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Article ; Online: Pharmacological Characterization of the Zebrafish (Danio Rerio) Histamine H

McNaught-Flores, Daniel A / Kooistra, Albert J / Chen, Yu-Chia / Arias-Montano, Jose-Antonio / Panula, Pertti / Leurs, Rob

Molecular pharmacology

2024 Volume 105, Issue 2, Page(s) 84–96

Abstract: The zebrafish (Danio rerio) histamine ... ...

Abstract	The zebrafish (Danio rerio) histamine H
MeSH term(s)	Animals ; Humans ; Histamine ; Receptors, Histamine H1/genetics ; Receptors, Histamine H1/metabolism ; Pyrilamine/pharmacology ; Pyrilamine/metabolism ; Zebrafish ; Signal Transduction
Chemical Substances	Histamine (820484N8I3) ; Receptors, Histamine H1 ; Pyrilamine (HPE317O9TL)
Language	English
Publishing date	2024-01-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	124034-1
ISSN	1521-0111 ; 0026-895X
ISSN (online)	1521-0111
ISSN	0026-895X
DOI	10.1124/molpharm.123.000741
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Article: Baseline gut microbiome and metabolites are correlated with alcohol consumption in a zonisamide clinical trial of heavy drinking alcoholic civilians.

Dedon, Liv R / Yuan, Hanshu / Chi, Jinhua / Gu, Haiwei / Arias, Albert J / Covault, Jonathan M / Zhou, Yanjiao

medRxiv : the preprint server for health sciences

2024

Abstract: Development and severity of alcohol use disorder (AUD) has been linked to variations in gut microbiota and their associated metabolites in both animal and human studies. However, the involvement of the gut microbiome in alcohol consumption of individuals ...

Abstract	Development and severity of alcohol use disorder (AUD) has been linked to variations in gut microbiota and their associated metabolites in both animal and human studies. However, the involvement of the gut microbiome in alcohol consumption of individuals with AUD undergoing treatment remains unclear. To address this, stool samples (n=48) were collected at screening (baseline) and trial completion from a single site of a multi-site double-blind, placebo-controlled trial of Zonisamide in individuals with AUD. Alcohol consumption, gamma-glutamyl transferase (GGT), and phosphatidylethanol (PEth)levels were measured both at baseline and endpoint of 16-week trial period. Fecal microbiome was analyzed
Language	English
Publishing date	2024-04-03
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.04.02.24305199
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Article ; Online: Analysis of Drugs in Saliva of US Military Veterans Treated for Substance Use Disorders Using Supported Liquid Extraction and Surface-Enhanced Raman Spectral Analysis.

Farquharson, Stuart / Shende, Chetan / Newcomb, Jenelle / Petrakis, Ismene L / Arias, Albert J

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 5

Abstract: According to the Center for Disease Control, there were more than 107,000 US drug overdose deaths in 2021, over 80,000 of which due to opioids. One of the more vulnerable populations is US military veterans. Nearly 250,000 military veterans suffer from ... ...

Abstract	According to the Center for Disease Control, there were more than 107,000 US drug overdose deaths in 2021, over 80,000 of which due to opioids. One of the more vulnerable populations is US military veterans. Nearly 250,000 military veterans suffer from substance-related disorders (SRD). For those seeking treatment, buprenorphine is prescribed to help treat opioid use disorder (OUD). Urinalysis is currently used to monitor buprenorphine adherence as well as to detect illicit drug use during treatment. Sometimes sample tampering occurs if patients seek to generate a false positive buprenorphine urine test or mask illicit drugs, both of which can compromise treatment. To address this problem, we have been developing a point-of-care (POC) analyzer that can rapidly measure both medications used for treatment and illicit drugs in patient saliva, ideally in the physi-cian's office. The two-step analyzer employs (1) supported liquid extraction (SLE) to isolate the drugs from the saliva and (2) surface-enhanced Raman spectroscopy (SERS) to detect the drugs. A prototype SLE-SERS-POC analyzer was used to quantify buprenorphine at ng/mL concentrations and identify illicit drugs in less than 1 mL of saliva collected from 20 SRD veterans in less than 20 min. It correctly detected buprenorphine in 19 of 20 samples (18 true positives, 1 true negative and 1 false negative). It also identified 10 other drugs in patient samples: acetaminophen, amphetamine, cannabidiol, cocaethylene, codeine, ibuprofen, methamphetamine, methadone, nicotine, and norbuprenorphine. The prototype analyzer shows evidence of accuracy in measuring treatment medications and relapse to drug use. Further study and development of the system is warranted.
MeSH term(s)	Humans ; Buprenorphine ; Illicit Drugs/analysis ; Opioid-Related Disorders/drug therapy ; Saliva/chemistry ; Veterans
Chemical Substances	Buprenorphine (40D3SCR4GZ) ; Illicit Drugs
Language	English
Publishing date	2023-02-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28052010
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Article ; Online: Analysis of Drugs in Saliva of US Military Veterans Treated for Substance Use Disorders Using Supported Liquid Extraction and Surface-Enhanced Raman Spectral Analysis

