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  1. Article ; Online: Salt and Hypertension: 'Switch'ing the Focus to Potassium.

    Ruzicka, Marcel / Hiremath, Swapnil

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2023  Volume 83, Issue 4, Page(s) 546–548

    MeSH term(s) Humans ; Potassium ; Hypertension ; Sodium Chloride, Dietary ; Sodium Chloride ; Blood Pressure
    Chemical Substances Potassium (RWP5GA015D) ; Sodium Chloride, Dietary ; Sodium Chloride (451W47IQ8X)
    Language English
    Publishing date 2023-12-09
    Publishing country United States
    Document type Editorial
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2023.12.001
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    Zs.A 1669: Show issues Location:
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  2. Article ; Online: Blood Pressure Control Should Focus on More Potassium: Controversies in Hypertension.

    Chan, Ryan J / Parikh, Namrata / Ahmed, Sumaiya / Ruzicka, Marcel / Hiremath, Swapnil

    Hypertension (Dallas, Tex. : 1979)

    2023  Volume 81, Issue 3, Page(s) 501–509

    MeSH term(s) Humans ; Blood Pressure/physiology ; Potassium ; Hypertension/drug therapy ; Cardiovascular Diseases ; Potassium, Dietary
    Chemical Substances Potassium (RWP5GA015D) ; Potassium, Dietary
    Language English
    Publishing date 2023-08-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.123.20545
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  3. Article ; Online: Cause, Consequence or confounding? The kidney in hypertension.

    Ruzicka, Marcel / Hiremath, Swapnil

    Journal of human hypertension

    2019  Volume 33, Issue 9, Page(s) 639–640

    MeSH term(s) Blood Pressure ; Blood Pressure Determination ; Humans ; Hypertension ; Kidney ; Renal Insufficiency, Chronic
    Language English
    Publishing date 2019-04-16
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 639472-3
    ISSN 1476-5527 ; 0950-9240
    ISSN (online) 1476-5527
    ISSN 0950-9240
    DOI 10.1038/s41371-019-0199-6
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    Zs.A 2380: Show issues Location:
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  4. Article ; Online: Nonadherence Is Common in Patients With Apparent Resistant Hypertension: A Systematic Review and Meta-analysis.

    Bourque, Gabrielle / Ilin, Julius Vladimir / Ruzicka, Marcel / Hundemer, Gregory L / Shorr, Risa / Hiremath, Swapnil

    American journal of hypertension

    2023  Volume 36, Issue 7, Page(s) 394–403

    Abstract: Background: The prevalence of medication nonadherence in the setting of resistant hypertension (RH) varies from 5% to 80% in the published literature. The aim of this systematic review was to establish the overall prevalence of nonadherence and evaluate ...

    Abstract Background: The prevalence of medication nonadherence in the setting of resistant hypertension (RH) varies from 5% to 80% in the published literature. The aim of this systematic review was to establish the overall prevalence of nonadherence and evaluate the effect of the method of assessment on this estimate.
    Methods: MEDLINE, EMBASE, Cochrane, CINAHL, and Web of Science (database inception to November 2020) were searched for relevant articles. We included studies including adults with a diagnosis of RH, with some measure of adherence. Details about the method of adherence assessment were independently extracted by 2 reviewers. Pooled analysis was performed using the random effects model and heterogeneity was explored with metaregression and subgroup analyses. The main outcome measured was the pooled prevalence of nonadherence and the prevalence using direct and indirect methods of assessment.
    Results: Forty-two studies comprising 71,353 patients were included. The pooled prevalence of nonadherence was 37% (95% confidence interval [CI] 27%-47%) and lower for indirect methods (20%, 95% CI 11%-35%), than for direct methods (46%, 95% CI 40%-52%). The study-level metaregression suggested younger age and recent publication year as potential factors contributing to the heterogeneity.
    Conclusions: Indirect methods (pill counts or questionnaires) are insufficient for diagnosis of nonadherence, and report less than half the rates as direct methods (direct observed therapy or urine assays). The overall prevalence of nonadherence in apparent treatment RH is extremely high and necessitates a thorough evaluation of nonadherence in this setting.
    MeSH term(s) Adult ; Humans ; Hypertension/diagnosis ; Hypertension/drug therapy ; Hypertension/epidemiology ; Medication Adherence
    Language English
    Publishing date 2023-01-31
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639383-4
    ISSN 1941-7225 ; 1879-1905 ; 0895-7061
    ISSN (online) 1941-7225 ; 1879-1905
    ISSN 0895-7061
    DOI 10.1093/ajh/hpad013
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    Zs.A 2329: Show issues Location:
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  5. Article ; Online: Potassium and Hypertension: A State-of-the-Art Review.

