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Article ; Online: Protein Backbone Alteration in Non-Hairpin β-Turns: Impacts on Tertiary Folded Structure and Folded Stability.

Harmon, Thomas W / Horne, W Seth

Chembiochem : a European journal of chemical biology

2023 Volume 24, Issue 11, Page(s) e202300113

Abstract: ... strands in a β-sheet (i. e., hairpins). Turns in other structural contexts are also common in nature and ...

Abstract	The importance of β-turns to protein folding has motivated extensive efforts to stabilize the motif with non-canonical backbone connectivity. Prior work has focused almost exclusively on turns between strands in a β-sheet (i. e., hairpins). Turns in other structural contexts are also common in nature and have distinct conformational preferences; however, design principles for their mimicry remain poorly understood. Here, we report strategies that stabilize non-hairpin β-turns through systematic evaluation of the impacts of backbone alteration on the high-resolution folded structure and folded stability of a helix-loop-helix prototype protein. Several well-established hairpin turn mimetics are shown detrimental to folded stability and/or hydrophobic core packing, while less-explored modification schemes that reinforce alternate turn types lead to improved stability and more faithful structural mimicry. Collectively, these results have implications in control over protein folding through chemical modification as well as the design of protein mimetics.
MeSH term(s)	Amino Acid Sequence ; Protein Structure, Secondary ; Proteins/chemistry ; Protein Folding ; Protein Conformation, beta-Strand
Chemical Substances	Proteins
Language	English
Publishing date	2023-03-30
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2020469-3
ISSN	1439-7633 ; 1439-4227
ISSN (online)	1439-7633
ISSN	1439-4227
DOI	10.1002/cbic.202300113
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Erratum to "The effects of the DASH dietary pattern on clinical outcomes and quality of life in adults with uncontrolled asthma: Design and methods of the ALOHA Trial" [Contemporary Clinical Trials 131 (2023) 107274].

Nyenhuis, S M / Dixon, A E / Wood, L / Lv, N / Wittels, N E / Ronneberg, C R / Xiao, L / Dosala, S / Marroquin, A / Barve, A / Harmon, W / Poynter, M E / Parikh, A / Camargo, C A / Appel, L J / Ma, J

Contemporary clinical trials

2024 Volume 138, Page(s) 107373

Language	English
Publishing date	2024-02-02
Publishing country	United States
Document type	Published Erratum
ZDB-ID	2182176-8
ISSN	1559-2030 ; 1551-7144
ISSN (online)	1559-2030
ISSN	1551-7144
DOI	10.1016/j.cct.2023.107373
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Zs.A 1581: Show issues

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Article ; Online: Molecular Dynamics and Surface Interactions of Nickelocene Adsorbed on Silica: A Paramagnetic Solid-State NMR Study.

Benzie, Jordon W / Harmon-Welch, Gabrielle E / Hoefler, John C / Bakhmutov, Vladimir I / Blümel, Janet

Langmuir : the ACS journal of surfaces and colloids

2022 Volume 38, Issue 24, Page(s) 7422–7432

Abstract: When grinding nickelocene with silica in the absence of a solvent at room temperature, it adsorbs on the surface within the pores. This has also been demonstrated visually by adsorbing green nickelocene in the pores of a large colorless silica gel ... ...

Abstract	When grinding nickelocene with silica in the absence of a solvent at room temperature, it adsorbs on the surface within the pores. This has also been demonstrated visually by adsorbing green nickelocene in the pores of a large colorless silica gel specimen. While this dry adsorption and translational mobility of nickelocene within the pores is proven visually, the site-to-site mobility of the nickelocene molecules and their orientation toward the surface are not yet understood. In this contribution, mesoporous silica is used as the support material for a systematic solid-state NMR study of these issues. Paramagnetic
Language	English
Publishing date	2022-06-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021/acs.langmuir.2c00301
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Article ; Online: Associations Between Sociodemographic Variables, Social Determinants of Health, and Diabetes: Findings From a Congregational Health Needs Assessment.

San Diego, Emily Rose N / West, Nathan T / Pichon, Latrice C / Jiang, Yu / Powell, Terrinieka W / Rugless, Fedoria / Lewis, Jonathan / Campbell, Bettina / McCann, Lauren / McNeals, Sterling / Harmon, Brook E

American journal of health promotion : AJHP

2024 , Page(s) 8901171241234662

Abstract: Purpose: To examine associations between sociodemographic variables, social determinants of health (SDOHs) and diabetes using health needs assessment data.: Design: Cross-sectional study.: Setting: Faith-based communities in the Mid-South U.S.: ... ...

