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  1. Article ; Online: Safety and efficacy of G-CSF in patients with ischemic heart failure: the CORNER (Cell Option For Recovery in the Non-Eligible Patients for Revascularization) study.

    Leone, Antonio Maria / Giannico, Maria Benedetta / Bruno, Isabella / Giordano, Alessandro / Zaccone, Vincenzo / Perfetti, Matteo / Niccoli, Giampaolo / Porto, Italo / Burzotta, Francesco / Rebuzzi, Antonio Giuseppe / Biasucci, Luigi Marzio / Crea, Filippo

    International journal of cardiology

    2011  Volume 150, Issue 1, Page(s) 75–78

    Abstract: ... heart failure in NYHA and/or CCS classes ≥ 3 unsuitable for revascularization received G-CSF ... assessed at baseline and at 4 month follow up.: Results: G-CSF was generally well tolerated. NYHA and ... unsuitable for revascularization, G-CSF is associated to a significant improvement of symptoms, possibly ...

    Abstract Background: Demonstration that the heart is not a post-mitotic organ has led to clinical trials trying to obtain myocardial repair even in patients with heart failure.
    Aim of the study: To evaluate as a less invasive method for promoting cardiac repair.
    Methods: Thirteen patients with ischemic heart failure in NYHA and/or CCS classes ≥ 3 unsuitable for revascularization received G-CSF, as a compassionate use, in addition to optimal medical therapy. Symptoms and cardiac perfusion by gated-SPECT were assessed at baseline and at 4 month follow up.
    Results: G-CSF was generally well tolerated. NYHA and CCS classes improved significantly from 3 (IR 2.5-3) to 2 (IR 1-2.5) (p = 0.012) and from 3 (IR 1-3) to 1 (IR 1-2) (p = 0.033). Heart failure severity symptoms according to the Minnesota Living with Heart Failure Questionnaire scores exhibited a non significant improvement from 52 ± 27 to 39 ± 26 (p = 0.15). At the Seattle Angina Questionnaire scores (ranging from 0 to 100, higher scores indicating better status), physical limitation improved from 39 ± 31 to 64 ± 29 (p = 0.03), angina stability from 42 ± 29 to 64 ± 28 (p = 0.05), angina frequency from 53 ± 33 to 73 ± 26 (p = 0.04), treatment satisfaction from 67 ± 29 to 83 ± 21 (p = 0.07), disease perception from 37 ± 29 to 66 ± 26 (p = 0.007). Quality of life assessed by a Visual Analogue Scale improved from 33 ± 24 to 64 ± 20 mm (p = 0.003). Stress and differential regional perfusion scores improved significantly from 1.78 ± 1.38 to 1.66 ± 1.38 (p = 0.05) and from 0.35 ± 0.68 to 0.23 ± 0.53 (p = 0.02) respectively.
    Conclusions: In patients with ischemic heart failure unsuitable for revascularization, G-CSF is associated to a significant improvement of symptoms, possibly reducing stress-induced ischemia.
    MeSH term(s) Adult ; Aged ; Compassionate Use Trials ; Female ; Follow-Up Studies ; Granulocyte Colony-Stimulating Factor/adverse effects ; Granulocyte Colony-Stimulating Factor/pharmacology ; Granulocyte Colony-Stimulating Factor/therapeutic use ; Heart Failure/drug therapy ; Heart Failure/physiopathology ; Humans ; Male ; Middle Aged ; Myocardial Ischemia/drug therapy ; Myocardial Ischemia/physiopathology ; Myocardial Revascularization/methods ; Quality of Life/psychology ; Recovery of Function/drug effects ; Recovery of Function/physiology ; Treatment Outcome
    Chemical Substances Granulocyte Colony-Stimulating Factor (143011-72-7)
    Language English
    Publishing date 2011-07-01
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2010.02.075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Endogenous G-CSF and CD34+ cell mobilization after acute myocardial infarction.