    Sriperumbuduri, Sriram / Welling, Paul / Ruzicka, Marcel / Hundemer, Gregory L / Hiremath, Swapnil

    American journal of hypertension

    2023  Volume 37, Issue 2, Page(s) 91–100

    Abstract: Hypertension is the single most important and modifiable risk factor for cardiovascular morbidity and mortality worldwide. Non pharmacologic interventions, in particular dietary modifications have been established to decrease blood pressure (BP) and ... ...

    Abstract Hypertension is the single most important and modifiable risk factor for cardiovascular morbidity and mortality worldwide. Non pharmacologic interventions, in particular dietary modifications have been established to decrease blood pressure (BP) and hypertension related adverse cardiovascular events. Among those dietary modifications, sodium intake restriction dominates guidelines from professional organizations and has garnered the greatest attention from the mainstream media. Despite guidelines and media exhortations, dietary sodium intake globally has not noticeably changed over recent decades. Meanwhile, increasing dietary potassium intake has remained on the sidelines, despite similar BP-lowering effects. New research reveals a potential mechanism of action, with the elucidation of its effect on natriuresis via the potassium switch effect. Additionally, potassium-substituted salt has been shown to not only reduce BP, but also reduce the risk for stroke and cardiovascular mortality. With these data, we argue that the focus on dietary modification should shift from a sodium-focused to a sodium- and potassium-focused approach with an emphasis on intervention strategies which can easily be implemented into clinical practice.
    MeSH term(s) Humans ; Potassium ; Hypertension ; Blood Pressure ; Sodium ; Cardiovascular System ; Potassium, Dietary
    Chemical Substances Potassium (RWP5GA015D) ; Sodium (9NEZ333N27) ; Potassium, Dietary
    Language English
    Publishing date 2023-09-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639383-4
    ISSN 1941-7225 ; 1879-1905 ; 0895-7061
    ISSN (online) 1941-7225 ; 1879-1905
    ISSN 0895-7061
    DOI 10.1093/ajh/hpad094
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  6. Article ; Online: High Anion Gap Metabolic Acidosis on Continuous Renal Replacement Therapy.

    Sriperumbuduri, Sriram / Clark, Edward / Biyani, Mohan / Ruzicka, Marcel

    Kidney international reports

    2020  Volume 5, Issue 10, Page(s) 1833–1835

    Language English
    Publishing date 2020-07-23
    Publishing country United States
    Document type Case Reports
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2020.07.014
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  7. Article ; Online: Blood pressure measurement: Should technique define targets?

    Hiremath, Swapnil / Ramsay, Tim / Ruzicka, Marcel

    Journal of clinical hypertension (Greenwich, Conn.)

    2021  Volume 23, Issue 8, Page(s) 1538–1546

    Abstract: Accurate assessment of blood pressure (BP) is the cornerstone of hypertension management. The objectives of this study were to quantify the effect of medical personnel presence during BP measurement by automated oscillometric BP (AOBP) and to compare ... ...

    Abstract Accurate assessment of blood pressure (BP) is the cornerstone of hypertension management. The objectives of this study were to quantify the effect of medical personnel presence during BP measurement by automated oscillometric BP (AOBP) and to compare resting office BP by AOBP to daytime average BP by 24-h ambulatory BP monitoring (ABPM). This study is a prospective randomized cross-over trial, conducted in a referral population. Patients underwent measurements of casual and resting office BP by AOBP. Resting BP was measured as either unattended (patient alone in the room during resting and measurements) or as partially attended (nurse present in the room during measurements) immediately prior to and after 24-h ABPM. The primary outcome was the effect of unattended 5-min rest preceding AOBP assessment as the difference between casual and resting BP measured by the Omron HEM 907XL. Ninety patients consented and 78 completed the study. The mean difference between the casual and Omron unattended systolic BP was 7.0 mm Hg (95% confidence interval [CI] 4.5, 9.5). There was no significant difference between partially attended and unattended resting office systolic BP. Resting office BP (attended and partially attended) underestimated daytime systolic BP load from 24-h ABPM. The presence or absence of medical personnel does not impact casual office BP which is higher than resting office AOBP. The requirement for unattended rest may be dropped if logistically challenging. Casual and resting office BP readings by AOBP do not capture the complexity of information provided by the 24-h ABPM.
    MeSH term(s) Automation ; Blood Pressure ; Blood Pressure Determination ; Blood Pressure Monitoring, Ambulatory ; Humans ; Hypertension/diagnosis ; Prospective Studies
    Language English
    Publishing date 2021-07-16
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2077222-1
    ISSN 1751-7176 ; 1524-6175
    ISSN (online) 1751-7176
    ISSN 1524-6175
    DOI 10.1111/jch.14324
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    Zs.A 5723: Show issues Location:
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  8. Article ; Online: Acute Severe Renal Artery Stenosis Presenting as Acute Kidney Injury With Severe Hypertension and Active Urine Sediment.