Abstract	Purpose: To examine associations between sociodemographic variables, social determinants of health (SDOHs) and diabetes using health needs assessment data. Design: Cross-sectional study. Setting: Faith-based communities in the Mid-South U.S. Sample: Of the 378 churches, 92 participated in the study (24% response rate); Measure: The Mid-South Congregational Health Survey assessed perceived health-related needs of congregations and the communities they serve. Analysis: Generalized linear mixed modeling examined the associations between sociodemographic variables (age, sex, race/ethnicity, educational level), SDOHs (affordable healthcare, healthy food, employment), and diabetes. Results: Individuals with less education had lower odds of reporting all SDOHs as health needs compared to individuals with more education (OR Conclusions: Future studies should evaluate strategies to merge healthcare and faith-based organizations' efforts to address SDOHs impacting diabetes.
Language	English
Publishing date	2024-02-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	645160-3
ISSN	2168-6602 ; 0890-1171
ISSN (online)	2168-6602
ISSN	0890-1171
DOI	10.1177/08901171241234662
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Zs.A 2531: Show issues

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Book: E. W. Harmon's annual sale of shorthorns

Harmon, E. W.

from Harmondale Farm, Rhodes, Iowa, at Marshalltown, Iowa, Thursday, April 22, 1920

1920

Institution	Harmondale Farm Wayne Caldwell Neely Collection of Shorthorn Cattle Catalogs
Author's details	Harmondale Farm
Keywords	Shorthorn cattle ; Shorthorn cattle.
Language	English
Dates of publication	1920-0422
Size	50 pages, 5 unnumbered pages :, illustrations, portraits, form ;, 23 cm
Publisher	Harmondale Farm ; Homestead Printing Co
Publishing place	Marshalltown, Iowa ; Des Moines
Document type	Book
Note	Includes hand-written notes.
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Catch the Calcium: T-Cell Histiocyte-Rich B-Cell Lymphoma Presenting as Hypercalcemia.

Okeke, Richard K / Harmon, Gabriella A / Okeke, Ijeoma G / Schuler, Jake W / Sangappa, Sahana J / Harmon, Jonathan S / Angelova, Evgeniya / Sun, Xiu / Chinnici, Angelo A

World journal of oncology

2023 Volume 14, Issue 6, Page(s) 570–574

Abstract: T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is an extremely rare and aggressive subtype of diffuse large B-cell lymphoma (DLBCL) that typically presents in middle-aged patients and carries a poor prognosis. Hypercalcemia presenting as the ... ...

Abstract	T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is an extremely rare and aggressive subtype of diffuse large B-cell lymphoma (DLBCL) that typically presents in middle-aged patients and carries a poor prognosis. Hypercalcemia presenting as the initial manifestation of the disease is rare, with only one other case reported in the literature. We report a case of a 90-year-old male who presented with progressive lethargy and unintentional weight loss. Initial workup showed elevated serum calcium of 14.6 mg/dL, corrected for albumin, and creatinine of 1.51 mg/dL. He had a suppressed iPTH of 6.3 pg/mL and normal PTHrP (13 pg/mL). Computed tomography (CT) scan of the abdomen and pelvis was performed to rule out underlying malignancy, which showed splenomegaly and enlarged retrocrural and porta hepatis lymph nodes. Bone marrow biopsy was performed to evaluate for hematological malignancy, which revealed findings diagnostic of THRLBCL. While rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) is one of the mainstay therapies for DLBCL and has been shown to have comparable outcomes in THRLBCL, there are documented concerns with its toxicity profile limiting the ability of older patients (60 years and older) to complete therapy. Our patient was treated with R-mini-CHOP, which is much better tolerated in this patient demographic. R-mini-CHOP features decreased doses of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) with the conventional dose of rituximab. This case discusses a rare subtype of non-Hodgkin lymphoma presenting with a unique manifestation of hypercalcemia. We highlight the importance of thorough investigation for causes of hypercalcemia as well as the efficacy and tolerability of R-mini-CHOP in this elderly patient demographic.
Language	English
Publishing date	2023-10-21
Publishing country	Canada
Document type	Case Reports
ZDB-ID	2548989-6
ISSN	1920-454X ; 1920-454X
ISSN (online)	1920-454X
ISSN	1920-454X
DOI	10.14740/wjon1610
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Article: Perceived Health Needs of Church Leaders and Members: A Secondary Data Analysis of the Mid-South Congregational Health Survey.

