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Article ; Online: Medication fill duration in pediatric hypertension: adherence, blood pressure control, and disparities.

McLaughlin, Meghan M / Gleber, Conrad D / Wang, Hongyue / Halterman, Jill S / Lande, Marc B

2024

Abstract: ... hypertension control. Patients with public insurance are markedly less likely to be dispensed 90-day fills ...

Abstract	Background: Medication nonadherence is a barrier to hypertension control. The Centers for Disease Control and Prevention recommends prescribing 90-day fills for maintenance medications yet antihypertensives are often dispensed as 30-day fills. Our objectives were to examine how often patients receive 30-day supplies of medication despite prescriptions for longer duration and to examine the effect of medication fill duration on adherence and hypertension control. Methods: We conducted a retrospective cohort study of pediatric patients with hypertension over a 3-year period. For each patient, days prescribed per fill were compared to days dispensed per fill using pharmacy reports and insurance claim data. Proportion of Days Covered (PDC) was calculated to estimate adherence. Hypertension control was determined by provider assessment of control and blood pressure measurement at the final visit. Results: Final cohort included 449 patients. A total of 70% had at least one prescription for ≥ 90 days but only 37% had at least one dispense for ≥ 90 days. There was no difference in the likelihood of being prescribed a 90-day fill by insurance type (public vs. private); however, patients with public insurance were less likely to be dispensed a 90-day fill (OR = 0.068, p < 0.001). Patients who received 90-day fills had better adherence (median PDC 77.5% vs. 58.1%, p < 0.001) and were more likely to have hypertension control based on provider assessment. Conclusions: Longer fill duration is associated with improved adherence and hypertension control. Patients with public insurance are markedly less likely to be dispensed 90-day fills, a modifiable barrier to improving adherence.
Language	English
Publishing date	2024-04-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	631932-4
ISSN	1432-198X ; 0931-041X
ISSN (online)	1432-198X
ISSN	0931-041X
DOI	10.1007/s00467-024-06363-z
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Article ; Online: Blood Pressure and Cognitive Function in Children and Adolescents.

Lande, Marc B / Kupferman, Juan C

Hypertension (Dallas, Tex. : 1979)

2019 Volume 73, Issue 3, Page(s) 532–540

MeSH term(s)	Adolescent ; Blood Pressure/physiology ; Child ; Cognition/physiology ; Disease Progression ; Humans ; Hypertension/physiopathology
Language	English
Publishing date	2019-01-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	423736-5
ISSN	1524-4563 ; 0194-911X ; 0362-4323
ISSN (online)	1524-4563
ISSN	0194-911X ; 0362-4323
DOI	10.1161/HYPERTENSIONAHA.118.11686
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Article: Case report and review of the literature: Successful transition from acute continuous veno-venous hemodiafiltration therapy to chronic peritoneal dialysis in a chronically ventilated child with hypoplastic left heart syndrome following fontan.

Martin, Susan D / Lande, Marc B / Kuebler, Joseph D / Cholette, Jill M

Frontiers in pediatrics

2022 Volume 10, Page(s) 1040869

Abstract: Fontan palliation depends on low pulmonary vascular resistance in order to maintain pulmonary blood flow and adequate oxygenation. This physiology results in higher central venous pressures with limited renal perfusion pressure and cardiac output. ... ...

Abstract	Fontan palliation depends on low pulmonary vascular resistance in order to maintain pulmonary blood flow and adequate oxygenation. This physiology results in higher central venous pressures with limited renal perfusion pressure and cardiac output. Positive pressure ventilation with mechanical ventilation increases intrathoracic pressure and raises central venous pressure and can further limit pulmonary and renal perfusion. Fluid removal with intermittent hemodialysis can be challenging in Fontan patients and can cause intolerable hypotension, however the increased abdominal filling pressures during peritoneal dialysis dwells can exacerbate systemic venous hypertension seen in Fontan patients and threaten adequate pulmonary blood flow and cardiac output. Successful transition to peritoneal dialysis in a chronically ventilated patient with hypoplastic left heart syndrome, end-stage renal disease and Fontan physiology has not been described. We present details outlining the successful transition across multiple modalities of renal replacement therapy to assist other teams faced with similar challenges in chronically ventilated Fontan patients with end-stage renal disease.
Language	English
Publishing date	2022-11-01
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2022.1040869
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Article ; Online: School-Based Telemedicine for Hypertension Management in Urban Adolescents.

