Article ; Online: Safety and efficacy of G-CSF in patients with ischemic heart failure: the CORNER (Cell Option For Recovery in the Non-Eligible Patients for Revascularization) study.
International journal of cardiology
2011 Volume 150, Issue 1, Page(s) 75–78
Abstract: ... heart failure in NYHA and/or CCS classes ≥ 3 unsuitable for revascularization received G-CSF ... assessed at baseline and at 4 month follow up.: Results: G-CSF was generally well tolerated. NYHA and ... unsuitable for revascularization, G-CSF is associated to a significant improvement of symptoms, possibly ...
Abstract | Background: Demonstration that the heart is not a post-mitotic organ has led to clinical trials trying to obtain myocardial repair even in patients with heart failure. Aim of the study: To evaluate as a less invasive method for promoting cardiac repair. Methods: Thirteen patients with ischemic heart failure in NYHA and/or CCS classes ≥ 3 unsuitable for revascularization received G-CSF, as a compassionate use, in addition to optimal medical therapy. Symptoms and cardiac perfusion by gated-SPECT were assessed at baseline and at 4 month follow up. Results: G-CSF was generally well tolerated. NYHA and CCS classes improved significantly from 3 (IR 2.5-3) to 2 (IR 1-2.5) (p = 0.012) and from 3 (IR 1-3) to 1 (IR 1-2) (p = 0.033). Heart failure severity symptoms according to the Minnesota Living with Heart Failure Questionnaire scores exhibited a non significant improvement from 52 ± 27 to 39 ± 26 (p = 0.15). At the Seattle Angina Questionnaire scores (ranging from 0 to 100, higher scores indicating better status), physical limitation improved from 39 ± 31 to 64 ± 29 (p = 0.03), angina stability from 42 ± 29 to 64 ± 28 (p = 0.05), angina frequency from 53 ± 33 to 73 ± 26 (p = 0.04), treatment satisfaction from 67 ± 29 to 83 ± 21 (p = 0.07), disease perception from 37 ± 29 to 66 ± 26 (p = 0.007). Quality of life assessed by a Visual Analogue Scale improved from 33 ± 24 to 64 ± 20 mm (p = 0.003). Stress and differential regional perfusion scores improved significantly from 1.78 ± 1.38 to 1.66 ± 1.38 (p = 0.05) and from 0.35 ± 0.68 to 0.23 ± 0.53 (p = 0.02) respectively. Conclusions: In patients with ischemic heart failure unsuitable for revascularization, G-CSF is associated to a significant improvement of symptoms, possibly reducing stress-induced ischemia. |
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MeSH term(s) | Adult ; Aged ; Compassionate Use Trials ; Female ; Follow-Up Studies ; Granulocyte Colony-Stimulating Factor/adverse effects ; Granulocyte Colony-Stimulating Factor/pharmacology ; Granulocyte Colony-Stimulating Factor/therapeutic use ; Heart Failure/drug therapy ; Heart Failure/physiopathology ; Humans ; Male ; Middle Aged ; Myocardial Ischemia/drug therapy ; Myocardial Ischemia/physiopathology ; Myocardial Revascularization/methods ; Quality of Life/psychology ; Recovery of Function/drug effects ; Recovery of Function/physiology ; Treatment Outcome |
Chemical Substances | Granulocyte Colony-Stimulating Factor (143011-72-7) |
Language | English |
Publishing date | 2011-07-01 |
Publishing country | Netherlands |
Document type | Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 779519-1 |
ISSN | 1874-1754 ; 0167-5273 |
ISSN (online) | 1874-1754 |
ISSN | 0167-5273 |
DOI | 10.1016/j.ijcard.2010.02.075 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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