    Leone, Antonio Maria / Rutella, Sergio / Bonanno, Giuseppina / Contemi, Anna Maria / de Ritis, Daniela G / Giannico, Maria Benedetta / Rebuzzi, Antonio G / Leone, Giuseppe / Crea, Filippo

    International journal of cardiology

    2006  Volume 111, Issue 2, Page(s) 202–208

    Abstract: ... cells, and mobilizing cyokines (G-CSF, SCF, VEGF, SDF1-alpha) were assessed.: Results: The peak ... cells/microl, p<0.001). However endogenous G-CSF was significantly higher in the serum of patients ... in AMI patients with respect to controls. CD34(+) cells were significantly correlated to G-CSF (directly ...

    Abstract Background: Several reports showed an increase of CD34(+) stem/progenitor cell count early after an acute myocardial infarction (AMI), suggesting a contribution of bone marrow cells in myocardial regeneration after the acute event. Nevertheless, at present plasma mediators of CD34(+) cell mobilization from bone marrow to peripheral blood in patients with AMI are poorly understood. Aim of our study was to establish the impact of different well-known mobilizing cytokines on spontaneous stem cell mobilization in patients with different ischemic heart syndromes, such as the AMI and the chronic stable angina (CSA), compared to healthy controls.
    Methods: In 16 patients with AMI, 18 with CSA and 22 healthy blood donors the concentration of CD34(+) cells, and mobilizing cyokines (G-CSF, SCF, VEGF, SDF1-alpha) were assessed.
    Results: The peak number of circulating CD34(+) cells in AMI patients (8.58+/-2.08 cells/microl) was higher than that observed in patients with CSA (3.41+/-0.56 cells/microl, p=0.0061) or in healthy controls (2.18+/-0.35 cells/microl, p<0.001). However endogenous G-CSF was significantly higher in the serum of patients with AMI compared to CSA patients and to controls and in CSA patients compared to controls. Interestingly, as regards VEGF, while this cytokine was increased in AMI with respect to control and CSA group, the latter showed a significantly lower concentration with respect to controls. Finally SDF-1 alpha was higher in AMI patients with respect to controls. CD34(+) cells were significantly correlated to G-CSF (directly) and to SCF (inversely) in patients with AMI.
    Conclusion: In the present study, we have demonstrated for the first time that the spontaneous mobilization of CD34(+) cells into the peripheral blood of patients with AMI is significantly correlated to endogenous G-CSF. Considering recent data suggesting a potential favourable effect of circulating CD34(+) cells on left ventricular function, the present evidence of a correlation between endogenous G-CSF and CD34(+) cell levels supports the pharmacological administration of G-CSF as a non-invasive option for regeneration of myocardial tissue after AMI.
    MeSH term(s) Aged ; Antigens, CD/blood ; Antigens, CD34/blood ; Chemokine CXCL12 ; Chemokines, CXC/blood ; Cytokines/blood ; Female ; Follow-Up Studies ; Granulocyte Colony-Stimulating Factor/blood ; Heart/physiopathology ; Hematopoietic Stem Cell Mobilization ; Humans ; Male ; Middle Aged ; Myocardial Infarction/blood ; Reference Values ; Regeneration
    Chemical Substances Antigens, CD ; Antigens, CD34 ; CXCL12 protein, human ; Chemokine CXCL12 ; Chemokines, CXC ; Cytokines ; Granulocyte Colony-Stimulating Factor (143011-72-7)
    Language English
    Publishing date 2006-08-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2005.06.043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Habitat overlap among native and introduced cold-water fishes in the Himalayas.

    Jan, Arif / Arismendi, Ivan / Giannico, Guillermo / Flitcroft, Rebecca

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 15033

    Abstract: Fish invasions threaten native freshwater ecosystems worldwide, yet methods to map biodiversity in data-deficient regions are scarce. Rainbow trout (Oncorhynchus mykiss) and brown trout (Salmo trutta fario) have been introduced to the Himalayan ecoregion ...

