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  1. Article ; Online: Diffusion Limitation of Volatile Anesthetic Uptake: Comment.

    Grigoryan, Artush / Khorasani, Arjang / Salem, M Ramez / Knezevic, Nebojsa Nick

    Anesthesiology

    2023  Volume 138, Issue 5, Page(s) 567–568

    MeSH term(s) Anesthetics, Inhalation
    Chemical Substances Anesthetics, Inhalation
    Language English
    Publishing date 2023-02-08
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 269-0
    ISSN 1528-1175 ; 0003-3022
    ISSN (online) 1528-1175
    ISSN 0003-3022
    DOI 10.1097/ALN.0000000000004446
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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: The evidence gap in low back pain management strategies - Authors' reply.

    Knezevic, Nebojsa Nick / Cohen, Steven P

    Lancet (London, England)

    2021  Volume 398, Issue 10306, Page(s) 1131–1132

    MeSH term(s) Humans ; Low Back Pain/therapy ; Pain Management
    Language English
    Publishing date 2021-09-25
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(21)01810-9
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    In stock of ZB MED Cologne/Königswinter

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  3. Article: A Review of Recent Pharmacological Advances in the Management of Diabetes-Associated Peripheral Neuropathy.

    Syed, Osman / Jancic, Predrag / Knezevic, Nebojsa Nick

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 6

    Abstract: Diabetic peripheral neuropathy is a common complication of longstanding diabetes mellitus. These neuropathies can present in various forms, and with the increasing prevalence of diabetes mellitus, a subsequent increase in peripheral neuropathy cases has ... ...

    Abstract Diabetic peripheral neuropathy is a common complication of longstanding diabetes mellitus. These neuropathies can present in various forms, and with the increasing prevalence of diabetes mellitus, a subsequent increase in peripheral neuropathy cases has been noted. Peripheral neuropathy has a significant societal and economic burden, with patients requiring concomitant medication and often experiencing a decline in their quality of life. There is currently a wide variety of pharmacological interventions, including serotonin norepinephrine reuptake inhibitors, gapentanoids, sodium channel blockers, and tricyclic antidepressants. These medications will be discussed, as well as their respective efficacies. Recent advances in the treatment of diabetes mellitus with incretin system-modulating drugs, specifically glucagon-like peptide-1 agonists, have been promising, and their potential implication in the treatment of peripheral diabetic neuropathy is discussed in this review.
    Language English
    Publishing date 2023-05-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16060801
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  4. Article ; Online: Investigator Initiated Studies - Industry or Investigator - "Who Wins?"

    Knezevic, Nebojsa Nick

    Pain physician

    2017  Volume 20, Issue 2, Page(s) E344

    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2146393-1
    ISSN 2150-1149 ; 1533-3159
    ISSN (online) 2150-1149
    ISSN 1533-3159
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  5. Article ; Online: A Review of Recent Pharmacological Advances in the Management of Diabetes-Associated Peripheral Neuropathy

    Osman Syed / Predrag Jancic / Nebojsa Nick Knezevic

    Pharmaceuticals, Vol 16, Iss 801, p

    2023  Volume 801

    Abstract: Diabetic peripheral neuropathy is a common complication of longstanding diabetes mellitus. These neuropathies can present in various forms, and with the increasing prevalence of diabetes mellitus, a subsequent increase in peripheral neuropathy cases has ... ...

    Abstract Diabetic peripheral neuropathy is a common complication of longstanding diabetes mellitus. These neuropathies can present in various forms, and with the increasing prevalence of diabetes mellitus, a subsequent increase in peripheral neuropathy cases has been noted. Peripheral neuropathy has a significant societal and economic burden, with patients requiring concomitant medication and often experiencing a decline in their quality of life. There is currently a wide variety of pharmacological interventions, including serotonin norepinephrine reuptake inhibitors, gapentanoids, sodium channel blockers, and tricyclic antidepressants. These medications will be discussed, as well as their respective efficacies. Recent advances in the treatment of diabetes mellitus with incretin system-modulating drugs, specifically glucagon-like peptide-1 agonists, have been promising, and their potential implication in the treatment of peripheral diabetic neuropathy is discussed in this review.
    Keywords diabetic peripheral neuropathy ; diabetes ; neuropathic pain ; GLP-1 ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
    Subject code 571
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Glucocorticoid Hormones as Modulators of the Kynurenine Pathway in Chronic Pain Conditions.

    Jovanovic, Filip / Jovanovic, Visnja / Knezevic, Nebojsa Nick

    Cells

    2023  Volume 12, Issue 8

    Abstract: The pathogenesis of chronic pain entails a series of complex interactions among the nervous, immune, and endocrine systems. Defined as pain lasting or recurring for more than 3 months, chronic pain is becoming increasingly more prevalent among the US ... ...

    Abstract The pathogenesis of chronic pain entails a series of complex interactions among the nervous, immune, and endocrine systems. Defined as pain lasting or recurring for more than 3 months, chronic pain is becoming increasingly more prevalent among the US adult population. Pro-inflammatory cytokines from persistent low-grade inflammation not only contribute to the development of chronic pain conditions, but also regulate various aspects of the tryptophan metabolism, especially that of the kynurenine pathway (KP). An elevated level of pro-inflammatory cytokines exerts similar regulatory effects on the hypothalamic-pituitary-adrenal (HPA) axis, an intricate system of neuro-endocrine-immune pathways and a major mechanism of the stress response. As the HPA axis counters inflammation through the secretion of endogenous cortisol, we review the role of cortisol along with that of exogenous glucocorticoids in patients with chronic pain conditions. Considering that different metabolites produced along the KP exhibit neuroprotective, neurotoxic, and pronociceptive properties, we also summarize evidence rendering them as reliable biomarkers in this patient population. While more in vivo studies are needed, we conclude that the interaction between glucocorticoid hormones and the KP poses an attractive venue of diagnostic and therapeutic potential in patients with chronic pain.
    MeSH term(s) Humans ; Kynurenine/metabolism ; Glucocorticoids/metabolism ; Hydrocortisone/metabolism ; Chronic Pain/metabolism ; Hypothalamo-Hypophyseal System/metabolism ; Pituitary-Adrenal System/metabolism ; Cytokines/metabolism ; Inflammation/metabolism
    Chemical Substances Kynurenine (343-65-7) ; Glucocorticoids ; Hydrocortisone (WI4X0X7BPJ) ; Cytokines
    Language English
    Publishing date 2023-04-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12081178
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  7. Article ; Online: The Role of Cortisol in Chronic Stress, Neurodegenerative Diseases, and Psychological Disorders.