    Jegatheswaran, Januvi / Hadziomerovic, Adnan / Ruzicka, Marcel

    The Canadian journal of cardiology

    2021  Volume 37, Issue 10, Page(s) 1671–1673

    Abstract: We present a case of severe renal artery stenosis that mimicked rapidly progressive glomerulonephritis with acute kidney injury, active urine sediments, and severe hypertension. Simultaneous presence of secondary hyperaldosteronism and hypokalemia ... ...

    Abstract We present a case of severe renal artery stenosis that mimicked rapidly progressive glomerulonephritis with acute kidney injury, active urine sediments, and severe hypertension. Simultaneous presence of secondary hyperaldosteronism and hypokalemia prompted renal angiography and subsequent renal artery angioplasty and stenting, leading to rapid resolution of acute kidney injury, proteinuria, and hypertension. This case emphasises the importance and benefits of prompt diagnosis and revascularisation of acute severe renal artery stenosis in a patient with history of atherosclerotic renovascular disease presenting with sudden onset of severe hypertension and acute kidney injury with active urine sediment mimicking rapidly progressive glomerulonephritis.
    MeSH term(s) Acute Kidney Injury/diagnosis ; Acute Kidney Injury/etiology ; Acute Kidney Injury/urine ; Aged ; Angioplasty/methods ; Biomarkers/urine ; Blood Pressure/physiology ; Blood Vessel Prosthesis Implantation/methods ; Computed Tomography Angiography ; Diagnosis, Differential ; Female ; Glomerulonephritis/diagnosis ; Humans ; Hypertension/diagnosis ; Hypertension/etiology ; Hypertension/physiopathology ; Kidney/diagnostic imaging ; Renal Artery/diagnostic imaging ; Renal Artery/surgery ; Renal Artery Obstruction/complications ; Renal Artery Obstruction/diagnosis ; Renal Artery Obstruction/surgery ; Severity of Illness Index ; Stents ; Ultrasonography
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-04-20
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2021.04.008
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  9. Article ; Online: Page kidney: Rare cause of acute kidney injury after complicated renal artery angioplasty.

    Douvris, Adrianna / Jegatheswaran, Januvi / Hadziomerovic, Adnan / Ruzicka, Marcel

    Journal of clinical hypertension (Greenwich, Conn.)

    2021  Volume 23, Issue 8, Page(s) 1631–1633

    Abstract: The authors present a case of a patient who experienced a rare complication after attempted renal angioplasty and stenting, Page kidney. This patient presented with new onset hypertension secondary to bilateral renal artery stenosis and was referred for ... ...

    Abstract The authors present a case of a patient who experienced a rare complication after attempted renal angioplasty and stenting, Page kidney. This patient presented with new onset hypertension secondary to bilateral renal artery stenosis and was referred for revascularization given hypertension refractory to medical management. The right renal artery underwent successful angioplasty and stenting; however, the left renal artery experienced recoil stenosis. Post-procedure the patient developed acute kidney injury secondary to Page kidney from subcapsular and extracapsular hematoma. This was managed conservatively with transfusions and the hematoma and acute kidney injury self-resolved over the next 4 months. This case highlights the importance of revascularization for refractory hypertension secondary to hemodynamically significant bilateral renal artery stenosis, the rare complication of Page kidney with attempted revascularization of renal artery stenosis and the involvement of a hypertension specialist in the decision of revascularization of renal artery stenosis.
    MeSH term(s) Acute Kidney Injury/diagnosis ; Acute Kidney Injury/etiology ; Acute Kidney Injury/therapy ; Angioplasty/adverse effects ; Angioplasty, Balloon/adverse effects ; Humans ; Hypertension/etiology ; Kidney ; Renal Artery/diagnostic imaging ; Renal Artery Obstruction/diagnostic imaging ; Renal Artery Obstruction/etiology ; Stents/adverse effects
    Language English
    Publishing date 2021-07-03
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2077222-1
    ISSN 1751-7176 ; 1524-6175
    ISSN (online) 1751-7176
    ISSN 1524-6175
    DOI 10.1111/jch.14318
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    Zs.A 5723: Show issues Location:
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  10. Article ; Online: Behind the Mask.

    Ruzicka, Marcel / Hiremath, Swapnil

    Hypertension (Dallas, Tex. : 1979)

    2018  Volume 72, Issue 4, Page(s) 841–842

    MeSH term(s) Blood Pressure ; Blood Pressure Determination ; Humans ; Renal Insufficiency, Chronic
    Language English
    Publishing date 2018-11-08
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.118.11681
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