West, Nathan T / Pichon, Latrice C / Ward, Kenneth D / Rose N San Diego, Emily / Ray, Meredith / Rugless, Fedoria / Powell, Terrinieka W / Campbell, Bettina / Lewis, Jonathan C / McCann, Lauren / McNeal, Sterling / Harmon, Brook E

Health promotion practice

2023 Volume 25, Issue 1, Page(s) 96–104

Abstract: Needs assessments have been successful in helping communities and congregations focus their health ministry efforts; however, most have used leader perceptions of congregational health needs. The purpose of this study was to examine and compare the self- ... ...

Abstract	Needs assessments have been successful in helping communities and congregations focus their health ministry efforts; however, most have used leader perceptions of congregational health needs. The purpose of this study was to examine and compare the self-reported needs of both church leaders and members to be addressed by their congregation. Church leaders (
MeSH term(s)	Humans ; Secondary Data Analysis ; Health Promotion ; Health Surveys ; Obesity/prevention & control ; Health Status ; Diabetes Mellitus
Language	English
Publishing date	2023-03-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2036801-X
ISSN	1552-6372 ; 1524-8399
ISSN (online)	1552-6372
ISSN	1524-8399
DOI	10.1177/15248399231160158
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Article ; Online: Transcriptional profiling of rare acantholytic disorders suggests common mechanisms of pathogenesis.

Roth-Carter, Quinn R / Burks, Hope E / Ren, Ziyou / Koetsier, Jennifer L / Tsoi, Lam C / Harms, Paul W / Xing, Xianying / Kirma, Joseph / Harmon, Robert M / Godsel, Lisa M / Perl, Abbey L / Gudjonsson, Johann E / Green, Kathleen J

JCI insight

2023 Volume 8, Issue 16

Abstract: Darier, Hailey-Hailey, and Grover diseases are rare acantholytic skin diseases. While these diseases have different underlying causes, they share defects in cell-cell adhesion in the epidermis and desmosome organization. To better understand the ... ...

Abstract	Darier, Hailey-Hailey, and Grover diseases are rare acantholytic skin diseases. While these diseases have different underlying causes, they share defects in cell-cell adhesion in the epidermis and desmosome organization. To better understand the underlying mechanisms leading to disease in these conditions, we performed RNA-seq on lesional skin samples from patients. The transcriptomic profiles of Darier, Hailey-Hailey, and Grover diseases were found to share a remarkable overlap, which did not extend to other common inflammatory skin diseases. Analysis of enriched pathways showed a shared increase in keratinocyte differentiation, and a decrease in cell adhesion and actin organization pathways in Darier, Hailey-Hailey, and Grover diseases. Direct comparison to atopic dermatitis and psoriasis showed that the downregulation in actin organization pathways was a unique feature in the acantholytic skin diseases. Furthermore, upstream regulator analysis suggested that a decrease in SRF/MRTF activity was responsible for the downregulation of actin organization pathways. Staining for MRTFA in lesional skin samples showed a decrease in nuclear MRTFA in patient skin compared with normal skin. These findings highlight the significant level of similarity in the transcriptome of Darier, Hailey-Hailey, and Grover diseases, and identify decreases in actin organization pathways as a unique signature present in these conditions.
MeSH term(s)	Humans ; Actins ; Skin/pathology ; Acantholysis/genetics ; Acantholysis/metabolism ; Skin Diseases/complications ; Skin Diseases/pathology
Chemical Substances	Actins
Language	English
Publishing date	2023-08-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ISSN	2379-3708
ISSN (online)	2379-3708
DOI	10.1172/jci.insight.168955
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Article ; Online: Deep learning-based decision forest for hereditary clear cell renal cell carcinoma segmentation on MRI.

Lay, Nathan / Anari, Pouria Yazdian / Chaurasia, Aditi / Firouzabadi, Fatemeh Dehghani / Harmon, Stephanie / Turkbey, Evrim / Gautam, Rabindra / Samimi, Safa / Merino, Maria J / Ball, Mark W / Linehan, William Marston / Turkbey, Baris / Malayeri, Ashkan A

Medical physics

2023 Volume 50, Issue 8, Page(s) 5020–5029

Abstract: ... of kidney and tumor structures on MRI in VHL patients is useful in lesion characterization (e.g., cyst vs ...

