstract: Background: international guidelines recommend treating fever in children not at a predefined body temperature limit but based on the presence of discomfort. However few studies evaluated discomfort relief after administration of antipyretics in ... ...

    Abstract Background: international guidelines recommend treating fever in children not at a predefined body temperature limit but based on the presence of discomfort. However few studies evaluated discomfort relief after administration of antipyretics in children.
    Methods: Between 1st January and 30th September 2021 a single-center prospective observational study was performed in febrile children consecutively admitted to a pediatric emergency department and treated with paracetamol orally. For each child, body temperature, presence and severity of discomfort, defined using a previously published semiquantitative likert scale, were evaluated at baseline and 60 min after administration of paracetamol, and differences were analyzed.
    Results: 172 children (males: 91/172; 52.9%; median age: 41.7 months) were included. Significant reductions in body temperature (median body temperature at T0: 38.9 °C; IQR: 38.3-39.4, median body temperature at T60: 36.9 °C; IQR: 36.4-37.5;
    Conclusions: paracetamol in febrile children is associated not only with significantly reduction in body temperature but also with discomfort relief.
    Language English
    Publishing date 2023-03-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2023.1075449
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Three-in-one: exploration of co-encapsulation of cabazitaxel, bicalutamide and chlorin e6 in new mixed cyclodextrin-crosslinked polymers.

    Pancani, Elisabetta / Veclani, Daniele / Agnes, Marco / Mazza, Arianna / Venturini, Alessandro / Malanga, Milo / Manet, Ilse

    RSC advances

    2023  Volume 13, Issue 16, Page(s) 10923–10939

    Abstract: We explored a series of cyclodextrin (CyD) polymers composed either of a single CyD type or a mixture of two CyD types to encapsulate simultaneously different compounds with potential therapeutic interest for multimodal prostate cancer treatment. New ... ...

    Abstract We explored a series of cyclodextrin (CyD) polymers composed either of a single CyD type or a mixture of two CyD types to encapsulate simultaneously different compounds with potential therapeutic interest for multimodal prostate cancer treatment. New mixed CyD polymers were prepared in alkaline water starting from the naturally occurring monomers and a low-cost crosslinking agent. Batches of 200 g of polymer were easily obtained. By means of optical spectroscopy we proved the co-encapsulation of 3 compounds in the polymers: the drugs cabazitaxel (CBX) and bicalutamide (BIC), and the photosensitizer chlorin e6 (Ce6). pβCyD and mixed pαβCyD polymers performed best for single drug solubilization. In the co-encapsulation of BIC and CBX by pβCyD and pαβCyD, pβCyD stands out in drug solubilization ability. Avoiding the use of organic solvents, it was possible to dissolve up to 0.1 mM CBX with 10 mg ml
    Language English
    Publishing date 2023-04-06
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra01782f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Old biomarkers in tuberculosis management: are they still useful? a systematic review.

    Fusani, Lara / Tersigni, Chiara / Chiappini, Elena / Venturini, Elisabetta / Galli, Luisa

    Expert review of anti-infective therapy

    2021  Volume 19, Issue 10, Page(s) 1191–1203

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Biomarkers/metabolism ; C-Reactive Protein/metabolism ; Child ; Diagnosis, Differential ; Humans ; Pneumonia/diagnosis ; Predictive Value of Tests ; Procalcitonin/metabolism ; Sputum/microbiology ; Tuberculosis/diagnosis ; Tuberculosis/therapy
    Chemical Substances Biomarkers ; Procalcitonin ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2021-03-16
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 2181279-2
    ISSN 1744-8336 ; 1478-7210
    ISSN (online) 1744-8336
    ISSN 1478-7210
    DOI 10.1080/14787210.2021.1898945
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Covalently Binding Adenosine A

    Cherchi, Federica / Venturini, Martina / Magni, Giada / Scortichini, Mirko / Jacobson, Kenneth A / Pugliese, Anna Maria / Coppi, Elisabetta

    Purinergic signalling

    2023  Volume 20, Issue 1, Page(s) 35–45

    Abstract: Interest has been focused in recent years on the analgesic effects exerted by adenosine and its receptors, ... ...

    Abstract Interest has been focused in recent years on the analgesic effects exerted by adenosine and its receptors, A
    MeSH term(s) Rats ; Animals ; Ganglia, Spinal/metabolism ; Chronic Pain/metabolism ; Neurons/metabolism ; Adenosine/metabolism ; Receptors, Purinergic P1/metabolism ; Receptor, Adenosine A3/metabolism ; Adenosine A3 Receptor Agonists/pharmacology
    Chemical Substances Adenosine (K72T3FS567) ; Receptors, Purinergic P1 ; Receptor, Adenosine A3 ; Adenosine A3 Receptor Agonists
    Language English
    Publishing date 2023-03-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2172143-9
    ISSN 1573-9546 ; 1573-9538
    ISSN (online) 1573-9546
    ISSN 1573-9538
    DOI 10.1007/s11302-023-09929-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Be Aware of the Risk of Phlebotominae.

    Fusco, Eleonora / Fusani, Lara / Trapani, Sandra / Mastrolia, Maria Vincenza / Simonini, Gabriele / Chiappini, Elena / Venturini, Elisabetta / Galli, Luisa

    The Pediatric infectious disease journal

    2022  Volume 41, Issue 11, Page(s) e503–e504

    MeSH term(s) Animals ; Humans ; Insect Vectors ; Psychodidae
    Language English
    Publishing date 2022-08-24
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000003675
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Chilblain-Like Lesions during COVID-19 Pandemic: The State of the Art.

    Bassi, Andrea / Russo, Teresa / Argenziano, Giuseppe / Mazzatenta, Carlo / Venturini, Elisabetta / Neri, Iria / Piccolo, Vincenzo

    Life (Basel, Switzerland)

    2021  Volume 11, Issue 1

    Abstract: SARS-CoV-2 infection has spread all over the world in the last year, causing millions of COVID-19 cases among humans with a large variability of symptoms and signs, including those on the skin. Among these, a contemporary cluster of chilblain-like ... ...

    Abstract SARS-CoV-2 infection has spread all over the world in the last year, causing millions of COVID-19 cases among humans with a large variability of symptoms and signs, including those on the skin. Among these, a contemporary cluster of chilblain-like lesions with no certain relationship with the infection has been reported. The aim of this paper is to delineate a profile of chilblain-like lesions and to establish the state-of-the-art knowledge about this new phenomenon.
    Language English
    Publishing date 2021-01-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life11010023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: New Insight into the Role of Adenosine in Demyelination, Stroke and Neuropathic Pain.

    Coppi, Elisabetta / Dettori, Ilaria / Cherchi, Federica / Bulli, Irene / Venturini, Martina / Pedata, Felicita / Pugliese, Anna Maria

    Frontiers in pharmacology

    2021  Volume 11, Page(s) 625662

    Language English
    Publishing date 2021-01-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2020.625662
    Database MEDical Literature Analysis and Retrieval System OnLINE

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