Lande, Marc B / Herendeen, Neil E / Little, Erika / Halterman, Jill S

The Journal of adolescent health : official publication of the Society for Adolescent Medicine

2022 Volume 72, Issue 4, Page(s) 640–642

Abstract: Purpose: The aim of this study is to determine if hypertensive adolescents from impoverished neighborhoods in Rochester, New York have improved blood pressure (BP) control with the use of school-based telemedicine.: Methods: Adolescents receiving ... ...

Abstract	Purpose: The aim of this study is to determine if hypertensive adolescents from impoverished neighborhoods in Rochester, New York have improved blood pressure (BP) control with the use of school-based telemedicine. Methods: Adolescents receiving antihypertensive medication had monthly study telemedicine visits at school. BP was measured by a telehealth clinical assistant (CTA) at the school using standard procedures, followed in real time by a teleconferencing visit with the study physician. Results: Six participants were enrolled, and all completed school-based telemedicine visits prior to school closure due to the SARS-CoV-2 pandemic. Mean systolic and diastolic BP at baseline were 139 ± 5 and 75 ± 8 mmHg. All six participants had significant improvement in their blood pressure (final school mean BPs, 127 ± 4 and 67 ± 5 mmHg; systolic, baseline vs. final, p = .003). Discussion: In this pilot study, adolescents with very high levels of neighborhood disadvantage had consistent adherence with school-based telemedicine and significant improvement in hypertension (HTN) control.
MeSH term(s)	Humans ; Adolescent ; Pilot Projects ; COVID-19 ; SARS-CoV-2 ; Hypertension/drug therapy ; Antihypertensive Agents/pharmacology ; Antihypertensive Agents/therapeutic use ; Blood Pressure ; Telemedicine/methods ; Medication Adherence
Chemical Substances	Antihypertensive Agents
Language	English
Publishing date	2022-12-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1063374-1
ISSN	1879-1972 ; 1054-139X
ISSN (online)	1879-1972
ISSN	1054-139X
DOI	10.1016/j.jadohealth.2022.10.035
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Article ; Online: New American Academy of Pediatrics Hypertension Guideline.

Lande, Marc B / Batisky, Donald L

Hypertension (Dallas, Tex. : 1979)

2018 Volume 73, Issue 1, Page(s) 31–32

MeSH term(s)	Academies and Institutes ; Child ; Humans ; Hypertension ; Pediatrics ; Prevalence ; United States
Language	English
Publishing date	2018-12-20
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	423736-5
ISSN	1524-4563 ; 0194-911X ; 0362-4323
ISSN (online)	1524-4563
ISSN	0194-911X ; 0362-4323
DOI	10.1161/HYPERTENSIONAHA.118.11819
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Zs.A 1488: Show issues

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Article: Ambulatory Blood Pressure and Number of Subclinical Target Organ Injury Markers in Youth: The SHIP AHOY Study.

Hamdani, Gilad / Urbina, Elaine M / Daniels, Stephen R / Falkner, Bonita E / Ferguson, Michael A / Flynn, Joseph T / Hanevold, Coral D / Ingelfinger, Julie R / Khoury, Philip R / Lande, Marc B / Meyers, Kevin E / Samuels, Joshua / Mitsnefes, Mark

medRxiv : the preprint server for health sciences

2024

Abstract: Background: Hypertension in adolescence is associated with subclinical target organ injury (TOI). We aimed to determine whether different blood pressure (BP) thresholds were associated with increasing number of TOI markers in healthy adolescents.: ... ...

