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  1. Book: Childhood onset developmental disorders

    Walkup, John T.

    (Annals of the New York Academy of Sciences ; 1304)

    2013  

    Author's details issue ed.: John T. Walkup
    Series title Annals of the New York Academy of Sciences ; 1304
    Collection
    Language English
    Size III, 76 S. : Ill., graph. Darst.
    Publisher Wiley
    Publishing place Hoboken, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT018172051
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    Se 110 -1304- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Editorial: Dialectical Behavior Therapy: More Is Not Always Better When Different Is Required.

    Janssen, Aron / Walkup, John T

    Journal of the American Academy of Child and Adolescent Psychiatry

    2022  Volume 61, Issue 9, Page(s) 1084–1086

    Abstract: The study by Berk et al. ...

    Abstract The study by Berk et al.
    MeSH term(s) Adolescent ; Humans ; Dialectical Behavior Therapy ; Psychotherapy ; Self-Injurious Behavior/therapy ; Suicidal Ideation ; Suicide, Attempted ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2022-06-03
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 392535-3
    ISSN 1527-5418 ; 0890-8567
    ISSN (online) 1527-5418
    ISSN 0890-8567
    DOI 10.1016/j.jaac.2022.05.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Tourette syndrome

    Walkup, John T.

    (Advances in neurology ; 99)

    2006  

    Author's details ed. John T. Walkup
    Series title Advances in neurology ; 99
    Collection
    Language English
    Size XX, 267 S. : Ill., graph. Darst.
    Publisher Lippincott Williams & Wilkins
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT014623212
    ISBN 0-7817-9970-8 ; 978-0-7817-9970-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    Se 198 -99- verfügbar in Königswinter Königswinter

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  4. Article ; Online: The Future of Ketamine in the Treatment of Teen Depression.

    Parikh, Tapan / Walkup, John T

    The American journal of psychiatry

    2021  Volume 178, Issue 4, Page(s) 288–289

    MeSH term(s) Adolescent ; Antidepressive Agents/therapeutic use ; Depression ; Depressive Disorder, Treatment-Resistant/drug therapy ; Humans ; Ketamine/therapeutic use ; Midazolam/therapeutic use
    Chemical Substances Antidepressive Agents ; Ketamine (690G0D6V8H) ; Midazolam (R60L0SM5BC)
    Language English
    Publishing date 2021-05-04
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 280045-7
    ISSN 1535-7228 ; 0002-953X
    ISSN (online) 1535-7228
    ISSN 0002-953X
    DOI 10.1176/appi.ajp.2020.21020172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Editorial: Dialectical Behavior Therapy and the Function of Self-Injury.

    Pochyly, Jonathan / Walkup, John T

    Journal of the American Academy of Child and Adolescent Psychiatry

    2021  Volume 60, Issue 9, Page(s) 1062–1063

    Abstract: The study by Asarnow et al. ...

    Abstract The study by Asarnow et al.
    MeSH term(s) Adolescent ; COVID-19 ; Dialectical Behavior Therapy ; Humans ; Pandemics ; SARS-CoV-2 ; Self-Injurious Behavior/therapy
    Language English
    Publishing date 2021-07-08
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 392535-3
    ISSN 1527-5418 ; 0890-8567
    ISSN (online) 1527-5418
    ISSN 0890-8567
    DOI 10.1016/j.jaac.2021.07.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Clomipramine in Combination with Fluvoxamine: A Potent Medication Combination for Severe or Refractory Pediatric OCD.

    Hardy, Nathan E / Walkup, John T

    Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent

    2021  Volume 30, Issue 4, Page(s) 273–277

    Abstract: Clomipramine (CMI) and fluvoxamine (FLV) combination therapy has been shown in adults to be a potent medication strategy for obsessive compulsive disorder (OCD). Fung et al. (2021) is the first to show similar benefit in pediatric OCD. The addition of ... ...

    Abstract Clomipramine (CMI) and fluvoxamine (FLV) combination therapy has been shown in adults to be a potent medication strategy for obsessive compulsive disorder (OCD). Fung et al. (2021) is the first to show similar benefit in pediatric OCD. The addition of FLV to CMI inhibits the metabolism of clomipramine to desmethylclomipramine (DCMI) and enhances the serotonergic potency of CMI by shifting the routine ratio of CMI<DCMI to CMI>DCMI via inhibition of the CYP450 system. The approach to CMI+FLV combination therapy outlined by Fung et al. requires close monitoring. This commentary reviews the benefits and challenges of the approach of Fung et al. (2021) and provides other strategies to take advantage of this combination. Clinicians may consider starting with CMI and adding FLV for patients with refractory OCD to offer a faster pathway to potentially more effective treatment. If a clinician prefers starting with SSRI monotherapy, choosing FLV initially allows for a simpler transition to CMI+FLV in the event that SSRI monotherapy fails.
    Language English
    Publishing date 2021-11-01
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2381637-5
    ISSN 2293-6122 ; 1719-8429
    ISSN (online) 2293-6122
    ISSN 1719-8429
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Screening for Pediatric Anxiety Disorders.