    Abstract Fish invasions threaten native freshwater ecosystems worldwide, yet methods to map biodiversity in data-deficient regions are scarce. Rainbow trout (Oncorhynchus mykiss) and brown trout (Salmo trutta fario) have been introduced to the Himalayan ecoregion where they are sympatric with vulnerable native snow trout Schizothorax plagiostomus and Schizothorax richardsonii. We aim to evaluate potential habitat overlap among snow trout and non-native trout in the Indus and Ganges River basins, Himalayan ecoregion. We transferred maximum entropy (MaxEnt) models developed with spatially continuous freshwater-specific environmental variables to map the distribution of potentially suitable habitats for rainbow and brown trout in the Himalayas. We adopted a similar procedure to map suitable habitats for snow trout species. There were substantial habitat overlaps (up to 96%) among snow trout and non-native trout. Yet, the physiography of receiving basins could play a role minimizing the impacts of each non-native trout on native snow trout. We generate high-resolution classified stream suitability maps as decision support tools to help managers in habitat allocation and policy formation to balance recreational fisheries with conservation of snow trout. Our workflow can be transferred to other basins and species for mapping freshwater biodiversity patterns in species-rich yet data-poor regions of the world.
    MeSH term(s) Animals ; Ecosystem ; Water ; Fresh Water ; Oncorhynchus mykiss ; Biodiversity
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2023-09-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-41778-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The unrelenting global expansion of the urban heat island over the last century.

    Ren, Yaxue / Lafortezza, Raffaele / Giannico, Vincenzo / Sanesi, Giovanni / Zhang, Xinna / Xu, Chengyang

    The Science of the total environment

    2023  Volume 880, Page(s) 163276

    Abstract: The past century has seen dramatic increases in global temperatures and mounting urbanization. As a result of these events, the urban heat island (UHI) effect has received growing attention in scientific research worldwide. A global search was initially ... ...

    Abstract The past century has seen dramatic increases in global temperatures and mounting urbanization. As a result of these events, the urban heat island (UHI) effect has received growing attention in scientific research worldwide. A global search was initially conducted using a scientific literature database to collect all available relevant publications to understand how the UHI has been expanding worldwide and affecting more cities across different latitudes and altitudes. Subsequently, a semantic analysis was performed to extract city names. The literature search and analysis combined resulted in 6078 publications in which UHI was investigated in 1726 cities worldwide in the 1901 to 2022 time period. The cities were grouped into 'first appearance' and 'recurrent appearance'. Results show that UHI was studied in only 134 cities during the 90-year period from 1901 to 1992, with a remarkable growth over time in the number of cities where interest in UHI increased. Interestingly, the number of first appearances was always notably higher than the number of recurrent appearances. The Shannon evenness index was employed to identify the spatial locations (hotspots) across the globe where UHI-related research has been concentrated in multiple cities over the last 120 years. Finally, Europe was selected as a testbed for conducting an analysis to shed light on how economic, demographic, and environmental factors can impact UHI. Our study is unique for having demonstrated not only the rapid growth of cities affected by UHI globally but also the increasing and unrelenting expansion of UHI occurrences across different latitudes and altitudes over time. These novel findings will undoubtedly be of interest to scientists investigating the UHI phenomenon and its trends. Stakeholders will acquire a broader perspective and deeper understanding of UHI in order to engage in more effective urban planning to offset and mitigate the phenomenon's adverse effects in the context of increasing climate change and urbanization.
    Language English
    Publishing date 2023-04-04
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.163276
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Objective greenness, connectedness to nature and sunlight levels towards perceived restorativeness in urban nature.

    Spano, Giuseppina / Ricciardi, Elisabetta / Theodorou, Annalisa / Giannico, Vincenzo / Caffò, Alessandro Oronzo / Bosco, Andrea / Sanesi, Giovanni / Panno, Angelo

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 18192

    Abstract: ... in a sample of 312 visitors to a large urban park. Variables investigating ecosystem services (ES, e.g ...

    Abstract The beneficial effect of exposure to nature and immersion in natural environments on perceived well-being is well established. Nevertheless, we acknowledge an emerging need to disentangle the role of specific environmental features from individual factors that encourage a positive person-environment interaction. This study aimed at evaluating the associations between four buffer distances of greenness and dimensions of perceived restorativeness, with connectedness towards nature (CTN) as a confounder variable, in a sample of 312 visitors to a large urban park. Variables investigating ecosystem services (ES, e.g., thermal comfort) were included as covariates. Results revealed differentiated effects of greenness level, sunlight intensity, and connectedness to nature in the pathways towards dimensions of restorativeness. Greenness level at 300 m was associated with Fascination, Scope, and Being Away, while at 500 m was associated with Coherence, Scope, and Being Away. ES was found to be associated with Coherence, while CTN with the other three dimensions of restorativeness. The moderating effect of sunlight level in the relationship between NDVI buffer distances and the total score of perceived restorativeness was also confirmed. The present work is intended to offer insights on the interplay between environmental features and individual differences for implications in several contexts, including the opportunity to develop tailor-made planning for urban forestry.
    MeSH term(s) Humans ; Ecosystem ; Sunlight
    Language English
    Publishing date 2023-10-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-45604-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: PCDD/Fs and PCBs in hen eggs from a contaminated area in Italy: a 9 years spatio-temporal monitoring study.