Abstract	Background: Hypertension in adolescence is associated with subclinical target organ injury (TOI). We aimed to determine whether different blood pressure (BP) thresholds were associated with increasing number of TOI markers in healthy adolescents. Methods: 244 participants (mean age 15.5±1.8 years, 60.1% male) were studied. Participants were divided based on both systolic clinic and ambulatory BP (ABP), into low- (<75 Results: 47.5% of participants had at least one TOI marker: 31.2% had one, 11.9% two, 3.7% three, and 0.8% four. The number of TOI markers increased according to the BP risk groups: the percentage of participants with more than one TOI in the low-, mid-, and high groups based on clinic BP was 6.7%, 19.1%, and 21.8% (p=0.02), and based on ABP was 9.6%, 15.8%, and 32.2% (p<0.001). In a multivariable regression analysis, both clinic BP percentile and ambulatory SBP index were independently associated with the number of TOI markers. When both clinic and ABP were included in the model, only the ambulatory SBP index was significantly associated with the number of markers. Conclusion: High SBP, especially when assessed by ABPM, was associated with an increasing number of subclinical cardiovascular injury markers in adolescents.
Language	English
Publishing date	2024-03-18
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.03.15.24304137
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Article ; Online: The Impact of Pediatric CKD on Educational and Employment Outcomes.

Harshman, Lyndsay A / Ward, Ryan C / Matheson, Matthew B / Dawson, Anne / Kogon, Amy J / Lande, Marc B / Molitor, Stephen J / Johnson, Rebecca J / Wilson, Camille / Warady, Bradley A / Furth, Susan L / Hooper, Stephen R

Kidney360

2023 Volume 4, Issue 10, Page(s) 1389–1396

MeSH term(s)	Humans ; Child ; Educational Status ; Employment ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/therapy
Language	English
Publishing date	2023-07-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	2641-7650
ISSN (online)	2641-7650
DOI	10.34067/KID.0000000000000206
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Article ; Online: Magnetic Resonance Imaging in Childhood Primary Hypertension: Potential in the Study of Cognitive Outcomes.

Uddin, Md Nasir / Tivarus, Madalina / Adams, Heather / Little, Erika / Schifitto, Giovanni / Lande, Marc B

Hypertension (Dallas, Tex. : 1979)

2021 Volume 77, Issue 3, Page(s) 751–758

Abstract: Primary hypertension in youth and young adulthood is associated with decreased neurocognitive test performance both in midlife and during youth itself, leading to concern of subsequent cognitive decline and dementia in later life. The early vascular ... ...

Abstract	Primary hypertension in youth and young adulthood is associated with decreased neurocognitive test performance both in midlife and during youth itself, leading to concern of subsequent cognitive decline and dementia in later life. The early vascular effects of hypertension in youth are likely involved in the pathogenesis of hypertensive target organ damage to the brain, but the potential impact of antihypertensive treatment from youth on subsequent cognitive health is not known. This review will highlight the need to answer the question of whether treatment of hypertension from early in life would slow cognitive decline in adulthood, and will then outline, for the nonneurologist, magnetic resonance imaging techniques potentially useful in the study of the pathogenesis of decreased cognition in hypertensive youth and for use as potential biomarkers for early antihypertensive treatment interventions.
MeSH term(s)	Adolescent ; Antihypertensive Agents/therapeutic use ; Blood Pressure/drug effects ; Blood Pressure/physiology ; Brain/diagnostic imaging ; Brain/pathology ; Child ; Cognitive Dysfunction/complications ; Cognitive Dysfunction/diagnostic imaging ; Humans ; Hypertension/complications ; Hypertension/drug therapy ; Hypertension/physiopathology ; Magnetic Resonance Imaging/methods ; Young Adult
Chemical Substances	Antihypertensive Agents
Language	English
Publishing date	2021-02-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	423736-5
ISSN	1524-4563 ; 0194-911X ; 0362-4323
ISSN (online)	1524-4563
ISSN	0194-911X ; 0362-4323
DOI	10.1161/HYPERTENSIONAHA.120.15242
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Article ; Online: Blood pressure in children with sickle cell disease is higher than in the general pediatric population.

