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  1. Article ; Online: Behçet's Syndrome.

    Saadoun, David / Bodaghi, Bahram / Cacoub, Patrice

    The New England journal of medicine

    2024  Volume 390, Issue 7, Page(s) 640–651

    MeSH term(s) Humans ; Behcet Syndrome/complications ; Behcet Syndrome/diagnosis
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMra2305712
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  2. Article ; Online: Hepatitis C Virus Infection, a New Modifiable Cardiovascular Risk Factor.

    Cacoub, Patrice

    Gastroenterology

    2019  Volume 156, Issue 4, Page(s) 862–864

    MeSH term(s) Antiviral Agents ; Cardiovascular Diseases ; Hepacivirus ; Hepatitis C ; Humans ; Risk Factors
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2019-02-15
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2019.02.009
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  3. Article ; Online: Vascularites cryoglobulinémiques.

    Mirouse, Adrien / Saadoun, David / Cacoub, Patrice

    La Revue du praticien

    2023  Volume 72, Issue 10, Page(s) 1122–1128

    Abstract: Cryoglobulins are immunoglobulins that precipitate in vitro when serum is incubated at temperatures lower than 37°C. Cryoglobulins are classified under three subgroups according to their components. Cryoglobulinemic vasculitis corresponds to ... ...

    Title translation Cryoglobulinemic vasculitis.
    Abstract Cryoglobulins are immunoglobulins that precipitate in vitro when serum is incubated at temperatures lower than 37°C. Cryoglobulins are classified under three subgroups according to their components. Cryoglobulinemic vasculitis corresponds to manifestations associated with vascular occlusion by cryoglobulins or inflammatory manifestations induced by the deposition of cryoglobulins containing immune complex. Main manifestations are skin lesions, including vascular purpura, necrosis, kidney involvement, and peripheral nerve involvement. Initial work-up aims at identifying the underlying disease, which may be a B-lineage hematological malignancy, a connective tissue disorder, or a chronic viral infection like hepatitis C. Treatment and prognosis are closely dependent of the underlying disease.
    MeSH term(s) Humans ; Cryoglobulins ; Hepatitis C, Chronic/complications ; Prognosis ; Cryoglobulinemia/diagnosis ; Cryoglobulinemia/therapy ; Vasculitis/diagnosis ; Vasculitis/etiology ; Vasculitis/therapy
    Chemical Substances Cryoglobulins
    Language French
    Publishing date 2023-02-22
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
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  4. Article: Comment on Nuño Solinís R, et al. "Value of Treating All Stages of Chronic Hepatitis C: A Comprehensive Review of Clinical and Economic Evidence".

    Cacoub, Patrice

    Infectious diseases and therapy

    2017  Volume 6, Issue 2, Page(s) 297–301

    Language English
    Publishing date 2017-03-29
    Publishing country New Zealand
    Document type Letter
    ZDB-ID 2701611-0
    ISSN 2193-6382 ; 2193-8229
    ISSN (online) 2193-6382
    ISSN 2193-8229
    DOI 10.1007/s40121-017-0155-0
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  5. Article ; Online: Extrahepatic Manifestations of Chronic HCV Infection. Reply.

    Cacoub, Patrice / Saadoun, David

    The New England journal of medicine

    2021  Volume 385, Issue 1, Page(s) 95–96

    MeSH term(s) Cryoglobulinemia ; Hepacivirus/genetics ; Hepatitis C ; Humans
    Language English
    Publishing date 2021-07-19
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2106143
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  6. Article ; Online: Extrahepatic Manifestations of Chronic HCV Infection.

    Cacoub, Patrice / Saadoun, David

    The New England journal of medicine

    2021  Volume 384, Issue 11, Page(s) 1038–1052

    MeSH term(s) Antiviral Agents/therapeutic use ; Cardiovascular Diseases/etiology ; Cryoglobulinemia/etiology ; Diabetes Mellitus, Type 2/etiology ; Hepacivirus ; Hepatitis C/complications ; Hepatitis C/drug therapy ; Humans ; Liver Cirrhosis/etiology ; Lymphoma, B-Cell/etiology ; Renal Insufficiency, Chronic/etiology
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2021-04-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMra2033539
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  7. Article ; Online: Hepatitis B Virus Infection and Extra-Hepatic Manifestations: A Systemic Disease.

    Cacoub, Patrice / Asselah, Tarik

    The American journal of gastroenterology

    2021  Volume 117, Issue 2, Page(s) 253–263

    Abstract: People living with hepatitis B virus (HBV) chronic infection are exposed to high rates of liver complications including end-stage liver disease and hepatocellular carcinoma. Extrahepatic manifestations of HBV infection have long been underestimated. ... ...

    Abstract People living with hepatitis B virus (HBV) chronic infection are exposed to high rates of liver complications including end-stage liver disease and hepatocellular carcinoma. Extrahepatic manifestations of HBV infection have long been underestimated. Several of these extrahepatic syndromes have been well described, including systemic vasculitides, glomerulonephritis, and cutaneous manifestations. Other manifestations have been more recently described such as hematological malignancies and neurological diseases. These extrahepatic manifestations are associated with significant morbidity and mortality. Although not completely understood, underlying mechanisms include HBV-induced local and systemic inflammation. Suppression of HBV replication usually improves extrahepatic manifestations. This review will discuss how HBV induces inflammation and the extrahepatic manifestations of HBV infection to guide clinical management.
    MeSH term(s) Antibodies, Viral/analysis ; Disease Management ; Glomerulonephritis/diagnosis ; Glomerulonephritis/etiology ; Hepatitis B virus/immunology ; Hepatitis B, Chronic/complications ; Hepatitis B, Chronic/diagnosis ; Hepatitis B, Chronic/virology ; Humans ; Liver/diagnostic imaging ; Liver/virology ; Skin Diseases/diagnosis ; Skin Diseases/etiology ; Vasculitis/diagnosis ; Vasculitis/etiology
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2021-12-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000001575
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Péricardites.