Stuart Farquharson / Chetan Shende / Jenelle Newcomb / Ismene L. Petrakis / Albert J. Arias

Molecules, Vol 28, Iss 2010, p

2023 Volume 2010

Abstract	According to the Center for Disease Control, there were more than 107,000 US drug overdose deaths in 2021, over 80,000 of which due to opioids. One of the more vulnerable populations is US military veterans. Nearly 250,000 military veterans suffer from substance-related disorders (SRD). For those seeking treatment, buprenorphine is prescribed to help treat opioid use disorder (OUD). Urinalysis is currently used to monitor buprenorphine adherence as well as to detect illicit drug use during treatment. Sometimes sample tampering occurs if patients seek to generate a false positive buprenorphine urine test or mask illicit drugs, both of which can compromise treatment. To address this problem, we have been developing a point-of-care (POC) analyzer that can rapidly measure both medications used for treatment and illicit drugs in patient saliva, ideally in the physi-cian’s office. The two-step analyzer employs (1) supported liquid extraction (SLE) to isolate the drugs from the saliva and (2) surface-enhanced Raman spectroscopy (SERS) to detect the drugs. A prototype SLE-SERS-POC analyzer was used to quantify buprenorphine at ng/mL concentrations and identify illicit drugs in less than 1 mL of saliva collected from 20 SRD veterans in less than 20 min. It correctly detected buprenorphine in 19 of 20 samples (18 true positives, 1 true negative and 1 false negative). It also identified 10 other drugs in patient samples: acetaminophen, amphetamine, cannabidiol, cocaethylene, codeine, ibuprofen, methamphetamine, methadone, nicotine, and norbuprenorphine. The prototype analyzer shows evidence of accuracy in measuring treatment medications and relapse to drug use. Further study and development of the system is warranted.
Keywords	buprenorphine ; patient compliance ; supported liquid extraction ; surface-enhanced Raman spectroscopy ; Organic chemistry ; QD241-441
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Clinical Effectiveness of Intravenous Racemic Ketamine Infusions in a Large Community Sample of Patients With Treatment-Resistant Depression, Suicidal Ideation, and Generalized Anxiety Symptoms: A Retrospective Chart Review.

Oliver, Patrick A / Snyder, Andrew D / Feinn, Richard / Malov, Stanislav / McDiarmid, Gray / Arias, Albert J

The Journal of clinical psychiatry

2022 Volume 83, Issue 6

Abstract: Introduction:: Methods:: Results:: Conclusions: ...

Abstract	Introduction: Methods: Results: Conclusions:
MeSH term(s)	Anxiety ; Depression ; Depressive Disorder, Major/drug therapy ; Humans ; Ketamine/adverse effects ; Retrospective Studies ; Suicidal Ideation ; Treatment Outcome
Chemical Substances	Ketamine (690G0D6V8H)
Language	English
Publishing date	2022-09-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	716287-x
ISSN	1555-2101 ; 0160-6689
ISSN (online)	1555-2101
ISSN	0160-6689
DOI	10.4088/JCP.21m14336
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Article ; Online: Topiramate Treatment of Alcohol Use Disorder in Clinical Practice.

Jefee-Bahloul, Hussam / Jorandby, Lantie / Arias, Albert J

Journal of addiction medicine

2018 Volume 13, Issue 1, Page(s) 23–27

Abstract: Topiramate is an anticonvulsant medication with increasingly strong evidence, supporting its use for treating alcohol use disorder (AUD) based on clinical trials. These clinical cases summarize the initiation and titration of topiramate in AUD ... ...

Abstract	: Topiramate is an anticonvulsant medication with increasingly strong evidence, supporting its use for treating alcohol use disorder (AUD) based on clinical trials. These clinical cases summarize the initiation and titration of topiramate in AUD treatment. The core issues of patient selection, consideration of comorbid psychiatric and medical conditions, side-effect profile, safety and effectiveness are reviewed. Addiction physicians should take a leading role in using topiramate to treat AUDs, working with patients to balance the benefits of topiramate with the risk.
MeSH term(s)	Alcoholism/drug therapy ; Central Nervous System Agents/administration & dosage ; Central Nervous System Agents/adverse effects ; Central Nervous System Agents/pharmacology ; Female ; Humans ; Male ; Middle Aged ; Topiramate/administration & dosage ; Topiramate/adverse effects ; Topiramate/pharmacology
Chemical Substances	Central Nervous System Agents ; Topiramate (0H73WJJ391)
Language	English
Publishing date	2018-08-09
Publishing country	United States
Document type	Case Reports ; Clinical Conference ; Journal Article
ISSN	1935-3227
ISSN (online)	1935-3227
DOI	10.1097/ADM.0000000000000444
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Topiramate Pharmacotherapy for Alcohol Use Disorder and Other Addictions: A Narrative Review.