Abstract	Background: von Hippel-Lindau syndrome (VHL) is an autosomal dominant hereditary syndrome with an increased predisposition of developing numerous cysts and tumors, almost exclusively clear cell renal cell carcinoma (ccRCC). Considering the lifelong surveillance in such patients to monitor the disease, patients with VHL are preferentially imaged using MRI to eliminate radiation exposure. Purpose: Segmentation of kidney and tumor structures on MRI in VHL patients is useful in lesion characterization (e.g., cyst vs. tumor), volumetric lesion analysis, and tumor growth prediction. However, automated tasks such as ccRCC segmentation on MRI is sparsely studied. We develop segmentation methodology for ccRCC on T1 weighted precontrast, corticomedullary, nephrogenic, and excretory contrast phase MRI. Methods: We applied a new neural network approache using a novel differentiable decision forest, called hinge forest (HF), to segment kidney parenchyma, cyst, and ccRCC tumors in 117 images from 115 patients. This data set represented an unprecedented 504 ccRCCs with 1171 cystic lesions obtained at five different MRI scanners. The HF architecture was compared with U-Net on 10 randomized splits with 75% used for training and 25% used for testing. Both methods were trained with Adam using default parameters ( Results: The HF achieved an average kidney, cyst, and tumor Dice similarity coefficient (DSC) of 0.75 ± 0.03, 0.44 ± 0.05, 0.53 ± 0.04, respectively, while U-Net achieved an average kidney, cyst, and tumor DSC of 0.78 ± 0.02, 0.41 ± 0.04, 0.46 ± 0.05, respectively. The HF significantly outperformed U-Net on tumors while U-Net significantly outperformed HF when segmenting kidney parenchymas ( Conclusions: For the task of ccRCC segmentation, the HF can offer better segmentation performance compared to the traditional U-Net architecture. The leaf maps can glean hints about deep learning features that might prove to be useful in other automated tasks such as tumor characterization.
MeSH term(s)	Humans ; Carcinoma, Renal Cell/diagnostic imaging ; Deep Learning ; Cysts ; Carcinoma ; Magnetic Resonance Imaging ; Kidney Neoplasms/diagnostic imaging
Language	English
Publishing date	2023-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	188780-4
ISSN	2473-4209 ; 0094-2405
ISSN (online)	2473-4209
ISSN	0094-2405
DOI	10.1002/mp.16303
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Zs.A 1210: Show issues

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Article: Release of coarse woody detritus-related carbon: a synthesis across forest biomes.

Harmon, Mark E / Fasth, Becky G / Yatskov, Misha / Kastendick, Douglas / Rock, Joachim / Woodall, Christopher W

Carbon balance and management

2020 Volume 15, Issue 1, Page(s) 1

Abstract: ... of carbon release from CWD is not well understood. We compiled CWD decomposition rate-constants (i.e., k ... to examine how tree species, piece diameter, position (i.e., standing versus downed), canopy openness, and ... of the remaining CWD changed. Variations in decomposition caused by disturbance (e.g., changes in species ...

Abstract	Background: Recent increases in forest tree mortality should increase the abundance coarse woody detritus (CWD) and ultimately lead to increased atmospheric carbon dioxide. However, the time course of carbon release from CWD is not well understood. We compiled CWD decomposition rate-constants (i.e., k) to examine how tree species, piece diameter, position (i.e., standing versus downed), canopy openness, and macroclimate influenced k. To illustrate their implications we modeled the effect of species and position on estimates of decomposition-related carbon flux. We examined a subset of currently used models to determine if their structure accounted for these factors. Results: Globally k of downed CWD varied at least 244-fold with interspecies variation at individual sites up to 76-fold. While k generally decreased with increasing piece diameter, under open canopies the opposite occurred. Standing CWD sometimes exhibited little decomposition, but sometimes had k values up to 3 times faster than downed CWD. There was a clear response of k to mean annual temperature of ≈ 2.6 times per 10 ℃; however, there was considerable variation for a given mean annual temperature related to species, diameter, and position. A key feature of carbon release from CWD after disturbance was the "evolution" of the ecosystem-level k value as positions and species mixtures of the remaining CWD changed. Variations in decomposition caused by disturbance (e.g., changes in species, positions, sizes, and microclimate) had the potential to cause net carbon fluxes to the atmosphere to be highly nonlinear. While several models currently being used for carbon accounting and assessing land-use/climate change would potentially capture some of these post disturbance changes in fluxes and carbon balances, many would not. Conclusions: While much has been learned in the last 5 decades about CWD decomposition, to fully understand the time course of carbon release from increased mortality and other aspects of global change a new phase of global CWD research that is more systematic, experimental, and replicated needs to be initiated. If our findings are to be fully applied in modeling, an approach acknowledging how the rate of carbon release evolves over time should be implemented.
Language	English
Publishing date	2020-01-15
Publishing country	England
Document type	Journal Article ; Review
ISSN	1750-0680
ISSN	1750-0680
DOI	10.1186/s13021-019-0136-6
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