    Knezevic, Emilija / Nenic, Katarina / Milanovic, Vladislav / Knezevic, Nebojsa Nick

    Cells

    2023  Volume 12, Issue 23

    Abstract: Cortisol, a critical glucocorticoid hormone produced by the adrenal glands, plays a pivotal role in various physiological processes. Its release is finely orchestrated by the suprachiasmatic nucleus, governing the circadian rhythm and activating the ... ...

    Abstract Cortisol, a critical glucocorticoid hormone produced by the adrenal glands, plays a pivotal role in various physiological processes. Its release is finely orchestrated by the suprachiasmatic nucleus, governing the circadian rhythm and activating the intricate hypothalamic-pituitary-adrenal (HPA) axis, a vital neuroendocrine system responsible for stress response and maintaining homeostasis. Disruptions in cortisol regulation due to chronic stress, disease, and aging have profound implications for multiple bodily systems. Animal models have been instrumental in elucidating these complex cortisol dynamics during stress, shedding light on the interplay between physiological, neuroendocrine, and immune factors in the stress response. These models have also revealed the impact of various stressors, including social hierarchies, highlighting the role of social factors in cortisol regulation. Moreover, chronic stress is closely linked to the progression of neurodegenerative diseases, like Alzheimer's and Parkinson's, driven by excessive cortisol production and HPA axis dysregulation, along with neuroinflammation in the central nervous system. The relationship between cortisol dysregulation and major depressive disorder is complex, characterized by HPA axis hyperactivity and chronic inflammation. Lastly, chronic pain is associated with abnormal cortisol patterns that heighten pain sensitivity and susceptibility. Understanding these multifaceted mechanisms and their effects is essential, as they offer insights into potential interventions to mitigate the detrimental consequences of chronic stress and cortisol dysregulation in these conditions.
    MeSH term(s) Animals ; Hydrocortisone ; Depressive Disorder, Major ; Neurodegenerative Diseases ; Hypothalamo-Hypophyseal System ; Pituitary-Adrenal System
    Chemical Substances Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2023-11-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12232726
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  8. Article: Drug Safety and Suicidality Risk of Chronic Pain Medications.

    Syed, Osman / Jancic, Predrag / Fink, Adam B / Knezevic, Nebojsa Nick

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 10

    Abstract: Chronic pain is one of the main leading causes of disability in the world at present. A variety in the symptomatology, intensity and duration of this phenomenon has led to an ever-increasing demand of pharmacological treatment and relief. This demand for ...

    Abstract Chronic pain is one of the main leading causes of disability in the world at present. A variety in the symptomatology, intensity and duration of this phenomenon has led to an ever-increasing demand of pharmacological treatment and relief. This demand for medication, ranging from well-known groups, such as antidepressants and benzodiazepines, to more novel drugs, was followed by a rise in safety concerns of such treatment options. The validity, frequency, and diversity of such concerns are discussed in this paper, as well as their possible effect on future prescription practices. A specific caution is provided towards the psychological safety and toll of these medications, regarding suicidality and suicidal ideation. Most significantly, this paper highlights the importance of pharmacovigilance and underscores the necessity of surveillance programs when considering chronic pain medication.
    Language English
    Publishing date 2023-10-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16101497
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  9. Article: Kynurenine Pathway Metabolites as Potential Biomarkers in Chronic Pain.

    Auyeung, Andrew / Wang, Hank C / Aravagiri, Kannan / Knezevic, Nebojsa Nick

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 5

    Abstract: Chronic pain is a pressing medical and socioeconomic issue worldwide. It is debilitating for individual patients and places a major burden on society in the forms of direct medical costs and lost work productivity. Various biochemical pathways have been ... ...

    Abstract Chronic pain is a pressing medical and socioeconomic issue worldwide. It is debilitating for individual patients and places a major burden on society in the forms of direct medical costs and lost work productivity. Various biochemical pathways have been explored to explain the pathophysiology of chronic pain in order to identify biomarkers that can potentially serve as both evaluators of and guides for therapeutic effectiveness. The kynurenine pathway has recently been a source of interest due to its suspected role in the development and sustainment of chronic pain conditions. The kynurenine pathway is the primary pathway responsible for the metabolization of tryptophan and generates nicotinamide adenine dinucleotide (NAD
    Language English
    Publishing date 2023-05-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16050681
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Investigator Initiated Studies - Industry or Investigator - "Who Wins?"

    Knezevic, Nebojsa Nick

    Pain physician

    2017  Volume 20, Issue 2, Page(s) E342–E343

    MeSH term(s) Analgesia ; Humans ; Industry ; Low Back Pain ; Pain Management ; Research Personnel
    Language English
    Publishing date 2017-02-02
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2146393-1
    ISSN 2150-1149 ; 1533-3159
    ISSN (online) 2150-1149
    ISSN 1533-3159
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    In stock of ZB MED Cologne/Königswinter

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