    Walkup, John T / Green, Cori M / Strawn, Jeffrey R

    JAMA

    2022  Volume 328, Issue 14, Page(s) 1399–1401

    MeSH term(s) Anxiety/diagnosis ; Anxiety Disorders/diagnosis ; Child ; Humans ; Mass Screening
    Language English
    Publishing date 2022-10-11
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2022.15224
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: High-quality antidepressant prescribing: please consider whether "perfection is the enemy of progress".

    Walkup, John T / Strawn, Jeffrey R

    BMC medicine

    2020  Volume 18, Issue 1, Page(s) 150

    MeSH term(s) Adolescent ; Antidepressive Agents/adverse effects ; Child ; Data Management ; Humans ; Primary Health Care ; Secondary Care
    Chemical Substances Antidepressive Agents
    Language English
    Publishing date 2020-05-21
    Publishing country England
    Document type Letter ; Research Support, N.I.H., Extramural ; Comment
    ISSN 1741-7015
    ISSN (online) 1741-7015
    DOI 10.1186/s12916-020-01621-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Identifying the best treatment for young people with depression.

    Strawn, Jeffrey R / Walkup, John T

    The lancet. Psychiatry

    2020  Volume 7, Issue 7, Page(s) 562–563

    MeSH term(s) Adolescent ; Antidepressive Agents ; Child ; Depression ; Depressive Disorder ; Humans ; Network Meta-Analysis ; Psychotherapy
    Chemical Substances Antidepressive Agents
    Language English
    Publishing date 2020-06-17
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2215-0374
    ISSN (online) 2215-0374
    DOI 10.1016/S2215-0366(20)30236-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Antidepressant Efficacy for Depression in Children and Adolescents: Industry- and NIMH-Funded Studies.

    Walkup, John T

    The American journal of psychiatry

    2017  Volume 174, Issue 5, Page(s) 430–437

    Abstract: Significant controversy surrounds the efficacy of the newer antidepressants for children and adolescents with depression. The controversy largely hinges on meta-analyses of studies that suggest that antidepressants are minimally effective, not effective, ...

    Abstract Significant controversy surrounds the efficacy of the newer antidepressants for children and adolescents with depression. The controversy largely hinges on meta-analyses of studies that suggest that antidepressants are minimally effective, not effective, or equivalent to placebo. In this review, the author discusses several scientific and clinical complexities that are important to understand in reviewing the antidepressant literature: the strengths and weaknesses of meta-analyses; the scientific and regulatory context for the large number of antidepressant trials in the late 1990s and early 2000s; and the distinction between a negative trial, where the treatment does not demonstrate efficacy, and a failed trial, where methodological problems make it impossible to draw any conclusion about efficacy. It is the premise of this review that meta-analyses that include the large number of industry-sponsored antidepressant trials distort the picture of antidepressant efficacy for teen depression. Industry-sponsored child and adolescent depression trials suffer from a number of implementation challenges and should be considered failed trials that are largely uninformative and not eligible to be included in efficacy meta-analyses. In contrast to the industry-sponsored trials, depression trials funded by the National Institute of Mental Health (NIMH) (N=2) are characterized by many methodological strengths, lower placebo response rates (30%-35%), and meaningful between-group differences (25%-30%) that support antidepressant efficacy. The NIMH-funded trials, taken together with the demonstrated efficacy of the serotonin reuptake inhibitors for childhood-onset obsessive-compulsive disorder and the anxiety disorders, suggest a broad and important role for antidepressant medications in pediatric internalizing conditions.
    MeSH term(s) Adolescent ; Antidepressive Agents/adverse effects ; Antidepressive Agents/therapeutic use ; Anxiety Disorders/drug therapy ; Child ; Clinical Trials as Topic ; Depressive Disorder/diagnosis ; Depressive Disorder/drug therapy ; Depressive Disorder/psychology ; Drug Industry ; Financing, Government ; Financing, Organized ; Humans ; Meta-Analysis as Topic ; National Institute of Mental Health (U.S.) ; Obsessive-Compulsive Disorder/drug therapy ; Research Design ; Research Support as Topic ; Serotonin Uptake Inhibitors/therapeutic use ; Treatment Failure ; Treatment Outcome ; United States
    Chemical Substances Antidepressive Agents ; Serotonin Uptake Inhibitors
    Language English
    Publishing date 2017-05-01
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Review
    ZDB-ID 280045-7
    ISSN 1535-7228 ; 0002-953X
    ISSN (online) 1535-7228
    ISSN 0002-953X
    DOI 10.1176/appi.ajp.2017.16091059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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