    Giannico, Orazio Valerio / Baldacci, Simona / Basile, Fabrizio Cosimo / Pellegrino, Angelo / Desiante, Francesco / Franco, Ettore / Diletti, Gianfranco / Conversano, Michele

    Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment

    2023  Volume 40, Issue 2, Page(s) 294–304

    Abstract: ... in Feed and Food. Median (IQR) values were: 0.28 (0.59) pg WHO-TEQ/g fat for PCDD/Fs, 0.89 (1.70) pg ... WHO-TEQ/g fat for PCDD/Fs + DL-PCBs, 0.57 (1.16) pg WHO-TEQ/g fat for DL-PCBs, 2.24 (5.51) ng/g fat ...

    Abstract Eggs can represent a food susceptible to contamination, with bioaccumulation potential for POPs. The Province of Taranto, Southern Italy, is of particular relevance in this context because of the presence of industrial sources of PCDD/Fs and PCBs. The aim of this study was to analyze and report the levels of these contaminants in hen eggs sampled in farms located within a radius of 20 km from the industrial area of Taranto. Between 2013 and 2021, 227 hen eggs were collected, according to a special monitoring plan of the Prevention Department. Samples were analyzed by the National Reference Laboratory for Halogenated POPs in Feed and Food. Median (IQR) values were: 0.28 (0.59) pg WHO-TEQ/g fat for PCDD/Fs, 0.89 (1.70) pg WHO-TEQ/g fat for PCDD/Fs + DL-PCBs, 0.57 (1.16) pg WHO-TEQ/g fat for DL-PCBs, 2.24 (5.51) ng/g fat for NDL-PCBs. Samples not-compliant (Reg. 1881/2006/EC and amendments) for at least one contaminant were 17 (7.5%). No contaminants values or exceedances showed a statistically significant correlation with distance from industrial area (
    MeSH term(s) Animals ; Female ; Polychlorinated Biphenyls/analysis ; Polychlorinated Dibenzodioxins/analysis ; Dioxins/analysis ; Dibenzofurans ; Chickens ; Food Contamination/analysis ; Eggs/analysis ; Italy ; Dibenzofurans, Polychlorinated
    Chemical Substances Polychlorinated Biphenyls (DFC2HB4I0K) ; Polychlorinated Dibenzodioxins ; Dioxins ; Dibenzofurans ; Dibenzofurans, Polychlorinated
    Language English
    Publishing date 2023-01-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2462951-0
    ISSN 1944-0057 ; 1944-0049
    ISSN (online) 1944-0057
    ISSN 1944-0049
    DOI 10.1080/19440049.2022.2157051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: PCDD/Fs and PCBs in hen eggs from a contaminated area in Italy: a 9 years spatio-temporal monitoring study

    Giannico, Orazio Valerio / Baldacci, Simona / Basile, Fabrizio Cosimo / Pellegrino, Angelo / Desiante, Francesco / Franco, Ettore / Diletti, Gianfranco / Conversano, Michele

    Food Additives & Contaminants: Part A. 2023 Feb. 1, v. 40, no. 2 p.294-304

    2023  

    Abstract: ... in Feed and Food. Median (IQR) values were: 0.28 (0.59) pg WHO-TEQ/g fat for PCDD/Fs, 0.89 (1.70) pg ... WHO-TEQ/g fat for PCDD/Fs + DL-PCBs, 0.57 (1.16) pg WHO-TEQ/g fat for DL-PCBs, 2.24 (5.51) ng/g fat ...