Manhapra, Ajay / Chakraborty, Anirban / Arias, Albert J

Journal of addiction medicine

2018 Volume 13, Issue 1, Page(s) 7–22

Abstract: Topiramate is a non-benzodiazepine anticonvulsant medication with multi-faceted pharmacologic action. It has emerged as an efficacious pharmacotherapeutic option for the treatment of addiction, especially alcohol use disorder (AUD). We present a broad ... ...

Abstract	: Topiramate is a non-benzodiazepine anticonvulsant medication with multi-faceted pharmacologic action. It has emerged as an efficacious pharmacotherapeutic option for the treatment of addiction, especially alcohol use disorder (AUD). We present a broad narrative review of the putative mechanism of action and clinical utility of topiramate with regard to AUD and other substance use disorders. Collective evidence suggests topiramate is an effective treatment option in AUD, with notable efficacy in reducing harmful drinking patterns in AUD. Though not currently approved by the United States Food and Drug Administration for the indication of AUD, topiramate should be considered as a pharmacological treatment option with high utility among AUD patients. Early pharmacogenetic studies raise the intriguing possibility of identifying patients likely to respond to topiramate using genetic testing, and initial studies show that topiramate may also be useful in treating cocaine use disorder, smoking cessation and behavioral addictions. However, further research is needed in all these areas.
MeSH term(s)	Alcohol-Related Disorders/drug therapy ; Behavior, Addictive/drug therapy ; Cocaine-Related Disorders/drug therapy ; Humans ; Neurotransmitter Agents/adverse effects ; Neurotransmitter Agents/pharmacokinetics ; Neurotransmitter Agents/pharmacology ; Smoking/drug therapy ; Topiramate/adverse effects ; Topiramate/pharmacokinetics ; Topiramate/pharmacology
Chemical Substances	Neurotransmitter Agents ; Topiramate (0H73WJJ391)
Language	English
Publishing date	2018-08-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ISSN	1935-3227
ISSN (online)	1935-3227
DOI	10.1097/ADM.0000000000000443
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A high-quality genome for the slender anole (Anolis apletophallus): an emerging model for field studies of tropical ecology and evolution.

Pirani, Renata M / Arias, Carlos F / Charles, Kristin / Chung, Albert K / Curlis, John David / Nicholson, Daniel J / Vargas, Marta / Cox, Christian L / McMillan, W Owen / Logan, Michael L

G3 (Bethesda, Md.)

2023 Volume 14, Issue 1

Abstract: The slender anole, Anolis apletophallus, is a small arboreal lizard of the rainforest understory of central and eastern Panama. This species has been the subject of numerous ecological and evolutionary studies over the past 60 years as a result of ... ...

Abstract	The slender anole, Anolis apletophallus, is a small arboreal lizard of the rainforest understory of central and eastern Panama. This species has been the subject of numerous ecological and evolutionary studies over the past 60 years as a result of attributes that make it especially amenable to field and laboratory science. Slender anoles are highly abundant, short-lived (nearly 100% annual turnover), easy to manipulate in both the lab and field, and are ubiquitous in the forests surrounding the Smithsonian Tropical Research Institute in Panama, where researchers have access to high-quality laboratory facilities. Here, we present a high-quality genome for the slender anole, which is an important new resource for studying this model species. We assembled and annotated the slender anole genome by combining 3 technologies: Oxford Nanopore, 10× Genomics Linked-Reads, and Dovetail Omni-C. We compared this genome with the recently published brown anole (Anolis sagrei) and the canonical green anole (Anolis carolinensis) genomes. Our genome is the first assembled for an Anolis lizard from mainland Central or South America, the regions that host the majority of diversity in the genus. This new reference genome is one of the most complete genomes of any anole assembled to date and should facilitate deeper studies of slender anole evolution, as well as broader scale comparative genomic studies of both mainland and island species. In turn, such studies will further our understanding of the well-known adaptive radiation of Anolis lizards.
MeSH term(s)	Animals ; Genome ; Genomics ; Lizards/genetics ; Trees/genetics
Language	English
Publishing date	2023-12-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2629978-1
ISSN	2160-1836 ; 2160-1836
ISSN (online)	2160-1836
ISSN	2160-1836
DOI	10.1093/g3journal/jkad248
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Article ; Online: Identification of FasL as a crucial host factor driving COVID-19 pathology and lethality.