    Marques, Cindy / Cacoub, Patrice

    La Revue du praticien

    2021  Volume 71, Issue 1, Page(s) 79–83

    Abstract: Pericarditis Acute pericarditis is a common disease, most often idiopathic or viral. This is usually a mild condition but recurrences are frequent. The predominant pathophysiological hypothesis is that of underlying dysimmune disorders, involving an ... ...

    Title translation Pericarditis.
    Abstract "Pericarditis Acute pericarditis is a common disease, most often idiopathic or viral. This is usually a mild condition but recurrences are frequent. The predominant pathophysiological hypothesis is that of underlying dysimmune disorders, involving an inflammatory response of the innate immune system typical of "autoinflammatory diseases", mainly mediated by interleukin-1 [IL-1] with activation of inflammasome; and an adaptive immune system response, typical of «autoimmune diseases», primarily mediated by autoantibodies and autoreactive T cells. The clinical picture associates fever, chest pain, changes in the electrocardiogram and possible pericardial effusion. Treatment is based on the combination of aspirin/nonsteroidal anti-inflammatory drugs and colchicine for several weeks. In refractory pericarditis, low dose corticosteroid therapy and / or immunosuppressive agents have been proposed with limited efficacy. Growing evidency suggest a place for IL-1 receptor antagonists in the treatment of recurrent pericarditis. Many studies have shown the effectiveness of anakinra with a good safety profile. Other IL-1 receptor antagonists have shown promising results (canakinumab, rilonacept). Further evaluation in larger prospective clinical trials is needed to confirm the long-term efficacy and safety of anti-IL1."
    MeSH term(s) Aspirin ; Colchicine/therapeutic use ; Humans ; Interleukin 1 Receptor Antagonist Protein/therapeutic use ; Pericarditis/diagnosis ; Pericarditis/drug therapy ; Prospective Studies ; Recurrence
    Chemical Substances Interleukin 1 Receptor Antagonist Protein ; Aspirin (R16CO5Y76E) ; Colchicine (SML2Y3J35T)
    Language French
    Publishing date 2021-06-23
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
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  9. Article ; Online: Neutrophil, NETs and Behçet's disease: A review.

    Le Joncour, Alexandre / Cacoub, Patrice / Boulaftali, Yacine / Saadoun, David

    Clinical immunology (Orlando, Fla.)

    2023  Volume 250, Page(s) 109318

    Abstract: Behçet's disease (BD) is a chronic systemic vasculitis characterized by recurrent oral and genital ulcers, skin lesions, articular, neurological, vascular and sight-threatening ocular inflammation. BD is thought to share both autoimmune and ... ...

    Abstract Behçet's disease (BD) is a chronic systemic vasculitis characterized by recurrent oral and genital ulcers, skin lesions, articular, neurological, vascular and sight-threatening ocular inflammation. BD is thought to share both autoimmune and autoinflammatory disease features. BD is triggered by environmental factors such as infectious agents in genetically predisposed subjects. Neutrophils seem to play an instrumental role in BD and recent works regarding the role of neutrophils extracellular traps (NETs) provides new insight in the pathophysiology of BD and the mechanisms involved in immune thrombosis. This review provides a recent overview on the role of neutrophils and NETs in the pathogenesis of BD.
    MeSH term(s) Humans ; Behcet Syndrome ; Neutrophils ; Extracellular Traps ; Inflammation/complications
    Language English
    Publishing date 2023-04-03
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2023.109318
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  10. Article ; Online: Screening for Lung Cancer by Chest Computed Tomography During Thromboangiitis Obliterans.

    Sow, Maïmouna / Saadoun, David / Cacoub, Patrice / Le Joncour, Alexandre

    Angiology

    2023  , Page(s) 33197231203575

    Abstract: Buerger's disease or thromboangiitis obliterans (TAO) is a non-atherosclerotic inflammatory arteritis strongly associated with smoking exposure. This tobacco use would expose patients to lung cancer. The French-speaking thoracic cancer intergroup ... ...

    Abstract Buerger's disease or thromboangiitis obliterans (TAO) is a non-atherosclerotic inflammatory arteritis strongly associated with smoking exposure. This tobacco use would expose patients to lung cancer. The French-speaking thoracic cancer intergroup recommends screening for lung cancer with a chest computed tomography (CT). Our study aims to evaluate lung cancer screening using chest CT during TAO. Ninety-seven TAO patients were included. The mean age of onset of TAO symptoms was 36.5 ± 10 years, and 73 (75%) were male. The mean follow-up was 8.5 ± 14 years. Overall, at least one chest CT was performed during follow-up in 32 (33%) patients. Twenty-three of the thirty-four (68%) patients who were over 50 at follow-up did not have a CT. An abnormality was found in 15 of the 32 (47%) patients who had a CT: lung nodules 6/15, lung mass 1/15, emphysema 6/15, and others 2. Two cases of lung adenocarcinoma were diagnosed. None died during 2 years follow-up. In conclusion, two-third of the TAO patients over 50 years of age did not receive the routine screening recommended in the general smoking population. Two cases of lung cancer have been diagnosed. Improving screening practices for lung cancer in this high-risk population is crucial.
    Language English
    Publishing date 2023-09-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80040-5
    ISSN 1940-1574 ; 0003-3197
    ISSN (online) 1940-1574
    ISSN 0003-3197
    DOI 10.1177/00033197231203575
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