    Abstract Eggs can represent a food susceptible to contamination, with bioaccumulation potential for POPs. The Province of Taranto, Southern Italy, is of particular relevance in this context because of the presence of industrial sources of PCDD/Fs and PCBs. The aim of this study was to analyze and report the levels of these contaminants in hen eggs sampled in farms located within a radius of 20 km from the industrial area of Taranto. Between 2013 and 2021, 227 hen eggs were collected, according to a special monitoring plan of the Prevention Department. Samples were analyzed by the National Reference Laboratory for Halogenated POPs in Feed and Food. Median (IQR) values were: 0.28 (0.59) pg WHO-TEQ/g fat for PCDD/Fs, 0.89 (1.70) pg WHO-TEQ/g fat for PCDD/Fs + DL-PCBs, 0.57 (1.16) pg WHO-TEQ/g fat for DL-PCBs, 2.24 (5.51) ng/g fat for NDL-PCBs. Samples not-compliant (Reg. 1881/2006/EC and amendments) for at least one contaminant were 17 (7.5%). No contaminants values or exceedances showed a statistically significant correlation with distance from industrial area (p > 0.05). Higher PCDD/Fs values were observed in first and second quarters (p < 0.05). All contaminants’ values pairwise combinations showed significant (p < 0.0001) strong (ρ > 0.7) correlation. According to our epidemiological investigations, the exceedances are to be attributed to factors mainly related to farmers’ wrong habits. These results confirmed the importance of the monitoring of contaminants’ levels in the matrices at risk as well as to focus on enhancing good management practices on eggs-producing farms.
    Keywords bioaccumulation ; hens ; risk ; Italy ; POPs ; PCDD/Fs ; dioxins ; furans ; PCBs ; eggs ; contamination
    Language English
    Dates of publication 2023-0201
    Size p. 294-304.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 2462951-0
    ISSN 1944-0057 ; 1944-0049
    ISSN (online) 1944-0057
    ISSN 1944-0049
    DOI 10.1080/19440049.2022.2157051
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: Characterizing green and gray space exposure for epidemiological studies: Moving from 2D to 3D indicators

    Giannico, Vincenzo / Stafoggia, Massimo / Spano, Giuseppina / Elia, Mario / Dadvand, Payam / Sanesi, Giovanni

    Urban forestry & urban greening. 2022 June, v. 72

    2022  

    Abstract: ... such as land use maps or, more recently, satellite derived indices (e.g., green space indices such as normalized ...

    Abstract The presence of green spaces has been associated with improved physical health and better mental health and wellbeing. In contrast, the presence of gray features including build-up areas might have a negative impact on the health and wellbeing of citizens. To date, the available evidence on the health effects of green and gray spaces have mainly relied on 2-dimensional (2D) indicators of these spaces such as land use maps or, more recently, satellite derived indices (e.g., green space indices such as normalized difference vegetation index (NDVI) or gray space indices such as imperviousness). Although they are acceptable proxies of these exposures, 2D indicators could have inaccuracies when characterizing diverse set of vegetation types in combination with different types of gray spaces, which is typical of urban environments. To overcome this gap, we developed a set of three-dimensional (3D) indicators derived mainly from airborne LiDAR (Light Detection and Ranging) acquired in 2008 and 2010 over the metropolitan area of Rome (Italy). In particular, we extracted volume of green features such as shrubs and trees (Green volume [m3/ha]), volume of buildings (Gray volume[m3/ha]), a novel index called Normalized Difference Green-Gray Volume index (NDGG) as well as indicators of the tree count. We compared the 3D indicators with two widely used 2D indicators for characterizing green and gray spaces (i.e., NDVI and imperviousness) in different buffers around 79140 address points in the city. For the green indicators, we found that the Pearson correlations between NDVI and Green Volume were 0.47 (50 m buffer) and 0.33 (300 m buffer) while the correlations between NDVI and number of trees were 0.56 (50 m buffer) and 0.58 (300 m buffer). For gray indicators, the correlations between imperviousness and gray volume were 0.62 (50 m buffer) and 0.79 (300 m buffer). For NDGG, the correlations were higher with both NDVI (0.76 and 0.83 for 50 m and 300 m buffers) and imperviousness (−0.75 and −0.83 for 50 m and 300 m buffers). Our results showed that the use of 3D indicators can have potential benefits, especially regarding green features which can be highly heterogeneous in complex urban landscapes such as the city of Rome.
    Keywords green infrastructure ; land use ; lidar ; mental health ; metropolitan areas ; normalized difference vegetation index ; physical health ; satellites ; trees ; urban forestry ; Italy
    Language English
    Dates of publication 2022-06
    Publishing place Elsevier GmbH
    Document type Article
    ISSN 1618-8667
    DOI 10.1016/j.ufug.2022.127567
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Two- and three-dimensional indicators of green and grey space exposure and psychiatric conditions and medicine use: A longitudinal study in a large population-based Italian cohort.