Albert, Marie-Christine / Uranga-Murillo, Iratxe / Arias, Maykel / De Miguel, Diego / Peña, Natacha / Montinaro, Antonella / Varanda, Ana Beatriz / Theobald, Sebastian J / Areso, Itziar / Saggau, Julia / Koch, Manuel / Liccardi, Gianmaria / Peltzer, Nieves / Rybniker, Jan / Hurtado-Guerrero, Ramón / Merino, Pedro / Monzón, Marta / Badiola, Juan J / Reindl-Schwaighofer, Roman /

Sanz-Pamplona, Rebeca / Cebollada-Solanas, Alberto / Megyesfalvi, Zsolt / Dome, Balazs / Secrier, Maria / Hartmann, Boris / Bergmann, Michael / Pardo, Julián / Walczak, Henning

Cell death and differentiation

2024

Abstract: The dysregulated immune response and inflammation resulting in severe COVID-19 are still incompletely understood. Having recently determined that aberrant death-ligand-induced cell death can cause lethal inflammation, we hypothesized that this process ... ...

Abstract	The dysregulated immune response and inflammation resulting in severe COVID-19 are still incompletely understood. Having recently determined that aberrant death-ligand-induced cell death can cause lethal inflammation, we hypothesized that this process might also cause or contribute to inflammatory disease and lung failure following SARS-CoV-2 infection. To test this hypothesis, we developed a novel mouse-adapted SARS-CoV-2 model (MA20) that recapitulates key pathological features of COVID-19. Concomitantly with occurrence of cell death and inflammation, FasL expression was significantly increased on inflammatory monocytic macrophages and NK cells in the lungs of MA20-infected mice. Importantly, therapeutic FasL inhibition markedly increased survival of both, young and old MA20-infected mice coincident with substantially reduced cell death and inflammation in their lungs. Intriguingly, FasL was also increased in the bronchoalveolar lavage fluid of critically-ill COVID-19 patients. Together, these results identify FasL as a crucial host factor driving the immuno-pathology that underlies COVID-19 severity and lethality, and imply that patients with severe COVID-19 may significantly benefit from therapeutic inhibition of FasL.
Language	English
Publishing date	2024-03-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1225672-9
ISSN	1476-5403 ; 1350-9047
ISSN (online)	1476-5403
ISSN	1350-9047
DOI	10.1038/s41418-024-01278-6
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Zs.A 4230: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: The conundrum of opioid tapering in long-term opioid therapy for chronic pain: A commentary.

Manhapra, Ajay / Arias, Albert J / Ballantyne, Jane C

Substance abuse

2017 Volume 39, Issue 2, Page(s) 152–161

Abstract: Background: In response to the opioid epidemic and new guidelines, many patients on high-dose long term opioid therapy (LTOT) for chronic pain are getting tapered off opioids. As a result, a unique clinical challenge is emerging: while many on LTOT have ...

Abstract	Background: In response to the opioid epidemic and new guidelines, many patients on high-dose long term opioid therapy (LTOT) for chronic pain are getting tapered off opioids. As a result, a unique clinical challenge is emerging: while many on LTOT have poor pain control, functional decline, psychiatric instability, aberrancies and misuse, these issues may often worsen with opioid tapering. Currently, a clear explanation and practical guidance on how to manage this perplexing clinical scenario is lacking. Methods: We offer a commentary with our perspective on possible mechanisms involved in this clinical phenomena and offer practical management guidance, supported by available evidence. Results: It is not well recognized that allostatic opponent process involved in development of opioid dependence can cause worsening pain, functional status, sleep and psychiatric symptoms over time, and significant fluctuation of pain and other affective symptoms due to their bidirectional dynamic interaction with opioid dependence ('affective dynamism'). These elements of complex persistent dependence (CPD), the grey area between simple dependence and addiction, can lead to escalating and labile opioid need, often generating aberrant behaviors. Opioid tapering, a seemingly logical intervention in this situation, may lead to worsening of pain, function and psychiatric symptoms due to development of protracted abstinence syndrome. We offer practicing clinicians management principles and practical guidance focused on management of CPD in addition to chronic pain in these difficult clinical scenarios. Conclusion: Awareness of the science of the neuroplasticity effects of repeated use of opioids is necessary to better manage these patients with complex challenges.
MeSH term(s)	Analgesics, Opioid/therapeutic use ; Chronic Pain/drug therapy ; Drug Administration Schedule ; Humans ; Opioid-Related Disorders/prevention & control ; Pain Management/methods ; Withholding Treatment
Chemical Substances	Analgesics, Opioid
Language	English
Publishing date	2017-10-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1458030-5
ISSN	1547-0164 ; 0889-7077
ISSN (online)	1547-0164
ISSN	0889-7077
DOI	10.1080/08897077.2017.1381663
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