Kupferman, Juan C / Rosenbaum, Janet E / Lande, Marc B / Stabouli, Stella / Wang, Yongsheng / Forman, Daniella / Zafeiriou, Dimitrios I / Pavlakis, Steven G

BMC pediatrics

2022 Volume 22, Issue 1, Page(s) 549

Abstract: Background: Sickle cell disease (SCD) is associated with an increased risk of cardiovascular disease that may be due to a variety of possible risk factors, including abnormal blood pressure. Blood pressure (BP) of children and adolescents with SCD has ... ...

Abstract	Background: Sickle cell disease (SCD) is associated with an increased risk of cardiovascular disease that may be due to a variety of possible risk factors, including abnormal blood pressure. Blood pressure (BP) of children and adolescents with SCD has been reported to be lower compared to the BP of the general pediatric population. Methods: To confirm this prior observation, we compared reference BP values for children with SCD with reference BP values of the general pediatric population. We hypothesized that children with SCD do not have lower BPs than children without SCD. Results: Systolic BP differed for both males and females, over the different age groups between pediatric subjects with and without SCD. Systolic BP was higher in children with SCD, in both obese and non-obese populations. Diastolic BP did not differ between the groups. Conclusions: Our analysis demonstrated that systolic BP values are indeed higher in children with SCD than in the general pediatric population. This finding is consistent with the most recent literature showing abnormal BP patterns in the SCD pediatric population utilizing 24-hour BP monitoring devices. This is an important step for recognizing abnormal BP as a risk factor for cardio- and neurovascular events in SCD.
MeSH term(s)	Adolescent ; Anemia, Sickle Cell/complications ; Blood Pressure ; Cardiovascular Diseases ; Child ; Female ; Humans ; Male ; Obesity/complications ; Risk Factors
Language	English
Publishing date	2022-09-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2041342-7
ISSN	1471-2431 ; 1471-2431
ISSN (online)	1471-2431
ISSN	1471-2431
DOI	10.1186/s12887-022-03584-9
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Article ; Online: Longitudinal changes of health-related quality of life in childhood chronic kidney disease.

Carlson, Joann / Gerson, Arlene C / Matheson, Matthew B / Manne, Sharon / Lande, Marc / Harshman, Lyndsay / Johnson, Rebecca J / Shinnar, Shlomo / Kogon, Amy J / Warady, Bradley / Furth, Susan / Hooper, Stephen

Pediatric nephrology (Berlin, Germany)

2023 Volume 38, Issue 12, Page(s) 4127–4136

Abstract: Background: Few longitudinal studies have evaluated the impact of chronic kidney disease (CKD) duration on health-related quality of life (HRQOL). The study's aim was to determine how HRQOL changes over time in childhood CKD.: Methods: Study ... ...

Abstract	Background: Few longitudinal studies have evaluated the impact of chronic kidney disease (CKD) duration on health-related quality of life (HRQOL). The study's aim was to determine how HRQOL changes over time in childhood CKD. Methods: Study participants were children in the chronic kidney disease in children (CKiD) cohort who completed the pediatric quality of life inventory (PedsQL) on three or more occasions over the course of two or more years. Generalized gamma (GG) mixed-effects models were applied to assess the effect of CKD duration on HRQOL while controlling for selected covariates. Results: A total of 692 children (median age = 11.2) with a median of 8.3 years duration of CKD were evaluated. All subjects had a GFR greater than 15 ml/min/1.73 m Conclusions: Longer duration of the disease is associated with improved HRQOL on child self-report scales; however, parent-proxy results were less likely to demonstrate any significant change over time. This divergence could be due to greater optimism and accommodation of CKD in children. Clinicians can use these data to better understand the needs of pediatric CKD patients. A higher resolution version of the Graphical abstract is available as Supplementary information.
MeSH term(s)	Child ; Humans ; Quality of Life/psychology ; Renal Insufficiency, Chronic ; Longitudinal Studies ; Emotions ; Time Factors ; Parents/psychology
Language	English
Publishing date	2023-07-10
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	631932-4
ISSN	1432-198X ; 0931-041X
ISSN (online)	1432-198X
ISSN	0931-041X
DOI	10.1007/s00467-023-06069-8
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