    Spano, Giuseppina / Nobile, Federica / Giannico, Vincenzo / Elia, Mario / Michelozzi, Paola / Bosco, Andrea / Dadvand, Payam / Sanesi, Giovanni / Stafoggia, Massimo

    Environment international

    2023  Volume 182, Page(s) 108320

    Abstract: Background: Evidence available on the associations between urban greenness and mental health is mainly based on cross-sectional studies and has relied on 2D indicators of greenness. This longitudinal study aimed at investigating the association between ... ...

    Abstract Background: Evidence available on the associations between urban greenness and mental health is mainly based on cross-sectional studies and has relied on 2D indicators of greenness. This longitudinal study aimed at investigating the association between 2D and 3D indicators of green and grey spaces and incident mental health-related outcomes in a large population-based cohort.
    Methods: Our study used data from 593,894 Italian adults (≥30 years) from the Rome Longitudinal Study. Mental health outcomes were defined using either drug prescriptions (antidepressants, antipsychotics, lithium and other mood stabilisers, and anxiolytics, hypnotics and sedatives), or hospitalisation records (for schizophrenia spectrum disorder, depression, anxiety, stress-related and somatoform, or substance use disorders). We obtained 2D and 3D indicators of green and grey exposures including Normalized Difference Vegetation Index (NDVI), green volume, grey volume, number of trees, and Normalized Difference Green-Grey Volume Index around participants' homes. Cox proportional hazards regression models were developed to estimate the association of green and grey space exposure and psychiatric conditions and medicine use, adjusted for relevant covariates.
    Results: We found beneficial associations of NDVI and the number of trees with antipsychotic and lithium and other mood stabiliser drugs. We also observed detrimental associations between grey volume and lithium and other mood stabilisers and anxiolytic, hypnotic and sedative drugs. Finally, we found a protective association of the NDGG with lithium and other mood stabilisers (HR: 0.977; 95% CI: 0.965-0.990) and anxiolytic, hypnotic and sedative drugs (HR: 0.851; 95% CI: 0.762-0.950). The associations for hospitalisation for psychiatric conditions were less consistent and generally not statistically significant.
    Conclusions: Findings suggested that higher greenness areas around residential addresses are associated with reduced use of drugs for psychiatric conditions, while the opposite is true for higher grey space exposure. The study highlights the importance of accurately characterising green and grey spaces, using novel exposure indicators.
    MeSH term(s) Adult ; Humans ; Longitudinal Studies ; Lithium ; Anti-Anxiety Agents/therapeutic use ; Cross-Sectional Studies ; Hypnotics and Sedatives ; Italy
    Chemical Substances Lithium (9FN79X2M3F) ; Anti-Anxiety Agents ; Hypnotics and Sedatives
    Language English
    Publishing date 2023-11-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 554791-x
    ISSN 1873-6750 ; 0160-4120
    ISSN (online) 1873-6750
    ISSN 0160-4120
    DOI 10.1016/j.envint.2023.108320
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: I SERVIZI IGIENICO-SANITARI DELLE DUE MODERNE TURBONAVI "G. MARCONI" E "G. GALILEI".

    GIANNICO, L

    Annali della sanita pubblica

    1964  Volume 25, Page(s) 1409–1422

    Title translation THE HYGIENICO-SANITARY SERVICES OF 2 MODERN STEAMSHIPS, "G. MARCONI" AND "G. GALILEI".
    MeSH term(s) Humans ; Naval Medicine ; Work
    Language Italian
    Publishing date 1964-11
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 603862-1
    ISSN 0021-3071
    ISSN 0021-3071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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